Anti Acne Vulgaris Topical Cream From Combination Extract of Gymnanthemum Amygdalinum Del. and Elaeis Guineensis Jacq. Leaves

Acne is one problem in adolescents and adults who can reduce self-confidence. This study aimed to formulate the combination cream of African leaf extract and palm oil leaves to determine the antibacterial activity of African leaf extract against several acne-causing bacteria (Propionibacterium acne and Staphylococcus epidermidis). Test antibacterial activity of extracts and cream with disc diffusion method. The cream is made with concentration of 5, 10 and 20% w/w. The evaluation results of cream with concentration of 5, 10 and 20% were physically stable for 4 weeks of storage at temperature room, homogeneous, pH and it did not cause irritation. Based on the test results, a combination of African leaf extract with concentration of 5% effectively inhibited bacterial growth with an average inhibition zone diameter of 12.06 mm for Propionibacterium acne bacteria and 13.63 mm for Staphylococcus epidermidis bacteria. The result of this study suggest that combination of African leaf extract and palm leaves posses potent anti-bacterial activity against Propionibacterium acne and Staphylococcus epidermidis

Formulasi Sediaan Masker Gel Pell- Off Ekstrak Etanol Daun Kopi Arabika (Coffea Arabica) Sebagai Anti- Aging

Background: Arabica coffee leaves contain phenolic compounds and flavonoid compounds which act as antioxidants. Purpose: To find out whether arabica coffee leaf extract can be formulated in the form of an anti-aging pell-off gel mask. To find out at what concentration the arabica coffee leaf extract pell-off gel mask provides the best activity. Method: Arabica coffee leaf extract is made by maceration. Extract tested screening. Preparation of pell-off gel masks with concentrations of F0 (blanko), F1 (1%), F2 (3%), F3 (5%). Evaluation of the pell-off mask preparation included preparation stability, homogeneity, PH, irritation to volunteer skin, drying time, viscosity, spreadability, and anti-aging effectiveness using a skin analyzer. Results: Simplicia contains alkaloids, flavonoids, tannins, saponins, phenols, steroids. The resulting pell-off mask preparation of ethanol extract of Arabica coffee leaves is homogeneous, PH 5.1-6.1 stable in 4 weeks storage, does not irritate the skin and takes 22- 30 minutes to dry, spreadability is 5-7.5 cm and viscosity 7500- 27050cp. Conclusion: Arabica coffee leaf ethanol extract pell-off gel mask provides better anti- aging effectiveness for 4 weeks. F3(5%) pell-off gelmask provides better anti-aging effects than other formulas

Sosialisasi Teknik Penyimpanan Obat pada Gudang Farmasi di PBF wilayah Deli Serdang

Penataan obat di Instalasi Farmasi Rumah Sakit meliputi perencanaan, pengadaan, pendistribusian, dan pemanfaatan. Indikator penyimpanan obat adalah : kesesuaian antar barang dan kartu stok, TOR (Turn Over Ratio), persentase obat yang kadaluwarsa dan atau rusak, sistem penataan ruang penyimpanan, persentase dead stock, dan persentase final nilai saham. Kegiatan pengabdian ini merupakan penelitian deskriptif kualitatif dengan rancangan penelitian observasional. Subjek pada penelitian ini adalah Kepala Instalasi Farmasi, Kepala Ruang Penyimpanan Instalasi Farmasi, petugas Ruang Penyimpanan Instalasi Farmasi, dan Kepala Unit Pemeliharaan. Sarana penelitian yang digunakan adalah metode observatorium dan mendalam wawancara. Analisis data dilakukan dengan cara deskripsi kualitatif, dan teknik triangulasi dilakukan untuk menjamin keabsahan dat

EVALUASI PROTAP RECALL DI PEDAGANG BESAR FARMASI PT. MILLENNIUM PHARMACON INTERATIONAL TBK CABANG MEDAN

Penarikan kembali suatu produk atau lebih dikenal dengan product recall Hal ini biasa terjadi pada produk cacat yang disebabkan oleh kelalaian perusahaan pada saat produksi. Produsen melakukan tindakan product recall untuk meningkatkan citra produsen dan menjaga kepercayaan konsumen, karena produsen tentunya tidak ingin kehilangan konsumennya. Adapun tujuan recall adalah menjamin proses penarikan obat dari seluruh gudang (pusat/cabang) dan/atau pelanggan dalam batas waktu yang telah ditentukan, dengan prinsip: tepat waktu, dalam jumlah yang tepat, dan dengan proses yang baik dan benar sesuai dengan ketentuan yang berlaku. sesuai petunjuk BPOM/prinsipal agar tidak menimbulkan kerugian bagi masyaraka

Penyuluhan Pemberian Vitamin A Pada Anak Balita Di Puskesmas Wilayah Kota Medan

Salah satu permasalahan kesehatan terutama di negara  berkembang  yaitu  adanya  gangguan pertumbuhan  yang  terjadi  pada  semua  usia karena adanya kekurangan vitamin A. Hal ini mengakibatkan  penurunan  daya  tahan  tubuh terhadap   penyakit   yang   berpengaruh   pada kelangsungan  hidup  anak.  Tujuan  penelitian untuk   mengetahui   gambaran   pemanfaatan program  pemberian  kapsul  vitamin  A  pada balita.  Penelitian ini merupakan   penelitian   kuantitatif   deskriptif. Pengumpulan data dilakukan dengan observasi menggunakan  data  sekunder  yang  bersumber  dari aplikasi  e-PPGBM.   Analisis data dilakukan  secara  univariat. Hasil  penelitian  menunjukkan   jumlah   anak   terbanyak  yang menerima  kapsul  vitamin  A  adalah  815  anak  (62%)  yaitu  dari  Kelurahan  Bandar  Selamat  dan   pada   awal   tahun  2021  Februari   yang  menerima  kapsul  vitamin  A  terbanyak  adalah  sebanyak 580 anak (65%) yaitu dari Kelurahan  Bandar Selamat .Disarankan kepada puskesmas  untuk  meningkatkan  pengetahuan  dan  keterampilan  petugas  tentang kompetensi  dan  peran  masing -masing  khususnya  pada bidang gizi melalui sebuah pelatihan, seminar  atau workshop yang berkaitan dengan gizi dan gangguan gizi

Pembuatan Krim Pelembab Kulit Dari Saripati Buah Salak (Salacca sumatrana Becc.)

Buah salak mengandung fenol dan flavonoid. Mengandung vitamin A, pro vitamin B5, C, E yang sangat penting untuk menangkal radikal bebas. Buah salak juga berpotensi sebagai antioksidan alami yang baik. Adanya vitamin C dan juga antioksidan dalam buah salak berkhasiat untuk meningkatkan kecantikan kulit secara alami. Saripati buah salak diformulasikan dalam krim tipe m/a untuk membuat sediaan yang berfungsi sebagai pelembab kulit. Tujuan dari kegiatan ini adalah untuk optimalisasi potensi buah salak untuk menjadi krim pelembab kulit. Kegiatan ini dilaksanakan dengan metode edukatif dan partisipatif. Solusi yang  ditawarkan  untuk  mengatasi  permasalahan  yang  ada  yaitu: 1. Observasi kelompok mitra, 2. Pelakasanaan perumusan masalah, 3. Merumuskan solusi, 4. Sosialisai dan pelatihan, 5. Pendampingan dan evaluasi. Hasil dari evaluasi berjumlah 30 peserta didapat hasil tingkat pengetahuan peserta baik sebesar 90%. Pengetahuan cukup sebesar 10 %. Pada tingkat kebermanfaatan pelatihan baik sebesar 100% begitu juga dengan minat kepuasan sebesar 100%. Respon positif yang diberikan peserta pada kegiatan PKM dan Pelatihan

UJI EFEK ANTIINFLAMASI KOMBINASI EKSTRAK ETANOL DAUN GYMNANTHEMUM AMYGDALINUM DEL. DAN ELAEIS GUINEENSIS JACQ.

Inflammation is a response from the body to injury or infection, flavonoids contained in African leaves (Gymnanthemum Amygdalinum Del.) And palm oil leaves (Elaeis Guineensis Jacq.) have anti-inflammatory effects. This study aims to examine the anti-inflammatory effects of a combination of ethanol extracts of Gymnanthemum Amygdalinum Del. And Elaeis Guineensis Jacq. on white rat foot edema which is induced by carrageenan 1% subplantar, and effective dosage as anti-inflammatory. The extract was made by maceration method using 96% ethanol solvent. The antiinflammatory effect test was divided into 5 treatment groups. The first group (negative control) was given 0.5% CMC Na suspension, the group (positive control) was given diclofenac Na suspension 2.25 mg / kg bw, and the suspension group was a combination of African leaf extract (Gymnanthemum Amygdalinum Del.) And palm oil leaves ( Elaeis Guineensis Jacq.) Dose 200 + 62.5 mg / kg bw, 400 + 125 mg / kg bw, and 800 + 250 mg / kg bw. Inflammation volume measurements were measured using a pletismometer for 180 minutes at 30 minute intervals after 1% carrageenan was induced. The results showed that negative controls had significant differences with other treatment groups which did not show anti-inflammatory effects. In conclusion, the suspension of a combination of ethanol extract of African leaves and palm oil leaves has an effective anti-inflammatory effect at a dose of 800 + 250 mg / kg bw

Oral acute toxicity study of ethanol extract of Mobe leaves (Artocarpus lacucha Buch-Ham) in Wistar rats

Many medicinal plants are now being chosen because the treatment is safer and cheaper. Artocarpus lacucha Buch-Ham is a plant with many pharmacological activities and is efficacious; its safety has not been studied. Acute oral toxicity evaluation followed Organization for Economic Co-operation and Development guidelines using the fixed dose method. The evaluation began with a preliminary test, then a primary test with three groups: a 2000 mg/Kg BW dose test group, a 5000 mg/Kg BW dose test group, and a control group. The results of visual observations, haematological and clinical examinations, and histological examination of organs (liver, spleen, kidneys, lungs and heart) showed no toxicity in the animals, and they did not die during testing. The findings of this study support the safety of Artocarpus lacucha Buch-Ham leaf ethanol extract, which did not produce harmful results in acute toxicity tests

The effect of 1.3 bis(p-Hydroxyphenyl)urea compound on IL-6, IL-1β, TNF-α and COX-2 protein expression on λ-Carrageenan-induced rats

Objectives: This study aims to determine the protein expression of IL-6, IL-1β, TNF-α, and COX-2 using an immunohistochemistry method based on the anti-inflammatory activity of intraplantar carrageenan solution in male rat paws. Materials and methods: Animals were provided with 1.3 bis(p-Hydroxyphenyl)urea at 12.5, 25, 50, 100, and 200 mg/kg BW. This was administered approximately one hour before the 1% carrageenan induction. As a control measure, diclofenac sodium and CMC sodium 0.5% was similarly administered. After 360 mins, all of the rats were sacrificed, and the inflammatory tissue in the rat’s paw was acquired. The immunohistochemistry preparations were carried out to observe the expression of IL-6, IL-1β, TNF-α, and COX-2. Results: The result showed a decrease in the expression of IL-6, IL-1β, TNF-α, and COX-2, all groups given 1.3 bis(p-Hydroxyphenyl)urea and diclofenac sodium compared to the control group CMC sodium 0.5% CMC sodium 0.5%. From the results of the mean difference test, it can be seen that the IL-1β expression at doses of 50, 100, and 200 mg/Kg BW was not significantly different from that of diclofenac sodium (p > 0.05). Meanwhile, the expression of COX-2, TNF-α, and IL-6 at doses of 100 and 200 mg/Kg BW was not significantly different from that of diclofenac sodium (p > 0.05). Conclusion: The 1.3 bis(p-Hydroxyphenyl)urea has anti-inflammatory activity by decreasing the percentage of IL-6, IL-1β, TNF-α, and COX-2 protein expression in rat’s paw inflammation tissue

The effect of 1.3 bis(p-Hydroxyphenyl)urea compound on IL-6, IL-1β, TNF-α and COX-2 protein expression on λ-Carrageenaninduced rats

Objectives: This study aims to determine the protein expression of IL-6, IL-1β, TNF-α, and COX-2 using an immunohistochemistry method based on the anti-inflammatory activity of intraplantar carrageenan solution in male rat paws. Materials and methods: Animals were provided with 1.3 bis(p-Hydroxyphenyl)urea at 12.5, 25, 50, 100, and 200 mg/kg BW. This was administered approximately one hour before the 1 carrageenan induction. As a control measure, diclofenac sodium and CMC sodium 0.5 was similarly administered. After 360 mins, all of the rats were sacrificed, and the inflammatory tissue in the rat’s paw was acquired. The immunohistochemistry preparations were carried out to observe the expression of IL-6, IL-1β, TNF-α, and COX-2. Results: The result showed a decrease in the expression of IL-6, IL-1β, TNF-α, and COX-2, all groups given 1.3 bis(p-Hydroxyphenyl) urea and diclofenac sodium compared to the control group CMC sodium 0.5 CMC sodium 0.5. From the results of the mean difference test, it can be seen that the IL-1β expression at doses of 50, 100, and 200 mg/Kg BW was not significantly different from that of diclofenac sodium (p > 0.05). Meanwhile, the expression of COX-2, TNF-α, and IL-6 at doses of 100 and 200 mg/Kg BW was not significantly different from that of diclofenac sodium (p > 0.05). Conclusion: The 1.3 bis(p-Hydroxyphenyl)urea has anti-inflammatory activity by decreasing the percentage of IL-6, IL-1β, TNF-α, and COX-2 protein expression in rat’s paw inflammation tissue. © Copyright Satria D et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited