Equal Access to Education

The purpose of our research study and presentation is to identify key factors in access to education in three regions of the world. We looked into access to education in China, India, and the United States (urban) education systems in order to understand the barriers within each educational system. The Chinese educational system has been seen as an exemplary model of education, with the majority of students excelling in their work. However, many different factors contribute to disparities in access to education such as social status, economic background, and ideology. India is a prominent global economic leader, yet struggles with a large illiteracy rate. Its educational system is world renowned for the number of existing schools in rural villages, as well as the complexity and variability of educational requirements. However, there are also challenges to the system, including teacher shortages, mandatory passage requirements and dangerous conditions of school facilities. The United States also has great disparities in access to education. Though education is available and mandated, urban schools lack funding and qualified teachers. Access to education in the U.S.A. is largely based on location. We have researched academic and professional journals, books, and personal testimonies in order to present accurate and thorough research on access to education in each of these areas

The Patient's Guide to Psoriasis Treatment. Part 4: Goeckerman Therapy.

BackgroundThe Goeckerman regimen remains one of the oldest, most reliable treatment options for patients with moderate to severe psoriasis. Goeckerman therapy currently consists of exposure to ultraviolet B light and application of crude coal tar. The details of the procedure can be confusing and challenging to understand for the first-time patient or provider.ObjectiveTo present a freely available online guide and video on Goeckerman treatment that explains the regimen in a patient-oriented manner.MethodsThe Goeckerman protocol used at the University of California-San Francisco Psoriasis and Skin Treatment Center as well as available information from the literature were reviewed to design a comprehensive guide for patients receiving Goeckerman treatment.ResultsWe created a printable guide and video resource that covers the supplies needed for Goeckerman regimen, the treatment procedure, expected results, how to monitor for adverse events, and discharge planning.ConclusionThis new resource is beneficial for prospective patients planning to undergo Goeckerman treatment, healthcare providers, and trainees who want to learn more about this procedure. Online media and video delivers material in a way that is flexible and often familiar to patients

The Patient's Guide to Psoriasis Treatment. Part 2: PUVA Phototherapy.

BackgroundPUVA treatment is photochemotherapy for psoriasis that combines psoralen with UVA radiation. Although PUVA is a very effective treatment option for psoriasis, there is an absence of patient resources explaining and demonstrating the process of PUVA. Studies have shown that patients who viewed videos explaining the treatment procedures for various medical conditions had a greater understanding of their treatment and were more active participants in their health.ObjectiveTo present a freely available online guide and video on PUVA treatment designed for patient education on PUVA.MethodsThe PUVA treatment protocol used at the University of California-San Francisco Psoriasis and Skin Treatment Center as well as available information from the literature was reviewed to design a comprehensive guide for patients receiving PUVA treatment.ResultsWe created a printable guide and video resource that reviews the benefits and risks of PUVA, discusses the three types of PUVA (hand-foot soak, full body soak, and systemic), demonstrates the PUVA process, and provides practical tips for safe use.ConclusionOnline media and video delivers material in a way that is flexible and often familiar to patients. This new format is beneficial for prospective patients planning to undergo PUVA treatment, health-care providers, and trainees who want to learn more about this treatment

Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation

Chromophobe renal cell carcinoma (chRCC) is one of the less common types of kidney cancer and generally portends a more favorable prognosis. RCC with sarcomatoid differentiation has a more aggressive clinical course with poor outcomes. Four cases of chRCC with varying degrees of sarcomatoid differentiation were retrospectively reviewed at our institution, and clinicopathologic data as well as clinical courses were reported. Patients with higher degrees of sarcomatoid differentiation and larger tumors at presentation generally had and worse overall survival. chRCC with sarcomatoid differentiation portends a poor prognosis with limited data on systemic treatment options for metastatic disease

Educación para la diversidad afectivo-sexual desde la perspectiva de las familias homoparentales

Treball final de Grau en Mestre o Mestra d'Educació Infantil. Codi: MI1040. Curs acadèmic 2016-2017Este proyecto tiene como objetivos conocer la opinión de algunas familias homoparentales acerca del trabajo de la diversidad afectivo sexual en las escuelas, acercarnos al trato que reciben algunas familias homoparentales en lasaulas y descubrir qué mejoras educativas proponen las familias homoparentales para fomentar la inclusión del colectivo LGBT en el ámbito escolar. Para llevar a cabo este trabajo, en primer lugar, se ha realizado una primera aproximación a la materia a través de la búsqueda de autores y documentos que avalen la necesidad de trabajar este tipo de diversidad, cómo se trata este tema en el sistema educativo actual, así como la necesidad de introducir a las familias en las aulas. Después, para averiguar de primera mano la visión de las familias homoparentales acerca de este tema, se han realizado entrevistas a tres familia de diferentes edades, procedentes de diferentes lugares y con diferente grado de participación en asociaciones LGBT. Para llevar a término estas entrevistas, se ha utilizado una metodología cualitativa, basada en una entrevista semiestructurada y preguntas abiertas. Estas preguntas están separadas en temas, todos relacionados con los objetivos propuestos (sistema educativo, relación familiar, relación con la escuela,…). Para finalizar, a partir de las respuestas de las tres familias se ha realizado el análisis de datos. Este se ha llevado a cabo a través de la comparación y el contraste de las diferentes visiones de las familias. A raíz del análisis se han podido deducir las siguientes conclusiones: en las escuelas no se trabaja la diversidad afectivo-sexual o no se introduce en toda su complejidad, la educación para este tipo de diversidad podría solucionar el aumento de las agresiones homófobas, el colectivo LGTB continúa viviendo situaciones de desigualdad respecto a los heterosexuales y en el sistema educativo sigue vigente la heteronormatividad

Comparativa de la situación de la mujer en la educación Española y Alemana

Treball Final de Grau en Mestre o Mestra d'Educació Infantil. Codi: MI1040. Curs acadèmic: 2016/2017Este trabajo tiene como objetivo principal conocer el papel de la mujer en la sociedad y cómo esto influye en la educación infantil, además de ofrecer una comparativa con otros países Europeos con una ideología conservadora similar a la de España, como pueden ser Alemania o Inglaterra, cuya religión mayoritaria no es el catolicismo. Para conseguir nuestro objetivo hemos realizado un trabajo basado en la recogida de información de diversas fuentes, entre ellas, libros, artículos de revista, materiales digitales. Esto nos ha ayudado a comprender que hay una gran diferencia de género entre los docentes de educación infantil a consecuencia de una larga tradición histórica que sigue perdurando hoy en día. Para comprender esto también se ha analizado el desarrollo histórico de la educación infantil a lo largo de la historia, centrándonos principalmente en dos países como hemos dicho anteriormente, España y Alemania. Finalmente se presentan una serie de conclusiones donde se reúnen todas las informaciones encontradas y la síntesis a la que nosotros llegamos tras realizar el siguiente trabajo

Stratigraphic evidence of two historical tsunamis on the semi-arid coast of north-central Chile

On September 16, 2015, a Mw 8.3 earthquake struck the north-central Chile coast, triggering a tsunami observed along 500 km of coastline, between Huasco (28.5°S) and San Antonio (33.5°S). This tsunami provided a unique opportunity to examine the nature of tsunami deposits in a semi-arid, siliciclastic environment where stratigraphic and sedimentological records of past tsunamis are difficult to distinguish. To improve our ability to identify such evidence, we targeted one of the few low-energy, organic-rich depositional environments in north-central Chile: Pachingo marsh in Tongoy Bay (30.3°S).We found sedimentary evidence of the 2015 and one previous tsunami as tabular sand sheets. Both deposits are composed of poorly to moderately sorted, gray-brown, fine-to medium-grained sand and are distinct from underlying and overlying organic-rich silt. Both sand beds thin (from ∼20 cm to \u3c1 \u3ecm) and fine landward, and show normal grading. The older sand bed is thicker and extends over 125 m further inland than the 2015 tsunami deposit. To model the relative size of the tsunamis that deposited each sand bed, we employed tsunami flow inversion. Our results show that the older sand bed was produced by higher flow speeds and depths than those in 2015. Anthropogenic evidence along with 137Cs and 210Pb dating constrains the age of the older tsunami to the last ∼110 years. We suggest that the older sand bed was deposited by the large tsunami in 1922 CE sourced to the north of our study site. This deposit represents the first geologic evidence of a pre-2015 tsunami along the semi-arid north-central Chile coast and highlights the current and continuing tsunami hazard in the region

Glycolysis Upregulation Is Neuroprotective As A Compensatory Mechanism In Als

Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43 inclusions as a major pathological hallmark. Using a Drosophila model of TDP-43 proteinopathy we found significant alterations in glucose metabolism including increased pyruvate, suggesting that modulating glycolysis may be neuroprotective. Indeed, a high sugar diet improves locomotor and lifespan defects caused by TDP-43 proteinopathy in motor neurons or glia, but not muscle, suggesting that metabolic dysregulation occurs in the nervous system. Overexpressing human glucose transporter GLUT-3 in motor neurons mitigates TDP-43 dependent defects in synaptic vesicle recycling and improves locomotion. Furthermore, PFK mRNA, a key indicator of glycolysis, is upregulated in flies and patient derived iPSC motor neurons with TDP-43 pathology. Surprisingly, PFK overexpression rescues TDP-43 induced locomotor deficits. These findings from multiple ALS models show that mechanistically, glycolysis is upregulated in degenerating motor neurons as a compensatory mechanism and suggest that increased glucose availability is protective

Dynamic Changes of Circulating Tumor DNA Predict Clinical Outcome in Patients With Advanced Non-Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors

PURPOSE Immune checkpoint inhibitors (ICIs) are increasingly being used in non-small-cell lung cancer (NSCLC), yet biomarkers predicting their benefit are lacking. We evaluated if on-treatment changes of circulating tumor DNA (ctDNA) from ICI start (t0) to after two cycles (t1) assessed with a commercial panel could identify patients with NSCLC who would benefit from ICI. PATIENTS AND METHODS The molecular ctDNA response was evaluated as a predictor of radiographic tumor response and long-term survival benefit of ICI. To maximize the yield of ctDNA detection, de novo mutation calling was performed. Furthermore, the impact of clonal hematopoiesis (CH)-related variants as a source of biologic noise was investigated. RESULTS After correction for CH-related variants, which were detected in 75 patients (44.9%), ctDNA was detected in 152 of 167 (91.0%) patients. We observed only a fair agreement of the molecular and radiographic response, which was even more impaired by the inclusion of CH-related variants. After exclusion of those, a ≥ 50% molecular response improved progression-free survival (10 v 2 months; hazard ratio [HR], 0.55; 95% CI, 0.39 to 0.77; P =.0011) and overall survival (18.4 v 5.9 months; HR, 0.44; 95% CI, 0.31 to 0.62; P,.0001) compared with patients not achieving this end point. After adjusting for clinical variables, ctDNA response and STK11/KEAP1 mutations (HR, 2.08; 95% CI, 1.4 to 3.0; P,.001) remained independent predictors for overall survival, irrespective of programmed death ligand-1 expression. A landmark survival analysis at 2 months (n = 129) provided similar results. CONCLUSION On-treatment changes of ctDNA in plasma reveal predictive information for long-term clinical benefit in ICI-treated patients with NSCLC. A broader NSCLC patient coverage through de novo mutation calling and the use of a variant call set excluding CH-related variants improved the classification of molecular responders, but had no significant impact on survival