Biota parasitária gastrointestinal de caititus "Tayassu tajacu Linnaeus 1758" (Pecari tajacu Jacq.) criados em cativeiro.

Os caititus foram identificados como uma das espécies mais caçadas na região da Transamazônica ? PA. (BONAUDO et al., 2002). Nas regiões de colonização da Amazônia, encontram-se várias espécies silvestres cuja única exploração baseia-se na caça que é uma fonte de proteína alternativa para a população local. Esta, junto com o desmatamento, a fragmentação de habitats e o comércio ilegal pode causar a diminuição de espécies. Uma alternativa para solucionar este problema é o incentivo à criatórios, que são uma forma de utilização sustentável da biodiversidade, geração de renda e identificação das ações conservacionistas (MMA, 2001). Objetivou-se no presente trabalho estudar a biota parasitária gastrintestinal presente em caititus criados em cativeiro em 2 criatórios no Estado do Pará, um na Embrapa Amazônia Oriental, Belém-PA e outro em criatório de produtor comercial em Santa Izabel ? PA, por ser o fator sanitário mais importante desta espécie em cativeiro e afim de disponibilizar dados mais atuais literatura sobre os animais em questão. Para as análises de endoparasitas gastrintestinais foram realizadas análises de fezes com os seguintes métodos: Sedimentação e Mcmaster. A ocorrência de parasitas gastrintestinais até o presente momento é de 71,92% (41 animais), sendo que destes 85,36% (35 animais) apresentaram infecção simples e 14,63% (6 animais) apresentaram infecção múltipla. Os parasitas identificados e suas respectivas incidências foram Balantidium coli (64,91%); Ascaris suun (8,77%)e grupo dos Strongylideos (8,77%)

Training University Students About Autism Spectrum Disorder Through Outreach to School-Based Speech-Language Pathologists

Training preprofessional students about autism spectrum disorder (ASD) is crucial, particularly since students with ASD are represented on the caseloads of approximately 90% of school-based speech-language pathologists (SLPs). When this training can occur within the context of an outreach program, the results of such programming can be mutually beneficial for the individuals served as well as the students. Through the present program, six graduate students and four undergraduate students created materials for 15 SLPs working in the schools in a significantly underserved region of the United States. Students created nearly 800 materials for the SLPs to use in therapy with children with ASD. These included visual schedules and picture/icon cards and social stories. Students completed a survey and wrote a reflection paper about what they learned. Survey data from all participants indicated that the program met the needs of the SLPs and furthered students’ skills in creating materials and understanding more about the demands of working as an SLP in the schools. Implications for undergraduate and graduate training including increasing student knowledge and confidence as well as gaining student perspectives on the experience and collaboration are discussed. Future directions for extensions of this training program are proposed

Training Students Through a Community Outreach Program to Support Families of Children with Autism Spectrum Disorder

This outreach program involved training eight graduate and 19 undergraduate students to create evidence-based communication supports for families of children with autism spectrum disorder (ASD) within the context of a two-course sequence on ASD. During the training program, ten families in rural Appalachia benefited from our services. Student and family satisfaction data with the outreach program was highly positive. Undergraduate and graduate university students participating in the program met or partially met 97% of their goals set at the beginning of each semester. Undergraduate students’ self-ratings of their own knowledge about material covered in the course were significantly higher than their confidence in applying their knowledge about the materials. Thematic analyses of students’ comments about their experiences revealed that the hands-on experience and opportunities to create materials and collaborate with each other were among the aspects of the program they liked most. The value of outreach programs to foster training of undergraduate and graduate students through community connections will be discussed

Integrated strategies to prevent intradialytic hypotension: research protocol of the DialHypot study, a prospective randomised clinical trial in hypotension-prone haemodialysis patients

INTRODUCTION: In patients on maintenance haemodialysis (HD), intradialytic hypotension (IDH) is a clinical problem that nephrologists and dialysis nurses face daily in their clinical routine. Despite the technological advances in the field of HD, the incidence of hypotensive events occurring during a standard dialytic treatment is still very high. Frequently recurring hypotensive episodes during HD sessions expose patients not only to severe immediate complications but also to a higher mortality risk in the medium term. Various strategies aimed at preventing IDH are currently available, but there is lack of conclusive data on more integrated approaches combining different interventions. METHODS AND ANALYSIS: This is a prospective, randomised, open-label, crossover trial (each subject will be used as his/her own control) that will be performed in two distinct phases, each of which is divided into several subphases. In the first phase, 27 HD sessions for each patient will be used, and will be aimed at the validation of a new ultrafiltration (UF) profile, designed with an ascending/descending shape, and a standard dialysate sodium concentration. In the second phase, 33 HD sessions for each patient will be used and will be aimed at evaluating the combination of different UF and sodium profiling strategies through individualised dialysate sodium concentration. ETHICS AND DISSEMINATION: The trial protocol has been reviewed and approved by the local Institutional Ethics Committee (Comitato Etico AVEN, prot. 43391 22.10.19). The results of the trial will be presented at local and international conferences and submitted for publication to a peer-reviewed journal. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT03949088)

Accuracy of the recombination correction factor (ks) in FFF beams for three ion chamber types

Flattening filter free (FFF) beams pose particular considerations for absolute dosimetry. • These beams are capable to deliver high doses per pulse (DPP) which implies special consideration regarding recombination effects in ionization chambers. • We wanted to know which type of ionization chamber (Farmer, Semiflex or Pinpoint) would be more appropriate for commisioning our new FFF beam

The VELVET A Orthologue VEL1 of Trichoderma reesei Regulates Fungal Development and Is Essential for Cellulase Gene Expression

Trichoderma reesei is the industrial producer of cellulases and hemicellulases for biorefinery processes. Their expression is obligatorily dependent on the function of the protein methyltransferase LAE1. The Aspergillus nidulans orthologue of LAE1--LaeA--is part of the VELVET protein complex consisting of LaeA, VeA and VelB that regulates secondary metabolism and sexual as well as asexual reproduction. Here we have therefore investigated the function of VEL1, the T. reesei orthologue of A. nidulans VeA. Deletion of the T. reesei vel1 locus causes a complete and light-independent loss of conidiation, and impairs formation of perithecia. Deletion of vel1 also alters hyphal morphology towards hyperbranching and formation of thicker filaments, and with consequently reduced growth rates. Growth on lactose as a sole carbon source, however, is even more strongly reduced and growth on cellulose as a sole carbon source eliminated. Consistent with these findings, deletion of vel1 completely impaired the expression of cellulases, xylanases and the cellulase regulator XYR1 on lactose as a cellulase inducing carbon source, but also in resting mycelia with sophorose as inducer. Our data show that in T. reesei VEL1 controls sexual and asexual development, and this effect is independent of light. VEL1 is also essential for cellulase gene expression, which is consistent with the assumption that their regulation by LAE1 occurs by the VELVET complex

Sustained low-efficiency dialysis with regional citrate anticoagulation in critically ill patients with COVID-19 associated AKI: A pilot study

Acute Kidney Injury (AKI) is a frequent complication in critically ill patients with Coronavirus disease 2019 (COVID-19), and it has been associated with worse clinical outcomes, especially when Kidney Replacement Therapy (KRT) is required. A condition of hypercoagulability has been frequently reported in COVID-19 patients, and this very fact may complicate KRT management. Sustained Low Efficiency Dialysis (SLED) is a hybrid dialysis modality increasingly used in critically ill patients since it allows to maintain acceptable hemodynamic stability and to overcome the increased clotting risk of the extracorporeal circuit, especially when Regional Citrate Anticoagulation (RCA) protocols are applied. Notably, given the mainly diffusive mechanism of solute transport, SLED is associated with lower stress on both hemofilter and blood cells as compared to convective KRT modalities. Finally, RCA, as compared with heparin-based protocols, does not further increase the already high hemorrhagic risk of patients with AKI. Based on these premises, we performed a pilot study on the clinical management of critically ill patients with COVID-19 associated AKI who underwent SLED with a simplified RCA protocol. Low circuit clotting rates were observed, as well as adequate KRT duration was achieved in most cases, without any relevant metabolic complication nor worsening of hemodynamic status

Risk factors for liver decompensation and hcc in hcv-cirrhotic patients after daas: A multicenter prospective study

Background: Prospective studies on predictors of liver-related events in cirrhotic subjects achieving SVR after DAAs are lacking. Methods: We prospectively enrolled HCV cirrhotic patients in four Italian centers between November 2015 and October 2017. SVR and no-SVR cases were compared according to the presence or absence of liver-related events during a 24-month follow-up. Independent predictors of liver-related events were evaluated by Cox regression analysis. Results: A total of 706 subjects started DAAs therapy. SVR was confirmed in 687 (97.3%). A total of 61 subjects (8.9%) in the SVR group and 5 (26.3%) in the no-SVR group had liver-related events (p < 0.03). The incidence rate x 100 p/y was 1.6 for HCC, 1.7 for any liver decompensation, and 0.5 for hepatic death. Baseline liver stiffness (LSM) ≥ 20 kPa (HR 4.0; 95% CI 1.1–14.1) and genotype different from 1 (HR 7.5; 95% CI 2.1–27.3) were both independent predictors of liver decompensation. Baseline LSM > 20 KPa (HR 7.2; 95% CI 1.9–26.7) was the sole independent predictor of HCC. A decrease in liver stiffness (Delta LSM) by at least 20% at the end of follow-up was not associated with a decreased risk of liver-related events. Conclusion: Baseline LSM ≥ 20 kPa identifies HCV cirrhotic subjects at higher risk of liver-related events after SVR

Graduate Student Reflections on Mentorship in a Training and Outreach Program for Families of Children with Autism Spectrum Disorder

Undergraduate (n = 19) and graduate students (n = 8) participated in a two semester training program focused on learning about Autism Spectrum Disorder (ASD) and how to create individualized communication supports for families of children with ASD. The focus of this paper is on the graduate students’ training and mentoring experiences. Graduate students’ philosophies of mentoring undergraduate students and their final reflections of the experience were analyzed for themes and subthemes. Mentoring philosophies yielded four major themes: role of the mentor, mentoring goals, the mentor-mentee relationship, and learning. Graduate student reflections on their skills gained, what they learned about themselves, their leadership, and the challenges they faced were also categorized into themes. Analyses revealed undergraduate student ratings and qualitative comments regarding graduate student support. Implications and future directions for the development of hands-on training programs allowing graduate students in Communication Sciences and Disorders to assume mentorship roles will be discussed