DETAIL STUDY OF MAHA SHANKHA VATI - A LITERARY REVIEW

In Ayurveda Classics Sankha Vati seems with two names Sankha Vati and Maha Shankha Vati.  Both these preparations are selected for the present study are comes under Khalveeya Rasa Kalpana & Sagandha and Niragni Moorchhana preparation. This study having the aim of detailed literary study of Maha Sankha Vati & Sankha Vati. In Ayurveda classics Four different references of MahaSankha vati & ten references of Sankha Vati found. In Ayurveda Formulary of India Maha Shankha Vati is prescribed from Bhaishjya Ratnavali, but this reference actually originated from Rasendra Chintamani. After considering various reference in text, it was found that fourteen drugs are common according to all the references, these are Parada, Gandhaka, Vatsanabha, Shankha Bhasma, Hingu, Chincha Kshara, Panchalavana, Maricha, Pippali & Sunthi. In Bharat Bhaishajya Ratnakar mentioned that, if Loha & Vanga added in Sankha Vati formulation it can be called as Maha Shankha Vati. After studying various reference mentioned in Ras Shastra, Standard operative procedure of Maha Shankha Vati can be classified into two types:- In above two SOP only difference in Shankha Processing, in first SOP Shankha Bhasma is prepared by giving Gaja Puta and in second SOP Shankha Marana has been done by Quenching method. Variations found in Bhavana Dravya, Bhavana Sankhya, Size, Anupana, Grahan Kala of Maha Sankha Vati among all classics. like There are found references about Apamarga Patra Swaras, Apamarga Mula Kwath. In AFI Chitrak Mula & Apamarga Panchanga, mentioned in the form of Kwatha. Bhavana of Amlavarga Dravya must be given upto it becomes Amla in test. To go to details go through this Study which having mentioned all the details

Solvent-Washable Polymer Templated Synthesis of Mesoporous Materials and Solic-Acid Nanocatalysts in One-Pot

We report a new and simple one-pot synthetic method to produce mesoporous silica and nanoporous solid acid catalyst capable of catalyzing pinacole-pinacolone rearrangement and esterification reactions, by preparing a solvent washable phosphonated triblock copolymer template and self-assembling it in the presence of alkoxysilane

Influence of pre-bloom sprays of benzyladenine on in vitro recovery of hybrid embryos from crosses of Thompson Seedless and 8 seeded varieties of grape (Vitis spp.)

The present investigations are part of a study to introgress downy mildew resistance in Thompson Seedless through breeding and in ovulo embryo rescue methods. The influence of sprays of benzyladenine (BA) at prebloom and bloom on the percentage of embryo recovery, germination and development of hybrid plants is described. BA gave mixed results among the 8 cross combinations. With some crosses, BA drastically improved these parameters. In almost all crosses, germination increased significantly with BA sprays. The influence on plant development and recovery depended on BA treatment and the male parent

Stress induced hyperglycemia and the subsequent risk of type 2 diabetes in survivors of critical illness

OBJECTIVE: Stress induced hyperglycemia occurs in critically ill patients who have normal glucose tolerance following resolution of their acute illness. The objective was to evaluate the association between stress induced hyperglycemia and incident diabetes in survivors of critical illness. DESIGN: Retrospective cohort study. SETTING: All adult patients surviving admission to a public hospital intensive care unit (ICU) in South Australia between 2004 and 2011. PATIENTS: Stress induced hyperglycemia was defined as a blood glucose ≥ 11.1 mmol/L (200 mg/dL) within 24 hours of ICU admission. Prevalent diabetes was identified through ICD-10 coding or prior registration with the Australian National Diabetes Service Scheme (NDSS). Incident diabetes was identified as NDSS registration beyond 30 days after hospital discharge until July 2015. The predicted risk of developing diabetes was described as sub-hazard ratios using competing risk regression. Survival was assessed using Cox proportional hazards regression. MAIN RESULTS: Stress induced hyperglycemia was identified in 2,883 (17%) of 17,074 patients without diabetes. The incidence of type 2 diabetes following critical illness was 4.8% (821 of 17,074). The risk of diabetes in patients with stress induced hyperglycemia was approximately double that of those without (HR 1.91 (95% CI 1.62, 2.26), p<0.001) and was sustained regardless of age or severity of illness. CONCLUSIONS: Stress induced hyperglycemia identifies patients at subsequent risk of incident diabetes.Mark P. Plummer, Mark E. Finnis, Liza K. Phillips, Palash Kar, Shailesh Bihari, Vishwanath Biradar, Stewart Moodie, Michael Horowitz, Jonathan E. Shaw, Adam M. Dean

Lactic acidosis occurrence during exercises in the smoke chamber in a 53-year-old firefighter with no significant medical history

Lactic acidosis is a form of metabolic acidosis with a high anion gap, reduced rate of arterial blood pH under 7.35 mmol/l, and lactic acid concentration over 7 mmol/l. In the literature we can find some descriptions of the cases of lactic acidosis in patients with severe systemic diseases (cancer, acquired immunodeficiency syndrome, sepsis, diabetes with cardiovascular disease and after organ transplantations). We present the case of lactic acidosis in a patient with no chronic disease - a firefighter in whom lactic acidosis has developed during standard exercises in the smoke chamber

Morpho-Physiological Parameters Associated with Iron Deficiency Chlorosis Resistance and Their Effect on Yield and Its Related Traits in Groundnut

Iron deficiency chlorosis (IDC) causes a significant reduction in yield of groundnut grown in calcareous and alkaline soils in India. The main aim of the study was to assess genotypic differences for morpho-physiological parameters associated with IDC resistance across different stages and their effect on yield and its related traits. The factorial pot experiment was comprised of two major factors, i) soil-Fe status [normal-Fe, deficit-Fe], and ii) genotypes [five] with differential IDC response, constituting 10 treatments. They were assessed for five morpho-physiological parameters associated with IDC resistance across five crop growth stages and also yield and its related traits. Associations between these traits were also estimated. Under deficit-Fe conditions, IDC resistant genotypes recorded significantly lower visual chlorosis rating (VCR), higher SPAD values, active Fe, chlorophyll content, peroxidase activity, and high yield compared to susceptible ones. Between normal- to deficit-Fe soils, resistant compared to susceptible genotypes showed no change in VCR scores; a lower reduction in SPAD, chlorophyll, active Fe, peroxidase activity, and pod yield. Under deficit-Fe conditions, high yield among resistant genotypes could be attributed to higher seed weight, number of pods and haulm yield, while contrasting reduction in main stem height and number of primaries. The results indicate that for initial large-scale screening of groundnut genotypes for IDC resistance, SPAD values are most ideal while active Fe could be utilized for confirmation of identified lines

Genetic Differences for Iron Absorption Efficiency Related Traits in Groundnut

Iron deficiency chlorosis (IDC) is of common occurrence in groundnut growing areas with calcareous, alkaline and black SOils which accounts to one-third of the Indian soils. Groundnut is sensitive to iron deficiency, but shows genotypic differences for iron absorption efficiency (IAE) response. A pot experiment was conducted using five genotypes with varying degree of IAE [ICGV 86031 , A30b (efficient), TG 26 (moderately effiCient), TAG 24, TMV 2 (inefficient)] in normal and deficit Fe soil types to determine underlying mechanisms. They were assessed for IAE related traits like visual chlorotic rating (VCR), SPAD chlorophyll meter reading (SCMR), chlorophyll (a, b and total) content, active iron (Fe2+) content. and peroxidase activity in initial expanded leaves across five crop growth stages (20, 40, 60, 60, 100 days) and also for productivity traits. Iron absorption efficient groundnut genotypes recorded significantly lower VCR, higher SCMR, higher active iron, chlorophyll (a, b and total) and peroxidase activity across all five crop growth stages compared to inefficient genotypes. Severity of chlorosis was highest at 60 days during which significant negative correlation was observed between VCR and IAE related traits like SCMR, chlorophyll (a, band total) content, active iron content, and peroxidase activity indicating their utility as surrogate traits In screening for IAE in groundnut. IAE related traits showed significant positive association with productivity traits like pod yield, 100 seed weight, number of pods and primary branches. Pod yield reduction due to iron chlorosis in efficlent genotypes was very less compared to inefficient genotypes

Study of Prescribing Pattern, Identification of Drug Related Problems and Therapeutic Intervention in Cardio Vascular Diseases (CVD) Patients

Cardiovascular disease (CVD) is a disorder of heart and blood vessels. CVD is one of the major causes of deaths in India, which contributed around 30 to 40%. The aim of the study was to study the prescribing pattern of drugs, identification of drug related problems and therapeutic intervention in CVD patients. A hospital based prospective and observational study was carried out for a period of nine months in a south Indian tertiary care hospital. Among 120 selected patients, 79 were male&nbsp; (65.83%) and 41 were female&nbsp; (34.16%), more number of patients (35) were between the age group of 55-64 (29.16%) of which 27 were males &amp; 8 were females, and very less number of patients (6) were between the age group 85-94 (5%) of which all the 6 were male. Hypertension is the most commonest and dominant disorder, which affected 47(39.16%) patients, in which 30 were male (25%) and 17 were female (14.16%). Most common risk factor is HTN followed with smoking and diabetes of 45 patients (37.5%). The most often prescribed pattern adopted in CVD is Dual therapy, it is most frequently used therapy 50 (41.66%) and quadruple therapy is less frequently 6(6.5%) used. The diuretics and calcium channel blocker combination were maximally prescribed class of drugs as a dual therapy. A total of 47 drug-drug interactions were found, among 12 were major, 15 were moderate and 20 were minor interactions. Clinical pharmacist has intervened with the help of other health care professionals in order to reduce the risk factor and minimise the drug-drug interactions. The study provides the benefits of presence of clinical pharmacist in a hospital setting, in order to prevent the medication related errors and provide the expertise pharmacotherapy opinion in CVD patients, which improves the patient compliance.&nbsp; Hence study justifies a need of active collaboration between clinical pharmacist, physician and other health care professionals for the better management of CVD patients. Keywords: Prescribing Pattern; Cardio Vascular Diseases; Drug Related Problems; Therapeutic Intervention

White Paper: Shifting the goal post - from high impact journals to high impact data

The purpose of this white paper is to provide an overview of the ongoing initiatives at center level to respond to changing public expectations and to the challenge of improving the conduct of science by making research data widely available. We also attempt to provide a framework for implementing open access for research data to maximize CGIAR’s impact on development. The remainder of this paper proceeds as follows; firstly a summary of the diversity of research data produced by the centers is given, followed by an overview of the existing infrastructure for data management for each Center. Secondly, some of the limitations and barriers faced by the centers in their process to mainstream research data publishing are addressed. The paper concludes with recommendations for how these limitations and barriers can be tackled