2,371 research outputs found
Four-loop free energy for the 2D O(n) nonlinear sigma-model with 0-loop and 1-loop Symanzik improved actions
We calculate up to four loops the free energy of the two-dimensional (2D)
O(n) nonlinear sigma-model regularized on the lattice with the 0-loop and
1-loop Symanzik improved actions. An effective coupling constant based on this
calculation is defined.Comment: 26 pages, Revtex. More details about the calculation procedur
Sub-Subgiants in the Old Open Cluster M67?
We report the discovery of two spectroscopic binaries in the field of the old
open cluster M67 -- S1063 and S1113 -- whose positions in the color-magnitude
diagram place them approximately 1 mag below the subgiant branch. A ROSAT study
of M67 independently discovered these stars to be X-ray sources. Both have
proper-motion membership probabilities greater than 97%; precise center-of-mass
velocities are consistent with the cluster mean radial velocity. S1063 is also
projected within one core radius of the cluster center. S1063 is a single-lined
binary with a period of 18.396 days and an orbital eccentricity of 0.206. S1113
is a double-lined system with a circular orbit having a period of 2.823094
days. The primary stars of both binaries are subgiants. The secondary of S1113
is likely a 0.9 Mo main-sequence star, which implies a 1.3 Mo primary star. We
have been unable to explain securely the low apparent luminosities of the
primary stars; neither binary contain stars presently limited in radius by
their Roche lobes. We speculate that S1063 and S1113 may be the products of
close stellar encounters involving binaries in the cluster environment, and may
define alternative stellar evolutionary tracks associated with mass-transfer
episodes, mergers, and/or dynamical stellar exchanges
Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study.
Endothelial dysfunction contributes to the development of acute kidney injury (AKI) in animal models of ischemia reperfusion injury and sepsis. There are limited data on markers of endothelial dysfunction in human AKI. We hypothesized that Protein C (PC) and soluble thrombomodulin (sTM) levels could predict AKI. We conducted a multicenter prospective study in 80 patients to assess the relationship of PC and sTM levels to AKI, defined by the AKIN creatinine (AKI Scr) and urine output criteria (AKI UO). We measured marker levels for up to 10 days from intensive care unit admission. We used area under the curve (AUC) and time-dependent multivariable Cox proportional hazard model to predict AKI and logistic regression to predict mortality/non-renal recovery. Protein C and sTM were not different in patients with AKI UO only versus no AKI. On intensive care unit admission, as PC levels are usually lower with AKI Scr, the AUC to predict the absence of AKI was 0.63 (95%CI 0.44-0.78). The AUC using log10 sTM levels to predict AKI was 0.77 (95%CI 0.62-0.89), which predicted AKI Scr better than serum and urine neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C, urine kidney injury molecule-1 and liver-fatty acid-binding protein. In multivariable models, PC and urine NGAL levels independently predicted AKI (p=0.04 and 0.02) and PC levels independently predicted mortality/non-renal recovery (p=0.04). In our study, PC and sTM levels can predict AKI Scr but are not modified during AKI UO alone. PC levels could independently predict mortality/non-renal recovery. Additional larger studies are needed to define the relationship between markers of endothelial dysfunction and AKI
Superpotential de-sequestering in string models
Non-perturbative superpotential cross-couplings between visible sector matter
and K\"ahler moduli can lead to significant flavour-changing neutral currents
in compactifications of type IIB string theory. Here, we compute corrections to
Yukawa couplings in orbifold models with chiral matter localised on D3-branes
and non-perturbative effects on distant D7-branes. By evaluating a threshold
correction to the D7-brane gauge coupling, we determine conditions under which
the non-perturbative corrections to the Yukawa couplings appear. The flavour
structure of the induced Yukawa coupling generically fails to be aligned with
the tree-flavour structure. We check our results by also evaluating a
correlation function of two D7-brane gauginos and a D3-brane Yukawa coupling.
Finally, by calculating a string amplitude between n hidden scalars and visible
matter we show how non-vanishing vacuum expectation values of distant D7-brane
scalars, if present, may correct visible Yukawa couplings with a flavour
structure that differs from the tree-level flavour structure.Comment: 37 pages + appendices, 8 figure
Statistical mechanics of transcription-factor binding site discovery using Hidden Markov Models
Hidden Markov Models (HMMs) are a commonly used tool for inference of
transcription factor (TF) binding sites from DNA sequence data. We exploit the
mathematical equivalence between HMMs for TF binding and the "inverse"
statistical mechanics of hard rods in a one-dimensional disordered potential to
investigate learning in HMMs. We derive analytic expressions for the Fisher
information, a commonly employed measure of confidence in learned parameters,
in the biologically relevant limit where the density of binding sites is low.
We then use techniques from statistical mechanics to derive a scaling principle
relating the specificity (binding energy) of a TF to the minimum amount of
training data necessary to learn it.Comment: 25 pages, 2 figures, 1 table V2 - typos fixed and new references
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Woe from stones: commemoration, identity politics and Estonia's 'War of Monuments'
No abstract available
Observation of two relaxation mechanisms in transport between spin split edge states at high imbalance
Using a quasi-Corbino geometry to directly study electron transport between
spin-split edge states, we find a pronounced hysteresis in the I-V curves,
originating from slow relaxation processes. We attribute this long-time
relaxation to the formation of a dynamic nuclear polarization near the sample
edge. The determined characteristic relaxation times are 25 s and 200 s which
points to the presence of two different relaxation mechanisms. The two time
constants are ascribed to the formation of a local nuclear polarization due to
flip-flop processes and the diffusion of nuclear spins.Comment: Submitted to PR
International Guillain-Barré Syndrome Outcome Study (IGOS): protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multi-centre cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within two weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1000 patients with a follow-up of 1-3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1400 participants from 143 active centres in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modelling, treatment effects and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS. ClinicalTrials.gov Identifier: NCT01582763
Monte Carlo Methods for Estimating Interfacial Free Energies and Line Tensions
Excess contributions to the free energy due to interfaces occur for many
problems encountered in the statistical physics of condensed matter when
coexistence between different phases is possible (e.g. wetting phenomena,
nucleation, crystal growth, etc.). This article reviews two methods to estimate
both interfacial free energies and line tensions by Monte Carlo simulations of
simple models, (e.g. the Ising model, a symmetrical binary Lennard-Jones fluid
exhibiting a miscibility gap, and a simple Lennard-Jones fluid). One method is
based on thermodynamic integration. This method is useful to study flat and
inclined interfaces for Ising lattices, allowing also the estimation of line
tensions of three-phase contact lines, when the interfaces meet walls (where
"surface fields" may act). A generalization to off-lattice systems is described
as well.
The second method is based on the sampling of the order parameter
distribution of the system throughout the two-phase coexistence region of the
model. Both the interface free energies of flat interfaces and of (spherical or
cylindrical) droplets (or bubbles) can be estimated, including also systems
with walls, where sphere-cap shaped wall-attached droplets occur. The
curvature-dependence of the interfacial free energy is discussed, and estimates
for the line tensions are compared to results from the thermodynamic
integration method. Basic limitations of all these methods are critically
discussed, and an outlook on other approaches is given
Kaluza-Klein supergravity on AdS_3 x S^3
We construct a Chern-Simons type gauged N=8 supergravity in three spacetime
dimensions with gauge group SO(4) x T_\infty over the infinite dimensional
coset space SO(8,\infty)/(SO(8) x SO(\infty)), where T_\infty is an infinite
dimensional translation subgroup of SO(8,\infty). This theory describes the
effective interactions of the (infinitely many) supermultiplets contained in
the two spin-1 Kaluza-Klein towers arising in the compactification of N=(2,0)
supergravity in six dimensions on AdS_3 x S^3 with the massless supergravity
multiplet. After the elimination of the gauge fields associated with T_\infty,
one is left with a Yang Mills type gauged supergravity with gauge group SO(4),
and in the vacuum the symmetry is broken to the (super-)isometry group of AdS_3
x S^3, with infinitely many fields acquiring masses by a variant of the
Brout-Englert-Higgs effect.Comment: LaTeX2e, 24 pages; v2: references update
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