11 research outputs found
Anti-Inflammatory Properties of the Citrus Flavonoid Diosmetin: An Updated Review of Experimental Models
Inflammation is an essential contributor to various human diseases. Diosmetin (3′,5,7-trihydroxy-4′-methoxyflavone), a citrus flavonoid, can be used as an anti-inflammatory agent. All the information in this article was collected from various research papers from online scientific databases such as PubMed and Web of Science. These studies have demonstrated that diosmetin can slow down the progression of inflammation by inhibiting the production of inflammatory mediators through modulating related pathways, predominantly the nuclear factor-κB (NF-κB) signaling pathway. In this review, we discuss the anti-inflammatory properties of diosmetin in cellular and animal models of various inflammatory diseases for the first time. We have identified some deficiencies in current research and offer suggestions for further advancement. In conclusion, accumulating evidence so far suggests a very important role for diosmetin in the treatment of various inflammatory disorders and suggests it is a candidate worthy of in-depth investigation
Dissipation and residue determination of penicillin G and its two metabolites in citrus under field conditions by DSPE/UPLC–MS/MS
Determination of ten pyrethroids in various fruit juices: Comparison of dispersive liquid–liquid microextraction sample preparation and QuEChERS method combined with dispersive liquid–liquid microextraction
Controlled Growth of Gold Nanobipyramids Using Thiocholine for Plasmonic Colorimetric Detection of Organophosphorus Pesticides
Implementing suitable additives as morphology control
agents to
tune the shape of gold nanocrystals is a great challenge, as it requires
the production of additives in a controlled manner and subsequent
rational design of its applications. Herein, thiocholine-controllable
regulation of the shape of gold nanobipyramids (AuNBPs) is proposed
for the first time. Subsequently, it is used for constructing a plasmonic
colorimetric sensor for the detection of organophosphorus pesticides
(OPs). The principle of the platform is that first, highly uniform
AuNBPs are prepared in situ by a seed-mediated growth method. Then,
the thiocholine produced from the hydrolysis of acetylthiocholine
by acetylcholinesterase (AChE) can be selectively adsorbed on the
surface of the gold seeds, preventing the gold seeds from forming
AuNBPs. Transmission electron microscopy shows the evolution of the
shape of AuNBPs from bipyramid to cube and finally irregular sphere
as the concentration of thiocholine increases. Therefore, the AChE
concentration is highly correlated with the shape of the grown gold
nanoparticles. Consequently, a plasmonic colorimetric method is established
for the sensitive detection of OPs with the ability to irreversibly
inhibit AChE activity. The proposed method achieves highly sensitive
detection of paraoxon and demeton with limit of detections as low
as 1.07 and 6.48 ng mL–1, respectively. Owing to
the advantages of simple operation and high sensitivity, this method
has great potential in the monitoring of OPs in agricultural products