The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics

Estudio de factibilidad para la creación de una empresa comercializadora de repuestos y accesorios para vehículos automotores

The Project entitled (study of factibility to créate company of accessories and auto parts in Armenia city) was made by Carolina González Muñoz and José Alejandro Bermudez Ocampo for opting for the profesional degree of business administrator. This Project has been developed in order to fin dan opportunity for the City of Armenia in the autopart and automotive sectors in general, in the same way, applying the knowledge acquired in the professional training process. Looking for the feasibility of creating a Supply of Spares And Accessories For Motor Vehicles Company in the city, which is certainly one of the factors with most demand in the market, because it is evident the number of vehicles which are purchased every day. For the realization of this work, it was necessary to make an approach with the auto part’s business owner in the city of Armenia, as well as those working in the field of automotive maintenance, besides this has been based on the stores that are located in the City of Pitalito (Huila), which have been managed by close relatives of those who have been developing the Project in this way, it has been possible to get information about market, technical, administrative, environmental and financial aspects, to get their completion, so their viability and thriving realization are proved.El proyecto con el título ESTUDIO DE FACTIBILIDAD PARA CREAR EMPRESA DE ACCESORIOS Y REPUESTOS AUTOMOTORES EN LA CIUDAD DE ARMENIA* se elaboró por los autores Carolina González Muñoz y José Alejandro Bermudez Ocampo** para optar el título de administrador de negocios. El presente proyecto se ha desarrollado con el fin de encontrar una oportunidad para la Ciudad de Armenia en el sector autopartista y automotriz en general, así mismo aplicando los conocimientos adquiridos en el proceso de formación profesional. Buscando la factibilidad de crear Empresa comercializadora de repuestos y accesorios para vehículos automotores en la ciudad, que sin duda es uno de los factores con mayor demanda en el mercado, ya que es evidente la cantidad de vehículos que se adquieren día a día. Para la ejecución de este trabajo, fue necesario realizar un acercamiento con los empresarios de autopartes en la Ciudad de Armenia, como también las personas que trabajan en el sector de mantenimiento en los automotores, además se ha basado en los Almacenes que están ubicados en la Ciudad de Pitalito (Huila), los cuales están a cargo de parientes cercanos de quienes han venido elaborando el proyecto y de esta manera se ha logrado recopilar información necesaria como aspectos de mercado, técnicos, administrativos, ambientales y financieros para obtener su culminación de modo que se demuestre su viabilidad y prospera ejecución.Capítulo I: Anteproyecto ................................................................. 3 Capítulo II: Aspectos generales del entorno socio-económico ....... 14 Capítulo III: Estudio de mercados ................................................... 17 Capítulo IV: Estudio técnico ............................................................ 47 Capítulo V: Estudio de la organización, aspectos legales y ambientales del proyecto .................................................................................... 67 Capítulo VI: Estudio financiero........................................................ 80PregradoAdministrador de Negocio

Obtención de plantas transgénicas de papa resistentes al virus de la papa y al virus del enrollamiento de la hoja de papa mediante transformación con Agrobacteriumtumefaciens

IP 1101-12-004-93v.1. Informe final -- v.2. Tranformation of solanaceous specieswith coatprotein gene and full-length cDNAs of potato leafroll virus / by Liliana Franco Lara.LIBRO(S): Proceedings / International Workshop on Transgenic Technology inPlants (1 : 1994 Oct. 24-Nov. 4 :;resistance of potato crops in Colombia by transgenic technology/ O. Acosta, H. Barker and M.A. Mayo. -- En:;Fitopatologia colombiana. -- vol. 18, no. 1-2 (jun. 1994);p.66-77. -- ISSN 01200143.;Bogotá) ; edited by Orlando Acosta y Kara D. Webster. -- Bogotá: Universidad Nacional de Colombia :;Cientifica, c1996. -- 212 p. : il. ; 27 cm. -- PONENCIA(S)ENCONGRESO: Expression of bar gene in transgenic;tobacco plants / A. Chaparro ...[et al.] -- En: EncuentroLatinoamericanode Biotecnologia Vegetal (2 : 1995;jun. 4-9 : Puerto Iguazu, Argentina) -- [s.l. : s.n.], 1995. --p. ; 28 cm. -- Plantas transgenicas de tabaco;resistentes a fosfinotricina / Alejandro Chaparro ... [etal.]-'- en: Memorias Congreso de la Asociacion;Colombiana de Fitopatologia y Ciencias Afines (15 : 1994 ago.31-sep. 2 :Santafe de Bogotá). -- Santafe de;Bogotá : Ascolfi, 1994. -- p. ; 28 cm. -- Establecimientode unametodologia para el mejoramiento no;convencional de tabaco (Nicotiana tabacum) mediante transformacion con Agrobacterium tumefaciens / A. Chaparro;...[et al.] -- En: Memorias Congreso de la Asociacion Colombianade Fitopatologia y Ciencias Afines (15 : 1994;ago. 31-sep. 2 : Santafe de Bogotá). -- Santafe de Bogotá: Ascolfi, 1994.-- p. ; 28 cm. -- ARTICULO(S) EN;REVISTA: Caracterizacion molecular de plantas transgenicasdetabaco que expresan resistencia a Kanamicina,;beta-glucuronidasa / Liz Patricia Moreno ...[et al.]. -- En: Revista de laAsociacion Colombiana de Ciencias;Biologicas. -- vol. 10, no. 1-2 (jun.-dic. 1998); p. 58-67. --ISSN 01204173 -- Prospects for improving viru

Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study

We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids; and adjusted using a propensity-score for steroid treatment. From March-July 2020, 5.262 (35.26%) were treated with corticosteroids and 9.659 (64.73%) were not. In-hospital mortality overall was 20.50%; it was higher in patients treated with corticosteroids than in controls (28.5% versus 16.2%, OR 2.068 [95% confidence interval; 1.908 to 2.242]; p = 0.0001); however, when adjusting by occurrence of ARDS, mortality was significantly lower in the steroid group (43.4% versus 57.6%; OR 0.564 [95% confidence interval; 0.503 to 0.633]; p = 0.0001). Moreover, the greater the respiratory failure, the greater the impact on mortality of the steroid treatment. When adjusting these results including the propensity score as a covariate, in-hospital mortality remained significantly lower in the steroid group (OR 0.774 [0.660 to 0.907], p = 0.002). Steroid treatment reduced mortality by 24% relative to no steroid treatment (RRR 0.24). These results support the use of glucocorticoids in COVID-19 in this subgroup of patients

II Colombian Tromboemblism Venous Consensus

En el trombembolismo venoso (TEV), incluye la trombosis venosa profunda (TVP) y la embolia pulmonar (EP), como manifestaciones de una misma enfermedad. Constituye un fenómeno común con una incidencia de 300-600.000 casos de TVP y cerca de 50.000 muertes anuales causadas por EP, en Estados Unidos, y 10.000 muertes anuales, por la misma razón, en Francia.171-18

Paz en Colombia : perspectivas, desafíos, opciones

Este libro pretende ser un aporte para analizar las diversas dimensiones sociales, políticas, económicas, culturales, educativas y éticas de los retos que precedieron al acuerdo de paz y que se desplegarán a partir de ahora. Se publica a pocos días del plebiscito del 2 de octubre de 2016, en el que la sociedad colombiana tendrá en sus manos la posibilidad de refrendar este importantísimo acuerdo, abriendo y multiplicando los desafíos y oportunidades que nos permitieron llegar hasta aquí. La lectura de cada una de las contribuciones de este volumen permite no sólo entender que es urgente y necesario votar por el SÍ a los acuerdos de paz, sino también asumir la inmensa complejidad de una coyuntura que necesitará de muchísima imaginación, compromiso y participación democrática. ¡Viva la Paz! ¡Viva Colombia