Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum

Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitrobiological activity of four of the compounds on the Plasmodium falciparumchloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration

Dynamics of the attractive 1D Bose gas: analytical treatment from integrability

The physics of the attractive one-dimensional Bose gas (Lieb-Liniger model) is investigated with techniques based on the integrability of the system. Combining a knowledge of particle quasi-momenta to exponential precision in the system size with determinant representations of matrix elements of local operators coming from the Algebraic Bethe Ansatz, we obtain rather general analytical results for the zero-temperature dynamical correlation functions of the density and field operators. Our results thus provide quantitative predictions for possible future experiments in atomic gases or optical waveguides.Comment: 26 pages, 5 figure

Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH

Advances in light-sheet and confocal microscopy now allow imaging of cleared large biological tissue samples and enable the 3D appreciation of cell and protein localization in their native organ environment. However, the sample preparations for such imaging are often onerous, and their capability for antigen detection is limited. Here, we describe FLASH (fast light-microscopic analysis of antibody-stained whole organs), a simple, rapid, fully customizable technique for molecular phenotyping of intact tissue volumes. FLASH utilizes non-degradative epitope recovery and membrane solubilization to enable the detection of a multitude of membranous, cytoplasmic and nuclear antigens in whole mouse organs and embryos, human biopsies, organoids and Drosophila. Retrieval and immunolabeling of epithelial markers, an obstacle for previous clearing techniques, can be achieved with FLASH. Upon volumetric imaging, FLASH-processed samples preserve their architecture and integrity and can be paraffin-embedded for subsequent histopathological analysis. The technique can be performed by scientists trained in light microscopy and yields results in <1 week

Applied Personality Assessment: A 'Cronbachian' Perspective in Open Peer Commentary and Author's Response

Lievens's proposal that personality psychology would benefit from using applied tools of assessment—situation judgement tests and assessment centre exercises—was appropriate, especially as these tools focus on real-world criteria in high-stakes situations. Their use would help to integrate (specific) situationally influenced intra-individual differences (variability) and (general) inter-individual differences (diversity). Lievens's proposal also raised a broader issue: each assessment tool yields unique information, and together they have potential to provide a truly comprehensive model of personality based on the ‘Cronbachian’ perspective that has, so far, not been realized. Copyright © 2017 European Association of Personality Psycholog

Posttraumatic growth as positive personality change: evidence, controversies and future directions

This target article focuses on the construct of post-traumatic growth—positive psychological change experienced as a result of the struggle with highly challenging life circumstances. Prominent theories of post-traumatic growth define it in terms of personality change, and as a result, this area of research should be of great interest to personality psychologists. Despite this fact, most of the research on this topic has not been sufficiently informed by relevant research in personality psychology, and much of the extant research suffers from significant methodological limitations. We review the literature on post-traumatic growth, with a particular focus on how researchers have conceptualized it and the specific methodological issues associated with these conceptualizations. We outline some ways in which personality science can both be enriched by the study of this phenomenon and inform rigorous research on post-traumatic growth and provide a series of guidelines for future research of post-traumatic growth as positive personality change

Post-traumatic growth in mental health recovery: qualitative study of narratives.

OBJECTIVES: Post-traumatic growth, defined as positive psychological change experienced as a result of the struggle with challenging life circumstances, is under-researched in people with mental health problems. The aim of this study was to develop a conceptual framework for post-traumatic growth in the context of recovery for people with psychosis and other severe mental health problems. DESIGN: Qualitative thematic analysis of cross-sectional semi-structured interviews about personal experiences of mental health recovery. SETTING: England. PARTICIPANTS: Participants were adults aged over 18 and: (1) living with psychosis and not using mental health services (n=21); (2) using mental health services and from black and minority ethnic communities (n=21); (3) underserved, operationalised as lesbian, gay, bisexual and transgender community or complex needs or rural community (n=19); or (4) employed in peer roles using their lived experience with others (n=16). The 77 participants comprised 42 (55%) female and 44 (57%) white British. RESULTS: Components of post-traumatic growth were present in 64 (83%) of recovery narratives. Six superordinate categories were identified, consistent with a view that post-traumatic growth involves learning about oneself (self-discovery) leading to a new sense of who one is (sense of self) and appreciation of life (life perspective). Observable positively valued changes comprise a greater focus on self-management (well-being) and more importance being attached to relationships (relationships) and spiritual or religious engagement (spirituality). Categories are non-ordered and individuals may start from any point in this process. CONCLUSIONS: Post-traumatic growth is often part of mental health recovery. Changes are compatible with research about growth following trauma, but with more emphasis on self-discovery, integration of illness-related experiences and active self-management of well-being. Trauma-related growth may be a preferable term for participants who identify as having experienced trauma. Trauma-informed mental healthcare could use the six identified categories as a basis for new approaches to supporting recovery. TRIAL REGISTRATION NUMBER: ISRCTN11152837

Irregular breakfast eating and health status among adolescents in Taiwan

BACKGROUND: Regular breakfast eating (RBE) is an important contributor to a healthy lifestyle and health status. The aims of the present study were to evaluate the relationships among irregular breakfast eating (IRBE), health status, and health promoting behavior (HPB) for Taiwanese adolescents. METHODS: A cross-sectional, descriptive design was used to investigate a cluster sample of 1609 (7(th )-12(th )grade) adolescents located in the metropolitan Tao-Yuan area during the 2005 academic year. The main variables comprised breakfast eating pattern, body weight, and health promoting behaviors. Data were collected by a self-administered questionnaire. RESULTS: A total of 1609 participants were studied, 64.1% in junior high school and 35.9% in high school, boys (47.1%) and girls (52.9%) ranging in age from 12–20 years. Of the total participant population, 28.8% were overweight and nearly one quarter (23.6%) reported eating breakfast irregularly during schooldays. The findings indicated that adolescents with RBE had a lower risk of overweight (OR for IRBE vs. RBE = 1.51, 95% CI: 1.12, 2.04), and that the odds of becoming overweight were 51% greater for IRBE than for RBE even after controlling for demographical and HPB variables. IRBE also was a strong indicator for HPB. However, the profile of the high-risk IRBE group was predominantly junior high schoolchildren and/or children living without both parents. CONCLUSION: This study provides valuable information about irregular breakfast eating among adolescents, which is associated with being overweight and with a low frequency of health promoting behavior. School and family health promotion strategies should be used to encourage all adolescents to eat breakfast regularly