The gravitational wave detector VIRGO

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The Virgo data acquisition system

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Studies and optimization of scintillation light measurements for the development of the 3-gamma medical imaging XEMIS2 liquid xenon compton camera

International audienceWe report the studies and optimization of scintillation light measurements in an updated version of the XEMIS1 prototype for the development of the XEMIS2 camera. A novel monolithic liquid xenon Compton camera, named XEMIS2 (XEnon Medical Imaging System), attempts to achieve low-activity small-animal imaging using the 3-gamma imaging technique. This emerging detector relies on the time projection chamber technique: it will be able to perform a simultaneous detection of the three γ-rays emitted by a specific radionuclide, such as scandium-44, and to produce a good quality image with a remarkable diminution of radiopharmaceutical activity at the same time. Vacuum Ultraviolet (VUV) scintillation light and ionization charge carriers generated from the recoiling particles within the detector are detected and used to reconstruct the interaction position and deposited energy. A cost-effective self-triggering scintillation signal read-out and data acquisition (DAQ) system has been developed to achieve a continuous data read-out with negligible electronics dead time. The DAQ prototype has been installed and qualified in an updated version of the XEMIS1 detector. It reaches the performance specifications in scintillation light measurements. Moreover, scintillation signals can also be used for the virtual segmentation of the monolithic detection volume through the matching algorithm of the scintillation and ionization signals based on the Light Collection Map (LCM). This spatial pre-localization of the physical events, called the virtual fiducialization of the active volume, is used to lower the detector occupancy rate when the administered activity is increased to lessen the examination time. The XEMIS1 experimental LCMs indicate that each PMT owns an individual field of view so as to segment the active volume virtually. The preparation work for the XEMIS2 camera operation has been completed in the updated XEMIS1 detector while the XEMIS2 scintillation light measurement system is under commissioning in Nantes Centre Hospitalier Universitaire. •The XEMIS2 camera oriented to the whole-body small animal 3-gamma medical imaging is presented.•The XEMIS2 system is a monolithic liquid xenon Compton camera with a 24 cm axial field of view.•A cost-effective 16-channel self-triggering scintillation signal front-end read-out electronics named XSRETOT is reported.•The XEMIS1 experimental light collection maps can be used for the virtual segmentation of the monolithic detection volume

XEMIS2: A liquid xenon Compton camera to image small animals

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XEMIS2: A liquid xenon detector for small animal medical imaging

International audienceWe report a new liquid xenon Compton camera, called XEMIS2 (XEnon Medical Imaging System), developed to image for the first time small animals using 3 γ imaging. This technique proposes an alternative to reduce the administered radiopharmaceutical activity while preserving diagnostic image quality using liquid xenon as detection medium. Given the success of its predecessor, a small dimension liquid xenon time projection chamber called XEMIS1, we are currently building a larger scale detector for preclinical applications. This second prototype, XEMIS2, is a single phase liquid xenon cylindrical camera with a large axial field of view for full-body small animal imaging. XEMIS2 holds around 200 kg of xenon and it has been designed to enable high-efficiency and simultaneous detection of the three γ -rays emitted by a 44Sc radionuclide. The innovative geometry of XEMIS2 will allow to discriminate and measure the position and deposited energy of most Compton interactions inside the detector. In order to manage such a large quantity of xenon, an innovative high-pressure subsystem known as ReStoX has been developed and successfully qualified. ReStoX allows to maintain the xenon in liquid state at the desired temperature and pressure, transfer the xenon into XEMIS2 and store it during long term periods. XEMIS2 will be installed at a non controlled radioactive area of Nantes Hospital. The goal is to evaluate image quality of a 20 min whole-body preclinical exam with an injected activity of 20 kBq

XEMIS: Liquid Xenon Compton Camera for 3γ Imaging

International audienceAn innovative liquid xenon Compton camera project, XEMIS (XEnon Medical Imaging System) has been proposed by SUBATECH laboratory, for a new functional medical 3γ imaging technique based on the detection in coincidence of 3 γ-rays. The purpose of this 3γ imaging modality is to obtain a 3D image using 100 times less activity than in current PET systems. The combination of a liquid xenon time projection chamber (LXe TPC) and a specific (β$^{+}$, γ) radionuclide emitter$^{44}$Sc is investigated in this concept. In order to provide an experimental demonstration for the use of a LXe Compton camera for 3γ imaging, a succession of R&D programs, XEMIS1 and XEMIS2, have been carried out using innovative technologies. The first prototype XEMIS1 has been successfully validated showing very promising results for energy, spatial and angular resolutions with an ultra-low noise front-end electronics. The second phase dedicated to a 3D imaging of small animals, XEMIS2, is now under installation and qualification, while the characterizations of ionization signal using Monte Carlo simulation has shown preliminary good performances for energy measurement

Scintillation Signal in XEMIS2, a Liquid Xenon Compton Camera with 3γ Imaging Technique

International audienceThe XEMIS project (XEnon Medical Imaging System), which makes use of 3γ imaging technique and liquid xenon Compton camera, aims to make a precise 3D localization of a specific radioactive emitter and to reduce drastically (100 times less) the injected activity to the patient in cancer diagnosis. The 3γ imaging is characterized by the simultaneous detection of 3 γ-rays emitted by$^{44}$Sc which is a (β+, γ) emitter. The second prototype XEMIS2 is a liquid xenon cylindrical camera for small animal imaging. The active volume of XEMIS2 is surrounded by a set of VUV-sensitive Hamamatsu photomultipliers, for the scintillation signals detection. A pulse-shaping amplifier was tested in XEMIS1 for the readout of the scintillation signal of the PMT. The typical output pulse shows a relatively good performance of the pulse-shaping amplifier providing a possible solution for XEMIS2 scintillation DAQ. Meanwhile, the pulse-shaping amplifier and the constant fraction discriminator (CFD) have lay the foundation of the preliminary design of XEMIS2 scintillation signal detection chain

Commissioning of the ALICE Muon Spectrometer Trigger at LHC

International audienceALICE (a large ion collider experiment) is the LHC experiment dedicated to the study of ultra-relativistic heavy ion collisions. The ALICE muon spectrometer covers a large range in pseudo-rapidity and is designed to study quarkonia and heavy flavours decaying into (di-)muons. The high particle multiplicities environment in such collisions require a specific, fast and efficient trigger system, the muon trigger. It consists of four planes of RPC detectors, covering an area of 36 m2 each, 21k front-end channels and a fast-decision electronics. The muon trigger is designed to reconstruct (muon) tracks and deliver a trigger signal each 25 ns (40 MHz) with a total latency of 800 ns. The hit position on the RPC is measured in two orthogonal directions with an accuracy of about 1 cm. The performance measured with the first p–p collisions at sqrt (s)= 900 GeV carried out in December 2009 is reported