Forest Focus Monitoring Database System - Technical Report 2005 Level II Data

Forest Focus (Regulation (EC) No 2152/2003) is a Community scheme for harmonized, broad-based, comprehensive and long-term monitoring of European forest ecosystems. Under this scheme the monitoring of air pollution effects on forests is carried out by participating countries on the basis of the systematic network of observation points (Level I) and of the network of observation plots for intensive and continuous monitoring (Level II). According to Article 15(1) of the Forest Focus Regulation Member States shall annually, through the designated authorities and agencies, forward to the Commission geo-referenced data gathered under the scheme, together with a report on them by means of computer telecommunications and/or electronic technology. For managing the data JRC has implemented a Forest Focus Monitoring Database System. This Technical Report presents the results obtained from all processing stages (data reception, validation checks ¿ compliance, conformity, uniformity) for submitted data referring to the monitoring year 2005. This report presents the results at the end of the processing phase after data have been re-submitted in 2007. It presents in addition a brief comment on the data status for each NFC, for the reporting year, with respect to the parameter assessed and including analyses of spatial variability of data and temporal trends of parameters.JRC.DDG.H.7-Land management and natural hazard

Forest Focus Monitoring Database System - Technical Report 2001 Level II Data

Forest Focus (Regulation (EC) No 2152/2003 ) is a Community scheme for harmonised, broad-based, comprehensive and long-term monitoring of European forest ecosystems. It concentrates in particular on protecting forests against air pollution and fire. To supplement the monitoring system, Forest Focus stipulates the development of new instruments relating to soil monitoring, carbon sequestration, biodiversity, climate change and protective functions of forests. Under this scheme the monitoring of air pollution effects on forests is carried out by participating countries on the basis of the systematic network of observation points (Level I) and of the network of observation plots for intensive and continuous monitoring (Level II). The monitoring activity continues from the network and plots established and implemented under Council Regulation (EEC) No 3528/86 .and Regulations (EEC) No 1696/87 and (EC) No 1091/94 . The monitoring programme of air pollution effects is linked to International Cooperative Programme on Assessment and Monitoring of Air Pollution Effects on Forest (ICP Forests). ICP Forests reports to the working Group on Effects of the Convention of the Long-Range Trans-boundary Air Pollution (CLRTAP) of the United Nations Economic Commission for Europe (UN-ECE). Forest Focus Article 15(1) stipulates that the Member States shall annually, through the designated authorities and agencies, forward to the Commission geo-referenced data gathered under the scheme, together with a report on them by means of computer telecommunications and/or electronic technology. For managing the data DG JRC has implemented a Forest Focus Monitoring Database System. The system was developed and realized under contract by a Consortium, coordinated by I-MAGE Consult with Nouvelles Solutions Informatiques s.a. (NSI) as consortium partner and the Bundesforschungsanstalt für Forst- und Holzwirtschaft (BFH) as sub-contractor. The designated authorities and agencies submitted annually to DG Joint Research Centre of the European Commission their observations made on the network of observation plots for intensive and continuous monitoring (Level II). Data are submitted via a Web-Module specifically designed for the task as part of the Forest Focus Monitoring Database System.JRC.DDG.H.7-Land management and natural hazard

Molecular dynamics simulation of gallium phosphide zincblende cutting mechanism

Gallium Phosphide (GaP) has a low machinability, due to high tool wear and the need to induce a High-Pressure Phase Transformation (HPPT). HPPT changes GaP crystallographic structure from zincblende to β-tin. The latter is ductile and metastable, therefore, rather than be experimentally observably, must be simulated using atomistic methods. In this work, Classic Molecular Dynamics Simulations (CMDS) were used to analyse GaP HPPT and tool wear mechanisms during the cutting process. Diamond tools were modelled with 10 nm cutting edge radius, -20º and -10º rake angles, and -10º clearance angle. The simulations revealed that the main shear mechanism involved stacking faults, planar dislocations within the crystal structure, while HPPT had a limited role, being restricted to the deformation zone. A more significant surface crack and tool amorphization were observed for a rake angle -10º

Direct Genetics Referral Pathway for High-Grade Serous Ovarian Cancer Patients: The opt-Out Process

Purpose. In order to meet a clinical need for better pathways to access genetic testing for ovarian cancer patients, we implemented and reviewed an opt-out referral process for genetic consultation whereby a referral is automatically sent to genetics following a pathological diagnosis of HGSC. Methods. Following implementation of the opt-out referral process, each month a list of new cases of HGSC was generated from the synoptic pathology report and forwarded directly to the Cancer Genetics clinic. Using an advanced directive, patients were automatically referred for genetic counselling two months after surgery. If the patient declined genetic counselling (opted-out) after discussion with their surgeon within the two months after surgery, the Genetic Counsellor was informed and the patient was removed from the referral process. Results. Between January 1, 2015, and December 31, 2017, 168 women were diagnosed with HGSC, of whom 167 received a referral for genetic consultation. In only one case the referral was cancelled by the surgeon, resulting in a referral rate of 99.4%. By the end of the study period, 133 women attended a genetics consultation appointment and 125 (94%) agreed to proceed with genetic testing. Among those who completed genetic testing, 15% tested positive for a BRCA1 or BRCA2 gene mutation. Of the women who tested positive for a BRCA1/2 mutation, 56% had no family history of breast or ovarian cancer. Conclusions. The opt-out referral process described in this study is s a feasible, effective, and patient-centred approach to increase access to BRCA1/2 testing for patients with ovarian cancer

PGC-1α induced browning promotes involution and inhibits lactation in mammary glands

The PPARγ coactivator 1α (PGC-1α) is a transcriptional regulator of mitochondrial biogenesis and oxidative metabolism. Recent studies have highlighted a fundamental role of PGC-1α in promoting breast cancer progression and metastasis, but the physiological role of this coactivator in the development of mammary glands is still unknown. First, we show that PGC-1α is highly expressed during puberty and involution, but nearly disappeared in pregnancy and lactation. Then, taking advantage of a newly generated transgenic mouse model with a stable and specific overexpression of PGC-1α in mammary glands, we demonstrate that the re-expression of this coactivator during the lactation stage leads to a precocious regression of the mammary glands. Thus, we propose that PGC-1α action is non-essential during pregnancy and lactation, whereas it is indispensable during involution. The rapid preadipocyte–adipocyte transition, together with an increased rate of apoptosis promotes a premature mammary glands involution that cause lactation defects and pup growth retardation. Overall, we provide new insights in the comprehension of female reproductive cycles and lactation deficiency, thus opening new roads for mothers that cannot breastfeed

Magnetic nano-fluctuations in a frustrated magnet

Frustrated systems exhibit remarkable properties due to the high degeneracy of their ground states. Stabilised by competing interactions, a rich diversity of typically nanometre-sized phase structures appear in polymer and colloidal systems, while the surface of ice pre-melts due to geometrically frustrated interactions. Atomic spin systems where magnetic interactions are frustrated by lattice geometry provide a fruitful source of emergent phenomena, such as fractionalised excitations analogous to magnetic monopoles. The degeneracy inherent in frustrated systems may prevail all the way down to absolute zero temperature, or it may be lifted by small perturbations or entropic effects. In the geometrically frustrated Ising--like magnet Ca3Co2O6, we follow the temporal and spatial evolution of nanoscale magnetic fluctuations firmly embedded inside the spin--density--wave magnetic structure. These fluctuations are a signature of a competing ferrimagnetic phase with an incommensurability that is different from, but determined by the host. As the temperature is lowered, the fluctuations slow down into a super-paramagnetic regime of stable spatiotemporal nano-structures

Dynamic response of isolated Aharonov-Bohm rings coupled to an electromagnetic resonator

We have measured the flux dependence of both real and imaginary conductance of $GaAs/GaAlAs$ isolated mesoscopic rings at 310 MHz. The rings are coupled to a highly sensitive electromagnetic superconducting micro-resonator and lead to a perturbation of the resonance frequency and quality factor. This experiment provides a new tool for the investigation of the conductance of mesoscopic systems without any connection to invasive probes. It can be compared with recent theoretical predictions emphasizing the differences between isolated and connected geometries and the relation between ac conductance and persistent currents. We observe $\Phi_0/2$ periodic oscillations on both components of the magnetoconductance. The oscillations of the imaginary conductance whose sign corresponds to diamagnetism in zero field, are 3 times larger than the Drude conductance $G_0$. The real part of the periodic magnetoconductance is of the order of $0.2 G_0$ and is apparently negative in low field. It is thus notably different from the weak localisation oscillations observed in connected rings, which are much smaller and opposite in sign.Comment: 4 pages, revtex, epsf, 4 Postscript file

Optimization and characterization of a femtosecond tunable light source based on the soliton self-frequency shift in photonic crystal fiber

International audienceWe take advantage of the Raman soliton self-frequency shift experienced during the propagation in an anomalous dispersive photonic crystal fiber in order to continuously tune the central frequency of ultrashort pulses. We discuss the fiber properties to be favored to obtain high power spectral densities and we carry out an extensive experimental study of the properties of the frequency shifted pulses in terms of spectral, autocorrelation, and RF spectrum measurements

Spin-stiffness and topological defects in two-dimensional frustrated spin systems

Using a {\it collective} Monte Carlo algorithm we study the low-temperature and long-distance properties of two systems of two-dimensional classical tops. Both systems have the same spin-wave dynamics (low-temperature behavior) as a large class of Heisenberg frustrated spin systems. They are constructed so that to differ only by their topological properties. The spin-stiffnesses for the two systems of tops are calculated for different temperatures and different sizes of the sample. This allows to investigate the role of topological defects in frustrated spin systems. Comparisons with Renormalization Group results based on a Non Linear Sigma model approach and with the predictions of some simple phenomenological model taking into account the topological excitations are done.Comment: RevTex, 25 pages, 14 figures, Minor changes, final version. To appear in Phys.Rev.

Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids

Metastatic epithelial ovarian cancer (EOC) cells can form multicellular spheroids while in suspension and disperse directly throughout the peritoneum to seed secondary lesions. There is growing evidence that EOC spheroids are key mediators of metastasis, and they use specific intracellular signalling pathways to control cancer cell growth and metabolism for increased survival. Our laboratory discovered that AKT signalling is reduced during spheroid formation leading to cellular quiescence and autophagy, and these may be defining features of tumour cell dormancy. To further define the phenotype of EOC spheroids, we have initiated studies of the Liver kinase B1 (LKB1)-5′-AMP-activated protein kinase (AMPK) pathway as a master controller of the metabolic stress response. We demonstrate that activity of AMPK and its upstream kinase LKB1 are increased in quiescent EOC spheroids as compared with proliferating adherent EOC cells. We also show elevated AMPK activity in spheroids isolated directly from patient ascites. Functional studies reveal that treatment with the AMP mimetic AICAR or allosteric AMPK activator A-769662 led to a cytostatic response in proliferative adherent ovarian cancer cells, but they fail to elicit an effect in spheroids. Targeted knockdown of STK11 by RNAi to reduce LKB1 expression led to reduced viability and increased sensitivity to carboplatin treatment in spheroids only, a phenomenon which was AMPK-independent. Thus, our results demonstrate a direct impact of altered LKB1-AMPK signalling function in EOC. In addition, this is the first evidence in cancer cells demonstrating a pro-survival function for LKB1, a kinase traditionally thought to act as a tumour suppressor