Congenital Cytomegalovirus Infection: A Narrative Review of the Issues in Screening and Management From a Panel of European Experts.

Maternal primary and non-primary cytomegalovirus (CMV) infection during pregnancy can result in in utero transmission to the developing fetus. Congenital CMV (cCMV) can result in significant morbidity, mortality or long-term sequelae, including sensorineural hearing loss, the most common sequela. As a leading cause of congenital infections worldwide, cCMV infection meets many of the criteria for screening. However, currently there are no universal programs that offer maternal or neonatal screening to identify infected mothers and infants, no vaccines to prevent infection, and no efficacious and safe therapies available for the treatment of maternal or fetal CMV infection. Data has shown that there are several maternal and neonatal screening strategies, and diagnostic methodologies, that allow the identification of those at risk of developing sequelae and adequately detect cCMV. Nevertheless, many questions remain unanswered in this field. Well-designed clinical trials to address several facets of CMV treatment (in pregnant women, CMV-infected fetuses and both symptomatic and asymptomatic neonates and children) are required. Prevention (vaccines), biology and transmission factors associated with non-primary CMV, and the cost-effectiveness of universal screening, all demand further exploration to fully realize the ultimate goal of preventing cCMV. In the meantime, prevention of primary infection during pregnancy should be championed to all by means of hygiene education

Evidence for intermediate-age stellar populations in early-type galaxies from K-band spectroscopy

The study of stellar populations in early-type galaxies in different environments is a powerful tool for constraining their star formation histories. This study has been traditionally restricted to the optical range, where dwarfs around the turn-off and stars at the base of the RGB dominate the integrated light at all ages. The near-infrared spectral range is especially interesting since in the presence of an intermediate-age population, AGB stars are the main contributors. In this letter, we measure the near-infrared indices NaI and D$_{\rm CO}$ for a sample of 12 early-type galaxies in low density environments and compare them with the Fornax galaxy sample presented by Silva et al. (2008). The analysis of these indices in combination with Lick/IDS indices in the optical range reveals i) the NaI index is a metallicity indicator as good as C4668 in the optical range, and ii) D$_{\rm CO}$ is a tracer of intermediate-age stellar populations. We find that low-mass galaxies in low density environments show higher NaI and D$_{\rm CO}$ than those located in Fornax cluster, which points towards a late stage of star formation for the galaxies in less dense environments, in agreement with results from other studies using independent methods.Comment: 7 pages, 3 figures, accepted for publication in ApJ

Distribution of Greenland Halibut and By-catch Species that Overlap the 200-mile Limit Spatially and in Relation to Depth – Effect of Depth Restrictions in the Fishery. Distribution of the Fishable Biomass of the Main Commercial Species of Fish in Relation to Depth

It is thought that measures currently in operation in the NAFO Regulatory Area are not adequate for the protection of the juvenile fish. The largest fishery in the NRA and thus the one of greatest concern is that directing for Greenland halibut. As well, the need to reduce by-catch of any species in the Greenland halibut and other fisheries has been noted. Because of the range of depths currently fished, the Greenland halibut fishery not only focuses on the juvenile component of the population but also takes significant by-catch. This paper is a compendium of 12 papers presented recently to Scientific Council. Information on the distribution of Greenland halibut including distribution of undersized (below 35 cm, the Canadian minimum landing size) and mature and immature components of the population based on both survey and commercial information is presented. The paper also elaborates on the distribution of other commercial species that occur in the NRA, those that may be taken as by-catch in the directed Greenland halibut or other NRA fisheries, including those that overlap the Southeast Shoal

Threading Through Macrocycles Enhances the Performance of Carbon Nanotubes as Polymer Fillers

In this work we study the reinforcement of polymers by mechanically interlocked derivatives of single-walled carbon nanotubes (SWNTs). We compare the mechanical properties of fibers made of polymers and of composites with pristine single-walled carbon nanotubes (SWNTs), mechanically interlocked derivatives of SWNTs (MINTs) and the corresponding supramolecular models. Improvements of both Young's modulus and tensile strength of up to 200 % were observed for the polystyrene-MINTs samples with an optimized loading of just 0.01 wt.%, while the supramolecular models with identical chemical composition and loading showed negligible or even detrimental influence. This behavior is found for three different types of SWNTs and two types of macrocycles. Molecular dynamics simulations show that the polymer adopts an elongated conformation parallel to the SWNT when interacting with MINT fillers, irrespective of the macrocycle chemical nature, whereas a more globular structure is taken upon facing with either pristine SWNTs or supramolecular models. The MINT composite architecture thus leads to a more efficient exploitation of the axial properties of the SWNTs and of the polymer chain at the interface, in agreement with experimental results. Our findings demonstrate that the mechanical bond imparts distinctive advantageous properties to SWNT derivatives as polymer fillers.Comment: 39 pages, 19 figure

Recovering star formation histories: Integrated-light analyses vs stellar colour-magnitude diagrams

Accurate star formation histories (SFHs) of galaxies are fundamental for understanding the build-up of their stellar content. However, the most accurate SFHs - those obtained from colour-magnitude diagrams (CMDs) of resolved stars reaching the oldest main sequence turnoffs (oMSTO) - are presently limited to a few systems in the Local Group. It is therefore crucial to determine the reliability and range of applicability of SFHs derived from integrated light spectroscopy, as this affects our understanding of unresolved galaxies from low to high redshift. To evaluate the reliability of current full spectral fitting techniques in deriving SFHs from integrated light spectroscopy by comparing SFHs from integrated spectra to those obtained from deep CMDs of resolved stars. We have obtained a high signal--to--noise (S/N $\sim$ 36.3 per \AA) integrated spectrum of a field in the bar of the Large Magellanic Cloud (LMC) using EFOSC2 at the 3.6 meter telescope at La Silla Observatory. For this same field, resolved stellar data reaching the oMSTO are available. We have compared the star formation rate (SFR) as a function of time and the age-metallicity relation (AMR) obtained from the integrated spectrum using {\tt STECKMAP}, and the CMD using the IAC-star/MinnIAC/IAC-pop set of routines. For the sake of completeness we also use and discuss other synthesis codes ({\tt STARLIGHT} and {\tt ULySS}) to derive the SFR and AMR from the integrated LMC spectrum. We find very good agreement (average differences $\sim$ 4.1 $\%$) between the SFR(t) and the AMR obtained using {\tt STECKMAP} on the integrated light spectrum, and the CMD analysis. {\tt STECKMAP} minimizes the impact of the age-metallicity degeneracy and has the advantage of preferring smooth solutions to recover complex SFHs by means of a penalized $\chi^2$. [abridged]Comment: 23 pages, 24 figures. Accepted for publication in A&A (6 Sep 2015