927 research outputs found
Regularity of weak minimizers of the K-energy and applications to properness and K-stability
Let be a compact K\"ahler manifold and the space of
K\"ahler metrics cohomologous to . If a cscK metric exists in , we show that all finite energy minimizers of the extended K-energy are
smooth cscK metrics, partially confirming a conjecture of Y.A. Rubinstein and
the second author. As an immediate application, we obtain that existence of a
cscK metric in implies J-properness of the K-energy, thus
confirming one direction of a conjecture of Tian. Exploiting this properness
result we prove that an ample line bundle admitting a cscK metric in
is -polystable.Comment: v1 Comments welcome v2 New introduction and references added v3 Final
version. Preliminaries section added. Some notation changed. No other change
Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain.
Angelman syndrome (AS) is a neurological genetic disorder caused by loss of expression of the maternal copy of UBE3A in the brain. Due to brain-specific genetic imprinting at this locus, the paternal UBE3A is silenced by a long antisense transcript. Inhibition of the antisense transcript could lead to unsilencing of paternal UBE3A, thus providing a therapeutic approach for AS. However, widespread delivery of gene regulators to the brain remains challenging. Here, we report an engineered zinc finger-based artificial transcription factor (ATF) that, when injected i.p. or s.c., crossed the blood-brain barrier and increased Ube3a expression in the brain of an adult mouse model of AS. The factor displayed widespread distribution throughout the brain. Immunohistochemistry of both the hippocampus and cerebellum revealed an increase in Ube3a upon treatment. An ATF containing an alternative DNA-binding domain did not activate Ube3a. We believe this to be the first report of an injectable engineered zinc finger protein that can cause widespread activation of an endogenous gene in the brain. These observations have important implications for the study and treatment of AS and other neurological disorders
Renormalization and Quantum Scaling of Frenkel-Kontorova Models
We generalise the classical Transition by Breaking of Analyticity for the
class of Frenkel-Kontorova models studied by Aubry and others to non-zero
Planck's constant and temperature. This analysis is based on the study of a
renormalization operator for the case of irrational mean spacing using
Feynman's functional integral approach. We show how existing classical results
extend to the quantum regime. In particular we extend MacKay's renormalization
approach for the classical statistical mechanics to deduce scaling of low
frequency effects and quantum effects. Our approach extends the phenomenon of
hierarchical melting studied by Vallet, Schilling and Aubry to the quantum
regime.Comment: 14 pages, 1 figure, submitted to J.Stat.Phy
Plasma Dynamics
Contains reports on eight research projects split into two sections.National Science Foundation (Grant ENG79-07047)U.S. Air Force - Office of Scientific Research (Grant AFOSR-77-3143D)U.S. Department of Energy (Contract DE-ACO2-78ET-51013)U.S. Department of Energy (Contract DE-ACO2-78ET-53073.AO02)U.S. Department of Energy (Contract DE-ACO2-78ET-53074)U.S. Department of Energy (Contract DE-ACO2-78ET-53076)U.S. Department of Energy (Contract DE-ACO2-78ET-51002
Studying complex interventions : reflections from the FEMHealth project on evaluating fee exemption policies in West Africa and Morocco
Peer reviewedPublisher PD
Atom Interferometers
Interference with atomic and molecular matter waves is a rich branch of
atomic physics and quantum optics. It started with atom diffraction from
crystal surfaces and the separated oscillatory fields technique used in atomic
clocks. Atom interferometry is now reaching maturity as a powerful art with
many applications in modern science. In this review we first describe the basic
tools for coherent atom optics including diffraction by nanostructures and
laser light, three-grating interferometers, and double wells on AtomChips. Then
we review scientific advances in a broad range of fields that have resulted
from the application of atom interferometers. These are grouped in three
categories: (1) fundamental quantum science, (2) precision metrology and (3)
atomic and molecular physics. Although some experiments with Bose Einstein
condensates are included, the focus of the review is on linear matter wave
optics, i.e. phenomena where each single atom interferes with itself.Comment: submitted to Reviews of Modern Physic
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