128 research outputs found
Use of activated clotting time to monitor anticoagulation in patients receiving unfractionated heparin on renal replacement therapy
Legged Robots for Object Manipulation: A Review
Legged robots can have a unique role in manipulating objects in dynamic,
human-centric, or otherwise inaccessible environments. Although most legged
robotics research to date typically focuses on traversing these challenging
environments, many legged platform demonstrations have also included "moving an
object" as a way of doing tangible work. Legged robots can be designed to
manipulate a particular type of object (e.g., a cardboard box, a soccer ball,
or a larger piece of furniture), by themselves or collaboratively. The
objective of this review is to collect and learn from these examples, to both
organize the work done so far in the community and highlight interesting open
avenues for future work. This review categorizes existing works into four main
manipulation methods: object interactions without grasping, manipulation with
walking legs, dedicated non-locomotive arms, and legged teams. Each method has
different design and autonomy features, which are illustrated by available
examples in the literature. Based on a few simplifying assumptions, we further
provide quantitative comparisons for the range of possible relative sizes of
the manipulated object with respect to the robot. Taken together, these
examples suggest new directions for research in legged robot manipulation, such
as multifunctional limbs, terrain modeling, or learning-based control, to
support a number of new deployments in challenging indoor/outdoor scenarios in
warehouses/construction sites, preserved natural areas, and especially for home
robotics.Comment: Preprint of the paper submitted to Frontiers in Mechanical
Engineerin
The World Hip Trauma Evaluation Study 3 HEMIARTHROPLASTY EVALUATION BY MULTICENTRE INVESTIGATION - WHiTE 3: HEMI - AN ABRIDGED PROTOCOL
Approximately half of all hip fractures are displaced intracapsular fractures. The standard treatment for these fractures is either hemiarthroplasty or total hip arthroplasty. The recent National Institute for Health and Care Excellence (NICE) guidance on hip fracture management recommends the use of 'proven' cemented stem arthroplasty with an Orthopaedic Device Evaluation Panel (ODEP) rating of at least 3B (97% survival at three years). The Thompsons prosthesis is currently lacking an ODEP rating despite over 50 years of clinical use, likely due to the paucity of implant survival data. Nationally, adherence to these guidelines is varied as there is debate as to which prosthesis optimises patient outcomes.This study design is a multi-centre, multi-surgeon, parallel, two arm, standard-of-care pragmatic randomised controlled trial. It will be embedded within the WHiTE Comprehensive Cohort Study (ISRCTN63982700). The main analysis is a two-way equivalence comparison between Hemi-Thompson and Hemi-Exeter polished taper with Unitrax head. Secondary outcomes will include radiological leg length discrepancy measured as per Bidwai and Willett, mortality, re-operation rate and indication for re-operation, length of index hospital stay and revision at four months. This study will be supplemented by the NHFD (National Hip Fracture Database) dataset.Evidence on the optimum choice of prosthesis for hemiarthroplasty of the hip is lacking. National guidance is currently based on expert opinion rather than empirical evidence. The incidence of hip fracture is likely to continue to increase and providing high quality evidence on the optimumCite this article: A. L. Sims. The World Hip Trauma Evaluation Study 3: Hemiarthroplasty Evaluation by Multicentre Investigation - WHITE 3: HEMI - An Abridged Protocol. Bone Joint Res 2016;5:18-25. doi: 10.1302/2046-3758.51.2000473
Management of adults with primary frozen shoulder in secondary care (UK FROST): a multicentre, pragmatic, three-arm, superiority randomised clinical trial
Manipulation under anaesthesia and arthroscopic capsular release are costly and invasive treatments for frozen shoulder, but their effectiveness remains uncertain. We compared these two surgical interventions with early structured physiotherapy plus steroid injection. In this multicentre, pragmatic, three-arm, superiority randomised trial, patients referred to secondary care for treatment of primary frozen shoulder were recruited from 35 hospital sites in the UK. Participants were adults (≥18 years) with unilateral frozen shoulder, characterised by restriction of passive external rotation (≥50%) in the affected shoulder. Participants were randomly assigned (2:2:1) to receive manipulation under anaesthesia, arthroscopic capsular release, or early structured physiotherapy. In manipulation under anaesthesia, the surgeon manipulated the affected shoulder to stretch and tear the tight capsule while the participant was under general anaesthesia, supplemented by a steroid injection. Arthroscopic capsular release, also done under general anaesthesia, involved surgically dividing the contracted anterior capsule in the rotator interval, followed by manipulation, with optional steroid injection. Both forms of surgery were followed by postprocedural physiotherapy. Early structured physiotherapy involved mobilisation techniques and a graduated home exercise programme supplemented by a steroid injection. Both early structured physiotherapy and postprocedural physiotherapy involved 12 sessions during up to 12 weeks. The primary outcome was the Oxford Shoulder Score (OSS; 0-48) at 12 months after randomisation, analysed by initial randomisation group. We sought a target difference of 5 OSS points between physiotherapy and either form of surgery, or 4 points between manipulation and capsular release. The trial registration is ISRCTN48804508. Between April 1, 2015, and Dec 31, 2017, we screened 914 patients, of whom 503 (55%) were randomly assigned. At 12 months, OSS data were available for 189 (94%) of 201 participants assigned to manipulation (mean estimate 38·3 points, 95% CI 36·9 to 39·7), 191 (94%) of 203 participants assigned to capsular release (40·3 points, 38·9 to 41·7), and 93 (94%) of 99 participants assigned to physiotherapy (37·2 points, 35·3 to 39·2). The mean group differences were 2·01 points (0·10 to 3·91) between the capsular release and manipulation groups, 3·06 points (0·71 to 5·41) between capsular release and physiotherapy, and 1·05 points (-1·28 to 3·39) between manipulation and physiotherapy. Eight serious adverse events were reported with capsular release and two with manipulation. At a willingness-to-pay threshold of £20 000 per quality-adjusted life-year, manipulation under anaesthesia had the highest probability of being cost-effective (0·8632, compared with 0·1366 for physiotherapy and 0·0002 for capsular release). All mean differences on the assessment of shoulder pain and function (OSS) at the primary endpoint of 12 months were less than the target differences. Therefore, none of the three interventions were clinically superior. Arthoscopic capsular release carried higher risks, and manipulation under anaesthesia was the most cost-effective. The National Institute for Health Research Health Technology Assessment programme. [Abstract copyright: Copyright © 2020 The Author(s). Publishedx by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.
Stealth-spectacles: the discursive waves of the nuclear Asian seascape
When compared to the bombast of nuclear tests, nuclear submarines come with the relatively quiet fantasy of victory-to-come against neighbouring nuclear adversaries. Such political expressions are making their mark in Indian popular culture that hitherto had little commentary to offer on submarines. Outlets such as film and digital media on submarines rest on an aporia that resonates across the pleats and folds of secrecy and publicity: there is a felt need to keep covert underwater vessels under wraps, yet also an irrepressible desire to glorify the technological achievement and political posturings enabled by thesecond strike capability of a nuclear armed and powered submarine. Highlighting the tensile allure of both stealth and spectacle, the article considers the ways submarines make a mark in Indian audio-visual and digital media alongside the affective resonance of submarines more widely. By understanding their hegemonic dynamics, we can begin to raise questions about the ongoing nuclearisation of the Asian region and neighbouring arterial seas described here as the Asian seascape
The Formation of Preferences in Two‐Level Games: An Analysis of India’s Domestic and Foreign Energy Policy
Bacterial phytotoxin, syringomycin, induces a protein kinase-mediated phosphorylation of red beet plasma membrane polypeptides
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