A Study of the Production of Neutrons for Boron Neutron Capture Therapy using a Proton Accelerator

Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy particularly well-suited to treating aggressive tumours that exhibit a high degree of infiltration of the surrounding healthy tissue. Such tumours, for example of the brain and lung, provide some of the most challenging problems in oncology. The first element of the therapy is boron-10 which is preferentially introduced into the cancerous cells using a carrier compound. Boron-10 has a very high capture cross-section with the other element of the therapy, thermal neutrons, resulting in the production of a lithium nucleus and an alpha particle which destroy the cell they are created in. However, a large flux of neutrons is required and until recently the only source used was a nuclear reactor. In Birmingham, studies of an existing BNCT facility using a 2.8 MeV proton beam and a solid lithium target have found a way to increase the beam power to a sufficient level to allow clinical trials, while maintaining the target solid. In this paper, we will introduce BNCT, describe the work in Birmingham and compare with other accelerator-driven BNCT projects around the World

Overview of Solid Target Studies for a Neutrino Factory

The UK pro­gramme of high power tar­get de­vel­op­ments for a Neu­tri­no Fac­to­ry is cen­tred on the study of high-Z ma­te­ri­als (tung­sten, tan­ta­lum). A de­scrip­tion of life­time shock tests on can­di­date ma­te­ri­als is given as part of the re­search into a solid tar­get so­lu­tion. A fast high cur­rent pulse is ap­plied to a thin wire of the sam­ple ma­te­ri­al and the life­time mea­sured from the num­ber of puls­es be­fore fail­ure. These mea­sure­ments are made at tem­per­a­tures up to ~2000 K. The stress on the wire is cal­cu­lat­ed using the LS-DY­NA code and com­pared to the stress ex­pect­ed in the real Neu­tri­no Fac­to­ry tar­get. It has been found that tan­ta­lum is too weak to sus­tain pro­longed stress at these tem­per­a­tures but a tung­sten wire has reached over 26 mil­lion puls­es (equiv­a­lent to more than ten years of op­er­a­tion at the Neu­tri­no Fac­to­ry). An ac­count is given of the op­ti­mi­sa­tion of sec­ondary pion pro­duc­tion from the tar­get and the is­sues re­lat­ed to mount­ing the tar­get in the muon cap­ture solenoid and tar­get sta­tion are dis­cussed

Tungsten Behavior at High Temperature and High Stress

Re­cent­ly re­port­ed re­sults on the tung­sten life­time/fa­tigue tests under con­di­tions ex­pect­ed in the Neu­tri­no Fac­to­ry tar­get have strength­ened the case of solid tar­get op­tion for a Neu­tri­no Fac­to­ry. This paper gives de­scrip­tion of the de­tailed mea­sure­ments of the tung­sten prop­er­ties at high tem­per­a­ture and high stress. We have per­formed ex­ten­sive set of mea­sure­ments of the sur­face dis­place­ment and ve­loc­i­ty of the tung­sten wires that were stressed by pass­ing a fast, high cur­rent pulse through a thin sam­ple. Ra­di­al and lon­gi­tu­di­nal os­cil­la­tions of the wire were mea­sured by a Laser Doppler Vi­brom­e­ter. The wire was op­er­at­ed at tem­per­a­tures of 300-2500 K by ad­just­ing the pulse rep­e­ti­tion rate. In doing so we have tried to sim­u­late the con­di­tions (high stress and tem­per­a­ture) ex­pect­ed at the Neu­tri­no Fac­to­ry. Most im­por­tant re­sult of this study is an ex­per­i­men­tal con­fir­ma­tion that strength of tung­sten re­mains high at high tem­per­a­ture and high stress. The ex­per­i­men­tal re­sults have been found to agree very well with LS-DY­NA mod­elling re­sults

A 15-T Pulsed Solenoid for a High-Power Target Experiment

The MERIT experiment, which ran at CERN in 2007, is a proof-of-principle test for a target system that converts a 4-MW proton beam into a high-intensity muon beam for either a neutrino factory complex or a muon collider. The target system is based on a free mercury jet that intercepts an intense proton beam inside a 15-T solenoidal magnetic field. Here, we describe the design and performance of the 15-T, liquid-nitrogen-precooled, copper solenoid magnet

Proposal for a Joint German-British Interferometric Gravitational Wave Detector

For many years there has been steady progress towards the detection of gravitational radiation. It has now become clear that the next major step should be the construction of a number of long-baseline detectors around the world. An array of detectors of this type is expected to allow the observation of gravitational waves from a range of astrophysical sources, leading to improved insight in many areas including stellar collapse, binary coalescence and the expansion of the Universe. We propose that one of these detectors be built by a collaboration formed around the gravitational wave groups in Britain and Germany. In this document we present our case for this collaborative venture and outline the design philosophy of our proposed instrument - an interferometric detector with arms of length close to 3km. Two detectors of the same general type are planned for the USA (LIGO project), one is planned for Italy (Italian/French VIRGO project) and another is proposed for Australia (AIGO project). It is expected that all the long baseline detectors to be built will operate as part of a coordinated worldwide network

Overview of Solid Target Studies for a Neutrino Factory

The UK pro­gramme of high power tar­get de­vel­op­ments for a Neu­tri­no Fac­to­ry is cen­tred on the study of high-Z ma­te­ri­als (tung­sten, tan­ta­lum). A de­scrip­tion of life­time shock tests on can­di­date ma­te­ri­als is given as part of the re­search into a solid tar­get so­lu­tion. A fast high cur­rent pulse is ap­plied to a thin wire of the sam­ple ma­te­ri­al and the life­time mea­sured from the num­ber of puls­es be­fore fail­ure. These mea­sure­ments are made at tem­per­a­tures up to ~2000 K. The stress on the wire is cal­cu­lat­ed using the LS-DY­NA code and com­pared to the stress ex­pect­ed in the real Neu­tri­no Fac­to­ry tar­get. It has been found that tan­ta­lum is too weak to sus­tain pro­longed stress at these tem­per­a­tures but a tung­sten wire has reached over 26 mil­lion puls­es (equiv­a­lent to more than ten years of op­er­a­tion at the Neu­tri­no Fac­to­ry). An ac­count is given of the op­ti­mi­sa­tion of sec­ondary pion pro­duc­tion from the tar­get and the is­sues re­lat­ed to mount­ing the tar­get in the muon cap­ture solenoid and tar­get sta­tion are dis­cussed

Development of a higher power cooling system for lithium targets

The accelerator based Boron Neutron Capture Therapy beam at the University of Birmingham is based around a solid thick lithium target cooled by heavy water. Significant upgrades to Birmingham's Dynamitron accelerator are planned prior to commencing a clinical trial. These upgrades will result in an increase in maximum achievable beam current to at least 3 mA. Various upgrades to the target cooling system to cope with this increased power have been investigated. Tests of a phase change coolant known as “binary ice” have been carried out using an induction heater to provide a comparable power input to the Dynamitron beam. The experimental data shows no improvement over chilled water in the submerged jet system, with both systems exhibiting the same heat input to target temperature relation for a given flow rate. The relationship between the cooling circuit pumping rate and the target temperature in the submerged jet system has also been tested