Eulerian Statistically Preserved Structures in Passive Scalar Advection

We analyze numerically the time-dependent linear operators that govern the dynamics of Eulerian correlation functions of a decaying passive scalar advected by a stationary, forced 2-dimensional Navier-Stokes turbulence. We show how to naturally discuss the dynamics in terms of effective compact operators that display Eulerian Statistically Preserved Structures which determine the anomalous scaling of the correlation functions. In passing we point out a bonus of the present approach, in providing analytic predictions for the time-dependent correlation functions in decaying turbulent transport.Comment: 10 pages, 10 figures. Submitted to Phys. Rev.

Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions

Antimicrobials targeting cell wall biosynthesis are generally considered inactive against nonreplicating bacteria. Paradoxically, we found that under nonpermissive growth conditions, exposure of Mycobacterium bovis BCG bacilli to such antimicrobials enhanced their survival. We identified a transcriptional regulator, RaaS (for regulator of antimicrobial-assisted survival), encoded by bcg1279 (rv1219c) as being responsible for the observed phenomenon. Induction of this transcriptional regulator resulted in reduced expression of specific ATP-dependent efflux pumps and promoted long-term survival of mycobacteria, while its deletion accelerated bacterial death under nonpermissive growth conditions in vitro and during macrophage or mouse infection. These findings have implications for the design of antimicrobial drug combination therapies for persistent infectious diseases, such as tuberculosis

The pion photoproduction in the \Delta(1232) region

We investigate the pion photoproduction in the \Delta(1232) region in the framework of an effective Lagrangian including pions, nulceon and \Delta(1232). We work to third order in a small scale expansion with both $m_{\pi}$ and $M_{\Delta}-M_N$ treated as light scales. We note that in the $\Delta$ region, straightward power counting breaks as the amplitudes become very large, to deal with this problem, we suggest that the appropriate way to compare theoretical calculations with experimental data is via weighted integrals of the amplitudes through the $\Delta$ region.Comment: 34 pages and 5 figures,new counterterms arr adde

J.S. Bell's Concept of Local Causality

John Stewart Bell's famous 1964 theorem is widely regarded as one of the most important developments in the foundations of physics. It has even been described as "the most profound discovery of science." Yet even as we approach the 50th anniversary of Bell's discovery, its meaning and implications remain controversial. Many textbooks and commentators report that Bell's theorem refutes the possibility (suggested especially by Einstein, Podolsky, and Rosen in 1935) of supplementing ordinary quantum theory with additional ("hidden") variables that might restore determinism and/or some notion of an observer-independent reality. On this view, Bell's theorem supports the orthodox Copenhagen interpretation. Bell's own view of his theorem, however, was quite different. He instead took the theorem as establishing an "essential conflict" between the now well-tested empirical predictions of quantum theory and relativistic \emph{local causality}. The goal of the present paper is, in general, to make Bell's own views more widely known and, in particular, to explain in detail Bell's little-known mathematical formulation of the concept of relativistic local causality on which his theorem rests. We thus collect and organize many of Bell's crucial statements on these topics, which are scattered throughout his writings, into a self-contained, pedagogical discussion including elaborations of the concepts "beable", "completeness", and "causality" which figure in the formulation. We also show how local causality (as formulated by Bell) can be used to derive an empirically testable Bell-type inequality, and how it can be used to recapitulate the EPR argument.Comment: 19 pages, 4 figure

Oleoyl Coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in Mycobacteria

We have recently shown that RaaS (regulator of antimicrobial-assisted survival), encoded by Rv1219c in Mycobacterium tuberculosis and by bcg_1279c in Mycobacterium bovis bacillus Calmette-Guérin, plays an important role in mycobacterial survival in prolonged stationary phase and during murine infection. Here, we demonstrate that long chain acyl-CoA derivatives (oleoyl-CoA and, to lesser extent, palmitoyl-CoA) modulate RaaS binding to DNA and expression of the downstream genes that encode ATP-dependent efflux pumps. Moreover, exogenously added oleic acid influences RaaS-mediated mycobacterial improvement of survival and expression of the RaaS regulon. Our data suggest that long chain acyl-CoA derivatives serve as biological indicators of the bacterial metabolic state. Dysregulation of efflux pumps can be used to eliminate non-growing mycobacteria

Hot Hypernuclear Matter in the Modified Quark Meson Coupling Model

Hot hypernuclear matter is investigated in an explicit SU(3) quark model based on a mean field description of nonoverlapping baryon bags bound by the self-consistent exchange of scalar $\sigma, \zeta$ and vector $\omega, \phi$ mesons. The $\sigma, \omega$ mean fields are assumed to couple to the u,d-quarks while the $\zeta, \phi$ mean fields are coupled to the s-quark. The coupling constants of the mean fields with the quarks are assumed to satisfy SU(6) symmetry. The calculations take into account the medium dependence of the bag parameter on the scalar fields $\sigma, \zeta$. We consider only the octet baryons $N,\Lambda,\Sigma,\Xi$ in hypernuclear matter. An ideal gas of the strange mesons $K$ and $K^{*}$ is introduced to keep zero net strangeness density. Our results for symmetric hypernuclear matter show that a phase transition takes place at a critical temperature around 180 MeV in which the scalar mean fields $\sigma, \zeta$ take nonzero values at zero baryon density. Furthermore, the bag contants of the baryons decrease significantly at and above this critical temperature indicating the onset of quark deconfinement. The present results imply that the onset of quark deconfinement in SU(3) hypernuclear matter is much stronger than in SU(2) nuclear matter.Comment: LaTeX/TeX 11 pages (dfg3r.tex), 9 figures in eps forma

A Broken Trust: Lessons from the Vaccine–Autism Wars: Researchers long ago rejected the theory that vaccines cause autism, yet many parents don't believe them. Can scientists bridge the gap between evidence and doubt?

Researchers long ago rejected the theory that vaccines cause autism, yet many parents don't believe them. Can scientists bridge the gap between evidence and doubt

Evaluation of the Workplace Environment in the UK, and the Impact on Users’ Levels of Stimulation

The purpose of this study is to evaluate a number of recently completed workplaces in the UK. The first aim is to assess the impact of various aspects of the workplace environment on users’ levels of stimulation. The body of previous research undertaken into the workplace environment, identified the aspects to be investigated. Samples of employees from the sixteen businesses were surveyed to determine their perceptions of the workplaces. The results were entered into a regression analysis, and the most significant predictors of perceived stimulation identified. The data also revealed a dramatic reduction in staff arousal levels from mornings to afternoons. Thus, there is a second aim to determine whether changes to significant aspects of the workplace environment during the day can counteract the reduction in users’ stimulation. Two further workplaces were studied to enable changes to be made over a 12-week period. A sample of employees completed questionnaires, and semi-structured interviews revealed the reasons behind the results. It was found that provision of artwork, personal control of temperature and ventilation and regular breaks were the most significant contributions to increasing stimulation after lunch; while user choice of layout, and design and décor of workspaces and break areas, were the most significant aspects at design stage

The standard model at low energies

The hadronic sector of the standard model at low energies is described by a non--decoupling effective field theory, chiral perturbation theory. An introduction is given to the construction of effective chiral Lagrangians, both in the purely mesonic sector and with inclusion of baryons. The connection between the relativistic formulation and the heavy baryon approach to chiral perturbation theory with baryons is reviewed.Comment: Lectures given at the 6th Indian-Summer School on Intermediate Energy Physics, Prague, Aug. 1993, Latex, 26 pages (with a4.sty), UWThPh-1993-3

A Mean Field Approach To The Instanton-Induced Effect Close To The QCD Phase Transition

In the instanton models the chiral phase transition is driven by a transition from random instanton-antiinstanton liquid and correlated instanton-antiinstanton molecules. So far this phenomenon was studied by numerical simulations, while we develop alternative semi-analytic approach. For two massless quark flavors, both instantons and ``molecules" generate specific 4-fermion effective interactions. After those are derived, we determine the temperature dependence of the thermodynamic quantities, the quark condensate and the fraction of molecules using standard mean field method. Using Bethe-Salpeter equation, we calculate T-dependence of mesonic correlation functions.Comment: 26 pages, LaTeX, 6 postscript files of 6 figures in additio