The New Black on the Development Catwalk: Incorporating Rule of Law into the Sustainable Development Goals

As the post-2015 Development Agenda is set to replace the Millennium Development Goals (“MDGs”), one of the most controversial new elements of the new agenda is the rule of law. While all of the official fora for discussing and producing recommendations have concluded that the rule of law (or some variation) should be included, there are still significant challenges to its incorporation in the final Sustainable Development Goals (“SDGs”). The interrelated points of contention have included whether rule of law applies at the national government level, whether it encompasses domestic governance, and how the concept should be defined and measured. Going forward, there are a few key factors influencing whether and how the rule of law will be incorporated into the next round of development goals: 1) the compelling force of traditional views on development in determining member states’ positions in the debate; 2) the continued importance of the United Nations General Assembly (“UNGA”) Rule of Law Declaration; 3) the centrality of the General Assembly’s Open Working Group on Sustainable Development Goals (“OWG”); and 4) the ease of measurement and implementation of proposed indicators. If incorporated into the new agenda, a rule of law goal will likely include indicators that are easily evaluated and generate little political friction, such as legal identity

‘Whether you are gay or straight, I don’t like to see effeminate dancing’: effeminophobia in performance-level ballroom dance

This article discusses recent responses to performances of same-sex male ballroom dancing in order to consider the subtle difference which can exist between homophobia and effeminophobia. Given that the world of performance-level ballroom dancing is a gay-friendly environment, in which many participants are openly gay identified, this article will argue that a discourse of effeminophobia, rather than homophobia, underpins the world of performance-level ballroom dance. Performance-level ballroom dance is often read as camp not only because it represents exaggerated gender roles but because its official technique requires that the male dancer synthesise codes of masculinity and femininity in his dancing. What protects the gender-dissident male ballroom dancer from being read as effeminate is that he is paired with a female body performing excessive femininity. Without the foil of the hyper-feminine female partner, the same-sex couple draws attention to the fact that the male ballroom dancer is not dancing as a man but in accordance with ballroom’s queer construction of masculinity. Given that performance-level dance has struggled for so many years to be viewed as masculine sport, practitioners may, quite understandably, be anxious about any representation which suggests that ballroom dance may be an effeminate activity

The transcription factor ZNF469 regulates collagen production in liver fibrosis.

Non-alcoholic fatty liver disease (NAFLD) - characterized by excess accumulation of fat in the liver - now affects one third of the world's population. As NAFLD progresses, extracellular matrix components including collagen accumulate in the liver causing tissue fibrosis, a major determinant of disease severity and mortality. To identify transcriptional regulators of fibrosis, we computationally inferred the activity of transcription factors (TFs) relevant to fibrosis by profiling the matched transcriptomes and epigenomes of 108 human liver biopsies from a deeply-characterized cohort of patients spanning the full histopathologic spectrum of NAFLD. CRISPR-based genetic knockout of the top 100 TFs identified ZNF469 as a regulator of collagen expression in primary human hepatic stellate cells (HSCs). Gain- and loss-of-function studies established that ZNF469 regulates collagen genes and genes involved in matrix homeostasis through direct binding to gene bodies and regulatory elements. By integrating multiomic large-scale profiling of human biopsies with extensive experimental validation we demonstrate that ZNF469 is a transcriptional regulator of collagen in HSCs. Overall, these data nominate ZNF469 as a previously unrecognized determinant of NAFLD-associated liver fibrosis

The transcription factor ZNF469 regulates collagen production in liver fibrosis.

Metabolic dysfunction-associated steatotic liver disease (MASLD) - characterized by excess accumulation of fat in the liver - now affects one-third of the world's population. As MASLD progresses, extracellular matrix components including collagen accumulate in the liver, causing tissue fibrosis, a major determinant of disease severity and mortality. To identify transcriptional regulators of fibrosis, we computationally inferred the activity of transcription factors (TFs) relevant to fibrosis by profiling the matched transcriptomes and epigenomes of 108 human liver biopsies from a deeply characterized cohort of patients spanning the full histopathologic spectrum of MASLD. CRISPR-based genetic KO of the top 100 TFs identified ZNF469 as a regulator of collagen expression in primary human hepatic stellate cells (HSCs). Gain- and loss-of-function studies established that ZNF469 regulates collagen genes and genes involved in matrix homeostasis through direct binding to gene bodies and regulatory elements. By integrating multiomic large-scale profiling of human biopsies with extensive experimental validation, we demonstrate that ZNF469 is a transcriptional regulator of collagen in HSCs. Overall, these data nominate ZNF469 as a previously unrecognized determinant of MASLD-associated liver fibrosis

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the liver, metabolic zonation requires a Wnt/β-catenin signalling gradient, but the instructive mechanism controlling its spatiotemporal regulation is not known. We have now identified the RSPO-LGR4/5-ZNRF3/RNF43 module as a master regulator of Wnt/β-catenin-mediated metabolic liver zonation. Liver-specific LGR4/5 loss of function (LOF) or RSPO blockade disrupted hepatic Wnt/β-catenin signalling and zonation. Conversely, pathway activation in ZNRF3/RNF43 LOF mice or with recombinant RSPO1 protein expanded the hepatic Wnt/β-catenin signalling gradient in a reversible and LGR4/5-dependent manner. Recombinant RSPO1 protein increased liver size and improved liver regeneration, whereas LGR4/5 LOF caused the opposite effects, resulting in hypoplastic livers. Furthermore, we show that LGR4(+) hepatocytes throughout the lobule contribute to liver homeostasis without zonal dominance. Taken together, our results indicate that the RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration

Värdet av att arbeta med Assessment Center - en kvalitativ studie om hur verksamma organisationer upplever Assessment Center

I följande studie kommer rekryterings- och utvecklingsmetoden Assessment Center (AC) att studeras. Syftet med studien är att utifrån verksamma organisationers erfarenhet av AC skapa en ökad förståelse för; metodens innebörd, vilka argument som ligger till grund för organisationers användande av metoden samt dess värde för organisationer. Studien är av kvalitativ karaktär och fokus fästs vid tolkning och förståelse av AC baserat på respondenternas subjektiva uppfattningar och upplevelser. Studiens teoretiska referensram behandlar; Human Resource Management, rekrytering, personalekonomi, Talent Management och Assessment Center. Empiri har samlats från sex verksamma organisationer, varav fem organisationer vilka arbetar med AC samt en organisation som har påvisat ett eventuellt intresse av att utveckla ett AC. Studien har kunnat visa på att det å ena sidan råder en överensstämmande definition av AC, som en kombination av tester och övningar, samtidigt som metodens utformning å andra sidan skiljer sig åt organisationerna mellan. Argumenten för att använda AC är, baserat på respondenternas utsagor, många, dels med bakgrund i att metoden är rättvis, noggrann och dessutom träffsäker i fråga att finna rätt person till rätt position. Nackdelar som nämns är metodens tidsåtgång, vilken i sin tur skapar kostnader. Några av de värdeskapande aspekterna som AC för med sig är att metoden skapar värde för organisationer genom undvikandet av felrekryteringar, att metoden ses som varumärkesstärkande och att metoden har en gynnsam och utvecklande inverkan på såväl kandidaten som organisationen. Studiens slutsatser bottnar i den funna definitionsförvirringen, vilket följs av ett ifrågasättande av hur en metod som beskrivs och används så varierat kan stärka organisationers varumärke. Vidare visar AC på att vara en träffsäker och rättvis metod, då samtliga av studiens respondenter påvisar att den främjar undvikandet av felrekryteringar och därmed stora kostnader för organisationer. Slutligen finner vi det vara av största vikt att en allmänt vedertagen definition av AC skapas för att metoden ska kunna utgöra den kvalitetsstämpel som, enligt studien, AC idag fungerar som