In Blockchain We Trust: Does Blockchain Itself Generate Trust?

© 2020 by the Southwestern Social Science Association Objectives: This study considers the affordance of users\u27 perceived technological property of blockchains and investigates how users discover the possible actions that can be performed within blockchain media. With a focus on the role of trust, it analyzes how motivational affordances in blockchain media influence user experience. Methods: Qualitative methods are used to obtain the depth of understanding and elicit the perspective of blockchain media. We then conduct a survey to analyze the affordance of trust in the acceptance of blockchain media. Results: Our confirmed model indicates a heuristic dimension of trust regarding underlying ties to affective and technological affordances. These findings imply that cognitive heuristics affect users\u27 decision making about privacy and security on blockchain media. These heuristics lead users to engage in uncertain and even risky transactions in blockchain media. Conclusions: Despite the exponential growth in blockchain development, there has been little attention paid on how technological innovations of blockchains can produce value in the media sector. Our findings provide a lens to understand the blockchain\u27s usability problems by pairing heuristics to blockchain design and user experience principles

Canguilhem and Continental Philosophy of Biology

This edited volume presents papers on this alternative philosophy of biology that could be called “continental philosophy of biology,” and the variety of positions and solutions that it has spawned. In doing so, it contributes to debates in the history and philosophy of science and the history of philosophy of science, as well as to the craving for ‘history’ and/or ‘theory’ in the theoretical biological disciplines. In addition, however, it also provides inspiration for a broader image of philosophy of biology, in which these traditional issues may have a place. The volume devotes specific attention to the work of Georges Canguilhem, which is central to this alternative tradition of “continental philosophy of biology”. This is the first collection on Georges Canguilhem and the Continental tradition in philosophy of biology. The book should be of interest to philosophers of biology, continental philosophers, historians of biology and those interested in broader traditions in philosophy of science

One dimensional Si-in-Si(001) template for single-atom wire growth

Single atom metallic wires of arbitrary length are of immense technological and scientific interest. We describe a novel silicon-only template enabling the self-organised growth of isolated micrometer long surface and subsurface single-atom chains. It consists of a one dimensional, defect-free reconstruction - the Haiku core, here revealed for the first time in details - self-assembled on hydrogenated Si(001) terraces, independent of any step edges. We discuss the potential of this Si-in-Si template as an appealing alternative to vicinal surfaces for nanoscale patterning.Comment: 3 pages, 2 figure

Autonomous navigation with ROS for a mobile robot in agricultural fields

Autonomous monitoring of agricultural farms and fields has recently become feasible due to continuing advances in robotics technology, but many notable challenges remain. In this paper, we describe the state of ongoing work to create a fully autonomous ground rover platform for monitoring and intervention tasks on modern farms that is built using inexpensive and off the shelf hardware and Robot Operating System (ROS) software so as to be affordable to farmers. The hardware and software architectures used in this rover are described along with challenges and solutions in odometry and localization, object recognition and mapping, and path planning algorithms under the constraints of the current hardware. Results obtained from laboratory and field testing show both the key challenges to be overcome, and the current successes in applying a low-cost rover platform to the task of autonomously navigating the outdoor farming environment

Functionalized Carbon Nanotubes in the Brain: Cellular Internalization and Neuroinflammatory Responses

The potential use of functionalized carbon nanotubes (f-CNTs) for drug and gene delivery to the central nervous system (CNS) and as neural substrates makes the understanding of their in vivo interactions with the neural tissue essential. The aim of this study was to investigate the interactions between chemically functionalized multi-walled carbon nanotubes (f-MWNTs) and the neural tissue following cortical stereotactic administration. Two different f-MWNT constructs were used in these studies: shortened (by oxidation) amino-functionalized MWNT (oxMWNT-NH3+) and amino-functionalized MWNT (MWNT-NH3+). Parenchymal distribution of the stereotactically injected f-MWNTs was assessed by histological examination. Both f-MWNT were uptaken by different types of neural tissue cells (microglia, astrocytes and neurons), however different patterns of cellular internalization were observed between the nanotubes. Furthermore, immunohistochemical staining for specific markers of glial cell activation (GFAP and CD11b) was performed and secretion of inflammatory cytokines was investigated using real-time PCR (qRT-PCR). Injections of both f-MWNT constructs led to a local and transient induction of inflammatory cytokines at early time points. Oxidation of nanotubes seemed to induce significant levels of GFAP and CD11b over-expression in areas peripheral to the f-MWNT injection site. These results highlight the importance of nanotube functionalization on their interaction with brain tissue that is deemed critical for the development nanotube-based vector systems for CNS application

Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma

Expression of the apoptosis-promoting Fas gene is frequently reduced or lost during the development of colorectal carcinoma. However, loss of heterozygosity at the Fas locus or Fas gene rearrangements do not account for the loss of expression of Fas, raising the possibility that methylation of the Fas promoter may inhibit gene expression in colorectal carcinomas. We have examined the Fas promoter region CpG island for evidence of hypermethylation in colorectal tumours. Forty-seven specimens of colorectal adenoma and carcinoma, as well as six samples of normal colonic mucosa, were examined by Southern blotting for methylation at Hpa II and Cfo I sites in this region. No methylation was detected in any of the specimens, suggesting that hypermethylation is not primarily responsible for the loss of expression of the Fas gene during colorectal tumorigenesis. © 2000 Cancer Research Campaig

Deep learning approach for identification of HII regions during reionization in 21-cm observations

The upcoming Square Kilometre Array (SKA-Low) will map the distribution of neutral hydrogen during reionization, and produce a tremendous amount of 3D tomographic data. These images cubes will be subject to instrumental limitations, such as noise and limited resolution. Here we present SegU-Net, a stable and reliable method for identification of neutral and ionized regions in these images. SegU-Net is a U-Net architecture based convolutional neural network (CNN) for image segmentation. It is capable of segmenting our image data into meaningful features (ionized and neutral regions) with greater accuracy compared to previous methods. We can estimate the true ionization history from our mock observation of SKA with an observation time of 1000 h with more than 87 per cent accuracy. We also show that SegU-Net can be used to recover various topological summary statistics, such as size distributions and Betti numbers, with a relative difference of only a few per cent. These summary statistics characterise the non-Gaussian nature of the reionization process.Comment: 15 pages, 13 figures, 3 tables. Moderate and minor revision, consisting of rearranging sections and extend the discussion of the network uncertainty output