127 research outputs found
Cardiac hybrid imaging
Computed tomography coronary angiography (CTCA) and myocardial perfusion imaging techniques (single photon emission computed tomography, SPECT, or positron emission tomography, PET) are established non-invasive modalities for the diagnosis of coronary artery disease (CAD). Cardiac hybrid imaging consists of the combination (or ‘fusion') of both modalities and allows obtaining complementary morphological (coronary anatomy, stenoses) and functional (myocardial perfusion) information in a single setting. However, hybrid cardiac imaging has also generated controversy with regard to which patients should undergo such integrated examinations for clinical effectiveness and minimization of costs and radiation dose. The feasibility and clinical value of hybrid imaging has been documented in small cohort studies and selected series of patients. Hybrid imaging appears to offer superior diagnostic and prognostic information compared with stand-alone or side-by-side interpretation of data sets. Particularly in patients with multivessel disease, the hybrid approach allows identification of flow-limiting coronary lesions and thereby provides useful information for the planning of revascularization procedures. Furthermore, integration of the detailed anatomical information from CTCA with the high molecular sensitivity of SPECT and PET may be useful to evaluate targeted molecular and cellular abnormalities in the future. While currently still restricted to specialized cardiac centres, the ongoing efforts to reduce radiation exposure and the increasing clinical interest will further pave the way for an increasing use of cardiac hybrid imaging in clinical practic
Peptide Receptor–Targeted Radionuclide Therapy Alters Inflammation in Atherosclerotic Plaques
2098 Magnetic resonance imaging at 3 Tesla to quantify regional myocardial blood flow after myocardial infarction: comparison with 13N-ammonia positron emission tomography and microspheres
Приготовление суспензий нанопорошка ZnO в растворе глицина
The focus of the work was to make an attempt to prepare an aggregative-stable suspension of ZnO nanopowder with average particle size of 20-40 nm, which was prepared by plasma method in aminoacetic acid. The infrared spectrums of the solution before and after exposure to nanopowder in 2 M glycine solution was used to check the effectiveness of glycine sorption on the particle surface. It was experimentally revealed that the centrifugate, separated from the nanoparticles after incubation in 2M nanopowder surfactant solution with a particle concentration of 2, 10 and 20 wt.% during a week, had a peak height decrease from 11.1 (initial 2M glycine solution) to 9.45 ... 5.3 ... 4.5 units on the IR spectrum at a wavelength of 1250 cm{-1}, and the percentage of adsorbed glycine 15, 52 and 59.4 %, respectively. Selected surfactant has been efficiently adsorbed on the surface of ZnO particles and can be used to stabilize the nanoparticles in aqueous aggregative-stable suspensions
Effect of Deep Brain Stimulation on Regional Cerebral Blood Flow in Patients with Medically Refractory Tourette Syndrome
Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region
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Positron Emission Tomography Imaging Reveals Auditory and Frontal Cortical Regions Involved with Speech Perception and Loudness Adaptation
Considerable progress has been made in the treatment of hearing loss with
auditory implants. However, there are still many implanted patients that
experience hearing deficiencies, such as limited speech understanding or
vanishing perception with continuous stimulation (i.e., abnormal loudness
adaptation). The present study aims to identify specific patterns of cerebral
cortex activity involved with such deficiencies. We performed O-15-water
positron emission tomography (PET) in patients implanted with electrodes
within the cochlea, brainstem, or midbrain to investigate the pattern of
cortical activation in response to speech or continuous multi-tone stimuli
directly inputted into the implant processor that then delivered electrical
patterns through those electrodes. Statistical parametric mapping was
performed on a single subject basis. Better speech understanding was
correlated with a larger extent of bilateral auditory cortex activation. In
contrast to speech, the continuous multi-tone stimulus elicited mainly
unilateral auditory cortical activity in which greater loudness adaptation
corresponded to weaker activation and even deactivation. Interestingly,
greater loudness adaptation was correlated with stronger activity within the
ventral prefrontal cortex, which could be up-regulated to suppress the
irrelevant or aberrant signals into the auditory cortex. The ability to detect
these specific cortical patterns and differences across patients and stimuli
demonstrates the potential for using PET to diagnose auditory function or
dysfunction in implant patients, which in turn could guide the development of
appropriate stimulation strategies for improving hearing rehabilitation.
Beyond hearing restoration, our study also reveals a potential role of the
frontal cortex in suppressing irrelevant or aberrant activity within the
auditory cortex, and thus may be relevant for understanding and treating
tinnitus
2098 Magnetic resonance imaging at 3 Tesla to quantify regional myocardial blood flow after myocardial infarction: comparison with 13N-ammonia positron emission tomography and microspheres
Cardiac computed tomography: indications, applications, limitations, and training requirements: Report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology
As a consequence of improved technology, there is growing clinical interest in the use of multi-detector row computed tomography (MDCT) for non-invasive coronary angiography. Indeed, the accuracy of MDCT to detect or exclude coronary artery stenoses has been high in many published studies. This report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT (WG 5) of the European Society of Cardiology and the European Council of Nuclear Cardiology summarizes the present state of cardiac CT technology, as well as the currently available data concerning its accuracy and applicability in certain clinical situations. Besides coronary CT angiography, the use of CT for the assessment of cardiac morphology and function, evaluation of perfusion and viability, and analysis of heart valves is discussed. In addition, recommendations for clinical applications of cardiac CT imaging are given and limitations of the technique are describe
Risks and benefits of cardiac imaging: an analysis of risks related to imaging for coronary artery disease
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