Thermodiffusion in model nanofluids by molecular dynamics simulations

In this work, a new algorithm is proposed to compute single particle (infinite dilution) thermodiffusion using Non-Equilibrium Molecular Dynamics simulations through the estimation of the thermophoretic force that applies on a solute particle. This scheme is shown to provide consistent results for simple Lennard-Jones fluids and for model nanofluids (spherical non-metallic nanoparticles + Lennard-Jones fluid) where it appears that thermodiffusion amplitude, as well as thermal conductivity, decrease with nanoparticles concentration. Then, in nanofluids in the liquid state, by changing the nature of the nanoparticle (size, mass and internal stiffness) and of the solvent (quality and viscosity) various trends are exhibited. In all cases the single particle thermodiffusion is positive, i.e. the nanoparticle tends to migrate toward the cold area. The single particle thermal diffusion 2 coefficient is shown to be independent of the size of the nanoparticle (diameter of 0.8 to 4 nm), whereas it increases with the quality of the solvent and is inversely proportional to the viscosity of the fluid. In addition, this coefficient is shown to be independent of the mass of the nanoparticle and to increase with the stiffness of the nanoparticle internal bonds. Besides, for these configurations, the mass diffusion coefficient behavior appears to be consistent with a Stokes-Einstein like law

New insights on accretion in Supergiant Fast X-ray Transients from XMM-Newton and INTEGRAL observations of IGR J17544−-2619

XMM-Newton observations of the supergiant fast X-ray transient IGR$~$J17544$-$2619 are reported and placed in the context of an analysis of archival INTEGRAL/IBIS data that provides a refined estimate of the orbital period at 4.9272$\pm$0.0004 days. A complete outburst history across the INTEGRAL mission is reported. Although the new XMM-Newton observations (each lasting $\sim$15 ks) targeted the peak flux in the phase-folded hard X-ray light curve of IGR$~$J17544$-$2619, no bright outbursts were observed, the source spending the majority of the exposure at intermediate luminosities of the order of several 10$^{33}\,$erg$\,$s$^{-1}$ (0.5$\,-\,$10$\,$keV) and displaying only low level flickering activity. For the final portion of the exposure, the luminosity of IGR$~$J17544$-$2619 dropped to $\sim$4$\times$10$^{32}\,$erg$\,$s$^{-1}$ (0.5 - 10 keV), comparable with the lowest luminosities ever detected from this source, despite the observations being taken near to periastron. We consider the possible orbital geometry of IGR$~$J17544$-$2619 and the implications for the nature of the mass transfer and accretion mechanisms for both IGR$~$J17544$-$2619 and the SFXT population. We conclude that accretion under the `quasi-spherical accretion' model provides a good description of the behaviour of IGR$~$J17544$-$2619, and suggest an additional mechanism for generating outbursts based upon the mass accumulation rate in the hot shell (atmosphere) that forms around the NS under the quasi-spherical formulation. Hence we hope to aid in explaining the varied outburst behaviours observed across the SFXT population with a consistent underlying physical model.Comment: 12 pages, 5 figures, accepted for publication in MNRA

Rouse Chains with Excluded Volume Interactions: Linear Viscoelasticity

Linear viscoelastic properties for a dilute polymer solution are predicted by modeling the solution as a suspension of non-interacting bead-spring chains. The present model, unlike the Rouse model, can describe the solution's rheological behavior even when the solvent quality is good, since excluded volume effects are explicitly taken into account through a narrow Gaussian repulsive potential between pairs of beads in a bead-spring chain. The use of the narrow Gaussian potential, which tends to the more commonly used delta-function repulsive potential in the limit of a width parameter "d" going to zero, enables the performance of Brownian dynamics simulations. The simulations results, which describe the exact behavior of the model, indicate that for chains of arbitrary but finite length, a delta-function potential leads to equilibrium and zero shear rate properties which are identical to the predictions of the Rouse model. On the other hand, a non-zero value of "d" gives rise to a prediction of swelling at equilibrium, and an increase in zero shear rate properties relative to their Rouse model values. The use of a delta-function potential appears to be justified in the limit of infinite chain length. The exact simulation results are compared with those obtained with an approximate solution which is based on the assumption that the non-equilibrium configurational distribution function is Gaussian. The Gaussian approximation is shown to be exact to first order in the strength of excluded volume interaction, and is found to be accurate above a threshold value of "d", for given values of chain length and strength of excluded volume interaction.Comment: Revised version. Long chain limit analysis has been deleted. An improved and corrected examination of the long chain limit will appear as a separate posting. 32 pages, 9 postscript figures, LaTe

Accurate classification of 75 counterparts of objects detected in the 54 month Palermo Swift/BAT hard X-ray catalogue

Through an optical campaign performed at 4 telescopes located in the northern and the southern hemispheres, we have obtained optical spectroscopy for 75 counterparts of unclassified or poorly studied hard X-ray emitting objects detected with Swift/BAT and listed in the 54 month Palermo BAT catalogue. All these objects have also observations taken with Swift/XRT, ROSAT or Chandra satellites which allowed us to reduce the high energy error box and pinpoint the most likely optical counterpart/s. We find that 69 sources in our sample are Active Galactic Nuclei (AGNs); of them, 35 are classified as type 1 (with broad and narrow emission lines), 33 are classified as type 2 (with only narrow emission lines) and one is an high redshift QSO; the remaining 6 objects are galactic cataclysmic variables (CVs). Among type 1 AGNs, 32 are objects of intermediate Seyfert type (1.2-1.9) and one is Narrow Line Seyfert 1 galaxy; for 29 out of 35 type 1 AGNs, we have been able to estimate the central black hole mass and the Eddington ratio. Among type 2 AGNs, two display optical features typical of the LINER class, 3 are classified as transition objects, 1 is a starburst galaxy and 2 are instead X-ray bright, optically normal galaxies. All galaxies classified in this work are relatively nearby objects (0.006 - 0.213) except for one at redshift 1.137.Comment: 19 pages, 5 figures, 6 tables, accepted for publications on Astronomy and Astrophysics, main journal. arXiv admin note: text overlap with arXiv:1206.509

ADRIC: Adverse Drug Reactions In Children - a programme of research using mixed methods

Aims To comprehensively investigate the incidence, nature and risk factors of adverse drug reactions (ADRs) in a hospital-based population of children, with rigorous assessment of causality, severity and avoidability, and to assess the consequent impact on children and families. We aimed to improve the assessment of ADRs by development of new tools to assess causality and avoidability, and to minimise the impact on families by developing better strategies for communication. Review methods Two prospective observational studies, each over 1 year, were conducted to assess ADRs in children associated with admission to hospital, and those occurring in children who were in hospital for longer than 48 hours. We conducted a comprehensive systematic review of ADRs in children. We used the findings from these studies to develop and validate tools to assess causality and avoidability of ADRs, and conducted interviews with parents and children who had experienced ADRs, using these findings to develop a leaflet for parents to inform a communication strategy about ADRs. Results The estimated incidence of ADRs detected in children on admission to hospital was 2.9% [95% confidence interval (CI) 2.5% to 3.3%]. Of the reactions, 22.1% (95% CI 17% to 28%) were either definitely or possibly avoidable. Prescriptions originating in the community accounted for 44 out of 249 (17.7%) of ADRs, the remainder originating from hospital. A total of 120 out of 249 (48.2%) reactions resulted from treatment for malignancies. Off-label and/or unlicensed (OLUL) medicines were more likely to be implicated in an ADR than authorised medicines [relative risk (RR) 1.67, 95% CI 1.38 to 2.02; p  48 hours, the overall incidence of definite and probable ADRs based on all admissions was 15.9% (95% CI 15.0 to 16.8). Opiate analgesic drugs and drugs used in general anaesthesia (GA) accounted for > 50% of all drugs implicated in ADRs. The odds ratio of an OLUL drug being implicated in an ADR compared with an authorised drug was 2.25 (95% CI 1.95 to 2.59; p < 0.001). Risk factors identified were exposure to a GA, age, oncology treatment and number of medicines. The systematic review estimated that the incidence rates for ADRs causing hospital admission ranged from 0.4% to 10.3% of all children [pooled estimate of 2.9% (95% CI 2.6% to 3.1%)] and from 0.6% to 16.8% of all children exposed to a drug during hospital stay. New tools to assess causality and avoidability of ADRs have been developed and validated. Many parents described being dissatisfied with clinician communication about ADRs, whereas parents of children with cancer emphasised confidence in clinician management of ADRs and the way clinicians communicated about medicines. The accounts of children and young people largely reflected parents’ accounts. Clinicians described using all of the features of communication that parents wanted to see, but made active decisions about when and what to communicate to families about suspected ADRs, which meant that communication may not always match families’ needs and expectations. We developed a leaflet to assist clinicians in communicating ADRs to parents. Conclusion The Adverse Drug Reactions In Children (ADRIC) programme has provided the most comprehensive assessment, to date, of the size and nature of ADRs in children presenting to, and cared for in, hospital, and the outputs that have resulted will improve the management and understanding of ADRs in children and adults within the NHS. Recommendations for future research: assess the values that parents and children place on the use of different medicines and the risks that they will find acceptable within these contexts; focusing on high-risk drugs identified in ADRIC, determine the optimum drug dose for children through the development of a gold standard practice for the extrapolation of adult drug doses, alongside targeted pharmacokinetic/pharmacodynamic studies; assess the research and clinical applications of the Liverpool Causality Assessment Tool and the Liverpool Avoidability Assessment Tool; evaluate, in more detail, morbidities associated with anaesthesia and surgery in children, including follow-up in the community and in the home setting and an assessment of the most appropriate treatment regimens to prevent pain, vomiting and other postoperative complications; further evaluate strategies for communication with families, children and young people about ADRs; and quantify ADRs in other settings, for example critical care and neonatology

Canada and Slavery in Print, 1789-1889

The dominant national narrative for Canadians today is that Canada was an antislavery haven for formerly enslaved people from the United States in the nineteenth century. However, there were black and First Nations enslaved people in Canada, in New France before 1763 and then under the British until the early nineteenth century. George Elliott Clarke argues that the image of Canada in antebellum American slave narratives has obscured earlier narratives of slavery in Canada. In this thesis I look at newspapers and slave narratives to explore textual representations of Canada and slavery in print. My research question is: given that Canada is popularly understood as an antislavery haven, how can we use printed texts to produce a more complicated account of Canada’s relationship with slavery? I interrogate this in three case studies. In Chapter One I examine the textual presence of enslaved people in Canada in Canadian newspapers 1789-1793. In Chapter Two I explore how Canada appears in the classic American slave narrative after fugitive slaves cross the border into Canada. In Chapter Three I examine how slave narratives about American slavery were recirculated in Canada. In Chapter Four I suggest that Broken Shackles, a little-known slavery narrative published in 1889, most probably in Canada, can be best understood in the light of the three case studies. Through the case studies I interrogate the idea of Canada as an antislavery space. I argue that Canada could think about itself as antislavery and also hold enslaved people; it could see itself as beneficent and be exploitative; and recirculated American slave narratives in Canada could give moral capital to Canadians and benefit the white privileged reader. Collectively, the chapters show that the textual circulation of Canada and slavery presents a more nuanced account of Canada’s relationship to slavery

Velocity Slip and Temperature Jump in Hypersonic Aerothermodynamics

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76543/1/AIAA-2007-208-226.pd

Quantum dot dephasing by edge states

We calculate the dephasing rate of an electron state in a pinched quantum dot, due to Coulomb interactions between the electron in the dot and electrons in a nearby voltage biased ballistic nanostructure. The dephasing is caused by nonequilibrium time fluctuations of the electron density in the nanostructure, which create random electric fields in the dot. As a result, the electron level in the dot fluctuates in time, and the coherent part of the resonant transmission through the dot is suppressed