Wheeler DeWitt States of a Charged AdS4_4 Black Hole

We solve the Wheeler DeWitt equation for the planar Reissner-Nordstr\"om-AdS black hole in a minisuperspace approximation. We construct semiclassical Wheeler DeWitt states from Gaussian wavepackets that are peaked on classical black hole interior solutions. By using the metric component $g_{xx}$ as a clock, these states are evolved through both the exterior and interior horizons. Close to the singularity, we show that quantum fluctuations in the wavepacket become important, and therefore the classicality of the minisuperspace approximation breaks down. Towards the AdS boundary, the Wheeler DeWitt states are used to recover the Lorentzian partition function of the dual theory living on this boundary. This partition function is specified by an energy and a charge. Finally, we show that the Wheeler DeWitt states know about the black hole thermodynamics, recovering the grand canonical thermodynamic potential after an appropriate averaging at the black hole horizon.Comment: 28 pages with references, 1 figur

A Mild Hydration of Nitriles Catalysed by Copper (ll) Acetate

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields

A perturbative model for the feedback cooling of finite temperature Bose gases

Ultra-cold atomic gases are an ideal platform for precision measurement devices and analogue quantum simulators, which will prove instrumental in unlocking the secrets of quantum gravity and high-temperature superconductivity. However, current experimental techniques cannot cool atomic gases to simulatenously both the low entropies and high particle numbers necessary for these applications. A promising alternative is feedback cooling: using continuous-measurement feedback control to damp out energy fluctuations and cool a gas. So far, feedback cooling has been primarily studied at zero temperature, with the only finite temperature simulation achieved via a computationally expensive numerical method restricted to bosons. This thesis develops a perturbative model for the feedback cooling of a finite temperature condensed Bose gas using Bogoliubov theory, with the aim of deriving dynamic equations for the system that are both analytically tractable, and allow for fast numerical prototyping of new feedback control schemes. Using the measurement-feedback model of Szigeti \textit{et al.} \cite{szigeti_continuous_2009,szigeti_feedback_2010}, we derive a low temperature perturbative model for feedback cooling of a Bose gas in an arbitrary trapping and control potential. Using this general model, we then derive a model for the dynamics of a Bose gas in a hard box trap being cooled with an energy damping control. We complete preliminary simulations of this model in the no-backaction conditional measurement limit, damping out density fluctuations in a gas of $90\%$ condensate fraction and cooling it to $93.5 \pm 1\%$. We find that, in this limit, the dynamics of the gas are largely independent of number but significantly depend on the inter-particle interaction. We also find an optimal energy damping control strength in this limit. However, our model is not very efficient for simulation, particularly for a large number of particles and measurement strength. As an alternative, we propose an approximation scheme in which steady-state analytic solutions could be obtained from the model. Finally, we propose two methods to develop a Bogoliubov model for the feedback cooling of fermions, which would be the first finite temperature model for the Fermi gas case

Distinct NAD(P)H binding configurations revealed by fluorescence lifetime, anisotropy and polarised two-photon absorption

NADH and NADPH play key roles in the regulation of metabolism. Their endogenous fluorescence is sensitive to enzyme binding, allowing changes in cellular metabolic state to be determined using fluorescence lifetime imaging microscopy (FLIM). However, to fully uncover the underlying biochemistry, the relationships between their fluorescence and binding dynamics require greater understanding. Here we accomplish this through time- and polarisation-resolved fluorescence and polarised two-photon absorption measurements. Two lifetimes result from binding of both NADH to lactate dehydrogenase and NADPH to isocitrate dehydrogenase. The composite fluorescence anisotropy indicates the shorter (1.3-1.6ns) decay component to be accompanied by local motion of the nicotinamide ring, pointing to attachment solely via the adenine moiety. For the longer lifetime (3.2-4.4ns), the nicotinamide conformational freedom is found to be fully restricted. As full and partial nicotinamide binding are recognised steps in dehydrogenase catalysis, our results unify photophysical, structural and functional aspects of NADH and NADPH binding and clarify the biochemical processes that underlie their contrasting intracellular lifetimes

Quantifying the Role of Adverse Events in the Mortality Difference between First and Second-Generation Antipsychotics in Older Adults: Systematic Review and Meta-Synthesis

Background: Observational studies have reported higher mortality among older adults treated with first-generation antipsychotics (FGAs) versus second-generation antipsychotics (SGAs). A few studies examined risk for medical events, including stroke, ventricular arrhythmia, venous thromboembolism, myocardial infarction, pneumonia, and hip fracture. Objectives: 1) Review robust epidemiologic evidence comparing mortality and medical event risk between FGAs and SGAs in older adults; 2) Quantify how much these medical events explain the observed mortality difference between FGAs and SGAs. Data sources Pubmed and Science Citation Index. Study eligibility criteria, participants, and interventions Studies of antipsychotic users that: 1) evaluated mortality or medical events specified above; 2) restricted to populations with a mean age of 65 years or older 3) compared FGAs to SGAs, or both to a non-user group; (4) employed a “new user” design; (5) adjusted for confounders assessed prior to antipsychotic initiation; (6) and did not require survival after antipsychotic initiation. A separate search was performed for mortality estimates associated with the specified medical events. Study appraisal and synthesis methods For each medical event, we used a non-parametric model to estimate lower and upper bounds for the proportion of the mortality difference—comparing FGAs to SGAs—mediated by their difference in risk for the medical event. Results: We provide a brief, updated summary of the included studies and the biological plausibility of these mechanisms. Of the 1122 unique citations retrieved, we reviewed 20 observational cohort studies that reported 28 associations. We identified hip fracture, stroke, myocardial infarction, and ventricular arrhythmias as potential intermediaries on the causal pathway from antipsychotic type to death. However, these events did not appear to explain the entire mortality difference. Conclusions: The current literature suggests that hip fracture, stroke, myocardial infarction, and ventricular arrhythmias partially explain the mortality difference between SGAs and FGAs

GJ 9404 b:A Confirmed Eccentric Planet, and not a Candidate

Eccentric orbits can be decomposed into a series of sine curves which affects how the false alarm probability is computed when using traditional periodograms on radial-velocity data. Here we show that a candidate exoplanet orbiting the M dwarf GJ 9404, identified by the HADES survey using data from the HARPS-N spectrograph, is in fact a bona-fide planet on a highly eccentric orbit. Far from a candidate, GJ 9404 b is detected with a high confidence. We reach our conclusion using two methods that assume Keplerian functions rather than sines to compute a detection probability, a Bayes Factor, and the FIP periodogram. We compute these using nested sampling with {\tt kima}.Comment: 3 pages, 1 figur

Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke

<p>Abstract</p> <p>Background</p> <p>Vascular dysfunction and brain inflammation are thought to contribute to the pathophysiology of cerebral injury in acute stroke. However acute inflammation and vascular dysfunction may simply be markers of an acute phase response to cerebral injury, reflecting the size of the cerebral lesion. We aimed to determine if systemic markers of vascular dysfunction and inflammation are independently associated with concentrations of the astroglial protein S100B, a marker of brain injury, in participants with acute ischaemic stroke.</p> <p>Methods</p> <p>Fifty-seven men and women recruited within 96 hours of acute ischaemic stroke at two tertiary hospitals participated in this cross sectional observational study. Clinical, imaging (stroke lesions area measured with perfusion CT) and laboratory data were the independent variables and co-variates. The outcome variable was serum S100B concentration, analysed by multivariate regression.</p> <p>Results</p> <p>High sensitivity-CRP (<it>B </it>= 0.41) and lesion area (<it>B </it>= 0.69) were independently associated with S100B concentration (R²= 0.75, p < 0.01). Other variables with significant univariate associations with S100B concentration were not independently associated with S100B concentration in the final multivariate model.</p> <p>Conclusion</p> <p>The degree of systemic inflammation is associated with S100B concentration in acute ischaemic stroke, independent of the size of the ischaemic lesion.</p

Infiltrated carbon foam composites

An infiltrated carbon foam composite and method for making the composite is described. The infiltrated carbon foam composite may include a carbonized carbon aerogel in cells of a carbon foam body and a resin is infiltrated into the carbon foam body filling the cells of the carbon foam body and spaces around the carbonized carbon aerogel. The infiltrated carbon foam composites may be useful for mid-density ablative thermal protection systems

Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study

BACKGROUND Acute ischaemic stroke is associated with alteration in systemic markers of vascular function. We measured forearm vascular function (using forearm flow mediated dilatation) to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function. METHODS Prospective case control study enrolling 17 patients with recent acute ischaemic stroke/TIA and 17 sex matched controls with stroke more than two years previously. Forearm vascular function was measured using flow medicated dilatation (FMD). RESULTS Flow mediated dilatation was 6.0 ± 1.1% in acute stroke/TIA patients and 4.7 ± 1.0% among control subjects (p = 0.18). The mean paired difference in FMD between subjects with recent acute stroke and controls was 1.25% (95% CI -0.65, 3.14; p = 0.18). Endothelium independent dilatation was measured in six pairs of participants and was similar in acute stroke/TIA patients (22.6 ± 4.3%) and control subjects (19.1 ± 2.6%; p = 0.43). CONCLUSIONS Despite the small size of this study, these data indicate that recent acute stroke is not necessarily associated with a clinically important reduction in FMD.This study was funded by the Centre for Training in Clinical Cerebrovascular and Cardiovascular Research, a National Health and Medical Research Council funded Centre of Clinical Research Excellence