Diagnostic of the Metal-Dielectric Interface in a Collective Oscillation of Electrons

Light reflected from a dielectric- metal interface describe the existence of resonant modes of the collective oscillation in electron density. The experimental configuration proposed by Otto and Kretschmann- Raether can be used to characterizes the optical properties of thin metallic films in contact with a dielectric medium. In far-field detection, the angular dependence of the reflectivity on Ag/ ambient air shows a sharp minimum beyond attenuated total reflection. At a wavelength, λ the geometric parameters influence strongly the angular resonance θSP. In the case of Ag, λ = 633.0 nm, at the optimal thickness, d = 50.8nm, a resonant coupling is reaches between incident photons and free electrons in the angular range 45° < θSP < 46°. The angular resonance is associated with the optical phenomenon of an energetic transfer predicted theoretically.Light reflected from a dielectric- metal interface describe the existence of resonant modes of the collective oscillation in electron density. The experimental configuration proposed by Otto and Kretschmann- Raether can be used to characterizes the optical properties of thin metallic films in contact with a dielectric medium. In far-field detection, the angular dependence of the reflectivity on Ag/ ambient air shows a sharp minimum beyond attenuated total reflection. At a wavelength, λ the geometric parameters influence strongly the angular resonance θSP. In the case of Ag, λ = 633.0 nm, at the optimal thickness, d = 50.8nm, a resonant coupling is reaches between incident photons and free electrons in the angular range 45° < θSP < 46°. The angular resonance is associated with the optical phenomenon of an energetic transfer predicted theoretically

Abcès hypophysaire chez un hémodialysé chronique traité médicalement : à propos d’une observation

L’abcès hypophysaire est une pathologie rare et fatale en absence de traitement adéquat .Il est à évoquer devant un tableau clinique  d’hypertension intracrânienne, une dysrégulation hormonale hypophysaire et un contexte infectieux. Une conduite thérapeutique basée sur une  antibiothérapie pourrait être tenté si diagnostic précoce. Nous rapportons un cas d’abcès hypophysaire survenant chez un hémodialysé chronique pris en charge par une antibiothérapie seule dont l’évolution était favorable avec un recul de 2 ans

Evolution inhabituelle d’un adénofibrome mammaire A propos d'un cas et revue de la littérature

Le fibroadénome est une lésion bénigne fréquente rencontrées chez l’adolescente et la jeunefemme jeune. L’adénofibrome est une lésion épithéliale bénigne sans risque carcinologique. Lefibroadénome contenant des foyers de carcinome canalaire in situ (CCIS) sont de diagnosticdifficile. Nous illustrons un cas clinique du service, d’une patiente suivie pour mastopathiesfibrokystique, chez qui, à la suite de l’apparition d’une induration mammaire gauche, sagynécologue lui préconise de faire une mammographie et une échographie mammaire.L’imagerie standard met en évidence une masse suspecte intra mammaire gauche et une autremasse du prolongement axillaire homolatérale, connue et étiquetée adénofibrome contenantactuellement des microcalcifications.La microbiopsies des deux masses est revenue en faveur d’ un carcinome canalaire infiltrant etd’un adénofibrome avec hyperplasie canalaire avec atypie. La patiente est opérée. L’étudeanatomopathologique de la pièce opératoire retrouve un carcinome infiltrant type non spécifiquepour la masse du QSE et un fibroadénome axillaire avec un contingent épithélial colonisé pardes lésions de carcinome canalaire in situ

Effect of nitrogen level application on yield and fruit quality of Navel orange variety in a sandy soil

L’objectif de cet essai est d'évaluer l'effet de la dose d'azote sur le rendement et la qualité des fruits et de déterminer la dose optimale en azote pour les arbres de l’orange Navel greffé sur le porte-greffe citrange Troyer planté en 1964 en plein champ à un espacement de 7mx7m (204 arbres/ha) au niveau de la station expérimentale d’El Menzeh, INRA Maroc. Le dispositif adopté est un bloc aléatoire complet avec trois blocs rangés en 4 arbres consécutifs par bloc sur la même ligne. Quatre doses de N ont été testés : (T0 (Témoin) : 0, T1 : 100, T2 : 200, T3 : 300 Kg N/ha). Les paramètres mesurés sont : le calibre des fruits, le poids moyen par fruit, la qualité des fruits (le rendement en jus, l’acidité du jus, l’extrait sec soluble (ESS ou °Brix) et l’indice de maturité (E/A)) et le rendement en fruits. Le rendement en fruits, le poids moyen des fruits, le calibre des fruits, l’extrait sec soluble (TSS), l'acidité du jus et l'indice de maturité de l’orange Navel ont répondu significativement à l’augmentation de la dose d’azote. Le rendement en kg de fruits/arbre a été considérablement amélioré avec l'augmentation de la dose d'azote. Par ailleurs, les rendements les plus élevés (129.21 et 139.82 kg/arbre) ont été enregistrés sous les traitements T2 et T3 respectivement. Par contre, le rendement en fruits/arbre le plus faible a été obtenu chez les arbres non fertilisés (témoin). Le poids des fruits (268.54 et 276.50g) et la taille des fruits (78.94 et 80.87 mm) les plus élevés ont été enregistrés avec les même traitements T2 et T3 respectivement. La teneur totale en sucre soluble (TSS) la plus élevée a été enregistrée chez les arbres des traitements T2 et T3 (12.20 et 11.70 °Brix respectivement). Par ailleurs, une augmentation significative de l'acidité du jus de fruits de l’orange Navel a été également enregistrée en augmentant la dose d’azote. L'acidité la plus élevée a été obtenue par les mêmes traitements T2 et T3 (1,13 et 1.20 % respectivement). L’application de 200 Kg de N /ha a permis d’avoir un rendement maximal et une qualité optimale des fruits des oranges Navel greffés sur le porte-greffe citrange Troyer sur un sol sableux dans la région de Gharb.The objective of the present paper was to evaluate the effect of nitrogen level on yield and fruit quality of citrus and to determine the optimum N fertilizer rates of Navel orange variety budded on Troyer citrange rootstock in field conditions. The orange Navel orchard spaced 7mx7m (204 trees/ha) grown in 1964 on a sandy soil at the experimental station of El Menzeh, INRA Morocco. The experiment was set up in a complete randomized block design with three blocks and the experimental unit was composed on 4 consecutive trees in the row. Four fertilization treatments of N (Kg/ha) (T0 (control): 0, T1: 100, T2: 200, T3: 300) were applied to Navel citrus tree in field conditions over two seasons 2012-2013 and 2013-2014.Fruit yield, fruit weight, fruit size, total soluble sugar (TSS) content, acidity of juice and maturity index of Navel orange were significantly affected by increasing N level. Fruit yield/tree was improved significantly with increase in N rate. Significant highest yields (129.21 and 139.82. kg/tree) were recorded under treatments T2 and T3 respectively. The lowest fruit yield/tree was obtained from untreated control plot. Maximum fruit weight (268.54 and 276.50 g) and fruit size (78.94 and 80.87 mm) was recorded with the same treatments T2 and T3 respectively. Total soluble sugar content was also maximum in trees receiving treatment (T2) and treatment (T3) 12.20 and 11.70°Brix respectively. Significant increase in acidity of juice of fruit Navel orange was also recorded by increasing the rate of N. The highest acidity (1.13 and 1.20%) was achieved by the same treatments T2 and T3 respectively. Two-year studies showed that application of fertilizers at the rate of 200 Kg N/ha would be optimum for achieving higher yield and better fruit quality of Navel orange variety in sandy soil in Gharb area

Comparative evaluation of surface quality, tool wear, and specific cutting energy for wiper and conventional carbide inserts in hard turning of aisi 4340 alloy steel

This paper presents an experimental study into the comparative response of wiper and round-nose conventional carbide inserts coated with TiCN + AL$_{2}$O$_{3}$ + TiN when turning an AISI 4340 steel alloy. The optimal process parameters, as identified by pre-experiments, were used for both types of inserts to determine the machined surface quality, tool wear, and specific cutting energy for different cutting lengths. The wiper inserts provided a substantial improvement in the attainable surface quality compared with the results obtained using conventional inserts under optimal cutting conditions for the entire range of the machined lengths. In addition, the conventional inserts showed a dramatic increase in roughness with an increased length of the cut, while the wiper inserts showed only a minor increase for the same length of cut. A scanning electron microscope was used to examine the wear for both types of inserts. Conventional inserts showed higher trends for both the average and maximum flank wear with cutting length compared to the wiper inserts, except for lengths of 200–400 mm, where conventional inserts showed less average flank wear. A higher accumulation of deposited chips was observed on the flank face of the wiper inserts than the conventional inserts. The experimental results demonstrated that edge chipping was the chief tool wear mechanism on the rake face for both types of insert, with more edge chipping observed in the case of the conventional inserts than the wiper inserts, with negligible evidence of crater wear in either case. The wiper inserts were shown to have a higher specific cutting energy than those detected with conventional inserts. This was attributed to (i) the irregular nose feature of the wiper inserts differing from the simpler round nose geometry of the conventional inserts and (ii) a higher tendency of chip accumulation on the wiper inserts

The accumulation of assembly intermediates of the mitochondrial complex I matrix arm is reduced by limiting glucose uptake in a neuronal-like model of MELAS syndrome

Ketogenic diet (KD) which combined carbohydrate restriction and the addition of ketone bodies has emerged as an alternative metabolic intervention used as an anticonvulsant therapy or to treat different types of neurological or mitochondrial disorders including MELAS syndrome. MELAS syndrome is a severe mitochondrial disease mainly due to the m.3243A &gt; G mitochondrial DNA mutation. The broad success of KD is due to multiple beneficial mechanisms with distinct effects of very low carbohydrates and ketones. To evaluate the metabolic part of carbohydrate restriction, transmitochondrial neuronal-like cybrid cells carrying the m.3243A &gt; G mutation, shown to be associated with a severe complex I deficiency was exposed during 3 weeks to glucose restriction. Mitochondrial enzyme defects were combined with an accumulation of complex I (CI) matrix intermediates in the untreated mutant cells, leading to a drastic reduction in CI driven respiration. The severe reduction of CI was also paralleled in post-mortem brain tissue of a MELAS patient carrying high mutant load. Importantly, lowering significantly glucose concentration in cell culture improved CI assembly with a significant reduction of matrix assembly intermediates and respiration capacities were restored in a sequential manner. In addition, OXPHOS protein expression and mitochondrial DNA copy number were significantly increased in mutant cells exposed to glucose restriction. The accumulation of CI matrix intermediates appeared as a hallmark of MELAS pathophysiology highlighting a critical pathophysiological mechanism involving CI disassembly, which can be alleviated by lowering glucose fuelling and the induction of mitochondrial biogenesis, emphasizing the usefulness of metabolic interventions in MELAS syndrome

No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies

Aim: In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies (Hu-PNS), Hu antigens expressed by the tumour hypothetically trigger an immune response that also reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain more insight into the hypothesized CD8+T cell-mediated immune pathogenesis of these syndromes, we searched for circulating HuD-specific CD8+T cells in a large cohort of Hu-PNS patients and controls. Patients and methods: Blood was tested from 43 Hu-PNS patients, 31 Hu antibody negativ