134 research outputs found
Using value-based health care principles to "fix" orthopaedic care delivery
Despite differences in the structure of health care delivery systems, health care spending continues to outpace gross domestic product (GDP) and average wage globally. This highlights the stark reality that health systems today are â in many cases â financially unsustainable. Further, most health care services today are paid for via a fee-for-service or payment for each service provided mechanism, which does not ensure a focus on optimal health outcomes for patients; this includes clinical outcomes most important to them, such as function, pain, andquality of life. As such, bold reforms are needed to better align incentives to âbendâ the cost curve and to ensure high-quality health care and the best possible patient outcomes. This dissertation includes scientific studies that highlight how the core principles of value-based health care, which focuses on maximizing the outcomes achieved per dollar spent, may be able to begin to address some of the issues plaguing our strained health care delivery systems globally, including within orthopaedic surgery.LUMC / Geneeskund
Statistical Theory for Incoherent Light Propagation in Nonlinear Media
A novel statistical approach based on the Wigner transform is proposed for
the description of partially incoherent optical wave dynamics in nonlinear
media. An evolution equation for the Wigner transform is derived from a
nonlinear Schrodinger equation with arbitrary nonlinearity. It is shown that
random phase fluctuations of an incoherent plane wave lead to a Landau-like
damping effect, which can stabilize the modulational instability. In the limit
of the geometrical optics approximation, incoherent, localized, and stationary
wave-fields are shown to exist for a wide class of nonlinear media.Comment: 4 pages, REVTeX4. Submitted to Physical Review E. Revised manuscrip
Are detailed, patient-level social determinant of health factors associated with physical function and mental health at presentation among new patients with orthopaedic conditions?
Background: It is well documented that routinely collected patient sociodemographic characteristics (such as race and insurance type) and geography-based social determinants of health (SDoH) measures (for example, the Area Deprivation Index) are associated with health disparities, including symptom severity at presentation. However, the association of patient-level SDoH factors (such as housing status) on musculoskeletal health disparities is not as well documented. Such insight might help with the development of more-targeted interventions to help address health disparities in orthopaedic surgery. Questions/purposes: (1) What percentage of patients presenting for new patient visits in an orthopaedic surgery clinic who were unemployed but seeking work reported transportation issues that could limit their ability to attend a medical appointment or acquire medications, reported trouble paying for medications, and/or had no current housing? (2) Accounting for traditional sociodemographic factors and patient-level SDoH measures, what factors are associated with poorer patient-reported outcome physical health scores at presentation? (3) Accounting for traditional sociodemographic factor patient-level SDoH measures, what factors are associated with poorer patient-reported outcome mental health scores at presentation? Methods: New patient encounters at one Level 1 trauma center clinic visit from March 2018 to December 2020 were identified. Included patients had to meet two criteria: they had completed the Patient-Reported Outcome Measure Information System (PROMIS) Global-10 at their new orthopaedic surgery clinic encounter as part of routine clinical care, and they had visited their primary care physician and completed a series of specific SDoH questions. The SDoH questionnaire was developed in our institution to improve data that drive interventions to address health disparities as part of our accountable care organization work. Over the study period, the SDoH questionnaire was only distributed at primary care provider visits. The SDoH questions focused on transportation, housing, employment, and ability to pay for medications. Because we do not have a way to determine how many patients had both primary care provider office visits and new orthopaedic surgery clinic visits over the study period, we were unable to determine how many patients could have been included; however, 9057 patients were evaluated in this cross-sectional study. The mean age was 61 +/- 15 years, and most patients self-reported being of White race (83% [7561 of 9057]). Approximately half the patient sample had commercial insurance (46% [4167 of 9057]). To get a better sense of how this study cohort compared with the overall patient population seen at the participating center during the time in question, we reviewed all new patient clinic encounters (n = 135,223). The demographic information between the full patient sample and our study subgroup appeared similar. Using our study cohort, two multivariable linear regression models were created to determine which traditional metrics (for example, self-reported race or insurance type) and patient-specific SDoH factors (for example, lack of reliable transportation) were associated with worse physical and mental health symptoms (that is, lower PROMIS scores) at new patient encounters. The variance inflation factor was used to assess for multicollinearity. For all analyses, p values Orthopaedics, Trauma Surgery and Rehabilitatio
Primordial black holes in braneworld cosmologies: astrophysical constraints
In two recent papers we explored the modifications to primordial black hole
physics when one moves to the simplest braneworld model, Randall--Sundrum type
II. Both the evaporation law and the cosmological evolution of the population
can be modified, and additionally accretion of energy from the background can
be dominant over evaporation at high energies. In this paper we present a
detailed study of how this impacts upon various astrophysical constraints,
analyzing constraints from the present density, from the present high-energy
photon background radiation, from distortion of the microwave background
spectrum, and from processes affecting light element abundances both during and
after nucleosynthesis. Typically, the constraints on the formation rate of
primordial black holes weaken as compared to the standard cosmology if black
hole accretion is unimportant at high energies, but can be strengthened in the
case of efficient accretion.Comment: 17 pages RevTeX4 file with three figures incorporated; final paper in
series astro-ph/0205149 and astro-ph/0208299. Minor changes to match version
accepted by Physical Review
Digital medical history implementation to triage orthopaedic patients during COVID-19: findings from a rapid cycle, semi-randomised A/B testing quality improvement project
Introduction: The COVID-19 pandemic severely impacted musculoskeletal care. To better triage the notable backlog of patients, we assessed whether a digital medical history (DMH), a summary of health information and concerns completed by the patient prior to a clinic visit, could be routinely collected and utilised.Methods: We analysed 640 patients using a rapid cycle, semi-randomised A/B testing approach. Four rapid cycles of different randomised interventions were conducted across five unique patient groups. Descriptive statistics were used to report DMH completion rates by cycle/patient group and intervention. Multivariable logistic regression was used to determine whether age or anatomic injury location was associated DMH completion.Ethical Approval: N/A (Quality Improvement Project)Results: Across all patients, the DMH completion rate was 48% (307/640). Phone calls were time consuming and resource intensive without an increased completion rate. The highest rate of DMH completion was among patients who were referred and called the clinic themselves (78% of patients [63 out of 81 patients]). Across all patients, increasing age (odds ratio [OR]: 0.985 (95% CI: 0.976-0.995), p = 0.002), patients with back concerns (OR: 0.395 (95% CI: 0.234-0.666), p = 0.001), and patients with non-specific/other musculoskeletal concerns (OR: 0.331 (95% CI: 0.176-0.623), p = 0.001) were associated with decreased odds of DMH completion.Discussion and Conclusion: DMHs can be valuable in helping triage orthopaedic patients in resource-strapped settings, times of crisis, or as we transition towards value-based health care delivery. However, further work is needed to continue to increase the completion rate about 50%.Orthopaedics, Trauma Surgery and Rehabilitatio
The scintillation and ionization yield of liquid xenon for nuclear recoils
XENON10 is an experiment designed to directly detect particle dark matter. It
is a dual phase (liquid/gas) xenon time-projection chamber with 3D position
imaging. Particle interactions generate a primary scintillation signal (S1) and
ionization signal (S2), which are both functions of the deposited recoil energy
and the incident particle type. We present a new precision measurement of the
relative scintillation yield \leff and the absolute ionization yield Q_y, for
nuclear recoils in xenon. A dark matter particle is expected to deposit energy
by scattering from a xenon nucleus. Knowledge of \leff is therefore crucial for
establishing the energy threshold of the experiment; this in turn determines
the sensitivity to particle dark matter. Our \leff measurement is in agreement
with recent theoretical predictions above 15 keV nuclear recoil energy, and the
energy threshold of the measurement is 4 keV. A knowledge of the ionization
yield \Qy is necessary to establish the trigger threshold of the experiment.
The ionization yield \Qy is measured in two ways, both in agreement with
previous measurements and with a factor of 10 lower energy threshold.Comment: 8 pages, 9 figures. To be published in Nucl. Instrum. Methods
Weak lensing, dark matter and dark energy
Weak gravitational lensing is rapidly becoming one of the principal probes of
dark matter and dark energy in the universe. In this brief review we outline
how weak lensing helps determine the structure of dark matter halos, measure
the expansion rate of the universe, and distinguish between modified gravity
and dark energy explanations for the acceleration of the universe. We also
discuss requirements on the control of systematic errors so that the
systematics do not appreciably degrade the power of weak lensing as a
cosmological probe.Comment: Invited review article for the GRG special issue on gravitational
lensing (P. Jetzer, Y. Mellier and V. Perlick Eds.). V3: subsection on
three-point function and some references added. Matches the published versio
Design and Performance of the XENON10 Dark Matter Experiment
XENON10 is the first two-phase xenon time projection chamber (TPC) developed
within the XENON dark matter search program. The TPC, with an active liquid
xenon (LXe) mass of about 14 kg, was installed at the Gran Sasso underground
laboratory (LNGS) in Italy, and operated for more than one year, with excellent
stability and performance. Results from a dark matter search with XENON10 have
been published elsewhere. In this paper, we summarize the design and
performance of the detector and its subsystems, based on calibration data using
sources of gamma-rays and neutrons as well as background and Monte Carlo
simulations data. The results on the detector's energy threshold, energy and
position resolution, and overall efficiency show a performance that exceeds
design specifications, in view of the very low energy threshold achieved (<10
keVr) and the excellent energy resolution achieved by combining the ionization
and scintillation signals, detected simultaneously
Prospective organisation of neonatal arm movements : a motor foundation of embodied agency, disrupted in premature birth
Prospective motor control moves the body into the future, from where one is to where one wants to be. It is a hallmark of intentionality. But its origins in development is uncertain. In this study, we tested whether or not the arm movements of newborn infants were prospectively controlled. We measured the spatiotemporal organisation of 480 neonatal arm movements and 384 arm movements of infants prematurely born at-risk for neurodevelopmental disorder. We found 75% of healthy term-birth neonatal movements and 68% of prematurely-born infant movements conformed to the tauG-coupling model of prospective sensorimotor control. Prospective coupling values were significantly reduced in the latter (p = .010, r = .087). In both cases prospectively controlled movements were tightly organised by fixed-duration units with a base duration of 218 ms and additional temporal units of 145 ms. Yet distances remained constant. Thus, we demonstrate for the first time a precise prospective spatiotemporal organisation of neonatal arm movements and demonstrate at-risk infants exhibit reduced sensorimotor control. Prospective motor control is a hallmark of primary sensorimotor intentionality and gives a strong embodied foundation to conscious motor agency
Relic Neutrino Absorption Spectroscopy
Resonant annihilation of extremely high-energy cosmic neutrinos on big-bang
relic anti-neutrinos (and vice versa) into Z-bosons leads to sizable absorption
dips in the neutrino flux to be observed at Earth. The high-energy edges of
these dips are fixed, via the resonance energies, by the neutrino masses alone.
Their depths are determined by the cosmic neutrino background density, by the
cosmological parameters determining the expansion rate of the universe, and by
the large redshift history of the cosmic neutrino sources. We investigate the
possibility of determining the existence of the cosmic neutrino background
within the next decade from a measurement of these absorption dips in the
neutrino flux. As a by-product, we study the prospects to infer the absolute
neutrino mass scale. We find that, with the presently planned neutrino
detectors (ANITA, Auger, EUSO, OWL, RICE, and SalSA) operating in the relevant
energy regime above 10^{21} eV, relic neutrino absorption spectroscopy becomes
a realistic possibility. It requires, however, the existence of extremely
powerful neutrino sources, which should be opaque to nucleons and high-energy
photons to evade present constraints. Furthermore, the neutrino mass spectrum
must be quasi-degenerate to optimize the dip, which implies m_{nu} >~ 0.1 eV
for the lightest neutrino. With a second generation of neutrino detectors,
these demanding requirements can be relaxed considerably.Comment: 19 pages, 26 figures, REVTeX
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