10 research outputs found
Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein
- Author
- Publication venue
- Publication date
- 01/12/2003
- Field of study
Neuromyelitis optica in Austria in 2011: to bridge the gap between neuroepidemiological research and practice in a study population of 8.4 million people.
- Author
- Agathe Flamm-Horak
- Alena Skrobal
- Alexander Moser
- Alexander Tinchon
- Andreas Lutterotti
- Bettina Kuenz
- Bettina Raber
- Christian Eggers
- Claudia Franta
- Dorothea Stadlbauer
- Elisabeth Fertl
- Fahmy Aboul-Enein
- Fritz Leutmezer
- Georg Safoschnik
- Hamid Assar
- Helmut Rauschka
- Iris Schmeissner
- Julia Jecel
- Jörg Kraus
- Karl Vass
- Manfred Freimüller
- Margret Niederkorn-Duft
- Maria K Storch
- Mario Jeschow
- Markus Reindl
- Martin Reisz
- Martina Komposch
- Michael Guger
- Paulus Rommer
- Peter Schnabl
- Philipp Simschitz
- Robert Stepansky
- Siegrid Fuchs
- Simone Mader
- Stefan Guggenberger
- Stefan Koppi
- Susanne Schmidegg
- Thomas Berger
- Thomas Heller
- Thomas Schlager
- Thomas Seifert-Held
- Vera Weiser
- Wilfried Lang
- Wolfgang Kristoferitsch
- Publication venue
- Public Library of Science (PLoS)
- Publication date
- 05/11/2013
- Field of study
BACKGROUND: In 2008 the Austrian Task Force for Neuromyelitis Optica (NMO) started a nation-wide network for information exchange and multi-centre collaboration. Their aim was to detect all patients with NMO or NMO spectrum disorders (NMO-SD) in Austria and to analyse their disease courses and response to treatment. METHODS: (1) As of March 2008, 1957 serum samples (of 1557 patients) have been tested with an established cell based immunofluorescence aquaporin-4 antibody (AQP4-ab) assay with a high sensitivity and specificity (both >95%). All tests were performed in a single reference laboratory (Clinical Dept. of Neurology of the Innsbruck Medical University). (2) A nation-wide survey with several calls for participation (via email newsletters, articles in the official journal of the Austrian Society of Neurology, and workshops) was initiated in 2008. All collected data will be presented in a way that allows that every individual patient can be traced back in order to ensure transparency and to avoid any data distortion in future meta-analyses. The careful and detailed presentation allows the visualization and comparison of the different disease courses in real time span. Failure and response to treatment are made visible at one glance. Database closure was 31 December 2011. All co-operators were offered co-authorship. RESULTS: All 71 NMO- or NMO-SD patients with AQP4-ab positivity (age range 12.3 to 79.6 years) were analysed in detail. Sex ratio (m:f = 1:7) and the proportion of patients without oligoclonal bands in cerebrospinal fluid (86.6%) were in line with previously published results. All identified patients were Caucasians. CONCLUSIONS: A nationwide collaboration amongst Austrian neurologists with good network communications made it possible to establish a database of 71 AQP4-ab positive patients with NMO/NMO-SD. This database is presented in detail and provides the basis for further studies and international cooperation in order to investigate this rare disease
Descriptive epidemiological data, summary.
- Author
- Agathe Flamm-Horak (480202)
- Alena Skrobal (480215)
- Alexander Moser (480216)
- Alexander Tinchon (480229)
- Andreas Lutterotti (89552)
- Bettina Kuenz (89551)
- Bettina Raber (480226)
- Christian Eggers (292146)
- Claudia Franta (480222)
- Dorothea Stadlbauer (480218)
- Elisabeth Fertl (480204)
- Fahmy Aboul-Enein (351477)
- Fritz Leutmezer (480200)
- Georg Safoschnik (480207)
- Hamid Assar (480209)
- Helmut Rauschka (479532)
- Iris Schmeissner (480227)
- Julia Jecel (480228)
- Jörg Kraus (480208)
- Karl Vass (480201)
- Manfred Freimüller (480219)
- Margret Niederkorn-Duft (480225)
- Maria K. Storch (365016)
- Mario Jeschow (480217)
- Markus Reindl (89559)
- Martin Reisz (480211)
- Martina Komposch (480213)
- Michael Guger (480220)
- Paulus Rommer (480199)
- Peter Schnabl (480212)
- Philipp Simschitz (480214)
- Robert Stepansky (480203)
- Siegrid Fuchs (310904)
- Simone Mader (365012)
- Stefan Guggenberger (480210)
- Stefan Koppi (480224)
- Susanne Schmidegg (480221)
- Thomas Berger (72614)
- Thomas Heller (480206)
- Thomas Schlager (480205)
- Thomas Seifert-Held (435518)
- Vera Weiser (480223)
- Wilfried Lang (457651)
- Wolfgang Kristoferitsch (351482)
- Publication venue
- Publication date
- Field of study
<div><p>OCB typing according to established criteria (type 1 - 5, Andersson et al., 1994; [12]). </p>
<p><b>1</b>, OCB - type 3; </p>
<p><b>2</b>, OCB - type 2 and 3; </p>
<p><b>3</b>, in 3 NMO patients OCB changed (from negative to positive (types 2 and 3)).</p></div
Neuromyelitis Optica in Austria in 2011: To Bridge the Gap between Neuroepidemiological Research and Practice in a Study Population of 8.4 Million People
- Author
- A McKeon
- Agathe Flamm-Horak
- Alena Skrobal
- Alexander Moser
- Alexander Tinchon
- Andreas Lutterotti
- Bettina Kuenz
- Bettina Raber
- C Trebst
- Christian Eggers
- Claudia Franta
- DH Miller
- DM Wingerchuk
- DM Wingerchuk
- DM Wingerchuk
- Dorothea Stadlbauer
- Elisabeth Fertl
- F Aboul-Enein
- F Aboul-Enein
- Fahmy Aboul-Enein
- Fritz Leutmezer
- Georg Safoschnik
- Hamid Assar
- Helmut Rauschka
- Iris Schmeissner
- J Sellner
- JA Cabrera-Gómez
- JA Cabrera-Gómez
- JF Kurtzke
- JF Rivera
- JI O'Riordan
- JL Kitley
- Julia Jecel
- Jörg Kraus
- Karl Vass
- L Matthews
- M Andersson
- M Cossburn
- M Nakamura
- MA Mealy
- Manfred Freimüller
- Margret Niederkorn-Duft
- Maria K. Storch
- Mario Jeschow
- Markus Reindl
- Martin Reisz
- Martina Komposch
- Michael Guger
- N Asgari
- N Collongues
- N Serbecic
- N Serbecic
- Paulus Rommer
- Peter Schnabl
- Philipp Simschitz
- Ralf Andreas Linker
- Robert Stepansky
- S Jarius
- S Jarius
- S Jarius
- S Jarius
- S Jarius
- S Mader
- S Mader
- Siegrid Fuchs
- Simone Mader
- SJ Pittock
- Stefan Guggenberger
- Stefan Koppi
- Susanne Schmidegg
- T Kawazoe
- T Sinnecker
- Thomas Berger
- Thomas Heller
- Thomas Schlager
- Thomas Seifert-Held
- V Feigin
- Vera Weiser
- W Kim
- W Krampla
- Wilfried Lang
- Wolfgang Kristoferitsch
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Adam Christian
- Afshari Arash
- Alexandri Bogdan
- Amory Catherine
- Audren Noemie
- Baethge Sabine
- Barak Yuri
- Batoz Helene
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Becke Karin
- Bekavac Ivan
- Berghmans Johan
- Berton Jerome
- Biskupova Vera
- Boda Krisztina
- Boda Krisztina B.
- Bollinger Matthias
- Bordes Maryline
- Bottger Morten
- Bourdaud Nathalie
- Brackhahn Michael
- Breschan Christian
- Brezac Gilles
- Brotatsch Philipp
- Busche Rene
- Butkovic Diana
- Camus Blandine
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Chapotte Catherine
- Chazelet Chantal
- Chloropoulou Pelagia
- Chrysi Mpratzou
- Clausen Nicola G.
- Cnudde Steven
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Coucke Patricia
- Dadure Christophe
- Dahmani Souhayl
- Davin Isabelle
- De Baerdemaeker Luc
- De Groote Francoise
- De Hert Stefan
- de la Briere Francois
- De Pooter Francoise
- De Smet Karen
- De Ville Andree
- Debrabant Lise
- Dekens Jacky
- Delcuze Axelle
- Desjeux Luc
- Didier Anne
- Diers Anja
- Disma Nicola
- Divak Jan
- Djapic Dajana
- Druot Emilie
- Duflo Frederic
- Dupont Herve
- Ecoffey Claude
- Ehm Birgit
- Eich Christoph Bernhard
- Eisner Christoph
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Erb Christian
- Fabris Lada Kalagac
- Fiedler Fritz
- Fischer Thomas
- Fisher Haran
- Frelich Michal
- Frey Denise
- Fritzsche Katrin
- Funk Wolfgang
- Gaebler Ralf
- Gagey Anne-Charlotte
- Galvin Deborah
- Garrigue Delphine
- Geil Dfominik
- Gerin Marc
- Germann Reinhard
- Gernoth Christian
- Gillet Patricia
- Goebel Ulrich
- Grau Catharina
- Grein Elodie
- Grundmann Ulrich
- Guericke Holger
- Guerin Christilynn
- Guillier Marion
- Gutmann Anton
- Guzman Ines
- Habre Walid
- Hamonic Yann
- Hansen Tom G.
- Happo Johanna
- Harris Sarah
- Hayem Catherine
- Hein Maximilian
- Heyse Bjorn
- Himpe Dirk
- Hinz Jose
- Hochhold Christoph
- Hoeft Andreas
- Hoehne Claudia
- Hofmann Ulrich
- Holy Rolf
- Huber Matthias
- Huygens Christel
- Ilmoja Mari-Liis
- Iordanidou Despoina
- Irwin Janice
- Isohanni Mika
- Isselhorst Carsten
- Jacqmarcq Olivier
- Jamil Yosry
- Jetzek-Zader Martin
- Joehr Martin
- Johansen Mathias
- Jokinen Johanna
- Joukes Ellen
- Julien-Marsollier Florence
- Jureckova Lucie
- Kachko Ludmyla
- Kahn David
- Kalliardou Evagelia
- Karjagin Juri
- Katz Jacob
- Keilhauer Julia
- Kesi-Valpotic Gordana
- Kienbaum Peter
- Kikas Reet
- Kindermann Petra
- Kirilov Dmitry
- Kiviluoma Kai
- Klimscha Walter
- Kloessing Jan
- Knauss Kristina
- Koessler Herbert
- Konecny Regina
- Kortgen Andreas
- Kranke Peter
- Kroess Ruth
- Kuehhirt Thomas
- Laffargue Anne
- Lagarde Sylvaine
- Lalot Michael
- Lambelin Veronique
- Lambotte Patricia
- Larcher Claire
- Laschat Michael
- Lauweryns Julie
- Le Freche Helene
- Lechat Jean-Paul
- Leclercq Mickeal
- Legrand Aurelien
- Lehousse Thierry
- Lejus Corinne
- Lesmes Carlos
- Leva Brigitte
- Levinzon Michael
- Levitchi Roxana
- Lhubat Elizabeth
- Litvic Dubravka Heli
- Loveniers Birgit
- Ludot Hugues
- Luntzer Robert
- Lyly Anniina
- Mackova Iveta
- Mader Thomas
- Madsen Birgitte Ingeborg
- Magasich Natalia
- Magner Claire
- Malisiova Anna
- Manevich Yair
- Maniora Maud
- Manner Tuula
- Maretic Hrvoje
- Marie Anais
- Martikainen Kati
- Maupain Olivier
- Mausser Gerlinde
- Messerer Brigitte
- Meybohm Patrick
- Meyer-Treschan Tanja
- Micic Slobodan
- Mielke Golo
- Migeon Anne
- Milde Alexander
- Mission Jean Paul
- Mitchell John
- Mixa Vladimir
- Monrigal Jean
- Morawk-Wintersperger Ulrike
- Morton Neil S.
- Moscatello Djurdjica
- Najafi Nadia
- Nakhjavani Solmaz
- Neckebroek Martine
- Neiger Franz
- Nekrasov Konstantin
- Neumann Claudia
- Nilsson Jens Christian
- Nouette-Gaulain Karine
- Ntavlis Merkourios
- O'Hare Brendan
- Ochsenreiter Miriam
- Oeding Joachim
- Oppenrieder Karin
- Orliaguet Gilles
- Paal Peter
- Parashchanka Aliaksandra
- Pattar Alexander
- Pavlickova Jana
- Peled Elia
- Peresbota Daliana
- Peter Laura
- Picker Olaf
- Pilla Clotaire
- Pirat Philippe
- Pirotte Thierry
- Platzer Manuela
- Podvin Alexandre
- Poelaert Jan
- Popovic Ljiljana
- Pregardien Caroline
- Preussler Niels-Peter
- Quintel Michael
- Raber Manfred
- Raffoflandreur Celine
- Ramminger Axel
- Rarosi Ferenc
- Reindl Doris
- Reinert Jennifer
- Remond Charlotte
- Richart Pierre
- Riche Jean-Claude
- Robert Philippe
- Roofthooft Eva
- Rosu Lilica
- Roth Benjamin
- Roth Jens
- Roth Winfried
- Roulleau Philippe
- Russo Sebastian G.
- Rustemeyer Lydia
- Sabau Lucie
- Sabourdin Nada
- Sanko Elena
- Saour Anne-Charlotte
- Schaefer Maximilian S.
- Schierlinger Bettina
- Schindler Ehrenfried
- Schink Cornel
- Schmain Dmitri
- Schoeler Michael
- Schorer Clemens
- Schousboe Birgitte M. B.
- Schramm Michael
- Schwarzkopf Konrad
- Seidel-Ahyai Natascha
- Semjen Francois
- Sheinkin Olga
- Simhi Eliahu
- Simon Dominique
- Simurina Tatjana
- Sinner Barbara
- Skacel Monika
- Skordou Natalia
- Smitz Carine
- Sola Chrystelle
- Soric Ivana Kerovec
- Staiti Giuseppe
- Standl Thomas
- Steen Nick Phaff
- Steinmann Johannes
- Stevens France
- Stoegermuller Birgit
- Sulen Nina
- Supthut Hauke
- Takala Annika
- Tarabikin Alex
- Taright Hanna
- Thil Elke
- Toller Wolfgang
- Tonise Virge
- Torres Cristel Sanchez
- Trabkin Evelina
- Trieschmann Uwe
- Tsiotou Adelais
- Tus Ivana Stuck
- Uhrig Lynn
- Ulrici Johanna
- Urbanec Rene
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- Van Limmen Jurgen
- Van Mossevelde Veerle
- Van Reeth Veronique
- Vanpeteghem Caroline
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M.
- Veyckemans Francis
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Volger Hauke
- Wappler Frank
- Weber Stefan
- Weinlichova Stanislava
- Weyland Andreas
- Wiefelsputz Christina
- Wodey Eric
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Zaghet Brigitte
- Zang Aurelien
- Zangl Gregor
- Zederer Nicole
- Zeitlin Yelena
- Ziegler Bernhard
- Zielinska Marzena
- Zunser Igor
- Zurek Jiri
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Adam Christian
- Afshari Arash
- Alexandri Bogdan
- Amory Catherine
- Audren Noemie
- Baethge Sabine
- Barak Yuri
- Batoz Helene
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Becke Karin
- Becke Karin
- Bekavac Ivan
- Berghmans Johan
- Berton Jerome
- Biskupova Vera
- Boda Krisztina
- Boda Krisztina B.
- Bollinger Matthias
- Bordes Maryline
- Bottger Morten
- Bourdaud Nathalie
- Brackhahn Michael
- Breschan Christian
- Brezac Gilles
- Brotatsch Philipp
- Busche Rene
- Butkovic Diana
- Camus Blandine
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Chapotte Catherine
- Chazelet Chantal
- Chloropoulou Pelagia
- Chrysi Mpratzou
- Clausen Nicola G.
- Cnudde Steven
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Coucke Patricia
- Dadure Christophe
- Dahmani Souhayl
- Davin Isabelle
- De Baerdemaeker Luc
- De Groote Francoise
- De Hert Stefan
- de la Briere Francois
- De Pooter Francoise
- De Smet Karen
- De Ville Andree
- Debrabant Lise
- Dekens Jacky
- Delcuze Axelle
- Desjeux Luc
- Didier Anne
- Diers Anja
- Disma Nicola
- Divak Jan
- Djapic Dajana
- Druot Emilie
- Duflo Frederic
- Dupont Herve
- Ecoffey Claude
- Ehm Birgit
- Eich Christoph Bernhard
- Eisner Christoph
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Erb Christian
- Fabris Lada Kalagac
- Fiedler Fritz
- Fischer Thomas
- Fisher Haran
- Frelich Michal
- Frey Denise
- Fritzsche Katrin
- Funk Wolfgang
- Gaebler Ralf
- Gagey Anne-Charlotte
- Galvin Deborah
- Garrigue Delphine
- Geil Dfominik
- Gerin Marc
- Germann Reinhard
- Gernoth Christian
- Gillet Patricia
- Goebel Ulrich
- Grau Catharina
- Grein Elodie
- Grundmann Ulrich
- Guericke Holger
- Guerin Christilynn
- Guillier Marion
- Gutmann Anton
- Guzman Ines
- Habre Walid
- Hamonic Yann
- Hansen Tom G.
- Hansen Tom G.
- Happo Johanna
- Harris Sarah
- Hayem Catherine
- Hein Maximilian
- Heyse Bjorn
- Himpe Dirk
- Hinz Jose
- Hochhold Christoph
- Hoeft Andreas
- Hoehne Claudia
- Hofmann Ulrich
- Holy Rolf
- Huber Matthias
- Huygens Christel
- Ilmoja Mari-Liis
- Iordanidou Despoina
- Irwin Janice
- Isohanni Mika
- Isselhorst Carsten
- Jacqmarcq Olivier
- Jamil Yosry
- Jetzek-Zader Martin
- Joehr Martin
- Johansen Mathias
- Jokinen Johanna
- Joukes Ellen
- Julien-Marsollier Florence
- Jureckova Lucie
- Kachko Ludmyla
- Kahn David
- Kalliardou Evagelia
- Karjagin Juri
- Katz Jacob
- Keilhauer Julia
- Kesi-Valpotic Gordana
- Kienbaum Peter
- Kikas Reet
- Kindermann Petra
- Kirilov Dmitry
- Kiviluoma Kai
- Klimscha Walter
- Kloessing Jan
- Knauss Kristina
- Koessler Herbert
- Konecny Regina
- Kortgen Andreas
- Kranke Peter
- Kroess Ruth
- Kuehhirt Thomas
- Laffargue Anne
- Lagarde Sylvaine
- Lalot Michael
- Lambelin Veronique
- Lambotte Patricia
- Larcher Claire
- Laschat Michael
- Lauweryns Julie
- Le Freche Helene
- Lechat Jean-Paul
- Leclercq Mickeal
- Legrand Aurelien
- Lehousse Thierry
- Lejus Corinne
- Lesmes Carlos
- Leva Brigitte
- Levinzon Michael
- Levitchi Roxana
- Lhubat Elizabeth
- Litvic Dubravka Heli
- Loveniers Birgit
- Ludot Hugues
- Luntzer Robert
- Lyly Anniina
- Mackova Iveta
- Mader Thomas
- Madsen Birgitte Ingeborg
- Magasich Natalia
- Magner Claire
- Malisiova Anna
- Manevich Yair
- Maniora Maud
- Manner Tuula
- Maretic Hrvoje
- Marie Anais
- Martikainen Kati
- Maupain Olivier
- Mausser Gerlinde
- Messerer Brigitte
- Meybohm Patrick
- Meyer-Treschan Tanja
- Micic Slobodan
- Mielke Golo
- Migeon Anne
- Milde Alexander
- Mission Jean Paul
- Mitchell John
- Mixa Vladimir
- Monrigal Jean
- Morawk-Wintersperger Ulrike
- Morton Neil S.
- Moscatello Djurdjica
- Najafi Nadia
- Nakhjavani Solmaz
- Neckebroek Martine
- Neiger Franz
- Nekrasov Konstantin
- Neumann Claudia
- Nilsson Jens Christian
- Nouette-Gaulain Karine
- Ntavlis Merkourios
- O'Hare Brendan
- Ochsenreiter Miriam
- Oeding Joachim
- Oppenrieder Karin
- Orliaguet Gilles
- Paal Peter
- Parashchanka Aliaksandra
- Pattar Alexander
- Pavlickova Jana
- Peled Elia
- Peresbota Daliana
- Peter Laura
- Picker Olaf
- Pilla Clotaire
- Pirat Philippe
- Pirotte Thierry
- Platzer Manuela
- Podvin Alexandre
- Poelaert Jan
- Popovic Ljiljana
- Pregardien Caroline
- Preussler Niels-Peter
- Quintel Michael
- Raber Manfred
- Raffoflandreur Celine
- Ramminger Axel
- Rarosi Ferenc
- Reindl Doris
- Reinert Jennifer
- Remond Charlotte
- Richart Pierre
- Riche Jean-Claude
- Robert Philippe
- Roofthooft Eva
- Rosu Lilica
- Roth Benjamin
- Roth Jens
- Roth Winfried
- Roulleau Philippe
- Russo Sebastian G.
- Rustemeyer Lydia
- Sabau Lucie
- Sabourdin Nada
- Sanko Elena
- Saour Anne-Charlotte
- Schaefer Maximilian S.
- Schierlinger Bettina
- Schindler Ehrenfried
- Schink Cornel
- Schmain Dmitri
- Schoeler Michael
- Schorer Clemens
- Schousboe Birgitte M. B.
- Schramm Michael
- Schwarzkopf Konrad
- Seidel-Ahyai Natascha
- Semjen Francois
- Sheinkin Olga
- Simhi Eliahu
- Simon Dominique
- Simurina Tatjana
- Sinner Barbara
- Skacel Monika
- Skordou Natalia
- Smitz Carine
- Sola Chrystelle
- Soric Ivana Kerovec
- Staiti Giuseppe
- Standl Thomas
- Steen Nick Phaff
- Steinmann Johannes
- Stevens France
- Stoegermuller Birgit
- Sulen Nina
- Supthut Hauke
- Takala Annika
- Tarabikin Alex
- Taright Hanna
- Thil Elke
- Toller Wolfgang
- Tonise Virge
- Torres Cristel Sanchez
- Trabkin Evelina
- Trieschmann Uwe
- Tsiotou Adelais
- Tus Ivana Stuck
- Uhrig Lynn
- Ulrici Johanna
- Urbanec Rene
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- Van Limmen Jurgen
- Van Mossevelde Veerle
- Van Reeth Veronique
- Vanpeteghem Caroline
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M.
- Veyckemans Francis
- Veyckemans Francis
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Volger Hauke
- Wappler Frank
- Weber Stefan
- Weinlichova Stanislava
- Weyland Andreas
- Wiefelsputz Christina
- Wodey Eric
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Zaghet Brigitte
- Zang Aurelien
- Zangl Gregor
- Zederer Nicole
- Zeitlin Yelena
- Ziegler Bernhard
- Zielinska Marzena
- Zunser Igor
- Zurek Jiri
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela Rodríguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernhard Eich Christoph
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B
- Boegli Yann
- Bollinger Matthias
- Book Malte
- Bordes Maryline
- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
- Camus Blandine
- Capusan Alin
- Carachi Peter
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Castellheim Albert
- Casutt Mattias
- Catalina Ionescu Gabriela
- Cavalier Alison
- Cecini Mariateresa
- Cento Valeria
- Cerati Giorgia
- Cerne Uros
- Cerutti Elisabetta
- Cettler Maciej
- Ceuca Daniela
- Ceyda Meco Basak
- Chapotte Catherine
- Chazelet Chantal
- Checinska Magdalena
- Checuti Sarah
- Chee Lew-Chin
- Childs Sophie
- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem Tütüncü Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
- Crawford Michael
- Cristina Mondardini Maria
- Cuciuc Veaceslav
- Cucui-Cozma Cosmina
- Cullen Julia
- Cullen Pauline
- Cumming Craig
- D'Alessandro Sandra
- Dadure Christophe
- Dahmani Souhayl
- Dalton Andrew
- Dalton Mark
- Damps Maria
- Darwin Leanne
- Daugelavicius Vidunas
- Davidescu Irina
- Davidson Sarah
- Davies Jack
- Davies Kay
- Davin Isabelle
- Davison Rachel
- Day Alexandra
- De Abreu Leidy
- de Graaff Jurgen C.
- De Groote Françoise
- De Hert Stefan
- De Josemaria Belen
- de la Brière Francois
- De La Cruz Benito Fausto
- De Lorenzo Brita
- De Melo Eric
- De Pooter Françoise
- De Smet Karen
- De Villé Andrée
- Debrabant Lise
- Dei Giudici Luigi
- Dekens Jacky
- Dekker Elsa
- del Río Cristina
- Delcuze Axelle
- Desjeux Luc
- Diacono Jacques
- Dickinson Matthew
- Didier Anne
- Diers Anja
- Dirckx Maaike
- Disma Nicola
- Disma Nicola
- Divák Jan
- Diwan Rishi
- Dix Philippa
- Djapic Dajana
- Dockiene Ilona
- Dogger Jaap
- Dolci Mirko
- Dolinaj Vladimir
- Domingas Patuleia M.
- Domínguez Fernando
- Dons-Sinke Ilse
- Dorman Teresa
- Draskovic Biljana
- Druot Emilie
- Duflo Frédéric
- Dumitru Rusu Florin
- Dupont Hervé
- Eberl Susanne
- Ecoffey Claude
- Ehm Birgit
- Eisner Christoph
- Eissa Ayman
- Elena Malos Anca
- Elizabeth Biercamp Claire
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
- Engel Nicole
- Engelhardt Thomas
- Eniko Kovacs
- Ephraim Erik
- Erb Christian
- Erb Thomas
- Errass Loreen
- Fairgrieve Ross
- Faliszewski Isabella
- Farinelli Ivano
- Farquharson Pamela
- Feliu Montserrat
- Fiedler Fritz
- Fischer Thomas
- Fisher Haran
- Flewin Lisa
- Foster Brian
- Franco Teresa
- Fredrik Lund Ole
- Frelich Michal
- Frey Denise
- Fritzsche Katrin
- Funk Wolfgang
- Gabilondo Garcia Gustavo
- Gabriella Elena Clement Maria
- Gaebler Ralf
- Gagey Anne-Charlotte
- Gaidelyte Lina
- Galinescu Irena
- Galvin Deborah
- Gande Richard
- Gandhi Monica
- Garces Antonio
- García Irene
- Garrigue Delphine
- Garrioch Sweyn
- Gatt David
- Gaynor James
- Geary Tim
- Geil Dfominik
- Genco Daniele
- Gerin Marc
- Gerling Volker
- Germann Reinhard
- Gernoth Christian
- Gestautaite Dalia
- Ghent Robert
- Gillberg Lars
- Gillet Patricia
- Giuseppe Picardo Sergio
- Glasgow Russell
- Glazunov Anton
- Godsiff Leisha
- Goebel Ulrich
- Gomes Cristina
- Goncharenko Galyna
- Gonçalves Marta
- Gooch Ingrid
- Gordeeva Elena
- Grau Catharina
- Grazzini Maurizia
- Grein Elodie
- Grindheim Guro
- Grundmann Ulrich
- Grynyuk Andry
- Guarracino Fabio
- Guddo Annamaria
- Guedes Isabel
- Guericke Holger
- Guerin Christilynn
- Guido Locatelli Bruno
- Guillier Marion
- Gurita Adriana
- Gurita Adriana
- Guskov Igor
- Gutierrez Valcarcel Andrea
- Gutierrez Ignacio
- Gutmann Anton
- Guzman Ines
- Gymoese Berthelsen Kasper
- Habre Walid
- Habre Walid
- Hammerschlag Jacinda
- Hamonic Yann
- Hannie J.
- Hansen Tom G
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
- Hare Alison
- Harlet Pierre
- Harmen Herrema Idse
- Harris Sarah
- Harrison Richard
- Hasani Antigona
- Hashimi Medita
- Hatipoglu Zehra
- Hawksworth Chris
- Hayem Catherine
- Hearn Robert
- Hedlund Lars
- Hein Maximilian
- Helena Gaitan M.
- Heli Litvic Dubravka
- Helm Emma
- Heyse Björn
- Himpe Dirk
- Hinz José
- Hivey Sarah
- Hizal Ayse
- Hobbs Amy
- Hochhold Christoph
- Hodgetts Vanessa
- Hoeft Andreas
- Hoehne Claudia
- Hofmann Ulrich
- Hogea Cristiana
- Holy Rolf
- Homer Rachel
- Hopman Geranne A. J.
- Horhota Lucian
- Huber Matthias
- Hullatt Laurence
- Hunter Catherine
- Hurni Thomas
- Hussain Nageena
- Hussey Joseph
- Hutchinson Adel
- Huygens Christel
- Hölzle Martin
- Ilie Luminita
- Ilksen Toprak Huseyin
- Ilmoja Mari-Liis
- Ingeborg Madsen Birgitte
- Ioannou Ioannis
- Iordanidou Despoina
- Ireland Nicholas
- Irwin Janice
- Isohanni Mika
- Isselhorst Carsten
- Ivani Giorgio
- Ivanov Alexander
- Ivascu Constantin
- Izzo Francesca
- Jack Ewan
- Jacomet Alfred
- Jacqmarcq Olivier
- Jamil Yosry
- jan Scheffer Gert
- Janjevic Dusanka
- Jeng Min Law Savio
- Jerome Kevin
- Jetzek-Zader Martin
- Jiménez Anabel
- Joao Susano Maria
- Johanne Lynch
- Johansen Mathias
- John Robert
- Johnston Graham
- Jokinen Johanna
- Jones Gareth
- Joukes Ellen
- Julien-Marsollier Florence
- Jureckova Lucie
- Juzwa Magdalena
- Jöhr Martin
- Jöhr Martin
- Kachko Ludmyla
- Kahn David
- Kalagac Fabris Lada
- Kalliardou Evagelia
- Kappen Teus H.
- Karadeniz Meltem Savran
- Karjagin Juri
- Katz Jacob
- Kaufmann Nils
- Kazak Bengisun Zuleyha
- Keilhauer Julia
- Kelgeri Nivedita
- Kemal Arslantas Mustafa
- Kendigelen Pinar
- Kerovec Soric Ivana
- Kesic-Valpotic Gordana
- Khaffaf Ranj
- Khotcholava Magda
- Khrapak Maksym
- Kienbaum Peter
- Kikas Reet
- Kindermann Petra
- King Stephanie
- Kirilov Dmitry
- Kirton Christine
- Kiviluoma Kai
- Klimscha Walter
- Kloessing Jan
- Klymenko Tetyana
- Knauss Kristina
- Knezevic Mirjana
- Kochkin Vladimir
- Koessler Herbert
- Konecny Regina
- Kopycinska Renata
- Kortgen Andreas
- Kotecha Ami
- Kotzeva Svetlana
- Kranke Peter
- Krikstaponiene Jolita
- Kroess Ruth
- Kuehhirt Thomas
- Kuppers Beate
- Kusnirikova Zuzana
- Kyselova Iryna
- Ladak Nadia
- Laffargue Anne
- Lagarde Sylvaine
- Lako Sandra
- Lalot Michaël
- Lambelin Veronique
- Lambotte Patricia
- Lang Colin
- Lapi Maria
- Larcher Claire
- Laschat Michael
- Lauweryns Julie
- Lazarev Vladimir
- Lazaro Juan J
- Le Freche Hélène
- Leal Teresa
- Lechat Jean-Paul
- Leclercq Mickeal
- Lee Clover-Ann
- Lee Corina
- Lee Juliette
- Legrand Aurélien
- Lehousse Thierry
- Lejus Corinne
- Lesmes Carlos
- Leva Brigitte
- Leva Brigitte
- Levinzon Michael
- Levitchi Roxana
- Levy David
- León Carsi Irene
- Lhubat Elizabeth
- Lindenskov Pal H H
- Lipczynski Dariusz
- Liyanage Ganga
- Locke Christie
- Lofino Giuseppe
- Lomas Bernadette
- Longobardo Annalisa
- Lonsdale Hannah
- Love David
- Loveniers Birgit
- Lucia Pinciroli Rosa
- Ludot Hugues
- Lugovoy Alexander
- Lukosiene Laura
- Luntzer Robert
- Lyly Anniina
- López Galera Sílvia
- Machado Elvira
- Machotta Andreas
- Mackiewicz Tomasz
- Mackova Iveta
- Maddalena Schellino Maria
- Mader Thomas
- Magasich Natalia
- Magner Claire
- Mahadewsing Ravin
- Majid Saleem Mohammed
- Makin Andrew
- Malarkkan Nalini
- Malisiova Anna
- Mameli Leila
- Mandras Ana
- Manen Berga Ferran
- Manevich Yair
- Maniora Maud
- Manner Tuula
- Marchesini Laura
- Marchetti Giuliano
- Marco Valls Joan
- Marcucci Carine
- Marcus Ritchie
- Maretic Hrvoje
- Maria Gago Martinez Andrea
- Maria Nistor Alina
- Marie Drage Inger
- Marie Anais
- Marjanovic Vesna
- Marthe Ballovarre Kari
- Martikainen Kati
- Martinez Maldonado Ever
- Martínez Ruiz Alberto
- Mascarenhas Catia
- Masip Nuria
- Mauch Jacqueline
- Maupain Olivier
- Maurizio Raineri Santi
- Mausser Gerlinde
- Mawer Rebecca
- Mayell Antonia
- McClintock Joanna
- McKee Lesley
- Megens A. M.
- Meijer Patrick
- Melero Alicia
- Meneghini Luisa
- Merella Federica
- Mesbah Ahmed
- Messerer Brigitte
- Metrangolo Salvatore
- Meybohm Patrick
- Meyer-Treschan Tanja
- Michelon Stefania
- Micici Slobodan
- Mielke Golo
- Mierzewska-Schmidt Magdalena
- Mifsud Mark
- Mifsud Stephanie
- Migeon Anne
- Mihaela Gheorghe Ligia
- Mihaela Dubau
- Milde Alexander
- Milojevic Irina
- Minardi Carmelo
- Mircetic Maja
- Mitchell John
- Miulescu Magdalena
- Mixa Vladimir
- Mocioiu Gabriel
- Molies Dolors
- Monclus Enric
- Moncreiff Michael
- Moniz Antonio
- Monrigal Jean
- Montague James
- Montferrer Núria
- Montobbio Giovanni
- Moors Xavier
- Moraru-Draghici Lucia
- Morawk-Wintersperger Ulrike
- Morgan Judith
- Morton Neil
- Morton Neil S
- Moscaliuc Melania
- Moscatello Djurdjica
- Mossetti Valeria
- Muir Vimty
- Munar Francisca
- Munteanu Valentin
- Muro Cristina
- Najafi Nadia
- Nakhjavani Solmaz
- Nasser Leila
- Nastran Andraz
- Navaro Montserrat
- Nechaev Vladislav
- Neckebroek Martine
- Neiger Franz
- Nekrasov Konstantin
- Neri Simona
- Neumann Claudia
- Nicoleta Daraban
- Nolte Claire
- Noriega Bryant
- Nouette-Gaulain Karine
- Ntavlis Merkourios
- Numan Sandra C.
- Nuño Rosario
- O'Donahue Lizanne
- O'Hare Brendan
- Oberhauser Markus
- Ochsenreiter Miriam
- Oeding Joachim
- Olaru Valentin
- Oller Duque Lara
- Olmos Mendez Alberto
- Olteanu Dana
- Oppenrieder Karin
- Orliaguet Gilles
- Oshan Vimmi
- Ostreikov Ivan
- Ottolina Davide
- Ovezov Alexey
- Ozcengiz Dilek
- Ozer Yetkin
- Paal Peter
- Paiu Corneliu
- Paliokaite Evelina
- Pamies Carmen
- Pandurov Marina
- Parashchanka Aliaksandra
- Parasuraman Tamaraichelvi
- Pasini Lorena
- Passariello Leandro
- Patel Pradip
- Patel Shivali
- Pattar Alexander
- Paul Mission Jean
- Pauling Mark
- Pavlenko Vitaliy
- Pavlickova Jana
- Pearson Karen
- Pedro Pina António
- Pedrotti Dino
- Pegg Rachel
- Peiris Kawshala
- Peled Elia
- Pellegrini Michel
- Pereira Ricardo
- Perelló Marina
- Perera Remel
- Peresbota Daliana
- Perez Garcia Anibal
- Perez- Ferrer Antonio
- Perova-Sharonova Valentina
- Perry Nicole
- Peter Laura
- Petrescu Luxita
- Petrovic Sladjana
- Phaff Steen Nick
- Phillips Trudie
- Pick Darina
- Picker Olaf
- Pilla Clotaire
- Pino Gema
- Pirat Philippe
- Pirc Dejan
- Pirotte Thierry
- Pistidda Laura
- Pitino Sofia
- Plant Nina
- Platzer Manuela
- Plichon Benoit
- Plumb James
- Poduskov Evgeny
- Podvin Alexandre
- Poelaert Jan
- Popescu Barbura
- Popic Rok
- Popov Alexander
- Popovic Ljiljana
- Powell Alex
- Prat Mar
- Pratt Thomas
- Pregardien Caroline
- Preussler Niels-Peter
- Pribul Vicky
- Prysiazhniuk Dmytro
- Pryzmont Miroslaw
- Punt Kees
- Punzo Cinzia
- Puric Selena
- Pé d'Arca Sandra
- Quintel Michael
- Qureshi Arif
- Raber Manfred
- Rad Mandana
- Raffoflandreur Celine
- Raistrick Christopher
- Rajamani Balaji
- Ramminger Axel
- Ravi Radha
- Rawlinson Ellen
- Razlevice Ilona
- Reali Simone
- Rebac Vlatka
- Reikvam Tore
- Reindl Doris
- Reinert Jennifer
- Reinoso Barbero Francisco
- Retka Wlodzimierz
- Ribo Laura
- Richart Pierre
- Riche Jean-Claude
- Ricol Lainez Laura
- Riggenbach Christine
- Rizzo Giuliana
- Robert Philippe
- Roberts Steve
- Rodrigues Sara
- Rogerson David
- Roofthooft Eva
- Roos Torbjörn
- Rosada-Kurasinska Jowita
- Ross Mark
- Rossetti Francesca
- Rosu Lilica
- Roth Benjamin
- Roth Jens
- Roth Winfried
- Roulleau Philippe
- Roxo Helena
- Rubio Paloma
- Rudewicz Iwona
- Rudio Olga
- Rushman Sarah
- Russell Susan
- Russell William
- Russo Sebastian G.
- Rustemeyer Lydia
- Rutherford John
- Rutherford William
- Rémond Charlotte
- Sa Angela
- Sabau Lucie
- Sabourdin Nada
- Sage Frederic
- Saha Rita
- Salgado Helena
- Salici Fabiana
- Salota Vishal
- Salvo Ida
- Samani Amee
- Sammartino Maria
- Sanchez Torres Cristel
- Sandström Kerstin
- Sanko Elena
- Sanna Andrea
- Sansone Pasquale
- Santos Maria
- Saour Anne-Charlotte
- Saviciene Nijole
- Savu Anca
- Sawicki Piotr
- Sbaraglia Fabio
- Scalisi Rita
- Schaefer Maximilian S.
- Schierlinger Bettina
- Schindler Ehrenfried
- Schink Cornel
- Schmain Dmitri
- Schmucker Erika
- Schoeler Michael
- Scholten Harm
- Schorer Clemens
- Schousboe Birgitte MB
- Schouten Anton N. J.
- Schramm Michael
- Schwarzkopf Konrad
- Sciascia Angela
- Scordo Lucia
- Scott-Warren Victoria
- Seabra Manuel
- Seidel-Ahyai Natascha
- Semjen François
- Serrano Silvia
- Seyhan Ozkan Tulay
- Sharman Sarah-Jane
- Shaw Neil
- Sheinkin Olga
- Shepherd Elizabeth
- Short Judith
- Sidlovskaite-Baltake Dominika
- Sieben Anne
- Siemek-Mitela Jadzia
- Sileo Rosanna
- Simhi Eliahu
- Simic Dusica
- Simic Irena
- Simin Jovana
- Simitzes Helena
- Simon Dominique
- Simpson Joanna
- Simurina Tatjana
- Sinclair John
- Singh Piyush
- Sinner Barbara
- Sirghie Rodica
- Sivrikoz Nuket
- Skaaden Lene
- Skacel Monika
- Sketcher Jonathan
- Sklyar Vitaliy
- Skordou Natalia
- Slater Patricia
- Slavkovic Bojana
- Smith Carolyn
- Smith Fiona
- Smith Natalie
- Smitz Carine
- Snoek Aarjan
- Sobczyk Jaek
- Sodhi Puja
- Sola Ruiz Eva
- Sola Chrystelle
- Sonzogni Valter
- Soskova Tereza
- Spahr-Schopfer Isabelle
- Spanjer Vera
- Spanjersberg Rob
- Sponheim Sjur
- Staals Lonneke
- Stack Charles
- Staiti Giuseppe
- Standl Thomas
- Starita Giusi
- Stasevski Vladyslav
- Steel Simon
- Stefan Violeta
- Steiner Maria
- Steinmann Johannes
- Stevanovic Vesna
- Stevens France
- Stevens Markus F
- Stevic Marija
- Steward Heather
- Stoegermüller Birgit
- Stoia Paolo
- Strachan Dominic
- Stranjanac Vladimir
- Straume Zane
- Stuck Tus Ivana
- Stupnik Spela
- Sulen Nina
- Supthut Hauke
- Surkov Denis
- Sutherland Paul
- Suvejan Mirela
- Svircevic Vesna
- Sweeney Lorraine
- Tabacaru Radu
- Takala Annika
- Takil Arzu
- Talalaj Mariola
- Talbot Laura
- Tarabikin Alex
- Taright Hanna
- Taylor Christopher
- Taylor Matthew
- Taylor Matthew
- Teodora Nastase Alina
- Teresa Rocha Maria
- Tesoro Simonetta
- Thadsad Muthu
- Thil Elke
- Thomas Alun
- Thomas Deborah
- Thomson Wendy
- Tielens Luc
- Tognon Costanza
- Tolasov Konstantin
- Toller Wolfgang
- Tomlinson William
- Tonise Virge
- Tore Altun Gülbin
- Trabkin Evelina
- Trante Irinel
- Trieschmann Uwe
- Trifan Oana
- Trikash Nikolay
- Tsiotou Adelais
- Turner Nigel M.
- Uhrig Lynn
- Ullensvang Kyrre
- Ulrici Johanna
- Umuroglu Tumay
- Underhill Helen
- Urbanec René
- Vaidyanath Chandra
- Vail Hannah
- Vaitoskaite Agne
- Vallejo Tarrat Andrea
- Valzan Silvia
- van de Riet Yvette
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- van der Knijff - van Dortmont Anouk
- van der Marel Caroline
- van der Schatte Olivier Roelof
- Van Der Werff Désirée B. M.
- van der Zwan Tim
- van Doorn Thea
- Van Hecke Rachel
- Van Limmen Jurgen
- Van Mossevelde Veerle
- van Osch Rob
- Van Reeth Veronique
- van Stijn Mireille F M
- Vanpeteghem Caroline
- Varyvoda Mykhailo
- Vason Milo
- Velcev Ana
- Veldhuizen Marianne
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M
- Vermeulen Petronella M
- Veyckemans Francis
- Veyckemans Francis
- Viacava Rosanna
- Viken Oddbjorn
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Vittori Alessandro
- Vodianytskyi Sergii
- Voet Marieke
- Volger Hauke
- Volkers Martin
- Volpe Claudia
- Vons Mark Hendriks Kristy
- Vossen Carine
- Wai Carolynn
- Wappler Frank
- Wasiluk Malgorzata
- Watson Karen
- Weber Stefan
- Weinlichova Stanislava
- Weiss Katja
- Wellesley Hugo
- Wensing Renee T. M.
- Weyland Andreas
- Whiteside Jeanette
- Whiteside Jonathan
- Whyte Emma
- Wieczorek Pawel
- Wiefelspütz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Žurek Jirí
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31â127 anaesthetic procedures in 30â874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0â5·5) with an incidence of respiratory critical events of 3·1% (2·9â3·3). Cardiovascular instability occurred in 1·9% (1·7â2·1), with an immediate poor outcome in 5·4% (3·7â7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10â000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86â0·90; p<0·0001), medical history, and physical condition (1·60, 1·40â1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981â0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97â0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. Funding European Society of Anaesthesiology
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela Rodríguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J.
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B.
- Boegli Yann
- Bollinger Matthias
- Book Malte
- Bordes Maryline
- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
- Camus Blandine
- Capusan Alin
- Carachi Peter
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Castellheim Albert
- Casutt Mattias
- Catalina Ionescu Gabriela
- Cavalier Alison
- Cecini Mariateresa
- Cento Valeria
- Cerati Giorgia
- Cerne Uros
- Cerutti Elisabetta
- Cettler Maciej
- Ceuca Daniela
- Ceyda Meco Basak
- Chapotte Catherine
- Chazelet Chantal
- Checinska Magdalena
- Checuti Sarah
- Chee Lew-Chin
- Childs Sophie
- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem Tütüncü Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Clement Maria Gabriella Elena
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
- Crawford Michael
- Cristina Mondardini Maria
- Cuciuc Veaceslav
- Cucui-Cozma Cosmina
- Cullen Julia
- Cullen Pauline
- Cumming Craig
- D'Alessandro Sandra
- Dadure Christophe
- Dahmani Souhayl
- Dalton Andrew
- Dalton Mark
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- Davidescu Irina
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- del Río Cristina
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- Dolci Mirko
- Dolinaj Vladimir
- Domingas Patuleia M.
- Domínguez Fernando
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- Dorman Teresa
- Draskovic Biljana
- Druot Emilie
- Duflo Frédéric
- Dumitru Rusu Florin
- Dupont Hervé
- Eberl Susanne
- Ecoffey Claude
- Ehm Birgit
- Eich Christoph Bernhard
- Eisner Christoph
- Eissa Ayman
- Elena Malos Anca
- Elizabeth Biercamp Claire
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
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- Engelhardt Thomas
- Eniko Kovacs
- Ephraim Erik
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- Gestautaite Dalia
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- Guddo Annamaria
- Guedes Isabel
- Guericke Holger
- Guerin Christilynn
- Guido Locatelli Bruno
- Guillier Marion
- Gurita Adriana
- Gurita Adriana
- Guskov Igor
- Gutierrez Valcarcel Andrea
- Gutierrez Ignacio
- Gutmann Anton
- Guzman Ines
- Gymoese Berthelsen Kasper
- Habre Walid
- Habre Walid
- Hammerschlag Jacinda
- Hamonic Yann
- Hannie J.
- Hansen Tom G.
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
- Hare Alison
- Harlet Pierre
- Harmen Herrema Idse
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- Hedlund Lars
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- Hopman Geranne A. J.
- Horhota Lucian
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- Hullatt Laurence
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- Wiefelspütz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Žurek Jirí
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
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- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
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- Ashoushan Hana
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- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
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- Awesat Eman
- Awolowo Ajibola
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- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
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- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
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- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
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- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
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- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
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- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
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- Bengur Fuat Baris
- Benkabbou Amine
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- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
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- Binetti Margherita
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- Clements Joshua Michael
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- De Azevedo Bernardo
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- Doe Matthew
- Dogruoz Alper
- Doherty Ronan J
- Dollie Qaasim
- Dominguez Genieve
- Dominguez Joaquina
- Domini Edgar
- Dossou Francis
- Dousset Bertrand
- Draganic Brian
- Drake Thomas M
- Drane Andrew
- Duarte Marina
- Dudi-Venkata Nagendra Naidu
- Duggan William
- Duke Kathryn
- Duller Alexander
- Dulskas Audrius
- Dumitra Sinziana
- Dural Ahmet Cem
- Dworak Jadwiga
- Dzhumabaev Khasan
- Dziedzic Jacek
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- Eaazim Jose
- Eardley Nicola
- Echeverria-Davila Guillermo
- Edirisooriya Monisha
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- Ekwen Gerald
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- El Nakeeb Ayman
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- El-Kahlout Sahar
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- El-taweel Alaa
- Elazab Yasmin
- Elbarouni Sofian
- Elbealawy Mohamed
- Elbeshina Aya Elseed
- Elblbessy Mahmood
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- Eldeep Mostafa
- Eldmaty Asmaa
- Eldoseuky mohammed Amany
- Elemile Peter
- Elewaily Mohamed Ibrahim Elsayed
- Elfaituri Taha
- Elfallal Ahmed
- Elfanty Mahmoud
- ElFayoumy Ahmed Moustafa
- Elfeki Hossam
- Elfizri Zatira
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- Elghareeb Nourhan
- Elhadi Ahmed
- Elhadi Muhammed
- Elhajjaji Yasmine
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- Elkhadragy Ahmed
- Elkhalawy Aya
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- Elmahdy Marwa
- Elmeslemany Nehal
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- Elsayed Mai
- Elsayed Mohammad
- Elshafei Houssein
- Elshafey Ahmed
- Elshaibani Mahmoud
- Elshatby Bassant
- Elshawy Mohamed Elemam
- Elsherbeny Mohammed Yasser
- Elsherif Fawzia
- Elshimy Ahmed
- Elsobky Hager
- Elteir Hana
- Eltoum Ruba
- Elzanfaly Ali Abdelazez
- Emara Eman
- Emeghara Okechukwu
- Emile Sameh
- Enumah Zachary
- Eraslan Huseyin
- Eray Ismail Cem
- Erkul Oguz
- Esbaga Fatima
- Escobar Dennis
- Escrevente Ricardo
- Eskander John
- Eslam Sara
- Esmat Nourhan Ahmed
- Esper Asil
- Espin-Basany Eloy
- Espina Perez Beatriz
- Espinosa-Bravo Martin
- Esposito Giovanni
- Essam Ibrahim El Desouki Muhammad Ahmed Muhammad
- Essam Eman
- Estalagem Inês
- Estevez Tesouro José
- Eswaye Haitem
- Etchill Eric
- Etonyeaku Amarachukwu
- Eusebio Zegarra Ivan Edward
- Ezzat Helmy
- Fadel Ahmed
- Fahira Alessa
- Fahmawee Toqa
- Fairfield Cameron J
- Falato Armando
- Falco Giuseppe
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- NA N.A.
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- Ye Geoffrey
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- Zabiyaka Mikhail
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- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
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- Dominguez Joaquina
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- Wondoh Paul M.
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- Yanikoğlu Erkan
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- Ye Geoffrey
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- Yenidünya Nilüfer
- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
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- Yeşilsancak Merve
- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
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- Yong Shun Qi
- Yoong Andrel
- Yorke Joseph
- Yotsov Tsanko
- You Lucia
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- Yozgatli Tahir Koray
- Yu Kristin
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- Yusuf Baasil
- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research