The circumstellar environment of HD50138 revealed by VLTI/AMBER at high angular resolution

HD50138 is a Herbig B[e] star with a circumstellar disc detected at IR and mm wavelength. Its brightness makes it a good candidate for NIR interferometry observations. We aim to resolve, spatially and spectrally, the continuum and hydrogen emission lines in the 2.12-2.47 micron region, to shed light on the immediate circumstellar environment of the star. VLTI/AMBER K-band observations provide spectra, visibilities, differential phases, and closure phases along three long baselines for the continuum, and HI emission in Br$\gamma$ and five high-n Pfund lines. By computing the pure-line visibilities, we derive the angular size of the different line-emitting regions. A simple LTE model was created to constrain the physical conditions of HI emitting region. The continuum region cannot be reproduced by a geometrical 2D elongated Gaussian fitting model. We estimate the size of the region to be 1 au. We find the Br$\gamma$ and Pfund lines come from a more compact region of size 0.4 au. The Br$\gamma$ line exhibits an S-shaped differential phase, indicative of rotation. The continuum and Br$\gamma$ line closure phase show offsets of $\sim$-25$\pm$5 $^o$ and 20$\pm$10$^o$, respectively. This is evidence of an asymmetry in their origin, but with opposing directions. We find that we cannot converge on constraints for the HI physical parameters without a more detailed model. Our analysis reveals that HD50138 hosts a complex circumstellar environment. Its continuum emission cannot be reproduced by a simple disc brightness distribution. Similarly, several components must be evoked to reproduce the interferometric observables within the Br$\gamma$, line. Combining the spectroscopic and interferometric data of the Br$\gamma$ and Pfund lines favours an origin in a wind region with a large opening angle. Finally, our results point to an evolved source.Comment: accepted for publication in A&

Exploiting line metric reconstruction from non-central circular panoramas

In certain non-central imaging systems, straight lines are projected via a non-planar surface encapsulating the 4 degrees of freedom of the 3D line. Consequently the geometry of the 3D line can be recovered from a minimum of four image points. However, with classical non-central catadioptric systems there is not enough effective baseline for a practical implementation of the method. In this paper we propose a multi-camera system configuration resembling the circular panoramic model which results in a particular non-central projection allowing the stitching of a non-central panorama. From a single panorama we obtain well-conditioned 3D reconstruction of lines, which are specially interesting in texture-less scenarios. No previous information about the direction or arrangement of the lines in the scene is assumed. The proposed method is evaluated on both synthetic and real images

Nutrigenomics and Atherosclerosis: The Postprandial and Long-Term Effects of Virgin Olive Oil Ingestion

Metals technology / metallurg

Chapter Beyond Dietary Fatty Acids as Energy Source: A Point of View for the Prevention and Management of Type 2 Diabetes

Medical genetic

Membrane composition and dynamics: A target of bioactive virgin olive oil constituents

AbstractThe endogenous synthesis of lipids, which requires suitable dietary raw materials, is critical for the formation of membrane bilayers. In eukaryotic cells, phospholipids are the predominant membrane lipids and consist of hydrophobic acyl chains attached to a hydrophilic head group. The relative balance between saturated, monounsaturated, and polyunsaturated acyl chains is required for the organization and normal function of membranes. Virgin olive oil is the richest natural dietary source of the monounsaturated lipid oleic acid and is one of the key components of the healthy Mediterranean diet. Virgin olive oil also contains a unique constellation of many other lipophilic and amphipathic constituents whose health benefits are still being discovered. The focus of this review is the latest evidence regarding the impact of oleic acid and the minor constituents of virgin olive oil on the arrangement and behavior of lipid bilayers. We highlight the relevance of these interactions to the potential use of virgin olive oil in preserving the functional properties of membranes to maintain health and in modulating membrane functions that can be altered in several pathologies. This article is part of a Special Issue entitled: Membrane Structure and Function: Relevance in the Cell's Physiology, Pathology and Therapy

Enteric viruses in a mangrove lagoon, survival and shellfish incidence

Mangrove oysters (Crassostrea rhizophorae) were screened for enteric viruses. For 18 months oysters were collected from Cano Boqueron, a tropical mangrove lagoon on the southwest coast of Puerto Rico. This popular tourist resort has two primary sewage treatment plants which service 158 single family cabanas. In spite of the heavy seasonal input of sewage to Cano Boqueron and high densities of fecal coliform bacteria, enteric viruses were not detected in shellfish meat. Because no viruses were detected in the oysters, a virus survival study was performed. Poliovirus type 1 was placed in diffusion chambers in situ at two sites in Cano Boqueron. More than 95% of the poliovirus inactivation occurred within 24 h. Virus inactivation was significantly different by site, indicating different inactivation rates within the lagoon. Chamber studies done simultaneously with Escherichia coli did not reveal differences between sites. It is suggested that the sewage effluent had an antiviral effect in the absence of an antibacterial effect. This study demonstrates the importance for establishing microbial contamination standards for shellfish growing waters in the tropics based upon in situ studies with tropical species, e.g. mangrove oyster

REPORTE DEL PRIMER CASO DE RINOSPORIDIOSIS EN LA PROVINCIA CIEGO DE AVILA (CUBA)

Se presenta el primer caso de rinosporidiosis diangosticado en la provincia de Ciego de Avila, Cuba, analizándose las características clínico-epidemiológicas del caso. Paciente de 13 años de edad, de sexo masculino, proveniente de un area rural que presentaba localizacion nasal de las lesiones: Se revisa la literatura al respecto.

Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease

This study assessed the association of CD5L and soluble CD36 (sCD36) with the risk of a cardiovascular event (CVE), including CV death and all-cause mortality in CKD. We evaluated the association of CD5L and sCD36 with a predefined composite CV endpoint (unstable angina, myocardial infarction, transient ischemic attack, cerebrovascular accident, congestive heart failure, arrhythmia, peripheral arterial disease [PAD] or amputation by PAD, aortic aneurysm, or death from CV causes) and all-cause mortality using Cox proportional hazards regression, adjusted for CV risk factors. The analysis included 1,516 participants free from pre-existing CV disease followed up for 4 years. The median age was 62 years, 38.8% were female, and 26.8% had diabetes. There were 98 (6.5%) CVEs and 72 (4.8%) deaths, of which 26 (36.1%) were of CV origin. Higher baseline CD5L concentration was associated with increased risk of CVE (HR, 95% CI, 1.17, 1.0-1.36), and all-cause mortality (1.22, 1.01-1.48) after adjusting for age, sex, diabetes, systolic blood pressure, dyslipidemia, waist circumference, smoking, and CKD stage. sCD36 showed no association with adverse CV outcomes or mortality. Our study showed for the first time that higher concentrations of CD5L are associated with future CVE and all-cause mortality in individuals with CKD

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy

Background: Although genotyping allows family screening and influences risk-stratification in patients with nonischemic dilated cardiomyopathy (DCM) or isolated left ventricular systolic dysfunction (LVSD), its result is negative in a significant number of patients, limiting its widespread adoption. Objectives: This study sought to develop and externally validate a score that predicts the probability for a positive genetic test result (G+) in DCM/LVSD. Methods: Clinical, electrocardiogram, and echocardiographic variables were collected in 1,015 genotyped patients from Spain with DCM/LVSD. Multivariable logistic regression analysis was used to identify variables independently predicting G+, which were summed to create the Madrid Genotype Score. The external validation sample comprised 1,097 genotyped patients from the Maastricht and Trieste registries. Results: A G+ result was found in 377 (37%) and 289 (26%) patients from the derivation and validation cohorts, respectively. Independent predictors of a G+ result in the derivation cohort were: family history of DCM (OR: 2.29; 95% CI: 1.73-3.04; P < 0.001), low electrocardiogram voltage in peripheral leads (OR: 3.61; 95% CI: 2.38-5.49; P < 0.001), skeletal myopathy (OR: 3.42; 95% CI: 1.60-7.31; P = 0.001), absence of hypertension (OR: 2.28; 95% CI: 1.67-3.13; P < 0.001), and absence of left bundle branch block (OR: 3.58; 95% CI: 2.57-5.01; P < 0.001). A score containing these factors predicted a G+ result, ranging from 3% when all predictors were absent to 79% when ≥4 predictors were present. Internal validation provided a C-statistic of 0.74 (95% CI: 0.71-0.77) and a calibration slope of 0.94 (95% CI: 0.80-1.10). The C-statistic in the external validation cohort was 0.74 (95% CI: 0.71-0.78). Conclusions: The Madrid Genotype Score is an accurate tool to predict a G+ result in DCM/LVSD