10 research outputs found

    Multi-model assessment of the late-winter extra-tropical response to El Niño and La Niña

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    El Niño-Southern Oscillation (ENSO) is known to affect the Northern Hemisphere tropospheric circulation in late-winter (January-March), but whether El Niño and La Niña lead to symmetric impacts and with the same underlying dynamics remains unclear, particularly in the North Atlantic. Three state-of-the-art atmospheric models forced by symmetric anomalous sea surface temperature (SST) patterns, mimicking strong ENSO events, are used to robustly diagnose symmetries and asymmetries in the extra-tropical ENSO response. Asymmetries arise in the sea-level pressure (SLP) response over the North Pacific and North Atlantic, as the response to La Niña tends to be weaker and shifted westward with respect to that of El Niño. The difference in amplitude can be traced back to the distinct energy available for the two ENSO phases associated with the non-linear diabatic heating response to the total SST field. The longitudinal shift is embedded into the large-scale Rossby wave train triggered from the tropical Pacific, as its anomalies in the upper troposphere show a similar westward displacement in La Niña compared to El Niño. To fully explain this shift, the response in tropical convection and the related anomalous upper-level divergence have to be considered together with the climatological vorticity gradient of the subtropical jet, i.e. diagnosing the tropical Rossby wave source. In the North Atlantic, the ENSO-forced SLP signal is a well-known dipole between middle and high latitudes, different from the North Atlantic Oscillation, whose asymmetry is not indicative of distinct mechanisms driving the teleconnection for El Niño and La Niña

    Precipitation response to extreme soil moisture conditions over the Mediterranean

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    International audienceAbstract The intimate link between soil moisture and precipitation makes it a “chicken-and-egg situation” that challenges climate studies of the continental water cycle. This association is particularly acute over the Mediterranean, increasingly exposed to droughts with climate change. This study aims at deciphering the impact of spring soil moisture state in the Mediterranean on subsequent warm season precipitation. In an idealized setup, two distinct climate models are used to generate extreme dry or wet soil conditions, and run climate simulations initialized and/or forced by these conditions. Changes in precipitation distribution and persistence are analyzed and where applicable compared to composites from a reanalysis. Spring soil moisture anomalies are found to be very persistent, but the precipitation response is largely model dependent. Overall, dry soils lead to a reduction of precipitation for early summer months and conversely for wet soils although with a fainter and less robust signal. On the other hand, wet soils tend to favor the persistence of precipitation throughout summer over several sub-regions. Our results highlight the stringent need to reduce the wide array of uncertainties associated to soil moisture, land-atmosphere coupling and convection in climate models, before ascertaining that soil moisture initialization could provide more skillful sub-seasonal to seasonal precipitation prediction

    Multi-model assessment of the late-winter stratospheric response to El Niño and La Niña

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    International audienceAbstract The impact of El Niño-Southern Oscillation (ENSO) on the late-winter extra-tropical stratosphere (January–March) is assessed in a multi-model framework. Three state-of-the-art atmospheric models are run with prescribed SST anomalies representative of a strong ENSO event, with symmetric patterns for El Niño and La Niña. The well-known temperature perturbation in the lower stratosphere during El Niño is captured by two models, in which the anomalous warming at polar latitudes is accompanied by a positive geopotential height anomaly that extends over the polar cap. In the third model, which shows a lack of temperature anomalies over the pole, the anomalous anticyclone is confined over Canada and does not expand to the polar cap. This anomalous center of action emerges from the large-scale tropospheric Rossby wave train forced by ENSO, and shrinking/stretching around the polar vortex is invoked to link it to the temperature response. No disagreement across models is found in the lower stratosphere for La Niña, whose teleconnection is opposite in sign but weaker. In the middle-upper stratosphere (above 50 hPa) the geopotential height anomalies project on a wavenumber-1 (WN1) pattern for both El Niño and, more weakly, La Niña, and show a westward tilt with height up to the stratopause. It is suggested that this WN1 pattern arises from the high-latitude lower-stratospheric anomalies, and that the ENSO teleconnection to the polar stratosphere can be interpreted in terms of upward propagation of the stationary Rossby wave train and quasi-geostrophic balance, instead of wave breaking

    El Niño teleconnection to the Euro-Mediterranean late-winter: the role of extratropical Pacific modulation

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    International audienceAbstract El Niño Southern Oscillation (ENSO) represents the major driver of interannual climate variability at global scale. Observational and model-based studies have fostered a long-standing debate on the shape and intensity of the ENSO influence over the Euro-Mediterranean sector. Indeed, the detection of this signal is strongly affected by the large internal variability that characterizes the atmospheric circulation in the North Atlantic–European (NAE) region. This study explores if and how the low-frequency variability of North Pacific sea surface temperature (SST) may impact the El Niño-NAE teleconnection in late winter, which consists of a dipolar pattern between middle and high latitudes. A set of idealized atmosphere-only experiments, prescribing different phases of the anomalous SST linked to the Pacific Decadal Oscillation (PDO) superimposed onto an El Niño-like forcing in the tropical Pacific, has been performed in a multi-model framework, in order to assess the potential modulation of the positive ENSO signal. The modelling results suggest, in agreement with observational estimates, that the PDO negative phase (PDO − ) may enhance the amplitude of the El Niño-NAE teleconnection, while the dynamics involved appear to be unaltered. On the other hand, the modulating role of the PDO positive phase (PDO + ) is not reliable across models. This finding is consistent with the atmospheric response to the PDO itself, which is robust and statistically significant only for PDO − . Its modulation seems to rely on the enhanced meridional SST gradient and the related turbulent heat-flux released along the Kuroshio–Oyashio extension. PDO − weakens the North Pacific jet, whereby favoring more poleward propagation of wave activity, strengthening the El Niño-forced Rossby wave-train. These results imply that there might be conditional predictability for the interannual Euro-Mediterranean climate variability depending on the background state

    Summer temperature response to extreme soil water conditions in the Mediterranean transitional climate regime

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    Land surface and atmosphere are interlocked by the hydrological and energy cycles and the effects of soil water-air coupling can modulate near-surface temperatures. In this work, three paired experiments were designed to evaluate impacts of different soil moisture initial and boundary conditions on summer temperatures in the Mediterranean transitional climate regime region. In this area, evapotranspiration is not limited by solar radiation, rather by soil moisture, which therefore controls the boundary layer variability. Extremely dry, extremely wet and averagely humid ground conditions are imposed to two global climate models at the beginning of the warm and dry season. Then, sensitivity experiments, where atmosphere is alternatively interactive with and forced by land surface, are launched. The initial soil state largely affects summer near-surface temperatures: dry soils contribute to warm the lower atmosphere and exacerbate heat extremes, while wet terrains suppress thermal peaks, and both effects last for several months. Land-atmosphere coupling proves to be a fundamental ingredient to modulate the boundary layer state, through the partition between latent and sensible heat fluxes. In the coupled runs, early season heat waves are sustained by interactive dry soils, which respond to hot weather conditions with increased evaporative demand, resulting in longer-lasting extreme temperatures. On the other hand, when wet conditions are prescribed across the season, the occurrence of hot days is suppressed. The land surface prescribed by climatological precipitation forcing causes a temperature drop throughout the months, due to sustained evaporation of surface soil water. Results have implications for seasonal forecasts on both rain-fed and irrigated continental regions in transitional climate zones

    Growth-Inhibitory and Antiangiogenic Activity of the MEK Inhibitor PD0325901 in Malignant Melanoma with or without BRAF Mutations12

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    The Raf/MEK/ERK pathway is an important mediator of tumor cell proliferation and angiogenesis. Here, we investigated the growth-inhibitory and antiangiogenic properties of PD0325901, a novel MEK inhibitor, in human melanoma cells. PD0325901 effects were determined in a panel of melanoma cell lines with different genetic aberrations. PD0325901 markedly inhibited ERK phosphorylation and growth of both BRAF mutant and wild-type melanoma cell lines, with IC50 in the nanomolar range even in the least responsive models. Growth inhibition was observed both in vitro and in vivo in xenograft models, regardless of BRAF mutation status, and was due to G1-phase cell cycle arrest and subsequent induction of apoptosis. Cell cycle (cyclin D1, c-Myc, and p27KIP1) and apoptosis (Bcl-2 and survivin) regulators were modulated by PD0325901 at the protein level. Gene expression profiling revealed profound modulation of several genes involved in the negative control of MAPK signaling and melanoma cell differentiation, suggesting alternative, potentially relevant mechanisms of action. Finally, PD0325901 inhibited the production of the proangiogenic factors vascular endothelial growth factor and interleukin 8 at a transcriptional level. In conclusion, PD0325901 exerts potent growth-inhibitory, proapoptotic, and antiangiogenic activity in melanoma lines, regardless of their BRAF mutation status. Deeper understanding of the molecular mechanisms of action of MEK inhibitors will likely translate into more effective treatment strategies for patients experiencing malignant melanoma
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