The Third Sector as a Renewable Resource for Europe

Third sector impact; Volunteering; Charity; European Commission; Political legitimacy; Third Sector in Europe; Third Sector as a Renewable Resource; Obstacles to Third Sector Organisation; Development in Europ

Nonlinear response of electrons to a positive ion

Electric field dynamics at a positive ion imbedded in an electron gas is considered using a semiclassical description. The dependence of the field autocorrelation function on charge number is studied for strong ion-electron coupling via MD simulation. The qualitative features for larger charge numbers are a decreasing correlation time followed by an increasing anticorrelation. Stopping power and related transport coefficients determined by the time integral of this correlation function result from the competing effects of increasing initial correlations and decreasing dynamical correlations. An interpretation of the MD results is obtained from an effective single particle model showing good agreement with the simulation results.Comment: To be published in the proceedings of the International Workshop on Strongly Coupled Coulomb Systems, Journal of Physics

Stellar population and structural properties of dwarf galaxies and young stellar systems in the M81 group

We use Hyper Suprime-Cam on the Subaru Telescope to investigate the structural and photometric properties of early-type dwarf galaxies and young stellar systems at the center of the M81 Group. We have mapped resolved stars to $\sim2$ magnitudes below the tip of the red giant branch over almost 6.5 square degrees, corresponding to a projected area of $160\times160 \rm{kpc}$ at the distance of M81. The resulting stellar catalogue enables a homogeneous analysis of the member galaxies with unprecedented sensitivity to low surface brightness emission. The radial profiles of the dwarf galaxies are well-described by Sersic and King profiles, and show no obvious signatures of tidal disruption. The measured radii for most of these systems are larger than the existing literature values and we find the total luminosity of IKN ($\rm{M_{V,0}}=-14.29$) to be almost 3 magnitudes brighter than previously-thought. We identify new dwarf satellite candidates, d1006+69 and d1009+68, which we estimate to lie at a distance of $4.3\pm0.2$ Mpc and $3.5\pm0.5$ Mpc. With $\rm{M_{V,0}}=-8.91\pm0.40$ and $\rm{[M/H]}=-1.83\pm0.28$, d1006+69 is one of the faintest and most metal-poor dwarf satellites currently-known in the M81 Group. The luminosity functions of young stellar systems in the outlying tidal HI debris imply continuous star formation in the recent past and the existence of populations as young as 30 Myr old. We find no evidence for old RGB stars coincident with the young MS/cHeB stars which define these objects, supporting the idea that they are genuinely new stellar systems resulting from triggered star formation in gaseous tidal debris.Comment: 24 pages, 22 figures, Accepted for publication in Ap

High-resolution mass spectrometry identifies delayed biomarkers for improved precision in acetaminophen/paracetamol human biomonitoring

Paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) is a top selling analgesic used in more than 600 prescription and non-prescription pharmaceuticals. To study efficiently some of the potential undesirable effects associated with increasing APAP consumption (e.g., developmental disorders, drug-induced liver injury), there is a need to improve current APAP biomonitoring methods that are limited by APAP short half-life. Here, we demonstrate using high-resolution mass spectrometry (HRMS) in several human studies that APAP thiomethyl metabolite conjugates (S-methyl-3-thioacetaminophen sulfate and S-methyl-3-thioacetaminophen sulphoxide sulfate) are stable biomarkers with delayed excretion rates compared to conventional APAP metabolites, that could provide a more reliable history of APAP ingestion in epidemiological studies. We also show that these biomarkers could serve as relevant clinical markers to diagnose APAP acute intoxication in overdosed patients, when free APAP have nearly disappeared from blood. Using in vitro liver models (HepaRG cells and primary human hepatocytes), we then confirm that these thiomethyl metabolites are directly linked to the toxic N-acetyl-p-benzoquinone imine (NAPQI) elimination, and produced via an overlooked pathway called the thiomethyl shunt pathway. Further studies will be needed to determine whether the production of the reactive hepatotoxic NAPQI metabolites is currently underestimated in human. Nevertheless, these biomarkers could already serve to improve APAP human biomonitoring, and investigate, for instance, inter-individual variability in NAPQI production to study underlying causes involved in APAP-induced hepatotoxicity. Overall, our findings demonstrate the potential of exposomics-based HRMS approach to advance towards a better precision for human biomonitoring.</p

Association Between Raised Blood Pressure and Dysglycemia in Hong Kong Chinese

OBJECTIVE—To investigate the association between raised blood pressure and dysglycemia