From Compromise to Leadership in Pigeon Homing

SummaryA central problem faced by animals traveling in groups is how navigational decisions by group members are integrated, especially when members cannot assess which individuals are best informed or have conflicting information or interests [1–5]. Pigeons are now known to recapitulate faithfully their individually distinct habitual routes home [6–8], and this provides a novel paradigm for investigating collective decisions during flight under varying levels of interindividual conflict. Using high-precision GPS tracking of pairs of pigeons, we found that if conflict between two birds' directional preferences was small, individuals averaged their routes, whereas if conflict rose over a critical threshold, either the pair split or one of the birds became the leader. Modeling such paired decision-making showed that both outcomes—compromise and leadership—could emerge from the same set of simple behavioral rules. Pairs also navigated more efficiently than did the individuals of which they were composed, even though leadership was not necessarily assumed by the more efficient bird. In the context of mass migration of birds and other animals, our results imply that simple self-organizing rules can produce behaviors that improve accuracy in decision-making and thus benefit individuals traveling in groups [3, 9, 10]

Understanding the unexplained : the magnitude and correlates of individual differences in residual variance

Behavioral and physiological ecologists have long been interested in explaining the causes and consequences of trait variation, with a focus on individual differences in mean values. However, the majority of phenotypic variation typically occurs within individuals, rather than among individuals (as indicated by average repeatability being less than 0.5). Recent studies have further shown that individuals can also differ in the magnitude of variation that is unexplained by individual variation or environmental factors (i.e., residual variation). The significance of residual variation, or why individuals differ, is largely unexplained, but is important from evolutionary, methodological, and statistical perspectives. Here, we broadly reviewed literature on individual variation in behavior and physiology, and located 39 datasets with sufficient repeated measures to evaluate individual differences in residual variance. We then analyzed these datasets using methods that permit direct comparisons of parameters across studies. This revealed substantial and widespread individual differences in residual variance. The magnitude of individual variation appeared larger in behavioral traits than in physiological traits, and heterogeneity was greater in more controlled situations. We discuss potential ecological and evolutionary implications of individual differences in residual variance and suggest productive future research directions

Epithelial-to-mesenchymal stem cell transition in a human organ: Lessons from Lichen Planopilaris

YesEpithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in fibrotic disease and carcinoma. Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair follicles, during the inflammatory permanent alopecia, lichen planopilaris. We show that a molecular EMT signature can be experimentally induced in healthy human eSCs in situ by antagonizing E-cadherin, combined with transforming growth factor-β1, epidermal growth factor, and IFN-γ administration, which to our knowledge has not been reported previously. Moreover, induction of EMT within primary human eSCs can be prevented and even partially reversed ex vivo by peroxisome proliferator−activated receptor-γ agonists, likely through suppression of the transforming growth factor-β signaling pathway. Furthermore, we show that peroxisome proliferator−activated receptor-γ agonists also attenuates the EMT signature even in lesional lichen planopilaris hair follicles ex vivo. We introduce lichen planopilaris as a model disease for pathological EMT in human adult eSCs, report a preclinical assay for therapeutically manipulating eSC EMT within a healthy human (mini-)organ, and show that peroxisome proliferator−activated receptor-γ agonists are promising agents for suppressing and partially reversing EMT in human hair follicles eSCs ex vivo, including in lichen planopilaris

A Study of Parton Energy Loss in Au+Au Collisions at RHIC using Transport Theory

Parton energy loss in Au+Au collisions at RHIC energies is studied by numerically solving the relativistic Boltzmann equation for the partons including $2 \leftrightarrow 2$ and $2 \to 2 + final state radiation$ collision processes. Final particle spectra are obtained using two hadronization models; the Lund string fragmentation and independent fragmentation models. Recent, preliminary $\pi^0$ transverse momentum distributions from central Au+Au collisions at RHIC are reproduced using gluon-gluon scattering cross sections of 5-12 mb, depending upon the hadronization model. Comparisons with the HIJING jet quenching algorithm are made.Comment: 6 pages, 6 figures, attached files are replaced (wrong files were uploaded in version 1

Is There Such a Thing as Psychological Pain? and Why It Matters

Medicine regards pain as a signal of physical injury to the body despite evidence contradicting the linkage and despite the exclusion of vast numbers of sufferers who experience psychological pain. By broadening our concept of pain and making it more inclusive, we would not only better accommodate the basic science of pain but also would recognize what is already appreciated by the layperson—that pain from diverse sources, physical and psychological, share an underlying felt structure

Ecological and evolutionary consequences of anticancer adaptations

Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research

Dependence of energy loss of jets on the initial thermodynamic state of deconfined matter at RHIC

The dependence of the radiative energy loss of fast partons on the initial thermodynamic parameters is studied for deconfined matter to be expected at RHIC. We demonstrate that the specific QCD radiation pattern with a quadratic dependence of the energy loss on the propagated distance leads to a strong increase of the energy loss with increasing initial entropy of deconfined matter supposed its life-time is less than the average time to pass through the medium. This is in contrast to a parameterization with constant energy loss per unit length of propagation. For a sufficiently high initial temperature a two-regime behavior of the energy loss as a function of the initial parton momentum occurs. The angular structure of the energy loss of hard jets with respect to the initial temperature is also discussed for RHIC conditions.Comment: 10 pages with fig