Modeling Geometry and Progressive Failure of Material Interfaces in Plain Weave Composites

A procedure combining a geometrically nonlinear, explicit-dynamics contact analysis, computer aided design techniques, and elasticity-based mesh adjustment is proposed to efficiently generate realistic finite element models for meso-mechanical analysis of progressive failure in textile composites. In the procedure, the geometry of fiber tows is obtained by imposing a fictitious expansion on the tows. Meshes resulting from the procedure are conformal with the computed tow-tow and tow-matrix interfaces but are incongruent at the interfaces. The mesh interfaces are treated as cohesive contact surfaces not only to resolve the incongruence but also to simulate progressive failure. The method is employed to simulate debonding at the material interfaces in a ceramic-matrix plain weave composite with matrix porosity and in a polymeric matrix plain weave composite without matrix porosity, both subject to uniaxial cyclic loading. The numerical results indicate progression of the interfacial damage during every loading and reverse loading event in a constant strain amplitude cyclic process. However, the composites show different patterns of damage advancement

Simulation of Complex Cracking in Plain Weave C/SiC Composite under Biaxial Loading

Finite element analysis is performed on a mesh, based on computed geometry of a plain weave C/SiC composite with assumed internal stacking, to reveal the pattern of internal damage due to biaxial normal cyclic loading. The simulation encompasses intertow matrix cracking, matrix cracking inside the tows, and separation at the tow-intertow matrix and tow-tow interfaces. All these dissipative behaviors are represented by traction-separation cohesive laws. Not aimed at quantitatively predicting the overall stress-strain relation, the simulation, however, does not take the actual process of fiber debonding into account. The fiber tows are represented by a simple rule-of-mixture model where the reinforcing phase is a hypothetical one-dimensional material. Numerical results indicate that for the plain weave C/SiC composite, 1) matrix-crack initiation sites are primarily determined by large intertow matrix voids and interlayer tow-tow contacts, 2) the pattern of internal damage strongly depends on the loading path and initial stress, 3) compressive loading inflicts virtually no damage evolution. KEY WORDS: ceramic matrix composite, plain weave, cohesive model, brittle failure, smeared crack model, progressive damage, meso-mechanical analysis, finite element

Hierarchical-Structure-Based Fault Estimation and Fault-Tolerant Control for Multiagent Systems

This paper proposes a hierarchical-structure-based fault estimation and fault-tolerant control design with bidirectional interactions for nonlinear multiagent systems with actuator faults. The hierarchical structure consists of distributed multiagent system hierarchy, undirected topology hierarchy, decentralized fault estimation hierarchy, and distributed fault-tolerant control hierarchy. The states and faults of the system are estimated simultaneously by merging the unknown input observer in a decentralized fashion. The distributed-constant-gain-based and node-based fault-tolerant control schemes are developed to guarantee the asymptotic stability and H-infinity performance of multiagent systems, respectively, based on the estimated information in the fault estimation hierarchy and the relative output information from neighbors. Two simulation cases validate the efficiency of the proposed hierarchical structure control algorithm

Incidence, risk factor, and prognosis of end-stage renal disease after heart transplantation in Chinese recipients

Background/PurposeEnd-stage renal disease (ESRD) is an important complication arising after heart transplantation. At least 3–10% of recipients reach ESRD within 10 years after transplant. The incidence of ESRD in Chinese recipients has not been reported. Here we sought to assess the incidence, prognosis, and risk factors for ESRD in Chinese recipients.MethodsWe conducted a retrospective analysis of 248 heart recipients who survived >1 year from 1998 through 2007. ESRD was defined as the requirement of maintenance dialysis.ResultsRenal dysfunction was present in 20 patients (8%) prior to transplant. With a follow-up duration of 5.8 ± 3.9 years, 30 patients developed ESRD. The cumulative incidence of ESRD after heart transplantation was 2.1% ± 0.9%, 6.5% ± 1.8%, 16.8% ± 3.3%, and 36.5% ± 9.5% at 2, 5, 10, and 15 years after transplant, respectively. Median onset of ESRD was 6.9 years after transplant. Actuarial survival after dialysis was 74.8% ± 8.3%, 66.6% ± 9.2%, and 43.6% ± 12.6% at 1, 2, and 5 years, respectively. Independent risk factors for ESRD included pretransplant serum creatinine (hazard ratio, 1.84; p = 0.001), presence of diabetes prior to transplant (hazard ratio, 2.51; p = 0.017), and old age at transplant (hazard ratio, 1.05; p = 0.008).ConclusionThere was a high incidence of ESRD in Chinese heart recipients. Patients with ESRD had poor prognosis after dialysis

Fault-Tolerant Consensus of Multi-Agent Systems Subject to Multiple Faults and Random Attacks

This paper explores the consensus control problem of nonlinear multi-agent systems (MASs) under complex cyber-physical threats (CPTs), which encompass sensor/actuator faults, input/output channel noises, and random cyber-attacks. The multiple sensor/actuator faults are uniformly modeled as an exponential type, while random cyber-attacks are characterized by a Markov chain. To enhance the safety and security of MASs under CPTs, the distributed normalized observers are first developed, enabling precise estimations of unknown state and fault information. Subsequently, the distributed fault-tolerant consensus control (FTCC) scheme with a positive reconstruction mechanism is proposed to maintain resilience against attacks, compensation for faults, and robustness to noises in MASs under adverse CPTs. The two notable innovations can be outlined as follows: i) The achievement of FTCC objectives under complex CPTs, demonstrating strong algorithmic transferability in both non-attack and random attack scenarios. ii) The adoption of a double-layer distributed framework in the estimation layer and control layer, balancing computational complexity and efficiency improvements compared to a combination of decentralized and distributed approaches. Simulation results finally confirm the efficacy and feasibility of the proposed FTCC algorithm

Decentralized Output Sliding-Mode Fault-Tolerant Control for Heterogeneous Multiagent Systems

This paper proposes a novel decentralized output sliding-mode fault-tolerant control (FTC) design for heterogeneous multiagent systems (MASs) with matched disturbances, unmatched nonlinear interactions, and actuator faults. The respective iteration and iteration-free algorithms in the sliding-mode FTC scheme are designed with adaptive upper bounding laws to automatically compensate the matched and unmatched components. Then, a continuous fault-tolerant protocol in the observer-based integral sliding-mode design is developed to guarantee the asymptotic stability of MASs and the ultimate boundedness of the estimation errors. Simulation results validate the efficiency of the proposed FTC algorithm

Distributed Event-triggered Fault-tolerant Consensus Control of Multi-agent Systems under DoS Attacks

This study investigates the distributed fault-tolerant consensus issue of multi-agent systems subject to complicated abrupt and incipient time-varying actuator faults in physical hierarchy and aperiodic denial-of-service (DoS) attacks in networked hierarchy. Decentralized estimators are devised to estimate consecutive system states and actuator faults. A unified framework with an absolute local output-based closed-loop estimator in decentralized fault estimation design and a relative broadcasting state-based open-loop estimator in distributed event-triggered fault-tolerant consensus design is developed. Criteria of exponential consensus of the faulty multi-agent systems under DoS attacks are derived by virtue of average dwelling time and attack frequency technique. Simulations are outlined to confirm the efficacy of the proposed distributed fault-tolerant consensus control algorithm based on an event-triggered mechanism

Distributed Fault-Tolerant Consensus Tracking Control of Multi-Agent Systems under Fixed and Switching Topologies

This paper proposes a novel distributed fault-tolerant consensus tracking control design for multi-agent systems with abrupt and incipient actuator faults under fixed and switching topologies. The fault and state information of each individual agent is estimated by merging unknown input observer in the decentralized fault estimation hierarchy. Then, two kinds of distributed fault-tolerant consensus tracking control schemes with average dwelling time technique are developed to guarantee the mean-square exponential consensus convergence of multi-agent systems, respectively, on the basis of the relative neighboring output information as well as the estimated information in fault estimation. Simulation results demonstrate the effectiveness of the proposed fault-tolerant consensus tracking control algorithm

Pairs of Frequency-based Nonhomogeneous Dual Wavelet Frames in the Distribution Space

In this paper, we study nonhomogeneous wavelet systems which have close relations to the fast wavelet transform and homogeneous wavelet systems. We introduce and characterize a pair of frequency-based nonhomogeneous dual wavelet frames in the distribution space; the proposed notion enables us to completely separate the perfect reconstruction property of a wavelet system from its stability property in function spaces. The results in this paper lead to a natural explanation for the oblique extension principle, which has been widely used to construct dual wavelet frames from refinable functions, without any a priori condition on the generating wavelet functions and refinable functions. A nonhomogeneous wavelet system, which is not necessarily derived from refinable functions via a multiresolution analysis, not only has a natural multiresolution-like structure that is closely linked to the fast wavelet transform, but also plays a basic role in understanding many aspects of wavelet theory. To illustrate the flexibility and generality of the approach in this paper, we further extend our results to nonstationary wavelets with real dilation factors and to nonstationary wavelet filter banks having the perfect reconstruction property

Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9.

Background Studies in animals showed that PCSK9 is involved in HDL metabolism. We investigated the molecular mechanism by which PCSK9 regulates HDL cholesterol concentration and also whether Pcsk9 inactivation might affect cholesterol efflux capacity of serum and atherosclerotic fatty streak volume. Methods Mass spectrometry and western blot were used to analyze the level of apolipoprotein E (APOE) and A1 (APOA1). A mouse model overexpressing human LDLR was used to test the effect of high levels of liver LDLR on the concentration of HDL cholesterol and APOE-containing HDL subfractions. Pcsk9 knockout males lacking LDLR and APOE were used to test whether LDLR and APOE are necessary for PCSK9-mediated HDL cholesterol regulation. We also investigated the effects of Pcsk9 inactivation on cholesterol efflux capacity of serum using THP-1 and J774.A1 macrophage foam cells and atherosclerotic fatty streak volume in the aortic sinus of Pcsk9 knockout males fed an atherogenic diet. Results APOE and APOA1 were reduced in the same HDL subfractions of Pcsk9 knockout and human LDLR transgenic male mice. In Pcsk9/Ldlr double-knockout mice, HDL cholesterol concentration was lower than in Ldlr knockout mice and higher than in wild-type controls. In Pcsk9/Apoe double-knockout mice, HDL cholesterol concentration was similar to that of Apoe knockout males. In Pcsk9 knockout males, THP-1 macrophage cholesterol efflux capacity of serum was reduced and the fatty streak lesion volume was similar to wild-type controls. Conclusions In mice, LDLR and APOE are important factors for PCSK9-mediated HDL regulation. Our data suggest that, although LDLR plays a major role in PCSK9-mediated regulation of HDL cholesterol concentration, it is not the only mechanism and that, regardless of mechanism, APOE is essential. Pcsk9 inactivation decreases the HDL cholesterol concentration and cholesterol efflux capacity in serum, but does not increase atherosclerotic fatty streak volume.This work was supported by HL081162, HL077796 and HL095668 from the National Heart, Lung and Blood Institute and by the Canadian Institutes of Health Research grants 82946 and 102741. The Proteomics Core Facility is supported by the Vermont Genetics Network through NIH grant 8P20GM103449 from the INBRE program of the National Institute of General Medical Sciences (NIGMS) and the National Center for Research Resources (NCRR). BRP thanks the NIH (CA83831) for financial support. AP was supported by the Canadian Institutes of Health Research grants 82946 and 102741