Diagnosis-specific sickness absence among injured working-aged pedestrians: a sequence analysis

BACKGROUND: The knowledge about the long-term consequences in terms of sickness absence (SA) among pedestrians injured in a traffic-related accident, including falls, is scarce. Therefore, the aim was to explore diagnosis-specific patterns of SA during a four-year period and their association with different sociodemographic and occupational factors among all individuals of working ages who were injured as a pedestrian. METHODS: A nationwide register-based study, including all individuals aged 20-59 and living in Sweden, who in 2014-2016 had in- or specialized outpatient healthcare after a new traffic-related accident as a pedestrian. Diagnosis-specific SA (> 14\ua0days) was assessed weekly from one year before the accident up until three years after the accident. Sequence analysis was used to identify patterns (sequences) of SA, and cluster analysis to form clusters of individuals with similar sequences. Odds ratios (ORs) with 95% confidence intervals (CIs) for association of the different factors and cluster memberships were estimated by multinomial logistic regression. RESULTS: In total, 11,432 pedestrians received healthcare due to a traffic-related accident. Eight clusters of SA patterns were identified. The largest cluster was characterized by no SA, three clusters had different SA patterns due to injury diagnoses (immediate, episodic, and later). One cluster had SA both due to injury and other diagnoses. Two clusters had SA due to other diagnoses (short-term and long-term) and one cluster mainly consisted of individuals with disability pension (DP). Compared to the cluster "No SA", all other clusters were associated with older age, no university education, having been hospitalized, and working in health and social care. The clusters "Immediate SA", "Episodic SA" and "Both SA due to injury and other diagnoses" were also associated with higher odds of pedestrians who sustained a fracture. CONCLUSIONS: This nationwide study of the working-aged pedestrians observed diverging patterns of SA after their accident. The largest cluster of pedestrians had no SA, and the other seven clusters had different patterns of SA in terms of diagnosis (injury and other diagnoses) and timing of SA. Differences were found between all clusters regarding sociodemographic and occupational factors. This information can contribute to the understanding of long-term consequences of road traffic accidents

Taxonomic revision of the Afrotropical Agabus raffrayi species group with the description of four new species (Coleoptera, Dytiscidae)

We revise the Afrotropical Agabus raffrayi species group, motivated by the discovery of new diversity in Kenya and South Africa. Whilst Agabus is mainly a holarctic genus, the Agabus raffrayi group is restricted to high altitude regions of eastern Africa and temperate parts of South Africa, from where we describe the southernmost Agabus in the world. The following new species are introduced: Agabus anguluverpus sp. nov. from Mount Kenya in central Kenya, Agabus austellus sp. nov. a widespread species in South Africa, Agabus riberae sp. nov. from the Kamiesberg and northeastern Cederberg ranges in the Northern and Western Cape Provinces of South Africa and Agabus agulhas sp. nov. from the Agulhas Plain, Western Cape Province, South Africa. We provide a distribution map, a determination key for males, quantitative measurements of diagnostic characters, habitus photos and detailed photos of male genitalia for all described species in the group, as well as images of diagnostic characters and habitats. The presence or absence of an elongated section between the subapical broadening and the base of the apical and subapical teeth of the male aedeagus is a useful novel character, first revealed by our study. In contrast with the most recent revision of Afrotropical Agabus, we show that Agabus ruwenzoricus Guignot, 1936 is restricted to eastern Africa; South African records of this species having been based on misidentifications, no species of the group being common to southern and eastern Africa. We speculate that the raffrayi group may display phylogenetic niche conservatism, being restricted, as an originally temperate taxon, to higher elevations in tropical eastern Africa, but occurring at lower altitudes in temperate South Africa

Glucose metabolism and oscillatory behavior of pancreatic islets

A variety of oscillations are observed in pancreatic islets.We establish a model, incorporating two oscillatory systems of different time scales: One is the well-known bursting model in pancreatic beta-cells and the other is the glucose-insulin feedback model which considers direct and indirect feedback of secreted insulin. These two are coupled to interact with each other in the combined model, and two basic assumptions are made on the basis of biological observations: The conductance g_{K(ATP)} for the ATP-dependent potassium current is a decreasing function of the glucose concentration whereas the insulin secretion rate is given by a function of the intracellular calcium concentration. Obtained via extensive numerical simulations are complex oscillations including clusters of bursts, slow and fast calcium oscillations, and so on. We also consider how the intracellular glucose concentration depends upon the extracellular glucose concentration, and examine the inhibitory effects of insulin.Comment: 11 pages, 16 figure

Primary thermometry in the intermediate Coulomb blockade regime

We investigate Coulomb blockade thermometers (CBT) in an intermediate temperature regime, where measurements with enhanced accuracy are possible due to the increased magnitude of the differential conductance dip. Previous theoretical results show that corrections to the half width and to the depth of the measured conductance dip of a sensor are needed, when leaving the regime of weak Coulomb blockade towards lower temperatures. In the present work, we demonstrate experimentally that the temperature range of a CBT sensor can be extended by employing these corrections without compromising the primary nature or the accuracy of the thermometer.Comment: 8 pages, 4 figure

No Evidence for More Earth-sized Planets in the Habitable Zone of Kepler's M versus FGK Stars

Reliable detections of Earth-sized planets in the habitable zone remain elusive in the Kepler sample, even for M dwarfs. The Kepler sample was once thought to contain a considerable number of M dwarf stars ($T_\mathrm{eff} < 4000$ K), which hosted enough Earth-sized ($[0.5,1.5]$ R$_\oplus$) planets to estimate their occurrence rate ($\eta_\oplus$) in the habitable zone. However, updated stellar properties from Gaia have shifted many Kepler stars to earlier spectral type classifications, with most stars (and their planets) now measured to be larger and hotter than previously believed. Today, only one partially-reliable Earth-sized candidate remains in the optimistic habitable zone, and zero in the conservative zone. Here we performed a new investigation of Kepler's Earth-sized planets orbiting M dwarf stars, using occurrence rate models with considerations of updated parameters and candidate reliability. Extrapolating our models to low instellations, we found an occurrence rate of $\eta_\oplus={8.58}_{-8.22}^{+17.94}\%$ for the conservative habitable zone (and ${14.22}_{-12.71}^{+24.96}\%$ for the optimistic), consistent with previous works when considering the large uncertainties. Comparing these estimates to those from similarly comprehensive studies of Sun-like stars, we found that the current Kepler sample does not offer evidence to support an increase in $\eta_\oplus$ from FGK to M stars. While the Kepler sample is too sparse to resolve an occurrence trend between early and mid-to-late M dwarfs for Earth-sized planets, studies including larger planets and/or data from the K2 and TESS missions are well-suited to this task.Comment: 22 pages, 11 figures, 2 tables; Accepted for publication in A

Effect of floor type on the performance, physiological and behavioural responses of finishing beef steers

peer-reviewedBackground:The study objective was to investigate the effect of bare concrete slats (Control), two types of mats [(Easyfix mats (mat 1) and Irish Custom Extruder mats (mat 2)] fitted on top of concrete slats, and wood-chip to simulate deep bedding (wood-chip placed on top of a plastic membrane overlying the concrete slats) on performance, physiological and behavioral responses of finishing beef steers. One-hundred and forty-four finishing steers (503 kg; standard deviation 51.8 kg) were randomly assigned according to their breed (124 Continental cross and 20 Holstein–Friesian) and body weight to one of four treatments for 148 days. All steers were subjected to the same weighing, blood sampling (jugular venipuncture), dirt and hoof scoring pre study (day 0) and on days 23, 45, 65, 86, 107, 128 and 148 of the study. Cameras were fitted over each pen for 72 h recording over five periods and subsequent 10 min sampling scans were analysed. Results: Live weight gain and carcass characteristics were similar among treatments. The number of lesions on the hooves of the animals was greater (P < 0.05) on mats 1 and 2 and wood-chip treatments compared with the animals on the slats. Dirt scores were similar for the mat and slat treatments while the wood-chip treatment had greater dirt scores. Animals housed on either slats or wood-chip had similar lying times. The percent of animals lying was greater for animals housed on mat 1 and mat 2 compared with those housed on concrete slats and wood chips. Physiological variables showed no significant difference among treatments. Conclusions: In this exploratory study, the performance or welfare of steers was not adversely affected by slats, differing mat types or wood-chip as underfoot material

Scaling K2 VII: Evidence for a high occurrence rate of hot sub-Neptunes at intermediate ages

The NASA K2 mission obtained high precision time-series photometry for four young clusters, including the near-twin 600-800 Myr-old Praesepe and Hyades clusters. Hot sub-Neptunes are highly prone to mass-loss mechanisms, given their proximity to the the host star and the weakly bound gaseous envelopes, and analyzing this population at young ages can provide strong constraints on planetary evolution models. Using our automated transit detection pipeline, we recover 15 planet candidates across the two clusters, including 10 previously confirmed planets. We find a hot sub-Neptune occurrence rate of 79-107% for GKM stars in the Praesepe cluster. This is 2.5-3.5 sigma higher than the occurrence rate of 16.54+1.00-0.98% for the same planets orbiting the ~3-9 Gyr-old GKM field stars observed by K2, even after accounting for the slightly super-solar metallicity ([Fe/H]~0.2 dex) of the Praesepe cluster. We examine the effect of adding ~100 targets from the Hyades cluster, and extending the planet parameter space under examination, and find similarly high occurrence rates in both cases. The high occurrence rate of young, hot sub-Neptunes could indicate either that these planets are undergoing atmospheric evolution as they age, or that planetary systems that formed when the Galaxy was much younger are substantially different than from today. Under the assumption of the atmospheric mass-loss scenario, a significantly higher occurrence rate of these planets at the intermediate ages of Praesepe and Hyades appears more consistent with the core-powered mass loss scenario sculpting the hot sub-Neptune population, compared to the photoevaporation scenario.Comment: 14 pages, 6 figures, published in A

Using Photometrically-Derived Properties of Young Stars to Refine TESS's Transiting Young Planet Survey Completeness

The demographics of young exoplanets can shed light onto their formation and evolution processes. Exoplanet properties are derived from the properties of their host stars. As such, it is important to accurately characterize the host stars since any systematic biases in their derivation can negatively impact the derivation of planetary properties. Here, we present a uniform catalog of photometrically-derived stellar effective temperatures, luminosities, radii, and masses for 4,865 young (<1 Gyr) stars in 31 nearby clusters and moving groups within 200 pc. We compared our photometrically-derived properties to a subset of those derived from spectra, and found them to be in good agreement. We also investigated the effect of stellar properties on the detection efficiency of transiting short-period young planets with TESS as calculated in Fernandes et al. 2022, and found an overall increase in the detection efficiency when the new photometrically derived properties were taken into account. Most notably, there is a 1.5 times increase in the detection efficiencies for sub-Neptunes/Neptunes (1.8-6 Re) implying that, for our sample of young stars, better characterization of host star properties can lead to the recovery of more small transiting planets. Our homogeneously derived catalog of updated stellar properties, along with a larger unbiased stellar sample and more detections of young planets, will be a crucial input to the accurate estimation of the occurrence rates of young short-period planets.Comment: 16 pages, 5 Figures, 3 Tables. Revised and resubmitted to AJ after a favorable referee report. Co-First Author

Practising Mathematics Teacher Education: Expanding The Realm of Possibilities

It is often said that student teachers’ underlying beliefs of what mathematics consists of and how it should be taught are restricted in two ways. On the one hand, future elementary teachers in general use only weak mathematical conceptions, which often do not help them to realise their educational ambitions. On a general educational level, many of these students advocate discovery learning and collective problem solving, but when it comes down to the mathematical activities that have to be prepared, their experience of “traditional” school mathematics is of little help. On the other hand, future (higher) secondary teachers mostly are very well prepared with respect to formal academic mathematics when entering mathematics education programmes, either because they have already passed a mathematical formation at university or because their teacher education programmes emphasise the study of academic mathematics and not of educational or didactical modules