Review of Gabriele Schwab, Haunting Legacies: Violent Histories and Transgenerational Trauma.

Gabriele Schwab, Haunting Legacies: Violent Histories and Transgenerational Trauma. New York: Columbia University Press, 2010. xv + 227 pp. ISBN 9780231152563 (paper)

Review of Gabriele Schwab, Haunting Legacies: Violent Histories and Transgenerational Trauma.

Gabriele Schwab, Haunting Legacies: Violent Histories and Transgenerational Trauma. New York: Columbia University Press, 2010. xv + 227 pp. ISBN 9780231152563 (paper)

Mars Ascent Vehicle - Payload?, Spacecraft?, Launch Vehicle? - A Systems Approach to MAV

Significant effort has been expended over the past few years in order to examine propulsion technologies for an eventual robotic Mars Ascent Vehicle (MAV). The recent emphasis on studies for an overall sample return campaign, and specifically the Sample Return Lander (SRL) includes the full slate of systems required to implement a MAV. Depending on your point of view, the MAV is a major SRL flight system payload, a Mars Surface Spacecraft, or a Launch Vehicle. We will examine the MAV from these three perspectives in order to tease out the key architectural trades required to be completed prior to the start of a project Phase A activity

"Hope is that fiery feeling": Using Poetry as Data to Explore the Meanings of Hope for Young People

Poetic inquiry is a contentious area of qualitative research. In this article, we discuss some of the issues plaguing this field of inquiry. We then analyse a collection of poems about hope written by a sample of young people from Tasmania, Australia. The poems were written as part of the 2011 Tree of Hope project, which utilised multiple, arts-based methods to provide insights into what young people hope for in the future and the role of hope in their lives. Participants utilised one of three poetic structures. While each structure produced distinct themes, a connection between "hope and happiness" overlapped the two structured types of poetry—the acrostic and sense poetry. However, when writing free verse poetry, the expression of additional dimensions of hope, including the flipside of both having hope and losing hope was evident. We conclude that hope is particularly important to young people and that inviting participant-voiced poetry is an effective technique for investigating conceptual topics such as young people and hope

Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.

Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. However, assignment of these functions to specific proteoglycans has been limited by the lack of identified core proteins. We used a combination of biochemical purification, Western blotting, and mass spectrometry to identify nine C. elegans chondroitin proteoglycan core proteins, none of which have homologues in vertebrates or other invertebrates such as Drosophila melanogaster or Hydra vulgaris. CPG-1/CEJ-1 and CPG-2 are expressed during embryonic development and bind chitin, suggesting a structural role in the egg. RNA interference (RNAi) depletion of individual CPGs had no effect on embryonic viability, but simultaneous depletion of CPG-1/CEJ-1 and CPG-2 resulted in multinucleated single-cell embryos. This embryonic lethality phenocopies RNAi depletion of the SQV-5 chondroitin synthase, suggesting that chondroitin chains on these two proteoglycans are required for cytokinesis

The Role of PPARs in the Endothelium: Implications for Cancer Therapy

The growth and metastasis of cancers intimately involve the vasculature and in particular the endothelial cell layer. Tumours require new blood vessel formation via angiogenesis to support growth. In addition, inflammation, coagulation, and platelet activation are common signals in the growth and metastasis of tumour cells. The endothelium plays a central role in the homeostatic control of inflammatory cell recruitment, regulating platelet activation and coagulation pathways. PPARα, -β/δ, and -γ are all expressed in endothelial cells. This review will discuss the roles of PPARs in endothelial cells in relation to angiogenesis, inflammation, coagulation, and platelet control pathways. In particular, we will discuss the recent evidence that supports the hypothesis that PPARα and PPARγ are antiangiogenic receptors, while PPARβ/δ is proangiogenic

Deans\u27 Panel: Phases of Partnership: Implementing and Sustaining Digitization Projects

Have you ever wondered how digital ecosystems take root and are sustained into the future so invaluable resources are accessible for generations to come? Join Janet Bishop, Dean of The Claremont Colleges Library (TCCL), Karen Estlund, Dean of Libraries at Colorado State University (CSU) and Kelvin Watson, Executive Director of the Las Vegas - Clark County Library District for a deep dive into the various “life phases” of digitization projects. Gain insights from Janet on establishing collaborative partnerships with regional organizations to kickstart high-interest projects, as was done through TCCL’s grant-funded Western Water Archive. Learn about strategies to sustain digital archival collections through fundraising and creative partnerships from Karen, who will discuss CSU’s long-standing Water Resources Archive. And discover how to make coveted digitized collections accessible for community exploration and use through Kelvin’s discussion of diverse and topical collaborations, such as the Queens Memory Project, Virtual AARLCC, and Las Vegas-Clark County Library District initiatives

Mortality

This chapter of Beginning Population Studies (3rd edition) discusses mortality from a demographic perspective. There are separate chapters on Epidemics, and on Morbidity

Polyphenols for Cancer Treatment or Prevention

Polyphenols are commonly found in fruits and vegetables, and have been suggested to have protective effects against chronic diseases, such as cancers. They are a diverse group of molecules, many of which possess antioxidant, anti-inflammatory, epigenetic, drug sensitization, and/or modulation of xenobiotic metabolizing enzyme properties. However, there is mixed evidence regarding their protective effects with respect to various cancers. Some of this controversy may be due to the combination of polyphenols administered, synergistic effects of accompanying compounds, bio-accessibility, bioavailability, effect of gut microbiota, and the type of cancer investigated. The purpose of this Special Issue is to present the recent evidence for the effect of polyphenol intake on cancer, as well as mechanisms of action. This Special Issue, entitled "Polyphenols for Cancer Treatment or Prevention", welcomes manuscript submissions of original research, meta-analyses, or reviews of the scientific literature. Authors should focus their manuscripts on polyphenol bioactives or dietary patterns naturally rich in polyphenols that have been identified and used for the prevention and or treatment of cancer