The Devastating 2022 M6.2 Afghanistan Earthquake: Challenges, Processes, and Implications

On June 21st, a Mw6.2 earthquake struck the Afghan-Pakistan-border-region, situated within the India-Asia collision. Thousand thirty-nine deaths were reported, making the earthquake the deadliest of 2022. We investigate the event\u27s rupture processes by combining seismological and geodetic observations, aiming to understand what made it that fatal. Our Interferometric Synthetic Aperture Radar-constrained slip-model and regional moment-tensor inversion, confirmed through field observations, reveal a sinistral rupture with maximum slip of 1.8 m at 5 km depth on a N20°E striking, sub-vertical fault. We suggest that not only external factors (event-time, building stock) but fault-specific factors made the event excessively destructive. Surface rupture was favored by the rock foliation, coinciding with the fault strike. The distribution of Peak-Ground-Velocity was governed by the sub-vertical fault. Maximum slip was large compared to other events globally and might have resulted in peak-frequencies coinciding with resonance-frequencies of the local buildings and demonstrates the devastating impact of moderate-size earthquakes

Infiltration of Alternatively Activated Macrophages in Cancer Tissue Is Associated with MDSC and Th2 Polarization in Patients with Esophageal Cancer

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The devastating 2022 M6.2 Afghanistan earthquake: Challenges, processes, and implications

On June 21st, a Mw6.2 earthquake struck the Afghan-Pakistan-border-region, situated within the India-Asia collision. Thousand thirty-nine deaths were reported, making the earthquake the deadliest of 2022. We investigate the event's rupture processes by combining seismological and geodetic observations, aiming to understand what made it that fatal. Our Interferometric Synthetic Aperture Radar-constrained slip-model and regional moment-tensor inversion, confirmed through field observations, reveal a sinistral rupture with maximum slip of 1.8 m at 5 km depth on a N20°E striking, sub-vertical fault. We suggest that not only external factors (event-time, building stock) but fault-specific factors made the event excessively destructive. Surface rupture was favored by the rock foliation, coinciding with the fault strike. The distribution of Peak-Ground-Velocity was governed by the sub-vertical fault. Maximum slip was large compared to other events globally and might have resulted in peak-frequencies coinciding with resonance-frequencies of the local buildings and demonstrates the devastating impact of moderate-size earthquakes

Generation and physiological roles of linear ubiquitin chains

Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology. Ubiquitination usually involves the addition of ubiquitin chains to target protein molecules, and these may be of eight different types, seven of which involve the linkage of one of the seven internal lysine (K) residues in one ubiquitin molecule to the carboxy-terminal diglycine of the next. In the eighth, the so-called linear ubiquitin chains, the linkage is between the amino-terminal amino group of methionine on a ubiquitin that is conjugated with a target protein and the carboxy-terminal carboxy group of the incoming ubiquitin. Physiological roles are well established for K48-linked chains, which are essential for signaling proteasomal degradation of proteins, and for K63-linked chains, which play a part in recruitment of DNA repair enzymes, cell signaling and endocytosis. We focus here on linear ubiquitin chains, how they are assembled, and how three different avenues of research have indicated physiological roles for linear ubiquitination in innate and adaptive immunity and suppression of inflammation

Stamp transferred suspended graphene mechanical resonators for radio-frequency electrical readout

We present a simple micromanipulation technique to transfer suspended graphene flakes onto any substrate and to assemble them with small localized gates into mechanical resonators. The mechanical motion of the graphene is detected using an electrical, radio-frequency (RF) reflection readout scheme where the time-varying graphene capacitor reflects a RF carrier at f=5-6 GHz producing modulation sidebands at f +/- fm. A mechanical resonance frequency up to fm=178 MHz is demonstrated. We find both hardening/softening Duffing effects on different samples, and obtain a critical amplitude of ~40 pm for the onset of nonlinearity in graphene mechanical resonators. Measurements of the quality factor of the mechanical resonance as a function of DC bias voltage Vdc indicate that dissipation due to motion-induced displacement currents in graphene electrode is important at high frequencies and large Vdc

An Approach to the Bio-Inspired Control of Self-reconfigurable Robots

Self-reconfigurable robots are robots built by modules which can move in relationship to each other. This ability of changing its physical form provides the robots a high level of adaptability and robustness. Given an initial configuration and a goal configuration of the robot, the problem of self-regulation consists on finding a sequence of module moves that will reconfigure the robot from the initial configuration to the goal configuration. In this paper, we use a bio-inspired method for studying this problem which combines a cluster-flow locomotion based on cellular automata together with a decentralized local representation of the spatial geometry based on membrane computing ideas. A promising 3D software simulation and a 2D hardware experiment are also presented.National Natural Science Foundation of China No. 6167313

The Evolution of Mammalian Gene Families

Gene families are groups of homologous genes that are likely to have highly similar functions. Differences in family size due to lineage-specific gene duplication and gene loss may provide clues to the evolutionary forces that have shaped mammalian genomes. Here we analyze the gene families contained within the whole genomes of human, chimpanzee, mouse, rat, and dog. In total we find that more than half of the 9,990 families present in the mammalian common ancestor have either expanded or contracted along at least one lineage. Additionally, we find that a large number of families are completely lost from one or more mammalian genomes, and a similar number of gene families have arisen subsequent to the mammalian common ancestor. Along the lineage leading to modern humans we infer the gain of 689 genes and the loss of 86 genes since the split from chimpanzees, including changes likely driven by adaptive natural selection. Our results imply that humans and chimpanzees differ by at least 6% (1,418 of 22,000 genes) in their complement of genes, which stands in stark contrast to the oft-cited 1.5% difference between orthologous nucleotide sequences. This genomic “revolving door” of gene gain and loss represents a large number of genetic differences separating humans from our closest relatives