4,291 research outputs found
Radiative-Recoil Corrections of Order to Lamb Shift Revisited
The results and main steps of an analytic calculation of radiative-recoil
corrections of order to the Lamb shift in hydrogen
are presented. The calculations are performed in the infrared safe Yennie
gauge. The discrepancy between two previous numerical calculations of these
corrections existing in the literature is resolved. Our new result eliminates
the largest source of the theoretical uncertainty in the magnitude of the
deuterium-hydrogen isotope shift.Comment: 14 pages, REVTE
Hopping Conduction in Uniaxially Stressed Si:B near the Insulator-Metal Transition
Using uniaxial stress to tune the critical density near that of the sample,
we have studied in detail the low-temperature conductivity of p-type Si:B in
the insulating phase very near the metal-insulator transition. For all values
of temperature and stress, the conductivity collapses onto a single universal
scaling curve. For large values of the argument, the scaling function is well
fit by the exponentially activated form associated with variable range hopping
when electron-electron interactions cause a soft Coulomb gap in the density of
states at the Fermi energy. The temperature dependence of the prefactor,
corresponding to the T-dependence of the critical curve, has been determined
reliably for this system, and is proportional to the square-root of T. We show
explicitly that nevlecting the prefactor leads to substantial errors in the
determination of the scaling parameters and the critical exponents derived from
them. The conductivity is not consistent with Mott variable-range hopping in
the critical region nor does it obey this form for any range of the parameters.
Instead, for smaller argument of the scaling function, the conductivity of Si:B
is well fit by an exponential form with exponent 0.31 related to the critical
exponents of the system at the metal- insulator transition.Comment: 13 pages, 6 figure
Preliminarily Investigation on Nutritional Properties of \u3cem\u3eArtemesia maritime\u3c/em\u3e Linn.
Wild plants play a vital role in the health security of Himalayan inhabitants and contribute significantly to their diet. In this report we investigated the nutritional composition of Artemisia maritime growing at high altitudes in the Himalayas. Aerial parts of the species showed the maximum amount of Vitamin C (228.09 mg/100 g), followed by phenolics (196.70 mg/100 g) and total carbohydrate (46.93 mg/100 g). The calorific value was approximately 254.91 mg/100 g in dry aerial parts of the species. As far as the nutritional composition is concerned, potassium content (1753.53 mg/100g) was highest as compared to nitrogen (1366.24 mg/100 g) and calcium (213.9 (mg/100 g) content, respectively
Loss of correlation between HIV viral load and CD4+ T-cell counts in HIV/HTLV-1 co-infection in treatment naive Mozambican patients
Seven hundred and four HIV-1/2-positive, antiretroviral therapy (ART) naïve patients were screened for HTLV-1 infection. Antibodies to HTLV-1 were found in 32/704 (4.5%) of the patients. Each co-infected individual was matched with two HIV mono-infected patients according to World Health Organization clinical stage, age +/-5 years and gender. Key clinical and laboratory characteristics were compared between the two groups. Mono-infected and co-infected patients displayed similar clinical characteristics. However, co-infected patients had higher absolute CD4+ T-cell counts (P = 0.001), higher percentage CD4+ T-cell counts (P < 0.001) and higher CD4/CD8 ratios (P < 0.001). Although HIV plasma RNA viral loads were inversely correlated with CD4+ T-cell-counts in mono-infected patients (P < 0.0001), a correlation was not found in co-infected individuals (P = 0.11). Patients with untreated HIV and HTLV-1 co-infection show a dissociation between immunological and HIV virological markers. Current recommendations for initiating ART and chemoprophylaxis against opportunistic infections in resource-poor settings rely on more readily available CD4+ T-cell counts without viral load parameters. These guidelines are not appropriate for co-infected individuals in whom high CD4+ T-cell counts persist despite high HIV viral load states. Thus, for co-infected patients, even in resource-poor settings, HIV viral loads are likely to contribute information crucial for the appropriate timing of ART introduction
Synthesis and NMR Elucidation of Novel Octa-Amino Acid Resorcin[4]arenes Derivatives
The synthesis of nine novel protected amino acid cavitands is reported. All have four pendant n-undecyl chains and ‘headgroups’ connected by a two-carbon spacer at eight positions on the aromatic rings. The amino acids employed are glycine, alanine, phenylalanine, leucine, proline, tryptophan, serine, glutamine and lysine. The structures of the compounds were elucidated using one and two-dimensional NMR techniques which verified that all octa-substituted cavitands have symmetrical C2v conformation at room temperature. These compounds have potential synthetic ion channel applications.KEYWORDS Octa-amino acid resorcin[4]arenes, 1H-NMR, COSY, HSQC, C4v symmetry, C2v symmetry.PDF and Supp files attache
Conductivity of Metallic Si:B near the Metal-Insulator Transition: Comparison between Unstressed and Uniaxially Stressed Samples
The low-temperature dc conductivities of barely metallic samples of p-type
Si:B are compared for a series of samples with different dopant concentrations,
n, in the absence of stress (cubic symmetry), and for a single sample driven
from the metallic into the insulating phase by uniaxial compression, S. For all
values of temperature and stress, the conductivity of the stressed sample
collapses onto a single universal scaling curve. The scaling fit indicates that
the conductivity of si:B is proportional to the square-root of T in the
critical range. Our data yield a critical conductivity exponent of 1.6,
considerably larger than the value reported in earlier experiments where the
transition was crossed by varying the dopant concentration. The larger exponent
is based on data in a narrow range of stress near the critical value within
which scaling holds. We show explicitly that the temperature dependences of the
conductivity of stressed and unstressed Si:B are different, suggesting that a
direct comparison of the critical behavior and critical exponents for stress-
tuned and concentration-tuned transitions may not be warranted
Two dimensional Ising spin glasses with non-zero ordering temperatures
We demonstrate numerically that for Ising spins on square lattices with
ferromagnetic second neighbour interactions and random near neighbour
interactions, two dimensional Ising spin glass order with a non-zero freezing
temperature can occur. We compare some of the physical properties of these spin
glasses with those of standard spin glasses in higher dimensions.Comment: 9 page latex file and 9 ps figures. To appear in Phys. Rev. Let
Solution of two channel spin-flavor Kondo model
We investigate a model where an impurity couples to both the spin and the
flavor currents of the two channel conduction electrons. This model can be used
as a prototype model of a magnetic impurity tunneling between two sites in a
metal and of some heavy fermion systems where the ground state of the impurity
has a fourfold degeneracy. The system is shown to flow to a doubly degenerate
non fermi-liquid(NFL) fixed point; the thermodynamic quantities show NFL
behaviors, but the transport quantities show fermi liquid (FL) behaviors . A
spin-flavor coupling double tensor term is shown to drive the system to one of
the two singlet FL fixed points. The relation with SU(4) Coqblin-Schrieffer
model is studied. The implications on the possible experiments are given.Comment: 11 pages, REVTEX, no figures. To appear in Phys. Rev. B (Rapid Comm.)
July 1, 199
Critical exponents in Ising spin glasses
We determine accurate values of ordering temperatures and critical exponents
for Ising Spin Glass transitions in dimension 4, using a combination of finite
size scaling and non-equilibrium scaling techniques. We find that the exponents
and vary with the form of the interaction distribution, indicating
non-universality at Ising spin glass transitions. These results confirm
conclusions drawn from numerical data for dimension 3.Comment: 6 pages, RevTeX (or Latex, etc), 10 figures, Submitted to PR
Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers.
BACKGROUND: Ticagrelor is an oral P2Y12 inhibitor that is used with aspirin to reduce the risk of ischemic events among patients with acute coronary syndromes or previous myocardial infarction. Spontaneous major bleeding and bleeding associated with urgent invasive procedures are concerns with ticagrelor, as with other antiplatelet drugs. The antiplatelet effects of ticagrelor cannot be reversed with platelet transfusion. A rapid-acting reversal agent would be useful.
METHODS: In this randomized, double-blind, placebo-controlled, phase 1 trial, we evaluated intravenous PB2452, a monoclonal antibody fragment that binds ticagrelor with high affinity, as a ticagrelor reversal agent. We assessed platelet function in healthy volunteers before and after 48 hours of ticagrelor pretreatment and again after the administration of PB2452 or placebo. Platelet function was assessed with the use of light transmission aggregometry, a point-of-care P2Y12 platelet-reactivity test, and a vasodilator-stimulated phosphoprotein assay.
RESULTS: Of the 64 volunteers who underwent randomization, 48 were assigned to receive PB2452 and 16 to receive placebo. After 48 hours of ticagrelor pretreatment, platelet aggregation was suppressed by approximately 80%. PB2452 administered as an initial intravenous bolus followed by a prolonged infusion (8, 12, or 16 hours) was associated with a significantly greater increase in platelet function than placebo, as measured by multiple assays. Ticagrelor reversal occurred within 5 minutes after the initiation of PB2452 and was sustained for more than 20 hours (P\u3c0.001 after Bonferroni adjustment across all time points for all assays). There was no evidence of a rebound in platelet activity after drug cessation. Adverse events related to the trial drug were limited mainly to issues involving the infusion site.
CONCLUSIONS: In healthy volunteers, the administration of PB2452, a specific reversal agent for ticagrelor, provided immediate and sustained reversal of the antiplatelet effects of ticagrelor, as measured by multiple assays. (Funded by PhaseBio Pharmaceuticals; ClinicalTrials.gov number, NCT03492385.)
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