A Determination of the Centre-of-Mass Energy at LEP2 using Radiative 2-fermion Events

Using e+e- -> mu+mu-(gamma) and e+e- -> qqbar(gamma) events radiative to the Z pole, DELPHI has determined the centre-of-mass energy, sqrt{s}, using energy and momentum constraint methods. The results are expressed as deviations from the nominal LEP centre-of-mass energy, measured using other techniques. The results are found to be compatible with the LEP Energy Working Group estimates for a combination of the 1997 to 2000 data sets.Comment: 20 pages, 6 figures, Accepted by Eur. Phys. J.

Immunoglobulin A glycosylation differs between Crohn's disease and ulcerative colitis

Inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis (UC), are chronic and relapsing inflammations of the digestive tract with increasing prevalence, yet they have unknown origins or cure. CD and UC have similar symptoms but respond differently to surgery and medication. Current diagnostic tools often involve invasive procedures, while laboratory markers for patient stratification are lacking. Large glycomic studies of immunoglobulin G and total plasma glycosylation have shown biomarker potential in IBD and could help determine disease mechanisms and therapeutic treatment choice. Hitherto, the glycosylation signatures of plasma immunoglobulin A, an important immunoglobulin secreted into the intestinal mucin, have remained undetermined in the context of IBD. Our study investigated the associations of immunoglobulin A1 and A2 glycosylation with IBD in 442 IBD cases (188 CD and 254 UC) and 120 healthy controls by reversed-phase liquid chromatography electrospray-ionization mass spectrometry of tryptic glycopeptides. Differences of IgA O- and N-glycosylation (including galactosylation, bisection, sialylation, and antennarity) between patient groups were associated with the diseases, and these findings led to the construction of a statistical model to predict the disease group of the patients without the need of invasive procedures. This study expands the current knowledge about CD and UC and could help in the development of noninvasive biomarkers and better patient care. Proteomic

Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases

Proteomic

Herausforderung Wissenstransfer in Clustern : neues Wissen vom Biotechnologiestandort Martinsried

Wissen stellt in forschungsintensiven Industrien eine Schlüsselressource dar. Vor dem Hintergrund der noch weitgehend ungeklärten Frage nach den Konkurrenzbeziehungen und Kausalitäten in Wissenstransferprozessen ergründet der vorliegende Beitrag die verschiedenen Koordinationsweisen von Wissenstransfer am Beispiel des Biotechnologiestandorts Martinsried. Die empirisch auf qualitative Experteninterviews und eine Online-Befragung gestützte Untersuchung gibt Aufschluss über die Potentiale und Probleme von Wissensvernetzung, Wissensteilung und Wissensabfluss als zentrale Mechanismen des interorganisationalen Wissenstransfers. Die Ergebnisse der Fallstudie liefern sowohl konzeptionelle Einsichten in die raumzeitlichen Dynamiken von Wissenstransfer als auch praxisorientierte Hinweise bezüglich der Herausforderungen der Wissensintermediation im Biotech-Cluster Martinsried

A determination of the centre-of-mass energy at LEP2 using radiative two-fermion events

Using e(+)e(-) -> mu(+)mu(-)(gamma) and e(+)e(-) -> q (q) over bar(gamma) events radiative to the Z pole, DELPHI has determined the centre-of-mass energy, root s, using energy and momentum constraint methods. The results are expressed as deviations from the nominal LEP centre-of-mass energy, measured using other techniques. The results are found to be compatible with the LEP Energy Working Group estimates for a combination of the 1997 to 2000 data sets