Living Alone: Cognitive Aging In Tennessee

Living alone in old age is increasingly common. In the United States, the percentage of older adults living alone has more than quadrupled since the 1900s. “In 2014, 26% of older adults lived alone, representing 12.5 million people” (Portacolone et al., 2018). Those who live alone experience different aspects of aging, whether that be socially, cognitively, or physically. The data we used was gathered by mySidewalk, which offered over 600 points of data, aggregated at the zip code level, from across the entire state of Tennessee. The variables we examined more closely included Seniors in Family Households of 2 or More , Seniors Living Alone, and Seniors in Non-Family Households of Two or More , and “Poor Mental Health in Adults (2021)”. We examined whether living alone would have a negative effect on various aspects of health, specifically mental health. This study offers a more in-depth look of how there is a rising population of women living alone due to divorce and being widowed. Additionally, living alone doesn’t indicate positive mental health. There are still cognitive and even physical risks from isolated living that efforts should be made to mitigate. Also, previous literature indicates more women live alone, but studies show more data on elderly men. Lastly, mental health awareness movements emphasize teenagers and young adults, but the emotional health of adults has less attention as their ages increase. Our results indicate a notable negative effect on emotional and mental health regarding isolated living, indicating that additional attention should be provided to any older adults who are currently living alone. Further research in this area could investigate specific facets of emotional satisfaction seen in older adults with these circumstances to better understand the specific degree of cognitive decline caused by the lack of regular social interaction

Quantitative method for the assignment of hinge and shear mechanism in protein domain movements

Motivation: A popular method for classification of protein domain movements apportions them into two main types: those with a ‘hinge’ mechanism and those with a ‘shear’ mechanism. The intuitive assignment of domain movements to these classes has limited the number of domain movements that can be classified in this way. Furthermore, whether intended or not, the term ‘shear’ is often interpreted to mean a relative translation of the domains. Results: Numbers of occurrences of four different types of residue contact changes between domains were optimally combined by logistic regression using the training set of domain movements intuitively classified as hinge and shear to produce a predictor for hinge and shear. This predictor was applied to give a 10-fold increase in the number of examples over the number previously available with a high degree of precision. It is shown that overall a relative translation of domains is rare, and that there is no difference between hinge and shear mechanisms in this respect. However, the shear set contains significantly more examples of domains having a relative twisting movement than the hinge set. The angle of rotation is also shown to be a good discriminator between the two mechanisms. Availability and implementation: Results are free to browse at http:// www.cmp.uea.ac.uk/dyndom/interface/. Supplementary information: Supplementary data are available at Bioinformatics online

Lindsay Anderson and the Legacy of Free Cinema

Accepting that Free Cinema’s legacy has been found on British cinema and television screens in the work of directors other than Lindsay Anderson, this article investigates whether Anderson’s own films and television programmes made after the mid-1970s (including not only those that were released but others that were not completed) reveal a continuing commitment to what he liked to call the Free Cinema ‘tradition’ of film-making. In so doing it draws critical attention to Anderson’s lesser known later works such as The Old Crowd, Is That All There Is?, In Celebration, The Whales of August and Glory! Glory! as well as to unmade projects such as The Grand Babylon Hotel, Dress Gray, Vile Bodies, Empire and If (2). . .

No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a.

BackgroundNo evidence of disease activity (NEDA; defined as no 12-week confirmed disability progression, no protocol-defined relapses, no new/enlarging T2 lesions and no T1 gadolinium-enhancing lesions) using a fixed-study entry baseline is commonly used as a treatment outcome in multiple sclerosis (MS).ObjectiveThe objective of this paper is to assess the effect of ocrelizumab on NEDA using re-baselining analysis, and the predictive value of NEDA status.MethodsNEDA was assessed in a modified intent-to-treat population (n = 1520) from the pooled OPERA I and OPERA II studies over various epochs in patients with relapsing MS receiving ocrelizumab (600 mg) or interferon beta-1a (IFN β-1a; 44 μg).ResultsNEDA was increased with ocrelizumab vs IFN β-1a over 96 weeks by 75% (p < 0.001), from Week 0‒24 by 33% (p < 0.001) and from Week 24‒96 by 72% (p < 0.001). Among patients with disease activity during Weeks 0‒24, 66.4% vs 24.3% achieved NEDA during Weeks 24‒96 in the ocrelizumab and IFN β-1a groups (relative increase: 177%; p < 0.001).ConclusionSuperior efficacy with ocrelizumab compared with IFN β-1a was consistently seen in maintaining NEDA status in all epochs evaluated. By contrast with IFN β-1a, the majority of patients with disease activity early in the study subsequently attained NEDA status with ocrelizumab

Geometric Parameterization of J/ΨJ/\Psi Absorption in Heavy Ion Collisions

We calculate the survival probability of $J/\Psi$ particles in various colliding systems using a Glauber model. An analysis of recent data has reported a $J/\Psi$-nucleon breakup cross section of 6.2$\pm$0.7 mb derived from an exponential fit to the ratio of $J/\Psi$ to Drell-Yan yields as a function of a simple, linearly-averaged mean path length through the nuclear medium. Our calculations indicate that, due to the nature of the calculation, this approach yields an apparent breakup cross section which is systematically lower than the actual value.Comment: LaTex, 7 pages, 2 figure

Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis

Streptococcus pneumoniae is responsible for diseases causing major global public health problems, including meningitis, pneumonia and septicaemia. Despite recent advances in antimicrobial therapy, pneumococcal meningitis remains a life-threatening disease. Furthermore, long-term sequelae are a major concern for survivors. Hence, a better understanding of the processes occurring in the central nervous system is crucial to the development of more effective management strategies. We used mass spectrometry based quantitative proteomics to identify protein changes in cerebrospinal fluid from children with Streptococcus pneumoniae infection, compared with children admitted to hospital with bacterial meningitis symptoms but negative diagnosis. Samples were analysed, by label free proteomics, in two independent cohorts (cohort 1: cases (n = 8) and hospital controls (n = 4); cohort 2: cases (n = 8), hospital controls (n = 8)). Over 200 human proteins were differentially expressed in each cohort, of which 65% were common to both. Proteins involved in the immune response and exosome signalling were significantly enriched in the infected samples. For a subset of proteins derived from the proteome analysis, we corroborated the proteomics data in a third cohort (hospital controls (n = 15), healthy controls (n = 5), cases (n = 20)) by automated quantitative western blotting, with excellent agreement with our proteomics findings. Proteomics data are available via ProteomeXchange with identifier PXD004219

Covariance of Antiproton Yield and Source Size in Nuclear Collisions

We confront for the first time the widely-held belief that combined event-by-event information from quark gluon plasma signals can reduce the ambiguity of the individual signals. We illustrate specifically how the measured antiproton yield combined with the information from pion-pion HBT correlations can be used to identify novel event classes.Comment: 8 pages, 5 figures, improved title, references and readability; results unchange

Tackling Systematic Errors in Quantum Logic Gates with Composite Rotations

We describe the use of composite rotations to combat systematic errors in single qubit quantum logic gates and discuss three families of composite rotations which can be used to correct off-resonance and pulse length errors. Although developed and described within the context of NMR quantum computing these sequences should be applicable to any implementation of quantum computation.Comment: 6 pages RevTex4 including 4 figures. Will submit to Phys. Rev.