35 research outputs found
Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation
- Author
- A Barski
- A Bird
- A Blattler
- A Chatterjee
- A Chatterjee
- A Chatterjee
- A Chatterjee
- A Chatterjee
- A Chatterjee
- A Chatterjee
- A Hellman
- A Hellman
- A Portela
- AE Jaffe
- AE Peaston
- AL Teh
- AP Feinberg
- BA Buck-Koehntop
- BT Adalsteinsson
- C Bock
- C Bock
- C Gemma
- C Trapnell
- C Trapnell
- C Trapnell
- D Adams
- D Jjingo
- D Wang
- DK Ma
- H Heyn
- H Shen
- H Wang
- H Xie
- I Dunham
- J Auta
- J Cloud
- J Ernst
- J Gertz
- K Halachev
- K Iwamoto
- K Kerkel
- L de la Rica
- L Migliore
- L Wang
- LA Baker
- LA Hindorff
- LC Schalkwyk
- LD Moore
- LE Reinius
- LL Lam
- M Berdasco
- M Beyrau
- M Ehrlich
- M Ioannides
- M Ivanov
- M Rio
- M Xie
- MD Schultz
- MJ Fernandez-Nestosa
- MR Estecio
- N Elango
- PA Stockwell
- PY Chen
- RA Harris
- RA Harris
- RA Waterland
- RS Illingworth
- S Anders
- S Hu
- S Saxonov
- S Shukla
- SB Baylin
- T Hartung
- W Huang da
- WG Zhu
- WM Rideout 3rd
- X Zhang
- Y Guo
- ZD Smith
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/11/2015
- Field of study
The extent of variation in DNA methylation patterns in healthy individuals is not yet well documented. Identification of inter-individual epigenetic variation is important for understanding phenotypic variation and disease susceptibility. Using neutrophils from a cohort of healthy individuals, we generated base-resolution DNA methylation maps to document inter-individual epigenetic variation. We identified 12851 autosomal inter-individual variably methylated fragments (iVMFs). Gene promoters were the least variable, whereas gene body and upstream regions showed higher variation in DNA methylation. The iVMFs were relatively enriched in repetitive elements compared to non-iVMFs, and were associated with genome regulation and chromatin function elements. Further, variably methylated genes were disproportionately associated with regulation of transcription, responsive function and signal transduction pathways. Transcriptome analysis indicates that iVMF methylation at differentially expressed exons has a positive correlation and local effect on the inclusion of that exon in the mRNA transcript
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
- Anestiadou Elissavet
- Angelis Fragkiskos
- Angeslis Fragkiskos
- Aqeel Syed Talha Bin
- Aral Canan
- Arebi Jaber
- Arnaoutoglou Eleni
- Arslangilay Mert
- Arvanitaki Alexandra
- Asadyari-Lupo Shadie
- Ashar Nur Ayuni Khirul
- Ashour Amira
- Ashraf Hamza
- Ashur Abir Ben
- Asjad Imran
- Askar Aamal
- Askin Abdullah Emre
- Aslam Muhammad Nadeem
- Aslan Merve
- Aslangilay Mert
- Astal Mohammed
- Asudo Felicia
- Atadag Yildiz Buyukdereli
- Atef Dina
- Athamneh Tayseer
- Athanasiadis Apostolos
- Ather M Hammad
- Atherton Kristy
- Atia Ahmed
- Atici Semra Demirli
- Atilhan Ridvan
- Atim Terkaa
- Atiq Tabish
- Atta Raneem
- Attia Mohamed
- Attiya Omar
- Awad Hasan
- Awadallah Safaa
- Awoyinka Babatunde
- Ayasrah Salem
- Aydin Cemil
- Aydoğdu Erhan Onur
- Ayogu Emeka
- Ayoub Kerillos
- Ayyad Alaa
- Azboy Ibrahim
- Azer Armia
- Azhari Malaz
- Aziz Aliya Begum
- Babalola Olakunle
- Babar Daniyal
- Babekir Enas Mohammedtom Abdulhameed
- Babiker Afra
- Bacariza Loreto
- Baccar Marwen
- Badawy Asmaa
- Badi Hussameddin
- Badr Karim
- Badri Danniel
- Bagazi Doaa
- Bailey Ashley
- Bakare Adewumi
- Bakari Maisaratu A
- Bakeer Hibah Bileid
- Bakeer Mohammed
- Balciscueta Zutoia
- Ballah Shirahn
- Balogh Zsolt
- Baltacı Zeynep Hazal
- Banaga Essam Eldien Abuobaida
- Banerjee Arnab
- Banihani Farah
- Barbara Silvia Jasmine
- Barbaro Antonio
- Bareka Metaxia
- Bariun Yara
- Barka Sharf
- Barker John
- Barker Sally
- Barsoum Fady
- Basam Aya
- Basam Aya
- Bassam Ahmad
- Bassey Asi-oqua
- Bataineh Saad
- Bature Stephen Bodam
- Bayram Cigdem
- Baysallar Duygu
- Baziotis-Kalfas Kristian
- Beatson Nicholas
- Bei Michael
- Bektas Sebnem
- Bell David
- Benamor Oumayma
- Benek Duygu Ece
- Benham Emily
- Benismai Israa
- Bensalem Marya
- Bensalem Serien Hossain
- Benyani Simran Vinod
- Bernabei Massimiliano
- Betts Aisling
- Bezweek Adel
- Bhikha Jainey
- Bindra Randipsingh
- Binnawara Muhannud
- Bird Katie
- Bisgin Tayfun
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- Sahin Melek
- Sajo Isa Mienda
- Sakr Ahmed
- Sakthivel Mahesh
- Salah Asmaa
- Salah Doaa
- Salah Mohamed
- Salah Salem
- Salaheldein Mohamed
- Salameh Alaa Eddin
- Salawu Adedayo
- Salawu Hafeez
- Saleh Ahmad
- Saleh Sara Ahmed
- Salem Ebrahim
- Salem Mohammed
- Saliaris Konstantinos
- Salih Alaa A
- Salihu Makama Baje
- Sallam Abdelaziz
- Samalavicius Narimantas
- Sami Wesam
- Sammour Tarik
- Sampatha-Waduge Tharushi
- Sanad Aly
- Sandhu Jaspreet Kaur
- Sanguesa Maria Jose
- Sani Samuel Ali
- Sanli Ahmet Necati
- Sanz-Romera Jorge
- Sara Rachel
- Saraçoğlu Ayten
- Sarafi Aikaterini
- Sarangadasa Pavatharane
- Sarhan Osama
- Sarı Ahmet Can
- Sarih Monira
- Sarwar Albash
- Sathasivam Vinogi
- Sathiyaseelan Avinash
- Sawaftah Khaled
- Sayed Ahmed M
- Sayed Mohamed Al
- Sayed Yasmeen
- Saylar Alparslan
- Saylar Alparslan
- Sánchez Luis Antonio Heredia
- Schizas Dimitrios
- Segaran Sharrada
- Seldon Alexandra
- Selim Kamar
- Selim Osama
- Seneviratne Dharani
- Sengupta Shomik
- Senthilrajan Rahavi
- Seow Warren
- Shaaban Abdelrahman
- Shaban Aya
- Shaban Walid
- Shabaneh Amin
- Shafaat Amna
- Shagroun Esra
- Shah Jainil
- Shah Jainil
- Shahat Mohammed A
- Shaheen Nourhan
- Shahin Mahmoud
- Shalaby Mostafa
- Shalalfeh Sa'ed
- Shaltout Asmaa S
- Shamshoon Kerollos
- Shanag Hadeel
- Shanahan James
- Shang Mengge
- Shannaq Rabab
- Shaqran Osama Al
- Sharma Sonakshi
- Sharp James
- Shaw Haylee
- Shaw Henry
- Shehab Ali Fahmy
- Shehahda Sireen
- Shehata Mena
- Shen Yijia
- Sherif Yara
- Sheriff Arfaan
- Shetwan Sundes
- Shipa Ahmed
- Shiru Mariam Motunrayo
- Shrestha Pallavi
- Shuaibu Ibrahim Shaphat
- Shui Amanda
- Sibic Osman
- Sierra Oscar Alonso Verduzco
- Silem Yousra Othman Reham
- Silva Yannick De
- Silverii Julia
- Simiona Levi
- Simonetti Marta
- Singer David
- Singh Abhinav
- Singh Gopal
- Singh Jasraaj
- Singh Madhavi
- Singh Ramnik
- Singh Surya
- Singh Surya
- Singhal Megan
- Sinha Akansha
- Siribaddana Venesa
- Sivakumar Gananadha
- Sivakumar Seiyon
- Sivasuthan Goutham
- Sivrikaya Ramazan Kemal
- Skalidou Smaragda
- Skoufias Spyridon
- Slavec Mark
- Smadi Rayyan
- Smith Corinne
- Smith Nicolas
- Smith Quintin
- Smitham Peter
- Snider Ruth
- Sobhy George
- Soek Jenny
- Sofian Ahmad Anuar
- Soh Isabel
- Soh Jien Yen
- Soh Qi Rui
- Soh Rachel TingQian
- Sok Rumnea
- Sokmen Selman
- Solagbade Remi Sanyaolu
- Solanki Krisha
- Solar Caitlin Del
- Soliman Keroles
- Soliman Mahmoud Ayman
- Soliman Nisha Bianca
- Soliman Randa
- Soltan Hatem
- Songden Zumnan
- Soni Akshay
- Soula Enas
- Soytas Mustafa
- Sriranjan Roshni
- Sritharan Mithra
- Srivastava Shambhavi
- Standish Lucy
- Stavratis Fotios
- Stevens Sean
- Stewart Peter
- Stokes Andrew
- Struthers Jamie
- Studd Rod
- Sulaiman Bilal
- Suleiman Khadijah Richifa
- Suliman Hozifa Mohamed Abdalla
- Suliman Merna Ezz
- Sun Kexin
- Sun Phoebe
- Sun Selena
- Sung Nakjun
- Surkitt Amy
- Suttor Sean
- Swalem Aisha
- Swan Daniel
- Swansson Will
- Sweetapple Amie
- Syed Saifulla
- Syllaios Athanasios
- Symeonidis Savvas
- Şen Eminenur
- Şenödeyici Eylül
- Tabak Elif Zeynep
- Taha Hala Abdelhalim Mohamed
- Taha Ibrahim
- Taha Omima
- Tahir Farah
- Tahir Izza
- Taingson Mathew Chum
- Talaat Omnia
- Talavera Elena
- Taman Mohamed
- Tan Kevin
- Tan Sarah
- Tan Sarah
- Tan Suqi
- Tan Wen Po Jonathan
- Tandogan Yusuf Iskender
- Tang Howard
- Tang Patrick
- Tang-Ieam Pattarapan
- Tao Steve
- Tarek Yousef
- Tariq
- Tarmidi Jazmina
- Tasi Zoya
- Taşcı Muhammed Enes
- Taufiq Maliha
- Tay Kai Yun Jodene
- Taylor Emily
- Taylor Isobel
- Teema Eman
- Telci Hatice
- Temerik Abdallah Rashad
- Teng Cherilyn
- Tepe Mustafa Deniz
- Tepe Mustafa Deniz
- Terrosu Giovanni
- Theophilus Mary
- Thompson Nasya
- Thornton-Hume David
- Tiffany Lea
- Ting Clarissa
- Tiras Hale Nur
- Titan Ashley
- Toft Alexandra
- Traina Francesco
- Tran Anthony
- Tran Quang
- Tran Tam
- Tran Will
- Trotta Georgina
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
- Tun Than
- Tung Melody
- Tuzuner Filiz
- Tynan Dominic
- Ugool Mahmoud
- Uğurlu Mustafa Ümit
- Ukrani Ronika Devi
- Ukwuoma Ohia Ernest
- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
- Uyanık Mustafa Safa
- Uzair Ahmad
- Uzel Kadir
- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
- Valverde-Vazquez Rocio
- Vance Lucille
- Vanguardia Kristina
- Vanguardia Maria Kristina
- Vanzuylekom Katie
- Varesano Marco
- Varghese Chris
- Varghese Chris
- Velenciuc Natalia
- Vermeulen Wikus
- Vidanagama Sasini
- Vimalan Vineeth
- Virani Sehar Salim
- Vollenhoven Beverley
- Vong Crystal
- Vrakopoulou Gavriella Zoi
- Vu Jennifer
- Vu Jennifer
- Waaka Nicholas
- Wadhwa Sanya
- Wagaarachchi Prabhath
- Waheed Ayesha Akbar
- Waldin Lucy
- Walsh Eamon
- Walters Chris
- Wang Bill
- Wang Christine
- Wang Erica
- Wang Grace
- Wang Katie
- Wang Nicole Qiwen
- Wang Pengnan
- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M.
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S.Y.
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L.
- Berger Duncan J.
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brooks Tony T.
- Broos Alice
- Brown Julianne Rose
- Brown Paul E.
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K.
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L.
- Caller Laura G.
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Charles Ian G.
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K.J.
- Churcher Carol M.
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M.
- Connor Thomas R.
- Connor Thomas R.
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J.
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J.
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L.
- Fleming Vicki M.
- Forrest Leysa M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Frost Lucy R.
- Fuller William
- Gallagher Eileen
- Gallagher Michael D.
- Garcia-Casado Maria V.
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Gilroy Rachel A.J.
- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C.
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F.
- Haldenby Sam T.
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- Hall Grant
- Halstead Fenella
- Hamilton William L.
- Haque Tanzina
- Harper Katherine L.
- Harris Kathryn Ann
- Harrison Ewan M.
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- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Holden Matthew T.G.
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- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J.
- Howe Robin
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D.
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A.
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu S.
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R.
- Jesudason Natasha
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- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
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- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L.
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- Keatley Jon-Paul
- Keeley Alexander J.
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Khokhar Fahad A.
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- Kingsley Robert A.
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- Knight Bridget A.
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack C.D.
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Li Kathy
- Li Kathy K.
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
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- Loose Matthew W.
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- Lyons Ronan A.
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- Machin Nicholas W.
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T.
- Masoli Jane A.H.
- Mason Jenifer
- Mather Alison E.
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McCrone John T.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J.
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W.
- Merrick Ian
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- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F.
- Nascimento Fabricia F.
- Naydenova Plamena
- Neaverson Alexandra S.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M.
- Nichols Jenna
- Niebel Marc O.
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J.
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N.
- Pandey Sarojini
- Park Naomi
- Parker Matthew D.
- Parmar Surendra
- Parr Yasmin A.
- Parsons Paul J.
- Partridge David G.
- Pascall David J.
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan A.I.
- Peacock Sharon J.
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C.
- Rey Sara
- Rey Sara M.
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rogers Hazel A.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M.
- Sang Fei
- Scarlett Garry P.
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K.
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N.
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G.
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Simpson David A.
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Christen
- Smith Colin P.
- Smith Darren
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J.
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben E.W.
- Taylor Graham P.
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P.
- Temperton Ben
- Templeton Kate E.
- Thompson Thomas
- Thomson Emma C.
- Thomson Emma C.
- Thomson Nicholas M.
- Thornton Alicia
- Thurston Scott
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Tutill Helena J.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vamos Edith E.
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B.
- Volz Erik
- Volz Erik M.
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A.
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Willingham Iona
- Wilson Harry D.
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A.
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Elsevier
- Publication date
- 07/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
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- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
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- Dervisevic Samir
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- The COVID-19 Genomics UK (COG
- Thompson Thomas
- Thomson Emma C.
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
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- Yeats Corin A.
- Yew Wen Chyin
- Young Greg
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- Nature Publishing
- Publication date
- 01/01/2022
- Field of study
Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
- Author
- Aanensen David M.
- Abell Chris
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Ahmadi-Assalemi Gabriela
- Aigrain Louise
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angelis Daniela De
- Angelis Daniela De
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
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- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela H.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Lisa
- Berry Louise
- Berry Sarah
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
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- Bradshaw Daniel
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- Downing Fatima
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- du Plessis Louis
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- Kumziene-SummerhaYes Sara
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- Lackenby Angie
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- MacIntyre-Cockett George
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- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
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- Malone Cassandra S.
- Manesis Nikos
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- Mathieson Nick
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- McManus Georgina M.
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- Mori Matilde
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- Nebbia Gaia
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- Nelson Charlotte
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- Nicholls Sam
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- Nickbakhsh Seema
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- Nikitina Katya
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- Nsonwu Olisaeloka
- Nunez Rocio T. Martinez
- Oliver Karen
- Orton Alexandra
- Orton Richard J.
- Osman Husam
- Ott Sascha
- O’Brien Sarah
- O’Grady Justin
- O’Toole Elaine
- O’Toole Áine
- Pacchiarini Nicole
- Packer Simon
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Pandey Sarojini
- Park Naomi R.
- Parker Matthew D.
- Parlikad Ajith
- Parmar Surendra
- Parsons Paul J.
- Partridge David G.
- Patel Amita
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- Paterson Steve
- Paul Hannah
- Payne Brendan AI.
- Peacock Sharon J.
- Peacock Sharon J.
- Pearson Clare
- Percival Benita
- Perry Malorie
- Peto Timothy
- Pinckert Malte
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Poppitt Steve
- Prestwood Liam
- Price Anna
- Price James
- Prieto Jacqui A.
- Puethe Christoph
- Pusok Monika
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Quinnell Natalie
- Radecki Asako
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Rankin Jennifer
- Ratcliffe Liz
- Raub Gabor
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M.
- Rees Steve
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Ridgman Tom
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Russell Matthew
- Saeed Kordo
- Saluja Tranprit
- Samaraweera Buddhini
- Sambles Christine M.
- Samtani Vijay
- Samworth Richard
- Sang Fei
- Sato Aris
- Scarlett Garry P.
- Schaefer Ulf
- Scott Carol
- Scott Garren
- Searle Paul
- Shaaban Sharif
- Shah Divya
- Shah Rajiv N.
- Shankar Giri
- Shaw Ashley
- Sheldrake Zara
- Shepherd James G.
- Sheridan Linda
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Silveira Siona
- Simpson David A.
- Sing Robert
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Southgate Joel
- Spellman Karla
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Swindells Emma
- Symmonds Amanda
- Taha Yusri
- Tang Julian
- Taylor Ben E. W.
- Taylor Graham P.
- Taylor Peter
- Taylor Sarah
- Taylor-Joyce Grace
- Temperton Ben
- Templeton Kate E.
- The Cambridge Covid-19 testing Centre
- The COVID-19 Genomics UK (COG-UK) Consortium
- Thompson Thomas
- Thomson Emma C.
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tolhurst Jonathan
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Twohig Katherine A.
- Tynan Jo
- Underwood Anthony P.
- University of Cambridge Asymptomatic COVID-19 Screening Programm
- Unnikrishnan Meera
- Valletta Sally
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vignoles Anna
- Vinnell Martin
- Vipond Ian B.
- Volz Erik M.
- Waddell Ian
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Emmeline
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Weale Gillian
- Webster Hermione J.
- Weekes Michael P.
- Weldon Danni
- Westhorpe Adam P.
- White Phil
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Williman Jack
- Willingham Iona
- Wills Mark
- Wilson Harry D.
- Wilson Karl
- Wilson Rebekah E.
- Wilson-Davies Eleri
- Winster Jennifer
- Wise Emma
- Witele Eric
- Workman Chris
- Workman Trudy
- Wright Elizabeth
- Wright Elizabeth
- Wright Giles
- Wright Jo
- Wright Victoria
- Wyatt Tim
- Wyles Matthew
- Wyllie Sarah
- Xu-McCrae Li
- Yeats Corin A.
- Yew Wen Chyin
- Young Greg
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- Nature Communications
- Publication date
- 08/02/2022
- Field of study
AbstractUnderstanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.</jats:p
Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes
- Author
- Aanensen David M.
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton S.
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- Dabrer Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Delgado Callico Laia
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar R.
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- El Bouzidi Kate
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
- Fanaie Arezou
- Farr Ben W.
- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia T.
- Glaysher Sharon
- Goldstein Emily J.
- Golubchik Tanya
- Gomes Andrea N.
- Gonçalves Sónia
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R.
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Guest Martyn
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Haas J.G.
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- Hamilton William L.
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- Haque Tanzina
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- Harrison Ian
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- Hartley John A.
- Harvey Matthew
- Harvey William T.
- Hassan-Ibrahim Mohammed O.
- Heaney Judith
- Helmer Thomas
- Henderson John H.
- Hesketh Andrew R.
- Hey Jessica
- Heyburn David
- Higginson Ellen E.
- Hill Jack D.
- Hill Verity
- Hilson Rachel A.
- Hilvers Ember
- Holden Matthew TG.
- Hollis Amy
- Holmes Alison H.
- Holmes Christopher W.
- Holmes Nadine
- Hopes Richard
- Hornsby Hailey R.
- Hosmillo Myra
- Houlihan Catherine
- Howson-Wells Hannah C.
- Hsu Sharon N.
- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jackson Leigh M.
- Jahun Aminu S.
- James Keith
- James Victoria
- Jeanes Christopher
- Jeffries Aaron R.
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R.
- Jones Hannah
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kele Beatrix
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Kidd Stephen P.
- Killough Nicholas F.
- Kimuli Maimuna
- Kirk Stuart
- Kitchen Christine
- Kitchman Katie
- Knight Bridget A.
- Koshy Cherian
- Kraemer Moritz UG.
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G.
- Lampejo Temi
- Langford Cordelia F.
- Lavin Deborah
- Lawton Andrew I.
- Le-Viet Thanh
- Lee David
- Lee Jack CD.
- Lensing Stefanie V.
- Leonard Steven
- Levett Lisa J.
- Lewis Jonathan
- Lewis Kevin
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J.
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lo Stephanie
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana IK.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S.
- Maloney Daniel
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Markov Anna
- Martincorena Inigo
- Martinez Nunez Rocio T.
- Mather Alison E.
- Maxwell Patrick
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare M.
- McCarthy Shane A.
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McHugh M.P.
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McMurray Claire L.
- McNal Alan
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L.
- Michelsen Michelle L.
- Mirfenderesky Mariyam
- Mirza Jeremy
- Miskelly Julia
- Moles-Garcia Emma
- Moll Robin J.
- Molnar Zoltan
- Monahan Irene M.
- Mondani Matteo
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morris Arthur
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murray Abigail
- Murray Darren R.
- Murray Leanne J.
- Mutingwende Manasa
- Myers Richard
- Nastouli Eleni
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nicholls Sam
- Nichols Jenna
- Nicodemi Roberto
- Nomikou Kyriaki
- O'Brien Sarah
- O'Grady Justin
- O'Toole Áine
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
- Orton Richard J.
- Osman Husam
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Park Emily J.
- Park Naomi R.
- Parker Matthew D.
- Parmar Surendra
- Partridge David G.
- Pascall David
- Patel Amita
- Patel Bindi
- Paterson Steve
- Payne Brendan AI.
- Peacock Sharon J.
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Pinckert Malte L.
- Platt Steven
- Podplomyk FD Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F.
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R.
- Prieto Jacqui A.
- Pritch David T.
- Prosolek Sophie J.
- Pugh Georgia
- Pusok Monika
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A.
- Rambaut Andrew
- Ramble John
- Randell Paul
- Randell Paul A.
- Ratcliffe Liz
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M.
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robinson Esther
- Robson Samuel C.
- Rogan Fiona
- Rooke Stefan
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M.
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Sehmi Jasveen
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silviera Siona
- Simpson David A.
- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren L.
- Smith Ken
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Perminder
- Smollett Katherine L.
- Snell Luke B.
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
- Stanley Rachael
- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben EW.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton K.
- Templeton Kate E.
- Thomas Claire
- Thomas-McEwen Peter MD.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott AJ.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tonkin-Hill Gerry
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson DipHE Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workma Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/03/2023
- Field of study
Background
The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes.
Aim
To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave.
Methods
A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records.
Findings
In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home.
Conclusion
The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine
Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S Y
- Aigrain Louise
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Antonelli Michela
- Aranday-Cortes Elihu
- Ariani Cristina V
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen W
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew R
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela H
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L
- Berry Lisa
- Berry Louise
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- BoYes John
- Bradley Amanda
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Bronner Iraad F
- Brooks Ellena
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Bucca Giselda
- Buck David
- Bull Matthew
- Burton-Fanning Shirelle
- Campbell Sharon
- Canas Liane S
- Capdevila Joan
- Carabelli Alessandro M
- Carden Holli
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Cerda Alberto C
- Chalker Vicki
- Chan Andrew T
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey K.J.
- Churcher Carol M
- Clark Gemma
- Cogger Benjamin J
- Coll Francesc
- Collins Jennifer
- Connor Thomas R
- Constantinidou Chrystala
- Cook Kate
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nick
- Cotic Marius
- Cottrell Simon
- Coupland Lindsay
- Cowell Angela
- Cox Alison
- Craine Noel
- Crawford Liam
- Cronin Michelle
- Crook Derrick
- Cumley Nicola
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Dadrah Ashok
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davies Robert
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dent Hannah
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Dorman Matthew J
- Downing Fatima
- Drew David A
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Escalera Zamudio Marina
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
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- Lowe Helen L
- Lucaci Anita O
- Ludden Catherine
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- Wierzbicki Claudia
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- Willingham Iona
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- Wilson Rebekah E
- Wilson-Davies Eleri
- Wise Emma
- Witele Eric
- Wolf Jonathan
- Workman Trudy
- Wright Victoria
- Wyatt Tim
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- Wyllie Sarah
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- Yeats Corin A
- Yew Wen C
- Young Greg
- Young Jamie
- Zarebski Alex E
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2021
- Field of study
Background
The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease course, reinfection rates, or transmissibility.
Methods
We did an ecological study to examine the association between the regional proportion of infections with the SARS-CoV-2 B.1.1.7 variant and reported symptoms, disease course, rates of reinfection, and transmissibility. Data on types and duration of symptoms were obtained from longitudinal reports from users of the COVID Symptom Study app who reported a positive test for COVID-19 between Sept 28 and Dec 27, 2020 (during which the prevalence of B.1.1.7 increased most notably in parts of the UK). From this dataset, we also estimated the frequency of possible reinfection, defined as the presence of two reported positive tests separated by more than 90 days with a period of reporting no symptoms for more than 7 days before the second positive test. The proportion of SARS-CoV-2 infections with the B.1.1.7 variant across the UK was estimated with use of genomic data from the COVID-19 Genomics UK Consortium and data from Public Health England on spike-gene target failure (a non-specific indicator of the B.1.1.7 variant) in community cases in England. We used linear regression to examine the association between reported symptoms and proportion of B.1.1.7. We assessed the Spearman correlation between the proportion of B.1.1.7 cases and number of reinfections over time, and between the number of positive tests and reinfections. We estimated incidence for B.1.1.7 and previous variants, and compared the effective reproduction number, Rt, for the two incidence estimates.
Findings
From Sept 28 to Dec 27, 2020, positive COVID-19 tests were reported by 36 920 COVID Symptom Study app users whose region was known and who reported as healthy on app sign-up. We found no changes in reported symptoms or disease duration associated with B.1.1.7. For the same period, possible reinfections were identified in 249 (0·7% [95% CI 0·6–0·8]) of 36 509 app users who reported a positive swab test before Oct 1, 2020, but there was no evidence that the frequency of reinfections was higher for the B.1.1.7 variant than for pre-existing variants. Reinfection occurrences were more positively correlated with the overall regional rise in cases (Spearman correlation 0·56–0·69 for South East, London, and East of England) than with the regional increase in the proportion of infections with the B.1.1.7 variant (Spearman correlation 0·38–0·56 in the same regions), suggesting B.1.1.7 does not substantially alter the risk of reinfection. We found a multiplicative increase in the Rt of B.1.1.7 by a factor of 1·35 (95% CI 1·02–1·69) relative to pre-existing variants. However, Rt fell below 1 during regional and national lockdowns, even in regions with high proportions of infections with the B.1.1.7 variant.
Interpretation
The lack of change in symptoms identified in this study indicates that existing testing and surveillance infrastructure do not need to change specifically for the B.1.1.7 variant. In addition, given that there was no apparent increase in the reinfection rate, vaccines are likely to remain effective against the B.1.1.7 variant.
Funding
Zoe Global, Department of Health (UK), Wellcome Trust, Engineering and Physical Sciences Research Council (UK), National Institute for Health Research (UK), Medical Research Council (UK), Alzheimer's Society
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
- Author
- Aanensen David M.
- Abraham Priyanka
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Adele Sandra
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Ansari M. Azim
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Ashraf Shirin
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Austin James
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barnes Eleanor
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
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- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
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- Smith Nikki
- Smith Perminder
- Smollett Katherine
- Smollett Katherine L.
- Snell Luke B.
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
- Stanley Rachael
- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Szemiel Agnieszka
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben E. W.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton Kate
- Templeton Kate E.
- Thomas Claire
- Thomson Emma C.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vink Elen
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Wilkie Craig
- Willett Brian J.
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/08/2022
- Field of study
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant
Mobile 2.0: M-Money for the BOP in the Philippines
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2009
- Field of study