The impact of diffusion on confined oscillated bubbly fluid

We consider the dynamics of monodisperse bubbly fluid confined by two plane solid walls and subjected to small-amplitude high-frequency transversal oscillations. The frequency these oscillations is assumed to be high in comparison with typical relaxation times for a single bubble, but comparable with the eigenfrequency of volume oscillations. A time-averaged description accounting for mutual coupling of the phases and the diffusivity of bubbles is applied. We find nonuniform steady states with the liquid quiescent on average. At relatively low frequencies accumulation of bubbles either at the walls or in planes oriented parallel to the walls is detected. These one-dimensional states are shown to be unstable. At relatively high frequencies the bubbles accumulate at the central plane and the solution is stable.Comment: 12 pages, 9 figures, submitted to Phys. Fluid

Vannkvalitet og anadrom fisk i Høyanger- og Ortneviksvassdraget i Sogn og Fjordane

På oppdrag fra Fylkemannens miljøvernavdeling i Sogn og Fjordane har en undersøkt vannkvalitet, anadrom fisk og bunndyr i Ortneviksvassdraget og Høyangervassdraget (Daleelva). Målet for undersøkelsen, som ble gjennomført i september/oktober 1997, var å vurdere om forsuring er et problem for fisken i vassdragene, samt klarlegge effektene av regulering. Begge vassdagene er påvirket av sur nedbør, og prøvene viste små vannkjemiske forskjeller mellom dem. pH lå i området 5,7-6,0 i Ortneviksvassdraget, og 5,9-6,0 i Daleelva. Konsentrasjonen av labilt aluminium var opp mot 10 µg/L i begge vassdragene. pH er høyere og konsentrasjonen av labilt aluminium er lavere enn det som ble funnet ved prøvetakingen i vassdragene våren 1997. Fiskeundersøkelsen viste at Ortneviksvassdraget har en selvreproduserende og livskraftig bestand av aure. Det ble ikke fanget laks i vassdraget, og dette tyder på at laksebestanden pr.i dag enten er gått tapt eller er tilstede som en marginal restbestand. Dette har trolig sammenheng med den sure vannkvaliteten, og ANC verdiene i vårprøvene ligger i en område hvor en kan vente at laksebestanden er dødd ut. Høyangervassdraget har en selvproduserende bestand av laks, men tetthetene er lave. Aurebestanden derimot er livskraftig, med gjennomgående høye tettheter av ungfisk. Vannkvaliteten med lave ANC verdier og høye AL konsentrasjoner om våren kan bidra til å forklare de lave tetthetene av laks. Høyangervassdraget er i tillegg sterkt reguelert. Effektene av den omfattende reguleringen av vassdraget kan vanskelig tallfestes på bestandsnivå, men det er sannsynlig at den har medført en betydelig reduksjon av produksjonspotensialet for anadrom fisk

Acoustic force measurements on polymer-coated microbubbles in a microfluidic device

This work presents an acoustofluidic device for manipulating coated microbubbles, designed for the simultaneous use of optical and acoustical tweezers. A comprehensive characterization of the acoustic pressure in the device is presented, obtained by the synergic use of different techniques in the range of acoustic frequencies where visual observations showed aggregation of polymer-coated microbubbles. In absence of bubbles, the combined use of laser vibrometry and finite element modelling supported a non-invasive measurement of the acoustic pressure and an enhanced understanding of the system resonances. Calibrated holographic optical tweezers were used for direct measurements of the acoustic forces acting on an isolated microbubble, at low driving pressures, and to confirm the spatial distribution of the acoustic field. This allowed quantitative acoustic pressure measurements by particle tracking, using polystyrene beads, and an evaluation of the related uncertainties. This process facilitated the extension of tracking to microbubbles, which have a negative acoustophoretic contrast factor, allowing acoustic force measurements on bubbles at higher pressures than optical tweezers, highlighting four peaks in the acoustic response of the device. Results and methodologies are relevant to acoustofluidic applications requiring a precise characterization of the acoustic field and, in general, to biomedical applications with microbubbles or deformable particles

Global Existence and Regularity for the 3D Stochastic Primitive Equations of the Ocean and Atmosphere with Multiplicative White Noise

The Primitive Equations are a basic model in the study of large scale Oceanic and Atmospheric dynamics. These systems form the analytical core of the most advanced General Circulation Models. For this reason and due to their challenging nonlinear and anisotropic structure the Primitive Equations have recently received considerable attention from the mathematical community. In view of the complex multi-scale nature of the earth's climate system, many uncertainties appear that should be accounted for in the basic dynamical models of atmospheric and oceanic processes. In the climate community stochastic methods have come into extensive use in this connection. For this reason there has appeared a need to further develop the foundations of nonlinear stochastic partial differential equations in connection with the Primitive Equations and more generally. In this work we study a stochastic version of the Primitive Equations. We establish the global existence of strong, pathwise solutions for these equations in dimension 3 for the case of a nonlinear multiplicative noise. The proof makes use of anisotropic estimates, $L^{p}_{t}L^{q}_{x}$ estimates on the pressure and stopping time arguments.Comment: To appear in Nonlinearit

History of climate modeling

The history of climate modeling begins with conceptual models, followed in the 19th century by mathematical models of energy balance and radiative transfer, as well as simple analog models. Since the 1950s, the principal tools of climate science have been computer simulation models of the global general circulation. From the 1990s to the present, a trend toward increasingly comprehensive coupled models of the entire climate system has dominated the field. Climate model evaluation and intercomparison is changing modeling into a more standardized, modular process, presenting the potential for unifying research and operational aspects of climate science. WIREs Clim Change 2011 2 128–139 DOI: 10.1002/wcc.95 For further resources related to this article, please visit the WIREs websitePeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79438/1/95_ftp.pd

Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation

The idea that stem cells of adult tissues with high turnover are protected from DNA replication-induced mutations by maintaining the same 'immortal' template DNA strands together through successive divisions has been tested in several tissues. In the epithelium of the small intestine, the provided evidence was based on the assumption that stem cells are located above Paneth cells. The results of genetic lineage-tracing experiments point instead to crypt base columnar cells intercalated between Paneth cells as bona fide stem cells. Here we show that these cells segregate most, if not all, of their chromosomes randomly, both in the intact and in the regenerating epithelium. Therefore, the 'immortal' template DNA strand hypothesis does not apply to intestinal epithelial stem cells, which must rely on other strategies to avoid accumulating mutations

Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty

Context - Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement this method. Furthermore, previous studies have not explored the predictive value of endocrine profiling to determine female puberty onset. Objective - To integrate US breast staging with hypothalamic-pituitary-gonadal hormone references and test the predictive value of an endocrine profile to determine thelarche. Design Setting and Participants - Cross-sectional sample of 601 healthy Norwegian girls, ages 6 to 16 years. Main Outcome Measures - Clinical and ultrasound breast evaluations were performed for all included girls. Blood samples were analyzed by immunoassay and ultrasensitive liquid chromatography–tandem mass spectrometry (LC-MS/MS) to quantify estradiol (E2) and estrone (E1) from the subpicomolar range. Results - References for E2, E1, luteinizing hormone, follicle-stimulating hormone, and sex hormone–binding globulin were constructed in relation to chronological age, Tanner stages, and US breast stages. An endocrine profile index score derived from principal component analysis of these analytes was a better marker of puberty onset than age or any individual hormone, with receiver-operating characteristic area under the curve 0.91 (P < 0.001). Ultrasound detection of nonpalpable glandular tissue in 14 out of 264 (5.3%) girls with clinically prepubertal presentation was associated with significantly higher median serum levels of E2 (12.5 vs 4.9 pmol/L; P < 0.05) and a distinct endocrine profile (arbitrary units; P < 0.001). Conclusions - We provide the first hormone references for use with US breast staging and demonstrate the application of endocrine profiling to improve detection of female puberty onset

Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty

Context: Testicular growth represents the best clinical variable to evaluate male puberty, but current pediatric hormone references are based on chronological age and subjective assessments of discrete puberty development stages. Determination of testicular volume (TV) by ultrasound provides a novel approach to assess puberty progression and stratify hormone reference intervals. Objective: The objective of this article is to establish references for serum testosterone and key hormones of the male pituitary-gonadal signaling pathway in relation to TV determined by ultrasound. Design, Setting, and Participants: Blood samples from 414 healthy Norwegian boys between ages 6 and 16 years were included from the cross-sectional “Bergen Growth Study 2.” Participants underwent testicular ultrasound and clinical assessments, and serum samples were analyzed by liquid chromatography tandem–mass spectrometry and immunoassays. Main Outcome Measures: We present references for circulating levels of total testosterone, luteinizing hormone, follicle-stimulating hormone, and sex hormone–binding globulin in relation to TV, chronological age, and Tanner pubic hair stages. Results: In pubertal boys, TV accounted for more variance in serum testosterone levels than chronological age (Spearman r = 0.753, P < .001 vs r = 0.692, P < .001, respectively). Continuous centile references demonstrate the association between TV and hormone levels during puberty. Hormone reference intervals were stratified by TV during the pubertal transition. Conclusions: Objective ultrasound assessments of TV and stratification of hormone references increase the diagnostic value of traditional references based on chronological age or subjective staging of male puberty.acceptedVersio

Kysttorsk og miljø. Dataserier og verktøy for studier av miljøets betydning for bestandssituasjonen

Årsliste 2005Bestanden av kysttorsk har gått sammenhengende tilbake fra 1994. Overbeskatning anses som en hovedårsak. Kysttorsk består trolig av en mosaikk av ulike delbestander, og trusselfaktorene kan tenkes å variere mellom ulike områder. Denne rapporten gir en kortfattet oversikt over miljømessige trusselfaktorer for norsk kysttorsk, og peker på noen viktige oppgaver for å kartlegge årsaker, omfang av trusler mot kysttorskens habitat. Lange dataserier fra Kystovervåkingen kan danne grunnlag for nasjonale, regionale og lokale trendanalyser i tidsrommet før og under kysttorskens tilbakegang. Oversikt over miljøgifter knyttet til sedimenter kan utgjøre lokale trusselfaktorer. Det er også påvist omfattende skader på torskens oppvekst-habitat, både langs Skagrarrakkysten og i våre fire nordligste fylker. På Skagerrakkysten og lokalt i ferskvannspåvirkete fjorder på Vestlandet, kan estuarine blandsoner med tilførsler av forsuret, aluminiumsholdig vann ha spilt en rolle for overlevelse av ungstadier av torsk. Informasjon om kysttorskens gyteområder foreligger i en rekke ulike kilder, primært Fiskeridirektoratet, lokale kystsoneplaner og avgrensete pilotprosjekter av vitenskapelig karakter.NIV