Concepções práticas no ensino da física: avaliando os efeitos metodológicos no desempenho educacional em Manaus-AM

O estudo não se restringe ao aspecto de repasse de informações, ele vai além dos campos observacionais e à medida que experimenta um aspecto prático promove mudanças que são sentidas na expressão de novas concepções. A metodologia que se aplica no contexto educacional, se bem posta, gera resultados proeminentes. Com vista nessa premissa essa proposta tem na sua excentricidade a perspectiva de trazer para o ambiente de discussão a experimentação prática, contada em três eventos que retratam a abordagem experimental investigativa para elucidar parâmetros, como meio de acionar a proposta as atividades elaboradas percorrem o campo da dialética, com a exibição da prática e o reflexo em sua explicação, sanando o víeis conceitual, a expressão da matemática e a desfragmentação das dificuldades. A proposta se pauta nas regras que direcionam os experimentos e destaca a capacidade de relacionar os dados envolvidos na problemática.   Sabe-se que a dinâmica de ensinar/aprender é um exercício mobilizador que inclui a comunidade acadêmica e a sociedade como meio de amadurecimento de ideias. A humanidade passa a convergir forças que se incumbem da evolução e que busca compreender as bases do ensino como expressão de sabedoria e a física como ciência é um elo que não se admite inalcançável, pelo contrário rege sistemas e precisa ser entendida como útil. Neste estudo se dedica a observar as concepções práticas que mobilizam as atividades da física, como um instrumento metodológico integrador. Trata-se de um estudo exploratório, com característica qualitativa que busca associar a teoria à prática, socializar o problema a sua busca de esclarecimento e também instruir para desmistificar paradigmas e dificuldades oriundos da má interpretação e aplicação dos conceitos. Como resultado se observa a necessidade de intervenção em sistemas mórbidos e tendendo ao comodismo que precisam ser acionados por elementos simples e localizados que mudam sua performance na expressão da visão cientifica

Inductor destinations and regional tourism development: an intergovernmentalism problem?

The point of this article is to understand how actions directed by a central government can undermine policies, sub-national programs and projects related to local development in the tourism context. In this sense, the main objective is to analyze the interference of a national project of tourism regionalization in the planned actions of subnational governments in the touristic cities (destinations) in Brazil. Theoretically, issues have been addressed related to Tourism Management and Public Policies. We conducted documental and field research in Brazil, specifically 16 Minas Gerais State touristic destinations, whose data were processed using the content analysis technique. It was discovered that the analyzed national project contributed to the destabilization of a current state policy and centered on regionalization, presenting an intergovernmentalism problem, with weaknesses in coordination and planning

The sooner the better: clinical and neural correlates of impulsive choice in Tourette disorder.

Reward sensitivity has been suggested as one of the central pathophysiological mechanisms in Tourette disorder. However, the subjective valuation of a reward by introduction of delay has received little attention in Tourette disorder, even though it has been suggested as a trans-diagnostic feature of numerous neuropsychiatric disorders. We aimed to assess delay discounting in Tourette disorder and to identify its brain functional correlates. We evaluated delayed discounting and its brain functional correlates in a large group of 54 Tourette disorder patients and 31 healthy controls using a data-driven approach. We identified a subgroup of 29 patients with steeper reward discounting, characterised by a higher burden of impulse-control disorders and a higher level of general impulsivity compared to patients with normal behavioural performance or to controls. Reward discounting was underpinned by resting-state activity of a network comprising the orbito-frontal, cingulate, pre-supplementary motor area, temporal and insular cortices, as well as ventral striatum and hippocampus. Within this network, (i) lower connectivity of pre-supplementary motor area with ventral striatum predicted a higher impulsivity and a steeper reward discounting and (ii) a greater connectivity of pre-supplementary motor area with anterior insular cortex predicted steeper reward discounting and more severe tics. Overall, our results highlight the heterogeneity of the delayed reward processing in Tourette disorder, with steeper reward discounting being a marker of burden in impulsivity and impulse control disorders, and the pre-supplementary motor area being a hub region for the delay discounting, impulsivity and tic severity

Sources of pro-cyclicality in east Asian financial systems

Procyclicality is a normal feature of economic systems, but financial sector weaknesses can exacerbate it sufficiently to pose a threat to macroeconomic and financial stability. These include shortcomings in bank risk management and governance, in supervision and in terms of dependence on volatile sources of funds. The paper tests econometrically for the importance of such features leading to pro-cyclicality in the financial systems of 11 East Asian countries. This analysis makes it possible to identify specific policy measures for East Asian countries that could limit the extent to which financial systems exacerbate pro-cyclicality

Inductor Destinations and Regional Tourism Development: An Intergovernmentalism Problem?

O objetivo é compreender como ações direcionadas por um governo nacional pode afetar políticas, programas e projetos de desenvolvimento local no contexto do turismo. Assim, o objetivo central é analisar a interferência de um projeto nacional de regionalização do turismo nas ações planejadas de governos subnacionais de cidades turísticas (destinos) no Brasil. Teoricamente foram abordadas questões relacionadas à Gestão Pública e ao Turismo. Realizaram -se pesquisas documental e de campo em 16 destinos turísticos do Estado de Minas Gerais - Brasil, cujos dados coletados foram tratados com a técnica de análise de conteúdo. Constatou -se que o projeto nacional analisado contribuiu para a desestabilização de uma política estadual vigente, apresentando falhas relacionadas à intergovernabilidade, como problemas de coordenação e planejamento.The point of this article is to understand how actions directed by a central government can undermine policies, sub -national programs and projects related to local development in the tourism context. In this sense, the main objective is to analyze the interference of a national project of tourism regionalization in the planned actions of subnational governments in the touristic cities (destinations) in Brazil. Theoretically, issues have been addressed related to Tourism Management and Public Policies. We conducted documental and field research in Brazil, specifically 16 Minas Gerais State touristic destinations, whose data were processed using the content analysis technique. It was discovered that the analyzed national project contributed to the destabilization of a current state policy and centered on regionalization, presenting an intergovernmentalism problem, with weaknesses in coordination and plannin

Impulsive prepotent actions and tics in Tourette disorder underpinned by a common neural network.

Tourette disorder (TD), which is characterized by motor and vocal tics, is not in general considered as a product of impulsivity, despite a frequent association with attention deficit hyperactivity disorder and impulse control disorders. It is unclear which type of impulsivity, if any, is intrinsically related to TD and specifically to the severity of tics. The waiting type of motor impulsivity, defined as the difficulty to withhold a specific action, shares some common features with tics. In a large group of adult TD patients compared to healthy controls, we assessed waiting motor impulsivity using a behavioral task, as well as structural and functional underpinnings of waiting impulsivity and tics using multi-modal neuroimaging protocol. We found that unmedicated TD patients showed increased waiting impulsivity compared to controls, which was independent of comorbid conditions, but correlated with the severity of tics. Tic severity did not account directly for waiting impulsivity, but this effect was mediated by connectivity between the right orbito-frontal cortex with caudate nucleus bilaterally. Waiting impulsivity in unmedicated patients with TD also correlated with a higher gray matter signal in deep limbic structures, as well as connectivity with cortical and with cerebellar regions on a functional level. Neither behavioral performance nor structural or functional correlates were related to a psychometric measure of impulsivity or impulsive behaviors in general. Overall, the results suggest that waiting impulsivity in TD was related to tic severity, to functional connectivity of orbito-frontal cortex with caudate nucleus and to structural changes within limbic areas

PARP-1 and YY1 Are Important Novel Regulators of CXCL12 Gene Transcription in Rat Pancreatic Beta Cells

Despite significant progress, the molecular mechanisms responsible for pancreatic beta cell depletion and development of diabetes remain poorly defined. At present, there is no preventive measure against diabetes. The positive impact of CXCL12 expression on the pancreatic beta cell prosurvival phenotype initiated this study. Our aim was to provide novel insight into the regulation of rat CXCL12 gene (Cxcl12) transcription. The roles of poly(ADP-ribose) polymerase-1 (PARP-1) and transcription factor Yin Yang 1 (YY1) in Cxcl12 transcription were studied by examining their in vitro and in vivo binding affinities for the Cxcl12 promoter in a pancreatic beta cell line by the electrophoretic mobility shift assay and chromatin immunoprecipitation. The regulatory activities of PARP-1 and YY1 were assessed in transfection experiments using a reporter vector with a Cxcl12 promoter sequence driving luciferase gene expression. Experimental evidence for PARP-1 and YY1 revealed their trans-acting potential, wherein PARP-1 displayed an inhibitory, and YY1 a strong activating effect on Cxcl12 transcription. Streptozotocin (STZ)-induced general toxicity in pancreatic beta cells was followed by changes in Cxcl12 promoter regulation. PARP-1 binding to the Cxcl12 promoter during basal and in STZ-compromised conditions led us to conclude that PARP-1 regulates constitutive Cxcl12 expression. During the early stage of oxidative stress, YY1 exhibited less affinity toward the Cxcl12 promoter while PARP-1 displayed strong binding. These interactions were accompanied by Cxcl12 downregulation. In the later stages of oxidative stress and intensive pancreatic beta cell injury, YY1 was highly expressed and firmly bound to Cxcl12 promoter in contrast to PARP-1. These interactions resulted in higher Cxcl12 expression. The observed ability of PARP-1 to downregulate, and of YY1 to upregulate Cxcl12 promoter activity anticipates corresponding effects in the natural context where the functional interplay of these proteins could finely balance Cxcl12 transcription

Kiri Prosper Merimee'le

Beranger, Pierre Jean de, 1780-1857, prantsuse poeetMerimee, Prosper, 1803-1870, prantsuse kirjanikTänab käsikirja ees