153 research outputs found
Histoire et anthropologie historique de l’Amérique latine
Jean-Pierre Berthe, directeur d’études Enseignement suspendu durant l’année universitaire 2003-2004
Voltage transient analysis as a generic tool for solar junction characterization
International audienc
Investigating ramp wave propagation inside silica glass with laser experiments and molecular simulations
Under elastic shock compression silica glass exhibits a very specific behaviour. A shock propagating inside a material is usually seen as the propagation of a discontinuity. However in silica glass, shocks are unstable and lead to the propagation of a ramp wave where the shock front becomes gradually larger over time. Ramp waves were already reported in the literature, however their origin remain uncertain. This work presents an original study combining laser shock-induced experiments and molecular dynamics simulation aiming to improve the understanding of the mechanisms involved. Experimental ramp waves were directly observed using shadowgraphy technique allowing for an estimation of the head and tail velocities. Molecular dynamics simulations were carried out in order to reproduce ramp waves and to gain insight into the material properties. Ramp waves were observed for both elastic and plastic shockwaves. In the latter case, the plastic waves were preceded by an elastic ramp precursor. The sound speed, related to the material compressibility, was found to decrease with increasing pressure, as observed experimentally for quasi-static hydrostatic loading, thus providing an explanation for the instabilities that lead to the propagation of ramp waves
Laser induced dynamic fracture of fused silica: Experiments and simulations
Fused silica samples were subjected to laser induced shock loading. Laser flux was varied in order to obtain different amounts and characteristics of damage in the samples. Three dimensional damage and fracture maps of two identical samples impacted by high and low laser flux values were obtained using both optical microscopy and X-ray computed micro-tomography. Three prevalent fracture and damage patterns were identified. Peridynamic approach was used to simulate the laser impact conditions on the samples in order to explain the causes of the observed fracture and damage morphologies. A proprietary shock physics code, ESTHER, was used to calculate the transient kinetic energy imparted to the samples based on the experimental laser flux values. The kinetic energy values were then integrated over time and provided target values to match for the peridynamic impact conditions. The main fracture patterns were captured by peridynamic simulations with reasonable quantitative accuracy. Explanations for initiation and propagation of each of the fracture patterns were presented based on the peridynamic dynamic fracture simulations. Limitations of the computational approach and recommendations for future work is provided
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Bibliografia Americanista Española.. 1935-1963, XXIII.
Berthe Jean-Pierre. Bibliografia Americanista Española.. 1935-1963, XXIII.. In: Annales. Economies, sociétés, civilisations. 21ᵉ année, N. 1, 1966. pp. 231-232
Ernesto de la Torre Villar, Correspondencia diplomatica franco-mexicana (1808-1839), Vol. I
Berthe Jean-Pierre. Ernesto de la Torre Villar, Correspondencia diplomatica franco-mexicana (1808-1839), Vol. I. In: Annales. Économies, Sociétés, Civilisations. 13ᵉ année, N. 4, 1958. pp. 796-797
Marianne Mahn-Lot, Portrait historique de Christophe Colomb
Berthe Jean-Pierre. Marianne Mahn-Lot, Portrait historique de Christophe Colomb. In: Annales. Économies, Sociétés, Civilisations. 44ᵉ année, N. 3, 1989. pp. 605-606
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