Controlling Chaos through Compactification in Cosmological Models with a Collapsing Phase

We consider the effect of compactification of extra dimensions on the onset of classical chaotic "Mixmaster" behavior during cosmic contraction. Assuming a universe that is well-approximated as a four-dimensional Friedmann-Robertson--Walker model (with negligible Kaluza-Klein excitations) when the contraction phase begins, we identify compactifications that allow a smooth contraction and delay the onset of chaos until arbitrarily close the big crunch. These compactifications are defined by the de Rham cohomology (Betti numbers) and Killing vectors of the compactification manifold. We find compactifications that control chaos in vacuum Einstein gravity, as well as in string theories with N = 1 supersymmetry and M-theory. In models where chaos is controlled in this way, the universe can remain homogeneous and flat until it enters the quantum gravity regime. At this point, the classical equations leading to chaotic behavior can no longer be trusted, and quantum effects may allow a smooth approach to the big crunch and transition into a subsequent expanding phase. Our results may be useful for constructing cosmological models with contracting phases, such as the ekpyrotic/cyclic and pre-big bang models.Comment: 1 figure. v2/v3: minor typos correcte

POLG2 deficiency causes adult-onset syndromic sensory neuropathy, ataxia and parkinsonism

Objective: Mitochondrial dysfunction plays a key role in the pathophysiology of neurodegenerative disorders such as ataxia and Parkinson's disease. We describe an extended Belgian pedigree where seven individuals presented with adult-onset cerebellar ataxia, axonal peripheral ataxic neuropathy, and tremor, in variable combination with parkinsonism, seizures, cognitive decline, and ophthalmoplegia. We sought to identify the underlying molecular etiology and characterize the mitochondrial pathophysiology of this neurological syndrome. Methods: Clinical, neurophysiological, and neuroradiological evaluations were conducted. Patient muscle and cultured fibroblasts underwent extensive analyses to assess mitochondrial function. Genetic studies including genome-wide sequencing were conducted. Results: Hallmarks of mitochondrial dysfunction were present in patients' tissues including ultrastructural anomalies of mitochondria, mosaic cytochrome c oxidase deficiency, and multiple mtDNA deletions. We identified a splice acceptor variant in POLG2, c.970-1G>C, segregating with disease in this family and associated with a concomitant decrease in levels of POLG2 protein in patient cells. Interpretation: This work extends the clinical spectrum of POLG2 deficiency to include an overwhelming, adult-onset neurological syndrome that includes cerebellar syndrome, peripheral neuropathy, tremor, and parkinsonism. We therefore suggest to include POLG2 sequencing in the evaluation of ataxia and sensory neuropathy in adults, especially when it is accompanied by tremor or parkinsonism with white matter disease. The demonstration that deletions of mtDNA resulting from autosomal-dominant POLG2 variant lead to a monogenic neurodegenerative multicomponent syndrome provides further evidence for a major role of mitochondrial dysfunction in the pathomechanism of nonsyndromic forms of the component neurodegenerative disorders

The GABA Transaminase, ABAT, Is Essential for Mitochondrial Nucleoside Metabolism

SummaryABAT is a key enzyme responsible for catabolism of principal inhibitory neurotransmitter γ-aminobutyric acid (GABA). We report an essential role for ABAT in a seemingly unrelated pathway, mitochondrial nucleoside salvage, and demonstrate that mutations in this enzyme cause an autosomal recessive neurometabolic disorder and mtDNA depletion syndrome (MDS). We describe a family with encephalomyopathic MDS caused by a homozygous missense mutation in ABAT that results in elevated GABA in subjects’ brains as well as decreased mtDNA levels in subjects’ fibroblasts. Nucleoside rescue and co-IP experiments pinpoint that ABAT functions in the mitochondrial nucleoside salvage pathway to facilitate conversion of dNDPs to dNTPs. Pharmacological inhibition of ABAT through the irreversible inhibitor Vigabatrin caused depletion of mtDNA in photoreceptor cells that was prevented through addition of dNTPs in cell culture media. This work reveals ABAT as a connection between GABA metabolism and nucleoside metabolism and defines a neurometabolic disorder that includes MDS

Applied research contribution to Oregon's agricultural income : a biennial report of activities and accomplishments

Published December 1934. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalo

On uniqueness of tangent cones for Einstein manifolds

We show that for any Ricci-flat manifold with Euclidean volume growth the tangent cone at infinity is unique if one tangent cone has a smooth cross-section. Similarly, for any noncollapsing limit of Einstein manifolds with uniformly bounded Einstein constants, we show that local tangent cones are unique if one tangent cone has a smooth cross-section

Revised Pacific M-anomaly geomagnetic polarity timescale

Author Posting. © The Authors, 2010. This article is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Geophysical Journal International 182 (2010): 203-232, doi:10.1111/j.1365-246X.2010.04619.x.The current M-anomaly geomagnetic polarity timescale (GPTS) is mainly based on the Hawaiian magnetic lineations in the Pacific Ocean. M-anomaly GPTS studies to date have relied on a small number of magnetic profiles, a situation that is not ideal because any one profile contains an uncertain amount of geologic 'noise' that perturbs the magnetic field signal. Compiling a polarity sequence from a larger array of magnetic profiles is desirable to provide greater consistency and repeatability. We present a new compilation of the M-anomaly GPTS constructed from polarity models derived from magnetic profiles crossing the three lineation sets (Hawaiian, Japanese and Phoenix) in the western Pacific. Polarity reversal boundary locations were estimated with a combination of inverse and forward modelling of the magnetic profiles. Separate GPTS were established for each of the three Pacific lineation sets, to allow examination of variability among the different lineation sets, and these were also combined to give a composite timescale. Owing to a paucity of reliable direct dates of the M-anomalies on ocean crust, the composite model was time calibrated with only two ages; one at each end of the sequence. These two dates are 125.0 Ma for the base of M0r and 155.7 Ma for the base of M26r. Relative polarity block widths from the three lineation sets are similar, indicating a consistent Pacific-wide spreading regime. The new GPTS model shows slightly different spacings of polarity blocks, as compared with previous GPTS, with less variation in block width. It appears that the greater polarity chron irregularity in older models is mostly an artifact of modelling a small number of magnetic profiles. The greater averaging of polarity chron boundaries in our model gives a GPTS that is statistically more robust than prior GPTS models and a superior foundation for Late Jurassic–Early Cretaceous geomagnetic and chronologic studies.This work was supported by the Jane & R. Ken Williams'45 Chair of Ocean Drilling Science and Technology

Sugarcane (Saccharum X officinarum): A Reference Study for the Regulation of Genetically Modified Cultivars in Brazil

Global interest in sugarcane has increased significantly in recent years due to its economic impact on sustainable energy production. Sugarcane breeding and better agronomic practices have contributed to a huge increase in sugarcane yield in the last 30 years. Additional increases in sugarcane yield are expected to result from the use of biotechnology tools in the near future. Genetically modified (GM) sugarcane that incorporates genes to increase resistance to biotic and abiotic stresses could play a major role in achieving this goal. However, to bring GM sugarcane to the market, it is necessary to follow a regulatory process that will evaluate the environmental and health impacts of this crop. The regulatory review process is usually accomplished through a comparison of the biology and composition of the GM cultivar and a non-GM counterpart. This review intends to provide information on non-GM sugarcane biology, genetics, breeding, agronomic management, processing, products and byproducts, as well as the current technologies used to develop GM sugarcane, with the aim of assisting regulators in the decision-making process regarding the commercial release of GM sugarcane cultivars

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele