Dynamic autonomous intelligent control of an asteroid lander

One of the future flagship missions of the European Space Agency (ESA) is the asteroid sample return mission Marco-Polo. Although there have been a number of past missions to asteroids, a sample has never been successfully returned. The return of asteroid regolith to the Earth's surface introduces new technical challenges. This paper develops attitude control algorithms for the descent phase onto an asteroid in micro-gravity conditions and draws a comparison between the algorithms considered. Two studies are also performed regarding the Fault Detection Isolation and Recovery (FDIR) of the control laws considered. The potential of using Direct Adaptive Control (DAC) as a controller for the surface sampling process is also investigated. Use of a DAC controller incorporates increased levels of robustness by allowing realtime variation of control gains. This leads to better response to uncertainties encountered during missions

Induction of Bladder Tumours in Mice with Dibutylnitrosamine

Dibutylnitrosamine has been administered continuously in the drinking water to two groups of C57BL/6 mice. The first group (50 males, 50 females) received 30 mg./kg./day and the second (50 males, 50 females) 7.6 mg./kg./day. Of mice reaching autopsy squamous cell carcinoma of the bladder was found in 44/90 at the high dose and 19/89 at the low dose. Bladder tumours were found predominantly in males, the ratio of tumours in males and females being 4.4: 1 and 8.5: 1 at the high and low dose levels, respectively. Carcinomas and papillomas of the oesophagus were found in all but 2 of the females and all but 6 of the males. In addition 5 carcinomas of the fore-stomach in the low dose group and a total in both groups of 13 tumours of the soft palate and tongue were found. The mean cumulative doses and respective induction times for the high and low dose groups were 7.4 and 2.0 g./kg., and 240 and 260 days

Brauer group of moduli spaces of pairs

We show that the Brauer group of any moduli space of stable pairs with fixed determinant over a curve is zero.Comment: 12 pages. Final version, accepted in Communications in Algebr

Large conductance Ca²⁺-activated K⁺ (BK) channels promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs.

This is the final version of the article. Available from Wiley via the DOI in this record.Anterior pituitary corticotroph cells are a central component of the hypothalamic-pituitary-adrenal (HPA) axis essential for the neuroendocrine response to stress. Corticotrophs are excitable cells that receive input from two hypothalamic secretagogues, corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) to control the release of adrenocorticotrophic hormone (ACTH). Although corticotrophs are spontaneously active and increase in excitability in response to CRH and AVP the patterns of electrical excitability and underlying ionic conductances are poorly understood. In this study, we have used electrophysiological, pharmacological and genetic approaches coupled with mathematical modelling to investigate whether CRH and AVP promote distinct patterns of electrical excitability and to interrogate the role of large conductance calcium- and voltage-activated potassium (BK) channels in spontaneous and secretagogue-induced activity. We reveal that BK channels do not play a significant role in the generation of spontaneous activity but are critical for the transition to bursting in response to CRH. In contrast, AVP promotes an increase in single spike frequency, a mechanism independent of BK channels but dependent on background non-selective conductances. Co-stimulation with CRH and AVP results in complex patterns of excitability including increases in both single spike frequency and bursting. The ability of corticotroph excitability to be differentially regulated by hypothalamic secretagogues provides a mechanism for differential control of corticotroph excitability in response to different stressors.P.J.D. was supported by an MRC PhD studentship in the College of Medicine and Veterinary Medicine, University of Edinburgh. Work was supported by grants to M.J.S. and P.R. from the Wellcome Trust (082407), to M.J.S. from MRC (J008893), and to R.B. and J.T. from the National Institutes of Health (DK43200)

Intercomparisons of airborne measurements of aerosol ionic chemical composition during TRACE-P and ACE-Asia

As part of the two field studies, Transport and Chemical Evolution over the Pacific (TRACE-P) and the Asian Aerosol Characterization Experiment (ACE-Asia), the inorganic chemical composition of tropospheric aerosols was measured over the western Pacific from three separate aircraft using various methods. Comparisons are made between the rapid online techniques of the particle into liquid sampler (PILS) for measurement of a suite of fine particle a mist chamber/ion chromatograph (MC/IC) measurement of fine sulfate, and the longer time-integrated filter and micro-orifice impactor (MOI) measurements. Comparisons between identical PILS on two separate aircraft flying in formation showed that they were highly correlated (e.g., sulfate r2 of 0.95), but were systematically different by 10 ± 5% (linear regression slope and 95% confidence bounds), and had generally higher concentrations on the aircraft with a low-turbulence inlet and shorter inlet-to-instrument transmission tubing. Comparisons of PILS and mist chamber measurements of fine sulfate on two different aircraft during formation flying had an r 2 of 0.78 and a relative difference of 39% ± 5%. MOI ionic data integrated to the PILS upper measurement size of 1.3 mm sampling from separate inlets on the same aircraft showed that for sulfate, PILS and MOI were within 14% ± 6% and correlated with an r 2 of 0.87. Most ionic compounds were within ±30%, which is in the range of differences reported between PILS and integrated samplers from ground-based comparisons. In many cases, direct intercomparison between the various instruments is difficult due to differences in upper-size detection limits. However, for this study, the results suggest that the fine particle mass composition measured from aircraft agree to within 30–40%

Properties of Active Galaxies Deduced from H I Observations

We completed a new survey for H I emission for a large, well-defined sample of 154 nearby (z < 0.1) galaxies with type 1 AGNs. We make use of the extensive database presented in a companion paper to perform a comprehensive appraisal of the cold gas content in active galaxies and to seek new strategies to investigate the global properties of the host galaxies and their relationship to their central black holes (BHs). We show that the BH mass obeys a strong, roughly linear relation with the host galaxy's dynamical mass. BH mass follows a looser, though still highly significant, correlation with the maximum rotation velocity of the galaxy, as expected from the known scaling between rotation velocity and central velocity dispersion. Neither of these H I-based correlations is as tight as the more familiar relations between BH mass and bulge luminosity or velocity dispersion, but they offer the advantage of being insensitive to the glare of the nucleus and therefore are promising new tools for probing the host galaxies of both nearby and distant AGNs. We present evidence for substantial ongoing BH growth in the most actively accreting AGNs. In these nearby systems, BH growth appears to be delayed with respect to the assembly of the host galaxy but otherwise has left no detectable perturbation to its mass-to-light ratio or its global gas content. The host galaxies of type 1 AGNs, including those luminous enough to qualify as quasars, are generally gas-rich systems, possessing a cold interstellar medium reservoir at least as abundant as that in inactive galaxies of the same morphological type. This calls into question current implementations of AGN feedback in models of galaxy formation that predict strong cold gas depletion in unobscured AGNs. (Abridged)Comment: To appear in ApJ; 14 page

Experimental identification and validation of models in micro and macro plasticity

For micro-macro approaches to finite plasticity, one needs experimental results on both scales, the engineering scale (macro scale) and the crystal scale (micro scale). Since we know that a monocrystal behaves different from a crystallite embedded in a polycrystal, one is also interested in data obtained on the micro scale of a polycrystal. Such data is needed not only for the identification of the material parameters like hardening variables, but also for the validation of these models. In this paper, experiments on both scales and, in parallel, FEM-simulations are presented, in order to compare the results of both approaches. The specimens stem from a rolled sheet of the deep-drawing steel DC04. On the micro scale indenter tests have been performed and the orientation changes in the volume below the indent have been measured using micron-resolution 3D x-ray microscopy (Larson et al., 2004, 2008). On the macro scale the usual tension tests and additional shear tests in different directions (Bouvier etal.,2006) have been performed. In corresponding simulations, the micro-macro transition is performed by a full constrained Taylor-model and, in order to overcome the drawbacks of the Taylor-model, the RVE technique has been applied

No association between CTNNBL1 and episodic memory performance

Polymorphisms in the gene encoding catenin-β-like 1 (CTNNBL1) were recently reported to be associated with verbal episodic memory performance—in particular, delayed verbal free recall assessed between 5 and 30 min after encoding—in a genome-wide association study on healthy young adults. To further examine the genetic effects of CTNNBL1, we tested for association between 455 single-nucleotide polymorphisms (SNPs) in or near CTNNBL1 and 14 measures of episodic memory performance from three different tasks in 1743 individuals. Probands were part of a population-based study of mentally healthy adult men and women, who were between 20 and 70 years old and were recruited as participants for the Berlin Aging Study II. Associations were assessed using linear regression analysis. Despite having sufficient power to detect the previously reported effect sizes, we found no evidence for statistically significant associations between the tested CTNNBL1 SNPs and any of the 14 measures of episodic memory. The previously reported effects of genetic polymorphisms in CTNNBL1 on episodic memory performance do not generalize to the broad range of tasks assessed in our cohort. If not altogether spurious, the effects may be limited to a very narrow phenotypic domain (that is, verbal delayed free recall between 5 and 30 min). More studies are needed to further clarify the role of CTNNBL1 in human memory

Computer simulation of syringomyelia in dogs

Syringomyelia is a pathological condition in which fluid-filled cavities (syringes) form and expand in the spinal cord. Syringomyelia is often linked with obstruction of the craniocervical junction and a Chiari malformation, which is similar in both humans and animals. Some brachycephalic toy breed dogs such as Cavalier King Charles Spaniels (CKCS) are particularly predisposed. The exact mechanism of the formation of syringomyelia is undetermined and consequently with the lack of clinical explanation, engineers and mathematicians have resorted to computer models to identify possible physical mechanisms that can lead to syringes. We developed a computer model of the spinal cavity of a CKCS suffering from a large syrinx. The model was excited at the cranial end to simulate the movement of the cerebrospinal fluid (CSF) and the spinal cord due to the shift of blood volume in the cranium related to the cardiac cycle. To simulate the normal condition, the movement was prescribed to the CSF. To simulate the pathological condition, the movement of CSF was blocked