5,604 research outputs found
The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health
Our study reported significant findings of a âsocial genomeâ that can be quantified and studied to understand human health and behavior. In a national sample of more than 5,000 American adolescents, we found evidence of social forces that act to make friends and schoolmates more genetically similar to one another compared with random pairs of unrelated individuals. This subtle genetic similarity was observed across the entire genome and at sets of genomic locations linked with specific traitsâeducational attainment and body mass indexâa phenomenon we term âsocialâgenetic correlation.â We also find evidence of a âsocialâgenetic effectâ such that the genetics of a personâs friends and schoolmates influenced their own education, even after accounting for the personâs own genetics
Degenerate dispersive equations arising in the study of magma dynamics
An outstanding problem in Earth science is understanding the method of
transport of magma in the Earth's mantle. Models for this process, transport in
a viscously deformable porous media, give rise to scalar degenerate,
dispersive, nonlinear wave equations. We establish a general local
well-posedness for a physical class of data (roughly ) via fixed point
methods. The strategy requires positive lower bounds on the solution. This is
extended to global existence for a subset of possible nonlinearities by making
use of certain conservation laws associated with the equations. Furthermore, we
construct a Lyapunov energy functional, which is locally convex about the
uniform state, and prove (global in time) nonlinear dynamic stability of the
uniform state for any choice of nonlinearity. We compare the dynamics to that
of other problems and discuss open questions concerning a larger range of
nonlinearities, for which we conjecture global existence.Comment: 27 Pages, 7 figures are not present in this version. See
http://www.columbia.edu/~grs2103/ for a PDF with figures. Submitted to
Nonlinearit
The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation
We thank Manuel Kulagin for technical help, Pierre Bonnaventure for portal vein blood sampling, Francisco Sepulveda for technical assistance in GS-MS acquisition, and Dorothee Hahne (Metabolomics Australia, University of Western Australia) for human samples SCFA isolation, acquisition, and analysis. We also thank Cristina Cartoni (Phenotyping Unit, EPFL) for Milliplex analysis, Jessica Dessimoz and her team from the Histology Core Facility (EPFL), Miguel Garcia and his team from the Flow Cytometry Core Facility (EPFL), and staff from the EPFL CPG animal house for excellent animal care. The computations were partially performed at the Vital-IT Center for high-performance computing of the SIB Swiss Institute of Bioinformatics (http://www.vital-it.ch). The research leading to these results has received funding from the European Research Council under the European Unionâs Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement n. 310948. Funding for A.W.W. and a subset of the 16S rRNA gene sequencing was provided by the Wellcome Trust (grant number WT 098051). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
Erratum: Testing the key assumption of heritability estimates based on genome-wide genetic relatedness
Comparing genetic and phenotypic similarity among unrelated individuals seems a promising way to quantify the genetic component of traits while avoiding the problematic assumptions plaguing twin- and other kin-based estimates of heritability. One approach uses a Genetic Relatedness Estimation through Maximum Likelihood (GREML) model for individuals who are related at less than .025 to predict their phenotypic similarity by their genetic similarity. Here we test the key underlying assumption of this approach: that genetic relatedness is orthogonal to environmental similarity. Using data from the Health and Retirement Study (and two other surveys), we show two unrelated individuals may be more likely to have been reared in a similar environment (urban versus non-urban setting) if they are genetically similar. This effect is not eliminated by controls for population structure. However, when we include this environmental confound in GREML models, heritabilities do not change substantially and thus potential bias in estimates of most biological phenotypes is probably minimal
Observational Constraints on Red and Blue Helium Burning Sequences
We derive the optical luminosity, colors, and ratios of the blue and red
helium burning (HeB) stellar populations from archival Hubble Space Telescope
observations of nineteen starburst dwarf galaxies and compare them with
theoretical isochrones from Padova stellar evolution models across
metallicities from Z=0.001 to 0.009. We find that the observational data and
the theoretical isochrones for both blue and red HeB populations overlap in
optical luminosities and colors and the observed and predicted blue to red HeB
ratios agree for stars older than 50 Myr over the time bins studied. These
findings confirm the usefulness of applying isochrones to interpret
observations of HeB populations. However, there are significant differences,
especially for the red HeB population. Specifically we find: (1) offsets in
color between the observations and theoretical isochrones of order 0.15 mag
(0.5 mag) for the blue (red) HeB populations brighter than M_V ~ -4 mag, which
cannot be solely due to differential extinction; (2) blue HeB stars fainter
than M_V ~ -3 mag are bluer than predicted; (3) the slope of the red HeB
sequence is shallower than predicted by a factor of ~3; and (4) the models
overpredict the ratio of the most luminous blue to red HeB stars corresponding
to ages <50 Myr. Additionally, we find that for the more metal-rich galaxies in
our sample (Z> 0.5 Zsolar) the red HeB stars overlap with the red giant branch
stars in the color magnitude diagrams, thus reducing their usefulness as
indicators of star formation for ages >100 Myr.Comment: 18 pages, 11 figures, 3 table
Second harmonic generation in SiC polytypes
LMTO calculations are presented for the frequency dependent second harmonic
generation (SHG) in the polytypes 2H, 4H, 6H, 15R and 3C of SiC. All
independent tensor components are calculated. The spectral features and the
ratios of the 333 to 311 tensorial components are studied as a function of the
degree of hexagonality. The relationship to the linear optical response and the
underlying band structure are investigated. SHG is suggested to be a sensitive
tool for investigating the near band edge interband excitations.Comment: 12 pages, 10 figure
Geneâenvironment interactions related to body mass: School policies and social context as environmental moderators
This paper highlights the role of institutional resources and policies, whose origins lie in political processes, in shaping the genetic etiology of body mass among a national sample of adolescents. Using data from Waves I and II of the National Longitudinal Study of Adolescent Health, we decompose the variance of body mass into environmental and genetic components. We then examine the extent to which the genetic influences on body mass are different across the 134 schools in the study. Taking advantage of school differences in both health-related policies and social norms regarding body size, we examine how institutional resources and policies alter the relative impact of genetic influences on body mass. For the entire sample, we estimate a heritability of .82, with the remaining .18 due to unique environmental factors. However, we also show variation about this estimate and provide evidence suggesting that social norms and institutional policies often mask genetic vulnerabilities to increased weight. Empirically, we demonstrate that more-restrictive school policies and policies designed to curb weight gain are also associated with decreases the proportion of variance in body mass that is due to additive genetic influences
Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index
This study uses data from the Framingham Heart Study to examine the relevance of the gene-environment interaction paradigm for genome-wide association studies (GWAS). We use completed college education as our environmental measure and estimate the interactive effect of genotype and education on body mass index (BMI) using 260,402 single-nucleotide polymorphisms (SNPs). Our results highlight the sensitivity of parameter estimates obtained from GWAS models and the difficulty of framing genome-wide results using the existing gene-environment interaction typology. We argue that SNP-environment interactions across the human genome are not likely to provide consistent evidence regarding genetic influences on health that differ by environment. Nevertheless, genome-wide data contain rich information about individual respondents, and we demonstrate the utility of this type of data. We highlight the fact that GWAS is just one use of genome-wide data, and we encourage demographers to develop methods that incorporate this vast amount of information from respondents into their analyses
The Nature of Starbursts : II. The Duration of Starbursts in Dwarf Galaxies
The starburst phenomenon can shape the evolution of the host galaxy and the
surrounding intergalactic medium. The extent of the evolutionary impact is
partly determined by the duration of the starburst, which has a direct
correlation with both the amount of stellar feedback and the development of
galactic winds, particularly for smaller mass dwarf systems. We measure the
duration of starbursts in twenty nearby, ongoing, and "fossil" starbursts in
dwarf galaxies based on the recent star formation histories derived from
resolved stellar population data obtained with the Hubble Space Telescope.
Contrary to the shorter times of 3-10 Myr often cited, the starburst durations
we measure range from 450 - 650 Myr in fifteen of the dwarf galaxies and up to
1.3 Gyr in four galaxies; these longer durations are comparable to or longer
than the dynamical timescales for each system. The same feedback from massive
stars that may quench the flickering SF does not disrupt the overall burst
event in our sample of galaxies. While five galaxies present fossil bursts,
fifteen galaxies show ongoing bursts and thus the final durations may be longer
than we report here for these systems. One galaxy shows a burst that has been
ongoing for only 20 Myr; we are likely seeing the beginning of a burst event in
this system. Using the duration of the starbursts, we calculate that the bursts
deposited 10^(53.9)-10^(57.2) ergs of energy into the interstellar medium
through stellar winds and supernovae and produced 3%-26% of the host galaxy's
mass.Comment: 28 pages, 4 figure
A quantum spin transducer based on nano electro-mechancial resonator arrays
Implementation of quantum information processing faces the contradicting
requirements of combining excellent isolation to avoid decoherence with the
ability to control coherent interactions in a many-body quantum system. For
example, spin degrees of freedom of electrons and nuclei provide a good quantum
memory due to their weak magnetic interactions with the environment. However,
for the same reason it is difficult to achieve controlled entanglement of spins
over distances larger than tens of nanometers. Here we propose a universal
realization of a quantum data bus for electronic spin qubits where spins are
coupled to the motion of magnetized mechanical resonators via magnetic field
gradients. Provided that the mechanical system is charged, the magnetic moments
associated with spin qubits can be effectively amplified to enable a coherent
spin-spin coupling over long distances via Coulomb forces. Our approach is
applicable to a wide class of electronic spin qubits which can be localized
near the magnetized tips and can be used for the implementation of hybrid
quantum computing architectures
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