576 research outputs found
Visible light emission from reverse-biased silicon nanometer-scale diode-antifuses
Silicon nanometer-scale diodes have been fabricated to emit light in the visible range at low power consumption. Such structures are candidates for emitter elements in Si-based optical interconnect schemes. Spectral measurements of Electroluminescence (EL) on the reverse-biased nanometer-scale diodes brought into breakdown have been carried out over the photon energy range of 1.4-2.8 eV. Previously proposed mechanisms for avalanche emission from conventional silicon p-n junctions are discussed in order to understand the origin of the emission. Also the stability of the diodes has been tested. Results indicate that our nanometer-scale diodes are basically high quality devices. Furthermore due to the nanometer-scale dimensions, very high electrical fields and current densities are possible at low power consumption. This makes these diodes an excellent candidate to be utilized as a light source in Si-based sensors and actuator application
Properties of Interfaces in the two and three dimensional Ising Model
To investigate order-order interfaces, we perform multimagnetical Monte Carlo
simulations of the and Ising model. Following Binder we extract the
interfacial free energy from the infinite volume limit of the magnetic
probability density. Stringent tests of the numerical methods are performed by
reproducing with high precision exact results. In the physically more
interesting case we estimate the amplitude of the critical
interfacial tension to be . This
result is in good agreement with a previous MC calculation by Mon, as well as
with experimental results for related amplitude ratios. In addition, we study
in some details the shape of the magnetic probability density for temperatures
below the Curie point.Comment: 25 pages; sorry no figures include
Helix vs. Sheet Formation in a Small Peptide
Segments with the amino acid sequence EKAYLRT appear in natural occurring
proteins both in -helices and -sheets. For this reason, we have
use this peptide to study how secondary structure formation in proteins depends
on the local environment. Our data rely on multicanonical Monte Carlo
simulations where the interactions among all atoms are taken into account.
Results in gas phase are compared with that in an implicit solvent. We find
that both in gas phase and solvated EKAYLRT forms an -helix when not
interacting with other molecules. However, in the vicinity of a -strand,
the peptide forms a -strand. Because of this change in secondary
structure our peptide may provide a simple model for the
transition that is supposedly related to the outbreak of Prion diseases and
similar illnesses.Comment: to appear in Physical Review
Numerical comparison of two approaches for the study of phase transitions in small systems
We compare two recently proposed methods for the characterization of phase
transitions in small systems. The validity and usefulness of these approaches
are studied for the case of the q=4 and q=5 Potts model, i.e. systems where a
thermodynamic limit and exact results exist. Guided by this analysis we discuss
then the helix-coil transition in polyalanine, an example of structural
transitions in biological molecules.Comment: 16 pages and 7 figure
Extensive Modeling of a Coaxial Stub Resonator for Online Fingerprinting of Fluids
A straightforward method of extensive modeling of a lossy stub resonator system for online fingerprinting of fluids is presented in this paper. The proposed model solves the telegrapher's equations including the skin effect and dielectric losses and describes the amplitude versus frequency response of lossy coaxial stub resonators with a fluid under investigation as dielectric. The adequacy of the method is demonstrated by comparing simulations with experimentally obtained data. Even though we applied the model to a coaxial stub resonator for the online fingerprinting of fluids (e.g., for water quality monitoring), the potential applicability of the method reaches further. Indeed, the method introduced here may be useful for different types of sensors based on lossy transmission line theor
Deterministic and stochastic descriptions of gene expression dynamics
A key goal of systems biology is the predictive mathematical description of
gene regulatory circuits. Different approaches are used such as deterministic
and stochastic models, models that describe cell growth and division explicitly
or implicitly etc. Here we consider simple systems of unregulated
(constitutive) gene expression and compare different mathematical descriptions
systematically to obtain insight into the errors that are introduced by various
common approximations such as describing cell growth and division by an
effective protein degradation term. In particular, we show that the population
average of protein content of a cell exhibits a subtle dependence on the
dynamics of growth and division, the specific model for volume growth and the
age structure of the population. Nevertheless, the error made by models with
implicit cell growth and division is quite small. Furthermore, we compare
various models that are partially stochastic to investigate the impact of
different sources of (intrinsic) noise. This comparison indicates that
different sources of noise (protein synthesis, partitioning in cell division)
contribute comparable amounts of noise if protein synthesis is not or only
weakly bursty. If protein synthesis is very bursty, the burstiness is the
dominant noise source, independent of other details of the model. Finally, we
discuss two sources of extrinsic noise: cell-to-cell variations in protein
content due to cells being at different stages in the division cycles, which we
show to be small (for the protein concentration and, surprisingly, also for the
protein copy number per cell) and fluctuations in the growth rate, which can
have a significant impact.Comment: 23 pages, 5 figures; Journal of Statistical physics (2012
Instantons in N=2 magnetized D-brane worlds
In a toroidal orbifold of type IIB string theory we study instanton effects
in N=2 super Yang-Mills theories engineered with systems of wrapped magnetized
D9 branes and Euclidean D5 branes. We analyze the various open string sectors
in this brane system and study the 1-loop amplitudes described by annulus
diagrams with mixed boundary conditions, explaining their role in the stringy
instanton calculus. We show in particular that the non-holomorphic terms in
these annulus amplitudes precisely reconstruct the appropriate Kahler metric
factors that are needed to write the instanton correlators in terms of purely
holomorphic variables. We also explicitly derive the correct holomorphic
structure of the instanton induced low energy effective action in the Coulomb
branch.Comment: 40 pages, 5 figures, JHEP class. Some footnotes added and typos
corrected. Version published in JHE
Propagators in Noncommutative Instantons
We explicitly construct Green functions for a field in an arbitrary
representation of gauge group propagating in noncommutative instanton
backgrounds based on the ADHM construction. The propagators for spinor and
vector fields can be constructed in terms of those for the scalar field in
noncommutative instanton background. We show that the propagators in the
adjoint representation are deformed by noncommutativity while those in the
fundamental representation have exactly the same form as the commutative case.Comment: 28 pages, Latex, v2: A few typos correcte
Estimating the development of landrace and improved maize cultivars as a function of air temperature
The usefulness of electronic health records from preventive youth healthcare in the recognition of child mental health problems
Background and Objectives: Early identification of child mental health problems (MHPs) is important to provide adequate, timely treatment. Dutch preventive youth healthcare monitors all aspects of a child's healthy development. We explored the usefulness of their electronic health records (EHRs) in scientific research and aimed to develop prediction models for child MHPs.Methods: Population-based cohort study with anonymously extracted electronic healthcare data from preventive youth healthcare centers in the Leiden area, the Netherlands, from the period 2005-2015. Data was analyzed with respect to its continuity, percentage of cases and completeness. Logistic regression analyses were conducted to develop prediction models for the risk of a first recorded concern for MHPs in the next scheduled visit at age 3/4, 5/6, 10/11, and 13/14 years.Results: We included 26,492 children. The continuity of the data was low and the number of concerns for MHPs varied greatly. A large number of determinants had missing data for over 80% of the children. The discriminatory performance of the prediction models were poor.Conclusions: This is the first study exploring the usefulness of EHRs from Dutch preventive youth healthcare in research, especially in predicting child MHPs. We found the usefulness of the data to be limited and the performance of the developed prediction models was poor. When data quality can be improved, e.g., by facilitating accurate recording, or by data enrichment from other available sources, the analysis of EHRs might be helpful for better identification of child MHPs.Prevention, Population and Disease management (PrePoD)Public Health and primary car
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