116 research outputs found
the permo carboniferous oslo rift through six stages and 65 million years
The Oslo Rift is the northernmost part of the Rotliegendes basin system in Europe. The rift was formed by lithospheric stretching north of the Tornquist fault system and is related tectonically and in time to the last phase of the Variscan orogeny. The main graben forming period in the Oslo Region began in Late Carboniferous, culminating some 20-30 Ma later with extensive volcanism and rifting, and later with uplift and emplacement of major batholiths. It ended with a final termination of intrusions in the Early Triassic, some 65 Ma after the tectonic and magmatic onset. We divide the geological development of the rift into six stages. Sediments, even with marine incursions occur exclusively during the forerunner to rifting. The magmatic products in the Oslo Rift vary in composition and are unevenly distributed through the six stages along the length of the structure
Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation.
Elucidation of Phosphatidylcholine Composition in Krill Oil Extracted from Euphausia superba
High performance liquid chromatography-electrospray tandem mass spectrometry was used to elucidate the phospholipids in krill oil extracted from Euphausia superba, an emerging source for human nutritional supplements. The study was carried out in order to map the species of the choline-containing phospholipid classes: phosphatidylcholine and lyso-phosphatidylcholine. In addition, the prevalent phosphatidylcholine class was quantified and the results compared with prior analysis. The qualification was performed with separation on a reverse phase chromatography column, while the quantification was obtained with class separation on a normal phase chromatography column. An Orbitrap system was used for the detection, and pulsed-Q dissociation fragmentation was utilized for the identification of the species. An asymmetrical exclusion list was applied for detection of phospholipid species of lower concentration, significantly improving the number of species observed. A total of 69 choline-containing phospholipids were detected, whereof 60 phosphatidylcholine substances, among others seven with probable omega-3 fatty acids in both sn-1 and sn-2. The phosphatidylcholine concentration was estimated to be 34 ± 5 g/100 g oil (n = 5). These results confirm the complexity of the phospholipid composition of krill oil, and the presence of long chained, heavily unsaturated fatty acids
Københavns Universitet Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation
The ∼270 Ma palaeolatitude of Baltica and its significance for Pangea models
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86901/1/j.1365-246X.2011.05061.x.pd
The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1
We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis
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