1,147 research outputs found
Development of a cell population migration assay
Cellular migration is central to many physiological and pathological processes, from wound healing and the immune response to cancer cell invasion. Many in-vitro assays have been developed to study these processes and can be classified by the nature of the assay, for example migration of single cells or entire populations, as well as migration on a planar surface or through a 3D structure. This work concerns the development of an assay to study the migration of whole populations of cells across a deformable planar substratum, which may be coated in adsorbed adhesion molecules. The technique detailed below was developed from the Teflon fence assay
Surface modification of a polyether-urethane with RGD-containing peptides for enhanced cell attachment and signalling
Abstract of article examining the chemical modification of polyurethane with RGD-containing peptides offers a means of encouraging the adhesion, spreading and proliferation of cells cultured on its surface. This study assesses the efficacy of a modification procedure using surface analysis techniques and preliminary cell culture studies
Exact Study of the Effect of Level Statistics in Ultrasmall Superconducting Grains
The reduced BCS model that is commonly used for ultrasmall superconducting
grains has an exact solution worked out long ago by Richardson in the context
of nuclear physics. We use it to check the quality of previous treatments of
this model, and to investigate the effect of level statistics on pairing
correlations. We find that the ground state energies are on average somewhat
lower for systems with non-uniform than uniform level spacings, but both have
an equally smooth crossover from the bulk to the few-electron regime. In the
latter, statistical fluctuations in ground state energies strongly depend on
the grain's electron number parity.Comment: 4 pages, 3 eps figs, RevTe
Reduced planning efforts:Identification of rural potentials in selected key regions of Ratnapura
3D reconstruction of the fundus of a phantom eye through stereo imaging of slit lamp images
In the detection of glaucoma, the second leading cause of blindness worldwide, the alteration of the optic disc's morphology is a key clinical indicator. The current gold standard test, stereo funduscopy using stereo fundus cameras, is subjective. Quantitative devices exist but are prohibitively expensive. Work carried out elsewhere has demonstrated quantitative results from stereo matching fundus camera images. Building on this idea, the slit lamp microscope (a mainstay of eye diagnostics, present in practically all ophthalmology and optometry practices) has the potential to be used as a quantitative device. This study explored the feasibility of uncalibrated 3D reconstructions of retinal structures of a phantom eye's fundus using a slit lamp
Disordered Hubbard Model with Attraction: Coupling Energy of Cooper Pairs in Small Clusters
We generalize the Cooper problem to the case of many interacting particles in
the vicinity of the Fermi level in the presence of disorder. On the basis of
this approach we study numerically the variation of the pair coupling energy in
small clusters as a function of disorder. We show that the Cooper pair energy
is strongly enhanced by disorder, which at the same time leads to the
localization of pairs.Comment: revtex, 5 pages, 6 figure
Generation of analytic semigroups and domain characterization for degenerate elliptic operators with unbounded coefficients arising in financial mathematics. II.
Ultra-cold atoms in an optical cavity: two-mode laser locking to the cavity avoiding radiation pressure
The combination of ultra-cold atomic clouds with the light fields of optical
cavities provides a powerful model system for the development of new types of
laser cooling and for studying cooperative phenomena. These experiments
critically depend on the precise tuning of an incident pump laser with respect
to a cavity resonance. Here, we present a simple and reliable experimental
tuning scheme based on a two-mode laser spectrometer. The scheme uses a first
laser for probing higher-order transversal modes of the cavity having an
intensity minimum near the cavity's optical axis, where the atoms are confined
by a magnetic trap. In this way the cavity resonance is observed without
exposing the atoms to unwanted radiation pressure. A second laser, which is
phase-locked to the first one and tuned close to a fundamental cavity mode
drives the coherent atom-field dynamics.Comment: 7 pages, 7 figure
Mesoscopic interplay of superconductivity and ferromagnetism in ultra-small metallic grains
We review the effects of electron-electron interactions on the ground-state
spin and the transport properties of ultra-small chaotic metallic grains. Our
studies are based on an effective Hamiltonian that combines a superconducting
BCS-like term and a ferromagnetic Stoner-like term. Such terms originate in
pairing and spin exchange correlations, respectively. This description is valid
in the limit of a large dimensionless Thouless conductance. We present the
ground-state phase diagram in the fluctuation-dominated regime where the
single-particle mean level spacing is comparable to the bulk BCS pairing gap.
This phase diagram contains a regime in which pairing and spin exchange
correlations coexist in the ground-state wave function. We discuss the
calculation of the tunneling conductance for an almost-isolated grain in the
Coulomb-blockade regime, and present measurable signatures of the competition
between superconductivity and ferromagnetism in the mesoscopic fluctuations of
the conductance.Comment: 6 pages, 3 figures, To be published in the proceedings of the NATO
Advance Research Workshop "Recent Advances in Nonlinear Dynamics and Complex
System Physics.
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