Endogenous R&D Investment and Market Structure: A Case Study of the Agricultural Biotechnology Industry

Over the past three decades, the agricultural biotechnology sector has been characterized by rapid innovation, market consolidation, and a more exhaustive definition of property rights. The industry attributes consistently identified by the literature and important to this analysis include: (i) endogenous sunk costs in the form of expenditures on R&D; (ii) seed and agricultural chemical technologies that potentially act as complements within firms and substitutes across firms; and (iii) property rights governing plant and seed varieties that have become more clearly defined since the 1970s. This paper adds to the stylized facts of the agricultural biotechnology industry to include the ability of firms to license technology, a phenomenon observed only recently in the market as licensing was previously precluded by high transactions costs and “anti-stacking” provisions. We extend Sutton's theoretical framework of endogenous sunk costs and market structure to incorporate the ability of firms to license technology under well-defined property rights, an observed characteristic not captured in previous analyses of the sector. Our model implies that technology licensing leads to lower levels of industry concentration then what would be found under Sutton's model, but that industry concentration remains bounded away from perfect competition as market size becomes large.licensing, market structure, R&D, agricultural biotechnology, Research and Development/Tech Change/Emerging Technologies, L22, L24, Q16,

Approximate Approaches for Nuclear Weak Interaction Rates in Astrophysics

Nuclear weak interactions, like beta decay, are important inputs for modeling astrophysical explosions. In the allowed approximation, these processes proceed as Fermi or Gamow Teller (GT) processes where the spins of the electron and neutrino are anti-parallel or parallel, respectively. In the GT case, transition probability is spread over many final states in the daughter nucleus, with each probability determination requiring numerical integration of the available phase space. Developing a fast and accurate method for calculating each contribution to the total decay rate would provide reliable weak rate libraries for astrophysical modelers. The phase space integrand includes the classical statistical factor, a Coulomb correction, and the Fermi Dirac distribution of continuum electrons in the stellar material. In this paper, we specifically examine the phase space integration and discuss various approximations to the Coulomb correction, comparing computational speed and numerical accuracy. An approximate approach that is fast and accurate is introduced

Bovine Rhinitis Viruses Are Common in US Cattle with Bovine Respiratory Disease

Citation: Hause, B. M., Collin, E. A., Anderson, J., Hesse, R. A., & Anderson, G. (2015). Bovine Rhinitis Viruses Are Common in US Cattle with Bovine Respiratory Disease. Plos One, 10(3), 12. doi:10.1371/journal.pone.0121998Bovine rhinitis viruses (BRV) are established etiological agents of bovine respiratory disease complex however little research into their epidemiology and ecology has been published for several decades. In the U.S., only bovine rhinitis A virus 1 (BRAV1) has been identified while bovine rhinitis A virus 2 (BRAV2) and bovine rhinitis B virus (BRBV) were previously only identified in England and Japan, respectively. Metagenomic sequencing of a nasal swab from a bovine respiratory disease (BRD) diagnostic submission from Kansas identified contigs with approximately 90% nucleotide similarity to BRAV2 and BRBV. A combination of de novo and templated assemblies using reference genomes yielded near complete BRAV2 and BRBV genomes. The near complete genome of bovine rhinitis A virus 1 (BRAV1) was also determined from a historical isolate to enable further molecular epidemiological studies. A 5'-nuclease reverse transcription PCR assay targeting the 3D polymerase gene was designed and used to screen 204 archived BRD clinical specimens. Thirteen (6.4%) were positive. Metagenomic sequencing of six positive samples identified mixed BRAV1/BRAV2, BRAV1/BRBV and BRAV2/BRBV infections for five samples. One sample showed infection only with BRAV1. Seroprevalence studies using a cell culture adapted BRBV found immunofluorescence assay-reactive antibodies were common in the herds analyzed. Altogether, these results demonstrate that BRV infections are common in cattle with respiratory disease and that BRAV1, BRAV2 and BRBV co-circulate in U.S. cattle and have high similarity to viruses isolated more than 30 years ago from diverse locations

Single-qubit unitary gates by graph scattering

We consider the effects of plane-wave states scattering off finite graphs, as an approach to implementing single-qubit unitary operations within the continuous-time quantum walk framework of universal quantum computation. Four semi-infinite tails are attached at arbitrary points of a given graph, representing the input and output registers of a single qubit. For a range of momentum eigenstates, we enumerate all of the graphs with up to $n=9$ vertices for which the scattering implements a single-qubit gate. As $n$ increases, the number of new unitary operations increases exponentially, and for $n>6$ the majority correspond to rotations about axes distributed roughly uniformly across the Bloch sphere. Rotations by both rational and irrational multiples of $\pi$ are found.Comment: 8 pages, 7 figure

Short versus long silver nanowires: a comparison of in vivo pulmonary effects post instillation.

BackgroundSilver nanowires (Ag NWs) are increasingly being used to produce touchscreens for smart phones and computers. When applied in a thin film over a plastic substrate, Ag NWs create a transparent, highly-conductive network of fibers enabling the touch interface between consumers and their electronics. Large-scale application methods utilize techniques whereby Ag NW suspensions are deposited onto substrates via droplets. Aerosolized droplets increase risk of occupational Ag NW exposure. Currently, there are few published studies on Ag NW exposure-related health effects. Concerns have risen about the potential for greater toxicity from exposure to high-aspect ratio nanomaterials compared to their non-fibrous counterparts. This study examines whether Ag NWs of varying lengths affect biological responses and silver distribution within the lungs at different time-points.MethodsTwo different sizes of Ag NWs (2 μm [S-Ag NWs] and 20 μm [L-Ag NWs]) were tested. Male, Sprague-Dawley rats were intratracheally instilled with Ag NWs (0, 0.1, 0.5, or 1.0 mg/kg). Broncho-alveolar lavage fluid (BALF) and lung tissues were obtained at 1, 7, and 21 days post exposure for analysis of BAL total cells, cell differentials, and total protein as well as tissue pathology and silver distribution.Results and conclusionsThe two highest doses produced significant increases in BAL endpoints. At Day 1, Ag NWs increased total cells, inflammatory polymorphonuclear cells (PMNs), and total protein. PMNs persisted for both Ag NW types at Day 7, though not significantly so, and by Day 21, PMNs appeared in line with sham control values. Striking histopathological features associated with Ag NWs included 1) a strong influx of eosinophils at Days 1 and 7; and 2) formation of Langhans and foreign body giant cells at Days 7 and 21. Epithelial sloughing in the terminal bronchioles (TB) and cellular exudate in alveolar regions were also common. By Day 21, Ag NWs were primarily enclosed in granulomas or surrounded by numerous macrophages in the TB-alveolar duct junction. These findings suggest short and long Ag NWs produce pulmonary toxicity; thus, further research into exposure-related health effects and possible exposure scenarios are necessary to ensure human safety as Ag NW demand increases

Germline PTPRD mutations in Ewing sarcoma: biologic and clinical implications.

Ewing sarcoma occurs in children, adolescents and young adults. High STAT3 levels have been reported in approximately 50% of patients with Ewing sarcoma, and may be important in tumorigenesis. Protein tyrosine phosphatase delta (PTPRD) is a tumor suppressor that inhibits STAT3 activation. To date, while somatic mutations in PTPRD have been reported in diverse tumors, germline mutations of PTPRD have not been investigated in Ewing sarcoma or other cancers. We identified a novel germline mutation in the PTPRD gene in three of eight patients (37.5%) with metastatic Ewing sarcoma. Although the functional impact in two of the patients is unclear, in one of them the aberration was annotated as a W775stop germline mutation, and would be expected to lead to gene truncation and, hence, loss of the STAT3 dephosphorylation function of PTPRD. Since STAT3 is phosphorylated after being recruited to the insulin growth factor receptor (IGF-1R), suppression of IGF-1R could attenuate the enhanced STAT3 activation expected in the presence of PTPRD mutations. Of interest, two of three patients with germline PTPRD mutations achieved durable complete responses following treatment with IGF-1R monoclonal antibody-based therapies. Our pilot data suggest that PTPRD germline mutations may play a role in the development of Ewing sarcoma, a disease of young people, and their presence may have implications for therapy

Environmental benefits of chemical propulsion

This paper identifies the necessity of chemical propulsion to satellite usage and some of the benefits accrued through monitoring global resources and patterns, including the Global Climate Change Model (GCM). The paper also summarized how the satellite observations are used to affect national and international policies. Chemical propulsion, like all environmentally conscious industries, does provide limited, controlled pollutant sources through its manufacture and usage. However, chemical propulsion is the sole source which enables mankind to launch spacecraft and monitor the Earth. The information provided by remote sensing directly affects national and international policies designed to protect the environment and enhance the overall quality of life on Earth. The resultant of chemical propulsion is the capability to reduce overall pollutant emissions to the benefit of mankind

Circumstellar discs in Galactic centre clusters: Disc-bearing B-type stars in the Quintuplet and Arches clusters

We investigate the circumstellar disc fraction as determined from L-band excess observations of the young, massive Arches and Quintuplet clusters residing in the central molecular zone of the Milky Way. The Quintuplet cluster was searched for L-band excess sources for the first time. We find a total of 26 excess sources in the Quintuplet cluster and 21 in the Arches cluster, of which 13 are new detections. With the aid of proper motion membership samples, the disc fraction of the Quintuplet cluster was derived for the first time to be 4.0 +/- 0.7%. There is no evidence for a radially varying disc fraction in this cluster. In the case of the Arches cluster, a disc fraction of 9.2 +/- 1.2% approximately out to the cluster's predicted tidal radius, r < 1.5 pc, is observed. This excess fraction is consistent with our previously found disc fraction in the cluster in the radial range 0.3 < r < 0.8 pc. In both clusters, the host star mass range covers late A- to early B-type stars, 2 < M < 15 Msun, as derived from J-band photospheric magnitudes. We discuss the unexpected finding of dusty circumstellar discs in these UV intense environments in the context of primordial disc survival and formation scenarios of secondary discs. We consider the possibility that the L-band excess sources in the Arches and Quintuplet clusters could be the high-mass counterparts to T Tauri pre-transitional discs. As such a scenario requires a long pre-transitional disc lifetime in a UV intense environment, we suggest that mass transfer discs in binary systems are a likely formation mechanism for the B-star discs observed in these starburst clusters.Comment: 47 pages, 22 figures, accepted by A&

Regulation of DNA Synthesis: The Identification of New Drosophila melanogaster Cdc7 Regulatory Subunits

Cell division cycle 7 (Cdc7) is an enzyme required for the initiation of DNA replication. Cdc7 cannot act alone requiring the binding of its regulatory subunit Dbf4 to perform its enzymatic function. Previous studies show that Dbf4 and Cdc7 are well conserved across eukaryotic organisms. Humans and Xenopus have multiple Cdc7 regulatory subunits, and recent studies suggest that Drosophila melanogaster might as well. Human Dbf4 was discovered because of its similarity to yeast Dbf4. It is possible that finding additional Cdc7 regulatory subunits in D. melanogaster could reveal related proteins in humans. As cancer is a disease caused by improper cell cycling, furthering our understanding of Cdc7 and the cell cycle regulation could lead to advances in cancer treatment. This study seeks to identify possible Cdc7 regulatory subunits by screening for D. melanogaster proteins that directly interact with Cdc7. The first goal was to use a Yeast 2-Hybrid assay to repeat results that indicated an interaction between Cdc7 and Drosophila Dbf4, known as Chiffon. This allowed for testing media and the effectiveness of the assay. While not preformed yet, screening will be completed using a Yeast 2-Hybrid assay to determine interactions between Cdc7 and proteins from a D. melanogaster cDNA library. Further testing will remove false positives. Any remaining plasmids be sequenced and identified by the sequence comparison software, BLAST. Our study will test for D. melanogaster proteins that interact with Cdc7, but once these proteins are found further experimentation will be required to confirm interaction and function with Cdc7