Can an ancient Greek sceptic be eudaimôn (or happy)? And what difference does the answer make to us?

The paper explores how far the ancient Greek sceptics in fact accept, and how far they should accept, the central Greek ethical notion of eudaimonia, usually translated "happiness" - and what, if anything, the answers may tell us today. The first section shows that sceptics of both the Academic and Pyrrhonist traditions frequently employ the notion of eudaimonia, apparently without discomfort. The second section draws attention to a contrast within the relevant works of Sextus Empiricus - one of them being willing to speak of the sceptic's eudaimonia and the other entirely avoiding this - and considers some possible reasons why, at some point in his life, Sextus might have found the notion problematic. The answers suggested are, first, that the term eudaimonia, at least as normally used by non-sceptical philosophers, presupposes that it is possible to rank human lives objectively in terms of their levels of well-being, and second, that the term standardly carries with it a commitment to a certain kind of long-term structure in one's life; there is at least a serious question whether either of these is consistent with sceptical suspension of judgement. The third section examines how far a sceptic could aspire to happiness, where this is not assumed to be equivalent to eudaimonia, and touches on several modern philosophers who have focused on happiness or, more generally, on wellbeing. The conclusions are that the notions of happiness and eudaimonia are closer in their presuppositions than one might have expected; that a sceptic would be well advised to avoid either one; and that this constitutes a sobering lesson for anyone today who regards values as in some sense subjective, but who aims to construct a satisfactory conception of happiness.The paper explores how far the ancient Greek sceptics in fact accept, and how far they should accept, the central Greek ethical notion of eudaimonia, usually translated "happiness" - and what, if anything, the answers may tell us today. The first section shows that sceptics of both the Academic and Pyrrhonist traditions frequently employ the notion of eudaimonia, apparently without discomfort. The second section draws attention to a contrast within the relevant works of Sextus Empiricus - one of them being willing to speak of the sceptic's eudaimonia and the other entirely avoiding this - and considers some possible reasons why, at some point in his life, Sextus might have found the notion problematic. The answers suggested are, first, that the term eudaimonia, at least as normally used by non-sceptical philosophers, presupposes that it is possible to rank human lives objectively in terms of their levels of well-being, and second, that the term standardly carries with it a commitment to a certain kind of long-term structure in one's life; there is at least a serious question whether either of these is consistent with sceptical suspension of judgement. The third section examines how far a sceptic could aspire to happiness, where this is not assumed to be equivalent to eudaimonia, and touches on several modern philosophers who have focused on happiness or, more generally, on wellbeing. The conclusions are that the notions of happiness and eudaimonia are closer in their presuppositions than one might have expected; that a sceptic would be well advised to avoid either one; and that this constitutes a sobering lesson for anyone today who regards values as in some sense subjective, but who aims to construct a satisfactory conception of happiness

Why Care Whether Scepticism is Different from Other Philosophies ?

L’article porte sur la façon dont Sextus, dans les derniers chapitres du Livre I des Esquisses pyrrhoniennes, répond aux argumentations qui tendent à rattacher le scepticisme à diverses philosophies plus anciennes. Après une étude de la nature et des sources de ces argumentations à partir du témoignage de Diogène Laërce et d’autres auteurs, et le constat que bien des questions à ce sujet ne peuvent que rester sans réponse, la majeure partie de l’article est consacrée à l’analyse des contre-arguments avancés par Sextus. Dans presque tous les cas, il apparaît que Sextus s’oppose fermement à tout rapprochement du scepticisme avec d’autres philosophies. Cela est d’autant plus surprenant que la philosophie de l’Antiquité tardive manifeste une tendance marquée à se réclamer de prédécesseurs. L’attitude de Sextus s’explique par son désir de faire comprendre le plus clairement possible que le scepticisme, en réalité, n’a rien d’une philosophie au sens ordinaire du terme. La rareté, chez Sextus, des références à des prédécesseurs nommément désignés, y compris au sein de la tradition pyrrhonienne, peut aussi s’expliquer par le souhait de paraître complètement différent des philosophes tels qu’on les comprend habituellement.The article considers Sextus’ response, in the closing chapters of book 1 of Outlines of Pyrrhonism, to arguments connecting scepticism with numerous earlier philosophies. The nature and sources of such arguments, as indicated by evidence in Diogenes Laertius and elsewhere, is examined, although it is suggested that much about these questions must remain inconclusive. But most of the paper is devoted to a detailed analysis of Sextus’ counter-arguments. In almost every case, Sextus is shown to be very strongly opposed to any rapprochement of scepticism to other philosophies. This is all the more surprising given the increasing tendency in the philosophy of later antiquity to appeal to predecessors. Sextus’ attitude is explained as the product of a desire to make as clear as possible that scepticism is not in fact a philosophy at all, in the usual sense of the term. The fact that he makes very little reference to named predecessors even within the Pyrrhonist tradition itself may also be explained by the wish to seem quite different from philosophers as usually understood

Molecular epidemiology of human rhinovirus infections in Kilifi, coastal Kenya

This study reports pediatric surveillance over 3 years for human rhinovirus (HRV) at the District Hospital of Kilifi, coastal Kenya. Nasopharyngeal samples were collected from children presenting at outpatient clinic with no signs of acute respiratory infection, or with signs of upper respiratory tract infection, and from children admitted to the hospital with lower respiratory tract infection. Samples were screened by real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR) and classified further to species by nucleotide sequencing of the VP4/VP2 junction. Of 441 HRV positives by real-time RT-PCR, 332 were classified to species, with 47% (155) being HRV-A, 5% (18) HRV-B, and 48% (159) HRV-C. There was no clear seasonal pattern of occurrence for any species. The species were present in similar proportions in the inpatient and outpatient sample sets, and no significant association between species distribution and the severity of lower respiratory tract infection in the inpatients could be determined. HRV sequence analysis revealed multiple but separate clusters in circulation particularly for HRV-A and HRV-C. Most HRV-C clusters were distinct from reference sequences downloaded from GenBank. In contrast, most HRV-A and HRV-B sequences clustered with either known serotypes or strains from elsewhere within Africa and other regions of the world. This first molecular epidemiological study of HRV in the region defines species distribution in accord with reports from elsewhere in the world, shows considerable strain diversity and does not identify an association between any species and disease severity

Seroprevalence and related risk factors of Brucella spp. in livestock and humans in Garbatula subcounty, Isiolo county, Kenya

Background Brucellosis is a neglected zoonotic disease that affects both animals and humans, causing debilitating illness in humans and socio-economic losses in livestock-keeping households globally. The disease is endemic in many developing countries, including Kenya, but measures to prevent and control the disease are often inadequate among high-risk populations. This study aimed to investigate the human and livestock seroprevalence of brucellosis and associated risk factors of Brucella spp. in a pastoralist region of northern Kenya. Methods A cross-sectional survey was conducted using a two-stage cluster sampling method to select households, livestock, and humans for sampling. Blood samples were collected from 683 humans and 2157 animals, and Brucella immunoglobulin G (IgG) antibodies were detected using enzyme-linked immunosorbent assays. A structured questionnaire was used to collect data on potential risk factors associated with human and animal exposures. Risk factors associated with Brucella spp. exposures in humans and livestock were identified using Multivariate logistic regression. Results The results indicated an overall livestock Brucella spp. seroprevalence of 10.4% (95% Confidence Interval (CI): 9.2–11.7). Camels had the highest exposure rates at 19.6% (95% CI: 12.4–27.3), followed by goats at 13.2% (95% CI: 9.3–17.1), cattle at 13.1% (95% CI: 11.1–15.3) and sheep at 5.4% (95% CI: 4.0–6.9). The herd-level seroprevalence was 51.7% (95% CI: 47.9–55.7). Adult animals (Adjusted Odds Ratio (aOR) = 2.3, CI: 1.3–4.0), female animals (aOR = 1.7, CI: 1.1–2.6), and large herd sizes (aOR = 2.3, CI: 1.3–4.0) were significantly associated with anti-brucella antibody detection while sheep had significantly lower odds of Brucella spp. exposure compared to cattle (aOR = 1.3, CI: 0.8–2.1) and camels (aOR = 2.4, CI: 1.2–4.8). Human individual and household seroprevalences were 54.0% (95% CI: 50.2–58.0) and 86.4% (95% CI: 84.0–89.0), respectively. Significant risk factors associated with human seropositivity included being male (aOR = 2.1, CI:1.3–3.2), residing in Sericho ward (aOR = 1.6, CI:1.1–2.5) and having no formal education (aOR = 3.0, CI:1.5–5.9). There was a strong correlation between human seropositivity and herd exposure (aOR = 1.6, CI:1.2–2.3). Conclusions The study provides evidence of high human and livestock exposures to Brucella spp. and identifies important risk factors associated with disease spread. These findings emphasize the need for targeted prevention and control measures to curb the spread of brucellosis and implement a One Health surveillance to ensure early detection of the disease in Isiolo County, Northern Kenya

The Halos of Satellite Galaxies: the Companion of the Massive Elliptical Lens SL2S J08544-0121

Strong gravitational lensing by groups or clusters of galaxies provides a powerful technique to measure the dark matter properties of individual lens galaxies. We study in detail the mass distribution of the satellite lens galaxy in the group-scale lens SL2S J08544-0121 by modelling simultaneously the spatially extended surface brightness distribution of the source galaxy and the lens mass distribution using Markov chain Monte Carlo methods. In particular, we measure the dark matter halo size of the satellite lens galaxy to be 6.0^{+2.9}_{-2.0} kpc with a fiducial velocity dispersion of 127^{+21}_{-12} km/s. This is the first time the size of an individual galaxy halo in a galaxy group has been measured using strong gravitational lensing without assumptions of mass following light. We verify the robustness of our halo size measurement using mock data resembling our lens system. Our measurement of the halo size is compatible with the estimated tidal radius of the satellite galaxy, suggesting that halos of galaxies in groups experience significant tidal stripping, a process that has been previously observed on galaxies in clusters. Our mass model of the satellite galaxy is elliptical with its major axis misaligned with that of the light by ~50 deg. The major axis of the total matter distribution is oriented more towards the centre of the host halo, exhibiting the radial alignment found in N-body simulations and observational studies of satellite galaxies. This misalignment between mass and light poses a significant challenge to modified Newtonian dynamics.Comment: 13 pages, 10 figures, minor revisions based on referee's comments, accepted for publication in A&

Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya

Camels are increasingly becoming the livestock of choice for pastoralists reeling from effects of climate change in semi-arid and arid parts of Kenya. As the population of camels rises, better understanding of their role in the epidemiology of zoonotic diseases in Kenya is a public health priority. Rift Valley fever (RVF), brucellosis and Q fever are three of the top priority diseases in the country but the involvement of camels in the transmission dynamics of these diseases is poorly understood. We analyzed 120 camel serum samples from northern Kenya to establish seropositivity rates of the three pathogens and to characterize the infecting Brucella species using molecular assays. We found seropositivity of 24.2% (95% confidence interval [CI]: 16.5-31.8%) for Brucella, 20.8% (95% CI: 13.6-28.1%) and 14.2% (95% CI: 7.9-20.4%) for Coxiella burnetii and Rift valley fever virus respectively. We found 27.5% (95% CI: 19.5-35.5%) of the animals were seropositive for at least one pathogen and 13.3% (95% CI: 7.2-19.4%) were seropositive for at least two pathogens. B. melitensis was the only Brucella spp. detected. The high sero-positivity rates are indicative of the endemicity of these pathogens among camel populations and the possible role the species has in the epidemiology of zoonotic diseases. Considering the strong association between human infection and contact with livestock for most zoonotic infections in Kenya, there is immediate need to conduct further research to determine the role of camels in transmission of these zoonoses to other livestock species and humans. This information will be useful for designing more effective surveillance systems and intervention measures

Local and wide-scale livestock movement networks inform disease control strategies in East Africa

Livestock mobility exacerbates infectious disease risks across sub-Saharan Africa, but enables critical access to grazing and water resources, and trade. Identifying locations of high livestock traffic offers opportunities for targeted control. We focus on Tanzanian agropastoral and pastoral communities that account respectively for over 75% and 15% of livestock husbandry in eastern Africa. We construct networks of livestock connectivity based on participatory mapping data on herd movements reported by village livestock keepers as well as data from trading points to understand how seasonal availability of resources, land-use and trade influence the movements of livestock. In communities that practise agropastoralism, inter- and intra-village connectivity through communal livestock resources (e.g. pasture and water) was 1.9 times higher in the dry compared to the wet season suggesting greater livestock traffic and increased contact probability. In contrast, livestock from pastoral communities were 1.6 times more connected at communal locations during the wet season when they also tended to move farther (by 3 km compared to the dry season). Trade-linked movements were twice more likely from rural to urban locations. Urban locations were central to all networks, particularly those with potentially high onward movements, for example to abattoirs, livestock holding grounds, or other markets, including beyond national boundaries. We demonstrate how livestock movement information can be used to devise strategic interventions that target critical livestock aggregation points (i.e. locations of high centrality values) and times (i.e. prior to and after the wet season in pastoral and agropastoral areas, respectively). Such targeted interventions are a cost-effective approach to limit infection without restricting livestock mobility critical to sustainable livelihoods

Estimating the basic reproductive number (R0) for African swine fever virus (ASFV) transmission between pig herds in Uganda

African swine fever (ASF) is a highly contagious, lethal and economically devastating haemorrhagic disease of domestic pigs. Insights into the dynamics and scale of virus transmission can be obtained from estimates of the basic reproduction number (R0). We estimate R0 for ASF virus in small holder, free-range pig production system in Gulu, Uganda. The estimation was based on data collected from outbreaks that affected 43 villages (out of the 289 villages with an overall pig population of 26,570) between April 2010 and November 2011. A total of 211 outbreaks met the criteria for inclusion in the study. Three methods were used, specifically; (i) GIS- based identification of the nearest infectious neighbour based on the Euclidean distance between outbreaks, (ii) epidemic doubling time, and (iii) a compartmental susceptible-infectious (SI) model. For implementation of the SI model, three approaches were used namely; curve fitting (CF), a linear regression model (LRM) and the SI/ N proportion. The R0 estimates from the nearest infectious neighbour and epidemic doubling time methods were 3.24 and 1.63 respectively. Estimates from the SI-based method were 1.58 for the CF approach, 1.90 for the LRM, and 1.77 for the SI/N proportion. Since all these values were above one, they predict the observed persistence of the virus in the population. We hypothesize that the observed variation in the estimates is a consequence of the data used. Higher resolution and temporally better defined data would likely reduce this variation. This is the first estimate of R0 for ASFV in a free range smallholder pig keeping system in sub-Saharan Africa and highlights the requirement for more efficient application of available disease control measures.S1 Data. The data that was used in all the computations and Figures.S1 Fig. Generation tree following the nearest infectious neighbour route. Nearest infectious neighbour generation tree also known as a transmission network. Epidemic is suspected to have been introduced at herd/ node 1 coloured red (bottom extreme left). The critical node at which the disease could have been stopped from further spread as highlighted in green in the generation tree. (Designed in network analysis tool ORA)S2 Fig. The SIR model used to simulate outbreak data of African swine fever, Gulu District, Uganda, April 2010—November 2011.S3 Fig. Distribution of bootstrapped monthly transmission rate coefficient β estimates.S4 Fig. Sensitivity of basic reproduction number R0 to variation in initial number of herds.S5 Fig. Spatial distribution of ASF infected herds (April 2010—November 2011).S1 Text. Philosophical underpinning of R0.The Commonwealth Scientific and Industrial Research Organisation (CSIRO)- Australian Agency for International Development (AusAID) Africa-Australia Food Security Initiative (MBB, EAO,RPB); Consortium of International Agricultural Research Centers (CGIAR) Research Program for Agriculture for Nutrition and Health, led by IFPRI (BB, AS); Wellcome Trust (grant 085308) (EMF); the Swedish research council FORMAS (Grant No. 221-2009-1984) (KS, CM, TA); and CISA-INIA Grant no. TF069018 (MBB, RPB).http://www.plosone.orgam201

Flowering margins support natural enemies between cropping seasons

Here we investigated how agricultural landscapes support natural pest regulating insects between cropping seasons; an important challenge in Pest Management by Small-Holder Farmers so aligns with this special issue. Smallholders in East Africa clear margins to provide fodder for cattle or livestock or simply to reduce the ingression of weeds into crop fields. We show that there was a significant seasonal variation in plant species richness and diversity around crops and the abundance of margin plants was strongly linked to abundance of natural enemies in the off season. The time since harvesting was also a significant factor influencing the overall abundance of natural enemies. Our paper reinforces our understanding of the importance flowering plants in agricultural systems as a refuge for natural enemies and other beneficial insects but uniquely emphasising the time between cropping seasons. Improving agricultural landscapes between crops to better support invertebrates will lead to more effective natural pest regulation early in the following crop with positive outcomes for the farmers and their families