Rigor Mortis and News obtained by the Body\u2019s Scientific Reconstruction of the Turin Shroud Man

After various tentative to artistically build a tridimensional form of the Turin Shroud (TS) Man, the authors faced the problem of the scientific construction of a 3D model of this Man with an accuracy of the order of 1 cm. It is well known that the TS wrapped a human body heavily tortured, but it is not easy to build a 3D model starting only from the 2D information shown on two body images visible on a linen sheet and on the hypothesis that these images really corresponds to a real man wrapped in it. The study showed that, while the two TS body images (frontal and dorsal) seem to appear not coherent with the image of a human body because distorted in many parts, these two images are perfectly coherent with the distortions provoked by a man wrapped in this linen sheet. This model confirmed the evident rigor mortis of the human body and evidenced the particular posture corresponding to the position on the cross that also showed a rotation never detected previously of the human body around his spine. The study of this 3D model partially confirmed previous results but also evidenced interesting news, like the position of the exit hole of the nail posed on the palm of the hand. The Gospels place the Resurrection in the early hours of Sunday, at least 36 hours after death. The effect of the preservation of rigidity up to this moment may be not consistent with the thanato-chronological alterations expected in a man in the same pre-mortal clinical condition, but this problem has been solved by the \u201cmixture of aloe and myrrh\u201d that allowed the preservation of the corpse, thus prolonging the rigor mortis for tens of hours. In fact, this body seems not to have undergone any significant putrefactive phenomenon

Data fusion strategy for precise vehicle location for intelligent self-aware maintenance systems

Abstract— Nowadays careful measurement applications are handed over to Wired and Wireless Sensor Network. Taking the scenario of train location as an example, this would lead to an increase in uncertainty about position related to sensors with long acquisition times like Balises, RFID and Transponders along the track. We take into account the data without any synchronization protocols, for increase the accuracy and reduce the uncertainty after the data fusion algorithms. The case studies, we have analysed, derived from the needs of the project partners: train localization, head of an auger in the drilling sector localization and the location of containers of radioactive material waste in a reprocessing nuclear plant. They have the necessity to plan the maintenance operations of their infrastructure basing through architecture that taking input from the sensors, which are localization and diagnosis, maps and cost, to optimize the cost effectiveness and reduce the time of operation

Precise vehicle location as a fundamental parameter for intelligent selfaware rail-track maintenance systems

The rail industry in the UK is undergoing substantial changes in response to a modernisation vision for 2040. Development and implementation of these will lead to a highly automated and safe railway. Real-time regulation of traffic will optimise the performance of the network, with trains running in succession within an adjacent movable safety zone. Critically, maintenance will use intelligent trainborne and track-based systems. These will provide accurate and timely information for condition based intervention at precise track locations, reducing possession downtime and minimising the presence of workers in operating railways. Clearly, precise knowledge of trains’ real-time location is of paramount importance. The positional accuracy demand of the future railway is less than 2m. A critical consideration of this requirement is the capability to resolve train occupancy in adjacent tracks, with the highest degree of confidence. A finer resolution is required for locating faults such as damage or missing parts, precisely. Location of trains currently relies on track signalling technology. However, these systems mostly provide an indication of the presence of trains within discrete track sections. The standard Global Navigation Satellite Systems (GNSS), cannot precisely and reliably resolve location as required either. Within the context of the needs of the future railway, state of the art location technologies and systems were reviewed and critiqued. It was found that no current technology is able to resolve location as required. Uncertainty is a significant factor. A new integrated approach employing complimentary technologies and more efficient data fusion process, can potentially offer a more accurate and robust solution. Data fusion architectures enabling intelligent self-aware rail-track maintenance systems are proposed

Context-based and human-centred information fusion in diagnostics

Maintenance management and engineering practice has progressed to adopt approaches which aim to reach maintenance decisions not by means of pre-specified plans and recommendations but increasingly on the basis of best contextually relevant available information and knowledge, all considered against stated objectives. Different methods for automating event detection, diagnostics and prognostics have been proposed, which may achieve very high performance when appropriately adapted and tuned to serve the needs of well defined tasks. However, the scope of such solutions is often narrow and without a mechanism to include human contributed intervention and knowledge contribution. This paper presents a conceptual framework of integrating automated detection and diagnostics and human contributed knowledge in a single architecture. This is instantiated by an e-maintenance platform comprising tools for both lower level information fusion as well as for handling higher level knowledge. Well structured maintenance relationships, such as those present in a typical FMECA study, as well as on the job human contributed compact knowledge are exploited to this end. A case study presenting the actual workflow of the process in an industrial setting is employed to pilot test the approach

AVALIAÇÃO DO PROGRAMA DE SUPLEMENTAÇÃO ALIMENTAR NO MUNICÍPIO DE SÃO CARLOS

The authors carries out as study in São Carlos SP (Brazil) in order to evaluate the food supplementary program; which has been running in the Municipal Health Centre, since 1985. This program is regarded as one of the under nutrition control measures. It was reviewed the notes of all children, under five years followed in the Municipal Health Centres. Using some specific criteria, 163 children were included in this study. They were divided in subgroups according to the type of nutritional Supplementation. It was observed that nutricional suplementation had not been able to modify the nutritional figure, as an isolated undernutrition control measures.Os autores efetuaram um estudo em São Carlos-SP, com o objetivo de avaliar o programa de suplementação alimentar; o qual está sendo desenvolvido nos postos de saúde municipais, desde 1985. Foram analisadas as fichas de todas as crianças abaixo de cinco anos de idade, atendidas nos postos de saúde municipais, entretanto, foram incluídas neste estudo apenas 163 crianças de acordo com os critérios pré estabelecidos, sendo as mesmas divididas em subgrupos de acordo com o tipo de suplementação aumentar que recebiam. Foi observado na amostra estudada, que a suplementação alimentar não tem sido capaz de modificar o quadro nutricional, como uma medida isolada de controle da desnutrição

Anatomic characteristics of bileaflet mitral valve prolapse - Barlow disease – in patients undergoing mitral valve repair

Objective. Barlow disease is a still challenging pathology for the surgeon. Aim of the present study is to report anatomic abnormalities of mitral valve in patients undergoing mitral valve repair. Methods. Between January 1st, 2007, and December 31st, 2010, 85 consecutive patients (54 men and 31 women, mean age 59 ±14 years - range: 28-85 years) with the features of a Barlow mitral valve disease underwent mitral repair Forty seven percent of patients were in New York Heart Association functional class III or IV. Preoperative transesophageal echocardiography was compared with anatomical findings at the moment of surgery. Results. Transthoracic echocardiography diagnosis of Barlow disease according to the criteria described by Carpentier was confirmed at anatomical inspection. Annular calcifications were found in 28 patients while 7 patients presented single or multiple clefts. A flail posterior mitral leaflet was detected in 32 subjects, while a flail anterior leaflet in 8. Elongation of chordae tendineae was demonstrated in 45 patients and chordal rupture in 31. All patients showed at trans esophageal echocardiography the typical features of Barlow disease. Seventy-seven (90.6%) patients had severe mitral valve regurgitation, in the remaining 9.4% it was moderate to severe. Transesophageal echocardiography failed to identify clefts in 2/7 and chordal rupture in 4/31. Conclusions. bileaflet prolapse > 2 mm, billowing valve with excess tissue and thickened leaflets ≥ 3 mm, and severe annular dilatation, are characteristics of Barlow disease, however the identification of the associated and complex abnormalities of mitral valve is necessary to obtain optimal valve repair

Tissue engineered in-vitro vascular patch fabrication using hybrid 3D printing and electrospinning

Three-dimensional (3D) engineered cardiovascular tissues have shown great promise to replace damaged structures. Specifically, tissue engineering vascular grafts (TEVG) have the potential to replace biological and synthetic grafts. We aimed to design an in-vitro patient-specific patch based on a hybrid 3D print combined with vascular smooth muscle cells (VSMC) differentiation. Based on the medical images of a 2 months-old girl with aortic arch hypoplasia and using computational modelling, we evaluated the most hemodynamically efficient aortic patch surgical repair. Using the designed 3D patch geometry, the scaffold was printed using a hybrid fused deposition modelling (FDM) and electrospinning techniques. The scaffold was seeded with multipotent mesenchymal stem cells (MSC) for later maturation to derived VSMC (dVSMC). The graft showed adequate resistance to physiological aortic pressure (burst pressure 101 ​± ​15 ​mmHg) and a porosity gradient ranging from 80 to 10 ​μm allowing cells to infiltrate through the entire thickness of the patch. The bio-scaffolds showed good cell viability at days 4 and 12 and adequate functional vasoactive response to endothelin-1. In summary, we have shown that our method of generating patient-specific patch shows adequate hemodynamic profile, mechanical properties, dVSMC infiltration, viability and functionality. This innovative 3D biotechnology has the potential for broad application in regenerative medicine and potentially in heart disease prevention.This research was funded by ​Instituto de Salud Carlos III ​through the projects ​PI17/01409, PT20/00069 (Plataforma ISCIII de Biobancos y Biomodelos) and ​PI20/00467 ​(Co-funded by European Regional Development Fund/European Social Fund ​“A way to make Europe"/"Investing in your future”) ​and by the Foundation ​‘Menudos Corazones to help children with heart disease' and the Spanish Society of Paediatric Cardiology and Congenital Heart Disease (SECPCC), grant number ​‘Menudos Corazones 2020’. This work was also supported by the Spanish Ministry of Economy and Competitiveness (PID2019-104084GB-C22) and ANID – Millennium Science Initiative Program – ICN2021_004 and ANID – Millennium Science Initiative Program – NCN17_129, ANID FONDECYT de Iniciación en Investigación #11200481, ANID FONDECYT #1181057

Maturation signatures of conventional dendritic cell subtypes in COVID‐19 suggest direct viral sensing

Growing evidence suggests that conventional dendritic cells (cDCs) undergo aberrant maturation in COVID-19, which negatively affects T-cell activation. The presence of effector T cells in patients with mild disease and dysfunctional T cells in severely ill patients suggests that adequate T-cell responses limit disease severity. Understanding how cDCs cope with SARS-CoV-2 can help elucidate how protective immune responses are generated. Here, we report that cDC2 subtypes exhibit similar infection-induced gene signatures, with the upregulation of interferon-stimulated genes and interleukin (IL)-6 signaling pathways. Furthermore, comparison of cDCs between patients with severe and mild disease showed severely ill patients to exhibit profound downregulation of genes encoding molecules involved in antigen presentation, such as MHCII, TAP, and costimulatory proteins, whereas we observed the opposite for proinflammatory molecules, such as complement and coagulation factors. Thus, as disease severity increases, cDC2s exhibit enhanced inflammatory properties and lose antigen presentation capacity. Moreover, DC3s showed upregulation of anti-apoptotic genes and accumulated during infection. Direct exposure of cDC2s to the virus in vitro recapitulated the activation profile observed in vivo. Our findings suggest that SARS-CoV-2 interacts directly with cDC2s and implements an efficient immune escape mechanism that correlates with disease severity by downregulating crucial molecules required for T-cell activation

Guideline on carotid surgery for stroke prevention: updates from the Italian Society of Vascular and Endovascular Surgery. A trend towards personalized medicine

Background: This guideline (GL) on carotid surgery as updating of "Stroke: Italian guidelines for Prevention and Treatment" of the ISO-SPREAD Italian Stroke Organization-Group, has recently been published in the National Guideline System and shared with the Italian Society of Vascular and Endovascular Surgery (SICVE) and other Scientific Societies and Patient's Association. Methods: GRADE-SIGN version, AGREE quality of reporting checklist. Clinical questions formulated according to the PICO model. Recommendations developed based on clinical questions by a multidisciplinary experts' panel and patients' representatives. Systematic reviews performed for each PICO question. Considered judgements filled by assessing the evidence level, direction, and strength of the recommendations. Results: The panel provided indications and recommendations for appropriate, comprehensive, and individualized management of patients with carotid stenosis. Diagnostic and therapeutic processes of the best medical therapy, carotid endarterectomy (CEA), carotid stenting (CAS) according to the evidences and the judged opinions were included. Symptomatic carotid stenosis in elective and emergency, asymptomatic carotid stenosis, association with ischemic heart disease, preoperative diagnostics, types of anesthesia, monitoring in case of CEA, CEA techniques, comparison between CEA and CAS, post-surgical carotid restenosis, and medical therapy are the main topics, even with analysis of uncertainty areas for risk-benefit assessments in the individual patient (personalized medicine [PM]). Conclusions: This GL updates on the main recommendations for the most appropriate diagnostic and medical-surgical management of patients with atherosclerotic carotid artery stenosis to prevent ischemic stroke. This GL also provides useful elements for the application of PM in good clinical practice