Low- and high-frequency noise from coherent two-level systems

Recent experiments indicate a connection between the low- and high-frequency noise affecting superconducting quantum systems. We explore the possibilities that both noises can be produced by one ensemble of microscopic modes, made up, e.g., by sufficiently coherent two-level systems (TLS). This implies a relation between the noise power in different frequency domains, which depends on the distribution of the parameters of the TLSs. We show that a distribution, natural for tunneling TLSs, with a log-uniform distribution in the tunnel splitting and linear distribution in the bias, accounts for experimental observations.Comment: minor corrections, references adde

Wind tunnel investigation of an oblique wing transport model at mach numbers between 0.6 and 1.4

Models of three practical oblique-wing transport configurations were tested in the NASA Ames 11 foot wind tunnel. The three configurations used a common forward fuselage, wing, and support system but employed different aft fuselage sections simulating alternate propulsion system installations. These included an integrated propulsion system, pylon-mounted nacelles, and clean (no propulsion system) configuration. The tests were conducted over a Mach number range from 0.6 to 1.4 and at sweep angles from 0 to 60 degrees. The nominal unit Reynolds number was 1.83 million per meter and the angle of attack range was -3 to +6 degrees. The models were mounted in the tunnel by means of a lower blade support system. The interference effects of this lower blade and the flow inclination were determined by using an image blade system and testing the configuration in both the upright and inverted positions

Dynamic scaling approach to study time series fluctuations

We propose a new approach for properly analyzing stochastic time series by mapping the dynamics of time series fluctuations onto a suitable nonequilibrium surface-growth problem. In this framework, the fluctuation sampling time interval plays the role of time variable, whereas the physical time is treated as the analog of spatial variable. In this way we found that the fluctuations of many real-world time series satisfy the analog of the Family-Viscek dynamic scaling ansatz. This finding permits to use the powerful tools of kinetic roughening theory to classify, model, and forecast the fluctuations of real-world time series.Comment: 25 pages, 7 figures, 1 tabl

Teachers' classroom feedback: still trying to get it right

This article examines feedback traditionally given by teachers in schools. Such feedback tends to focus on children's acquisition and retrieval of externally prescribed knowledge which is then assessed against mandated tests. It suggests that, from a sociocultural learning perspective, feedback directed towards such objectives may limit children's social development. In this article, I draw on observation and interview data gathered from a group of 27 9- to 10-year olds in a UK primary school. These data illustrate the children's perceived need to conform to, rather than negotiate, the teacher's feedback comments. They highlight the children's sense that the teacher's feedback relates to school learning but not to their own interests. The article also includes alternative examples of feedback which draw on children's own inquiries and which relate to the social contexts within which, and for whom, they act. It concludes by suggesting that instead of looking for the right answer to the question of what makes teachers' feedback effective in our current classrooms, a more productive question might be how a negotiation can be opened up among teachers and learners themselves, about how teachers' feedback could support children's learning most appropriately

Dynamic Critical Behavior of a Swendsen-Wang-Type Algorithm for the Ashkin-Teller Model

We study the dynamic critical behavior of a Swendsen-Wang-type algorithm for the Ashkin--Teller model. We find that the Li--Sokal bound on the autocorrelation time ($\tau_{{\rm int},{\cal E}} \ge {\rm const} \times C_H$) holds along the self-dual curve of the symmetric Ashkin--Teller model, and is almost but not quite sharp. The ratio $\tau_{{\rm int},{\cal E}} / C_H$ appears to tend to infinity either as a logarithm or as a small power ($0.05 \leq p \leq 0.12$). In an appendix we discuss the problem of extracting estimates of the exponential autocorrelation time.Comment: 59 pages including 3 figures, uuencoded g-compressed ps file. Postscript size = 799740 byte

Some New Results on Complex-Temperature Singularities in Potts Models on the Square Lattice

We report some new results on the complex-temperature (CT) singularities of $q$-state Potts models on the square lattice. We concentrate on the problematic region $Re(a) < 0$ (where $a=e^K$) in which CT zeros of the partition function are sensitive to finite lattice artifacts. From analyses of low-temperature series expansions for $3 \le q \le 8$, we establish the existence, in this region, of complex-conjugate CT singularities at which the magnetization and susceptibility diverge. From calculations of zeros of the partition function, we obtain evidence consistent with the inference that these singularities occur at endpoints $a_e, \ a_e^*$ of arcs protruding into the (complex-temperature extension of the) FM phase. Exponents for these singularities are determined; e.g., for $q=3$, we find $\beta_e=-0.125(1)$, consistent with $\beta_e=-1/8$. By duality, these results also imply associated arcs extending to the (CT extension of the) symmetric PM phase. Analytic expressions are suggested for the positions of some of these singularities; e.g., for $q=5$, our finding is consistent with the exact value $a_e,a_e^*=2(-1 \mp i)$. Further discussions of complex-temperature phase diagrams are given.Comment: 26 pages, latex, with eight epsf figure

PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G(+) -Toxins

Gram positive (G(+)) infections make up similar to 50% of all acute lung injury cases which are characterized by extensive permeability edema secondary to disruption of endothelial cell (EC) barrier integrity. A primary cause of increased permeability are cholesterol-dependent cytolysins (CDCs) of G(+)-bacteria, such as pneumolysin (PLY) and listeriolysin-O (LLO) which create plasma membrane pores, promoting Ca2+-influx and activation of PKC alpha. In human lung microvascular endothelial cells (HLMVEC), pretreatment with the nitric oxide synthase (NOS) inhibitor, ETU reduced the ability of LLO to increase microvascular cell permeability suggesting an endothelial nitric oxide synthase (eNOS)-dependent mechanism. LLO stimulated superoxide production from HLMVEC and this was prevented by silencing PKC alpha or NOS inhibition suggesting a link between these pathways. Both LLO and PLY stimulated eNOS T495 phosphorylation in a PKC-dependent manner. Expression of a phosphomimetic T495D eNOS (human isoform) resulted in increased superoxide and diminished nitric oxide (NO) production. Transduction of HLMVEC with an active form of PKC alpha resulted in the robust phosphorylation of T495 and increased peroxynitrite production, indicative of eNOS uncoupling. To determine the mechanisms underlying eNOS uncoupling, HLMVEC were stimulated with LLO and the amount of hsp90 and caveolin-1 bound to eNOS determined. LLO stimulated the dissociation of hsp90, and in particular, caveolin-1 from eNOS. Both hsp90 and caveolin-1 have been shown to influence eNOS uncoupling and a peptide mimicking the scaffolding domain of caveolin-1 blocked the ability of PKC alpha to stimulate eNOS-derived superoxide. Collectively, these results suggest that the G(+) pore-forming toxins promote increased EC permeability via activation of PKC alpha, phosphorylation of eNOS-T495, loss of hsp90 and caveolin-1 binding which collectively promote eNOS uncoupling and the production of barrier disruptive superoxide

Phage Orf family recombinases:conservation of activities and involvement of the central channel in DNA binding

Genetic and biochemical evidence suggests that λ Orf is a recombination mediator, promoting nucleation of either bacterial RecA or phage Redβ recombinases onto single-stranded DNA (ssDNA) bound by SSB protein. We have identified a diverse family of Orf proteins that includes representatives implicated in DNA base flipping and those fused to an HNH endonuclease domain. To confirm a functional relationship with the Orf family, a distantly-related homolog, YbcN, from Escherichia coli cryptic prophage DLP12 was purified and characterized. As with its λ relative, YbcN showed a preference for binding ssDNA over duplex. Neither Orf nor YbcN displayed a significant preference for duplex DNA containing mismatches or 1-3 nucleotide bulges. YbcN also bound E. coli SSB, although unlike Orf, it failed to associate with an SSB mutant lacking the flexible C-terminal tail involved in coordinating heterologous protein-protein interactions. Residues conserved in the Orf family that flank the central cavity in the λ Orf crystal structure were targeted for mutagenesis to help determine the mode of DNA binding. Several of these mutant proteins showed significant defects in DNA binding consistent with the central aperture being important for substrate recognition. The widespread conservation of Orf-like proteins highlights the importance of targeting SSB coated ssDNA during lambdoid phage recombination

Structure and Evolution of Nearby Stars with Planets. I. Short-Period Systems

Using the Yale stellar evolution code, we have calculated theoretical models for nearby stars with planetary-mass companions in short-period nearly circular orbits: 51 Pegasi, Tau Bootis, Upsilon Andromedae, Rho Cancri, and Rho Coronae Borealis. We present tables listing key stellar parameters such as mass, radius, age, and size of the convective envelope as a function of the observable parameters (luminosity, effective temperature, and metallicity), as well as the unknown helium fraction. For each star we construct best models based on recently published spectroscopic data and the present understanding of galactic chemical evolution. We discuss our results in the context of planet formation theory, and, in particular, tidal dissipation effects and stellar metallicity enhancements.Comment: 48 pages including 13 tables and 5 figures, to appear in Ap