474 research outputs found
Observations of nitrogen isotope fractionation in deeply embedded protostars
(Abridged) The terrestrial planets, comets, and meteorites are significantly
enriched in 15N compared to the Sun and Jupiter. While the solar and jovian
nitrogen isotope ratio is believed to represent the composition of the
protosolar nebula, a still unidentified process has caused 15N-enrichment in
the solids. Several mechanisms have been proposed to explain the variations,
including chemical fractionation. However, observational results that constrain
the fractionation models are scarce. While there is evidence of 15N-enrichment
in prestellar cores, it is unclear how the signature evolves into the
protostellar phases. Our aim is to measure the 14N/15N ratio around three
nearby, embedded low-to-intermediate-mass protostars. Isotopologues of HCN and
HNC were used to probe the 14N/15N ratio. A selection of H13CN, HC15N, HN13C,
and H15NC transitions was observed with the APEX telescope. The 14N/15N ratios
were derived from the integrated intensities assuming a standard 12C/13C ratio.
The assumption of optically thin emission was verified using radiative transfer
modeling and hyperfine structure fitting. Two sources, IRAS 16293A and R CrA
IRS7B, show 15N-enrichment by a factor of around 1.5-2.5 in both HCN and HNC
with respect to the solar composition. Solar composition cannot be excluded for
the third source, OMC-3 MMS6. Furthermore, there are indications of a trend
toward increasing 14N/15N ratios with increasing outer envelope temperature.
The enhanced 15N abundances in HCN and HNC found in two Class~0 sources
(14N/15N of 160-290) and the tentative trend toward a temperature-dependent
14N/15N ratio are consistent with the chemical fractionation scenario, but
14N/15N ratios from additional tracers are indispensable for testing the
models. Spatially resolved observations are needed to distinguish between
chemical fractionation and isotope-selective photochemistry.Comment: Accepted for publication in Astronomy and Astrophysics. 16 pages, 13
figure
Thyroid Function after Subtotal Thyroidectomy in Patients with Graves' Hyperthyroidism
Background. Subtotal thyroidectomy is a surgical procedure, in which the surgeon leaves a small thyroid remnant in situ to preserve thyroid function, thereby preventing lifelong thyroid hormone supplementation therapy. Aim. To evaluate thyroid function after subtotal thyroidectomy for Graves' hyperthyroidism. Subjects and Methods. We retrospectively reviewed the medical records of all patients (n = 62) who underwent subtotal thyroidectomy for recurrent Graves' hyperthyroidism between 1992 and 2008 in our hospital. Thyroid function was defined according to plasma TSH and free T4 values.
Results. Median followup after operation was 54.6 months (range 2.1â204.2 months). Only 6% of patients were euthyroid after surgery. The majority of patients (84%) became hypothyroid, whereas 10% of patients had persistent or recurrent hyperthyroidism. Permanent recurrent laryngeal nerve palsy and permanent hypocalcaemia were noted in 1.6% and 3.2% of patients, respectively. Conclusion. In our series, subtotal thyroidectomy for Graves' hyperthyroidism was associated with a high risk of postoperative hypothyroidism and a smaller, but significant, risk of persistent hyperthyroidism. Our data suggest that subtotal thyroidectomy seems to provide very little advantage over total thyroidectomy in terms of postoperative thyroid function
Dynamical structure of the inner 100 AU of the deeply embedded protostar IRAS 16293-2422
A fundamental question about the early evolution of low-mass protostars is
when circumstellar disks may form. High angular resolution observations of
molecular transitions in the (sub)millimeter wavelength windows make it
possible to investigate the kinematics of the gas around newly-formed stars,
for example to identify the presence of rotation and infall. IRAS 16293-2422
was observed with the extended Submillimeter Array (eSMA) resulting in
subarcsecond resolution (0.46" x 0.29", i.e. 55 35~AU) images
of compact emission from the CO (3-2) and CS (7-6) transitions at
337~GHz (0.89~mm). To recover the more extended emission we have combined the
eSMA data with SMA observations of the same molecules. The emission of
CO (3-2) and CS (7-6) both show a velocity gradient oriented
along a northeast-southwest direction with respect to the continuum marking the
location of one of the components of the binary, IRAS16293A. Our combined eSMA
and SMA observations show that the velocity field on the 50--400~AU scales is
consistent with a rotating structure. It cannot be explained by simple
Keplerian rotation around a single point mass but rather needs to take into
account the enclosed envelope mass at the radii where the observed lines are
excited. We suggest that IRAS 16293-2422 could be among the best candidates to
observe a pseudo-disk with future high angular resolution observations.Comment: Accepted for publication in ApJ, 18 pages, 10 figure
An interferometric study of the low-mass protostar IRAS 16293-2422: small scale organic chemistry
Aims: To investigate the chemical relations between complex organics based on
their spatial distributions and excitation conditions in the low-mass young
stellar objects IRAS 16293-2422 A and B. Methods: Interferometric observations
with the Submillimeter Array have been performed at 5''x3'' resolution
revealing emission lines of HNCO, CH3CN, CH2CO, CH3CHO and C2H5OH. Rotational
temperatures are determined from rotational diagrams when a sufficient number
of lines are detected. Results: Compact emission is detected for all species
studied here. For HNCO and CH3CN it mostly arises from source A, CH2CO and
C2H5OH have comparable strength for both sources and CH3CHO arises exclusively
from source B. HNCO, CH3CN and CH3CHO have rotational temperatures >200 K. The
(u,v)-visibility data reveal that HNCO also has extended cold emission.
Conclusions: The abundances of the molecules studied here are very similar
within factors of a few to those found in high-mass YSOs. Thus the chemistry
between high- and low-mass objects appears to be independent of luminosity and
cloud mass. Bigger abundance differences are seen between the A and B source.
The HNCO abundance relative to CH3OH is ~4 times higher toward A, which may be
due to a higher initial OCN- ice abundances in source A compared to B.
Furthermore, not all oxygen-bearing species are co-existent. The different
spatial behavior of CH2CO and C2H5OH compared with CH3CHO suggests that
hydrogenation reactions on grain-surfaces are not sufficient to explain the
observed gas phase abundances. Selective destruction of CH3CHO may result in
the anti-coincidence of these species in source A. These results illustrate the
power of interferometric compared with single dish data in terms of testing
chemical models.Comment: 11 pages, 15 figures, accepeted by A&
A recent accretion burst in the low-mass protostar IRAS 15398-3359: ALMA imaging of its related chemistry
Low-mass protostars have been suggested to show highly variable accretion
rates through-out their evolution. Such changes in accretion, and related
heating of their ambient envelopes, may trigger significant chemical variations
on different spatial scales and from source-to-source. We present images of
emission from C17O, H13CO+, CH3OH, C34S and C2H toward the low-mass protostar
IRAS 15398-3359 on 0.5" (75 AU diameter) scales with the Atacama Large
Millimeter/submillimeter Array (ALMA) at 340 GHz. The resolved images show that
the emission from H13CO+ is only present in a ring-like structure with a radius
of about 1-1.5" (150-200 AU) whereas the CO and other high dipole moment
molecules are centrally condensed toward the location of the central protostar.
We propose that HCO+ is destroyed by water vapor present on small scales. The
origin of this water vapor is likely an accretion burst during the last
100-1000 years increasing the luminosity of IRAS 15398-3359 by a factor of 100
above its current luminosity. Such a burst in luminosity can also explain the
centrally condensed CH3OH and extended warm carbon-chain chemistry observed in
this source and furthermore be reflected in the relative faintness of its
compact continuum emission compared to other protostars.Comment: Accepted for publication in ApJ Letters; 14 pages, 5 figure
Bone Resorption Is Increased in Pheochromocytoma Patients and Normalizes following Adrenalectomy
Context: The sympathetic nervous system (SNS) controls bone turnover in rodents, but it is uncertain whether a similar role for the SNS exists in humans. Pheochromocytomas are catecholamine-producing neuroendocrine tumors. Because catecholamines are the neurotransmitters of the SNS, we hypothesized that pheochromocytoma patients have increased bone turnover. Objective: Our objective was to compare bone turnover in pheochromocytoma patients and controls. Design and Setting: This retrospective case-control study was performed at the Endocrine Department of the Academic Medical Center of the University of Amsterdam in The Netherlands from 2007 until 2011. Patients: All patients were screened for pheochromocytoma. Cases (n = 21) were identified by 24-h urinary excretion of fractionated metanephrines above the institutional reference value and confirmed by histology after adrenalectomy. All patients screened and diagnosed as not having pheochromocytoma served as controls (n = 126). Main Outcome Measure: The difference in bone turnover markers C-terminal cross-linking telopeptides of collagen type I (CTx) and procollagen type 1 N propeptide (P1NP) between cases and controls was the main outcome measure. Results: CTx concentrations were higher in cases [343 ng/liter; interquartile range (IQR), 295 ng/liter] than in controls (232 ng/liter; IQR, 168 ng/liter; P <0.001) and decreased after adrenalectomy [before, 365 ng/liter (IQR, 450 ng/liter); after, 290 ng/liter (IQR, 241 ng/liter); P = 0.044]. The effect remained after adjustment for possible confounders. P1NP concentrations did not differ. Conclusions: This study shows that pheochromocytoma patients have increased bone resorption, which normalizes after adrenalectomy. This finding supports the concept of regulation of bone remodeling by the SNS in humans. (J Clin Endocrinol Metab 97: E2093-E2097, 2012
Infrared spectroscopy of HCOOH in interstellar ice analogues
Context: HCOOH is one of the more common species in interstellar ices with
abundances of 1-5% with respect to solid H2O. Aims: This study aims at
characterizing the HCOOH spectral features in astrophysically relevant ice
mixtures in order to interpret astronomical data. Methods: The ices are grown
under high vacuum conditions and spectra are recorded in transmission using a
Fourier transform infrared spectrometer. Pure HCOOH ices deposited at 15 K and
145 K are studied, as well as binary and tertiary mixtures containing H2O, CO,
CO2 and CH3OH. The mixture concentrations are varied from 50:50% to ~10:90% for
HCOOH:H2O. Binary mixtures of HCOOH:X and tertiary mixtures of HCOOH:H2O:X with
X = CO, CO2, and CH3OH, are studied for concentrations of ~10:90% and
~7:67:26%, respectively. Results: Pure HCOOH ice spectra show broad bands which
split around 120 K due to the conversion of a dimer to a chain-structure. Broad
single component bands are found for mixtures with H2O. Additional spectral
components are present in mixtures with CO, CO2 and CH3OH. The resulting peak
position, full width at half maximum and band strength depend strongly on ice
structure, temperature, matrix constituents and the HCOOH concentration.
Comparison of the solid HCOOH 5.9, 7.2, and 8.1 micron features with
astronomical data toward the low mass source HH 46 and high mass source W 33A
shows that spectra of binary mixtures do not reproduce the observed ice
features. However, our tertiary mixtures especially with CH3OH match the
astronomical data very well. Thus interstellar HCOOH is most likely present in
tertiary or more complex mixtures with H2O, CH3OH and potentially also CO or
CO2, providing constraints on its formation.Comment: 11 pages, 10 figures, accepted by A&
Rational use of <sup>18</sup>F-FDG PET/CT in patients with advanced cutaneous melanoma:A systematic review
18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is increasingly used in patients with advanced melanoma. Immune checkpoint inhibitors and BRAF/MEK-targeted therapy have transformed the therapeutic landscape of metastatic melanoma. Consequently, a need for markers predicting (early) response to treatment and for monitoring treatment (toxicity) has arisen. This systematic review appraises the current literature evidence for rational use of 18F-FDG PET/CT scans in staging, clinical decision-making, treatment monitoring and follow-up in advanced melanoma. 18F-FDG PET/CT has high overall accuracy for detection of distant metastases and is, combined with cerebral MRI, the preferred imaging strategy for staging metastatic melanoma. In contrast, strong evidence supporting the standard use of 18F-FDG PET/CT for predicting and monitoring therapy response and toxicity is currently lacking. Essential for determining the position of 18F-FDG PET/CT during treatment course in advanced melanoma are well-designed studies with standardized scanning protocols, incorporation of clinical parameters and comparison with contrast-enhanced CT alone
Cold gas as an ice diagnostic toward low mass protostars
Up to 90% of the chemical reactions during star formation occurs on ice
surfaces, probably including the formation of complex organics. Only the most
abundant ice species are however observed directly by infrared spectroscopy.
This study aims to develop an indirect observational method of ices based on
non-thermal ice desorption in the colder part of protostellar envelopes. For
that purpose the IRAM 30m telescope was employed to observe two molecules that
can be detected both in the gas and the ice, CH3 OH and HNCO, toward 4 low mass
embedded protostars. Their respective gas-phase column densities are determined
using rotational diagrams. The relationship between ice and gas phase
abundances is subsequently determined. The observed gas and ice abundances span
several orders of magnitude. Most of the CH3OH and HNCO gas along the lines of
sight is inferred to be quiescent from the measured line widths and the derived
excitation temperatures, and hence not affected by thermal desorption close to
the protostar or in outflow shocks. The measured gas to ice ratio of ~10-4
agrees well with model predictions for non-thermal desorption under cold
envelope conditions and there is a tentative correlation between ice and gas
phase abundances. This indicates that non-thermal desorption products can serve
as a signature of the ice composition. A larger sample is however necessary to
provide a conclusive proof of concept.Comment: accepted by A&A letters, 10 pages including 5 figure
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