Key inflammatory pathway activations in the MCI stage of Alzheimer's disease

OBJECTIVE: To determine the key inflammatory pathways that are activated in the peripheral and CNS compartments at the mild cognitive impairment (MCI) stage of Alzheimer's disease (AD). METHODS: A cross-sectional study of patients with clinical and biomarker characteristics consistent with MCI-AD in a discovery cohort, with replication in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Inflammatory analytes were measured in the CSF and plasma with the same validated multiplex analyte platform in both cohorts and correlated with AD biomarkers (CSF Aβ42, total tau (t-tau), phosphorylated tau (p-tau) to identify key inflammatory pathway activations. The pathways were additionally validated by evaluating genes related to all analytes in coexpression networks of brain tissue transcriptome from an autopsy confirmed AD cohort to interrogate if the same pathway activations were conserved in the brain tissue gene modules. RESULTS: Analytes of the tumor necrosis factor (TNF) signaling pathway (KEGG ID:4668) in the CSF and plasma best correlated with CSF t-tau and p-tau levels, and analytes of the complement and coagulation pathway (KEGG ID:4610) best correlated with CSF Aβ42 levels. The top inflammatory signaling pathways of significance were conserved in the peripheral and the CNS compartments. They were also confirmed to be enriched in AD brain transcriptome gene clusters. INTERPRETATION: A cell-protective rather than a proinflammatory analyte profile predominates in the CSF in relation to neurodegeneration markers among MCI-AD patients. Analytes from the TNF signaling and the complement and coagulation pathways are relevant in evaluating disease severity at the MCI stage of AD

Three Charge Supertubes in Type IIB Plane Wave Backgrounds

We deform the supersymmetric black ring of five dimensional supergravity coupled to N-1 vector multiplets to obtain an asymptotically Goedel supersymmetric black ring. For the U(1)^3 model we lift this solution to obtain a three charge D1-D5-P supertube which asymptotes to a 1/2 supersymmetric plane wave of Type IIB supergravity. Further, we also show how one may deform the asymptotically flat three charge supertube of type IIB, in the special case of vanishing KK dipole charge, to a three charge supertube which asymptotes to the maximally supersymmetric plane wave.Comment: 1+14 pages, JHEP

Non-Supersymmetric Loop Amplitudes and MHV Vertices

We show how the MHV diagram description of Yang-Mills theories can be used to study non-supersymmetric loop amplitudes. In particular, we derive a compact expression for the cut-constructible part of the general one-loop MHV multi-gluon scattering amplitude in pure Yang-Mills theory. We show that in special cases this expression reduces to known amplitudes - the amplitude with adjacent negative-helicity gluons, and the five gluon non-adjacent amplitude. Finally, we briefly discuss the twistor space interpretation of our result.Comment: 31 pages, 5 figures, Typos Correcte

Long-term follow-up of type II endoleak embolization reveals the need for close surveillance

ObjectiveAneurysm growth after endovascular aneurysm repair (EVAR) in patients with type II endoleak is associated with adverse outcomes. This study evaluated the long-term success of embolization of type II endoleaks in preventing aneurysm sac growth.MethodsWe retrospectively reviewed outcomes of patients who underwent infrarenal EVAR who were treated for a type II endoleak between 2000 and 2008. Computed tomography scans were evaluated for aneurysm sac growth or shrinkage from the time of treatment of the endoleak. The embolization material used, graft type, target vessel embolized, and comorbidities were evaluated for their association with sac growth or shrinkage.ResultsNinety-five patients underwent 140 embolization procedures. The mean time from EVAR to embolization was 26.1 ± 22.2 months, and the average increase in size of the aneurysm sac from EVAR to treatment was 0.7 × 0.5 cm. Patients underwent an average of 1.6 ± 0.8 embolization procedures after EVAR. Thirteen patients underwent initial simultaneous embolization of two targets. Embolization was with glue (61%), coils (29%), glue and coils (7%), and Gelfoam (3%; Pfizer Inc, New York, NY). No abdominal aortic aneurysms (AAA) ruptured. Eight patients (8.4%) underwent graft explant and open repair; 19 (20%) required two or more embolization procedures. There was no difference in the target vessel treated or the treatment used in halting sac expansion (>5 mm). Coil embolization alone resulted in more second procedures. The 5-year cumulative survival was 65% (95% confidence interval [CI], 52%-77%), freedom from explant was 89% (95% CI, 81%-97%), freedom from second embolization was 76% (95% CI, 66%-86%), and freedom from sac expansion >5 mm was 44% (95% CI 30%-50%). Univariable analysis identified continued tobacco use (hazard ratio [HR], 2.30; 95% CI, 1.02-5.13; P = .04) was associated with continued sac expansion, and hyperlipidemia (HR, 9.64; 95% CI, 2.22-41.86) was associated with patients requiring a second embolization procedure.ConclusionsEmbolization of type II endoleaks is successful early in preventing aneurysm sac growth and rupture after EVAR. However, a significant number of patients require more than one procedure, and at 5 years, many patients who underwent embolization of a type II endoleak continued to experience sac growth. Patients with hyperlipidemia who undergo coil embolization are more likely to require a second embolization procedure, and patients who smoke have a higher likelihood of AAA sac expansion after embolization. Continued long-term surveillance is necessary in this cohort of patients

Dual Giant Gravitons in Sasaki-Einstein Backgrounds

We study the dynamics of a BPS D3-brane wrapped on a three-sphere in AdS_5 x L, a so-called dual giant graviton, where L is a Sasakian five-manifold. The phase space of these configurations is the symplectic cone X over L, and geometric quantisation naturally produces a Hilbert space of L^2-normalisable holomorphic functions on X, whose states are dual to scalar chiral BPS operators in the dual superconformal field theory. We define classical and quantum partition functions and relate them to earlier mathematical constructions by the authors and S.-T. Yau, hep-th/0603021. In particular, a Sasaki-Einstein metric then minimises an entropy function associated with the D3-brane. Finally, we introduce a grand canonical partition function that counts multiple dual giant gravitons. This is related simply to the index-character of the above reference, and provides a method for counting multi-trace scalar BPS operators in the dual superconformal field theory.Comment: 38 pages, no figures; minor changes, reference adde

DarkCarb: An Innovative Approach to Infrared Imaging

DarkCarb is a pioneering Earth observation (EO) satellite, under development at SSTL, designed to acquire high resolution Mid Wave Infrared (MWIR) imagery and video from low Earth orbit. The mission will set a precedent in IR performance from a small and capable satellite platform while maintaining the SSTL cost effective approach thereby enabling a spacecraft price which makes building constellations, capable of delivering rapid re-visit and wide area coverage, an attractive and worthwhile commercial investment. The DarkCarb satellite features an innovative low mass and volume MWIR imager which, when combined with the implementation of novel image enhancement algorithms, will achieve high quality 3.5m GSD imagery. The instrument is assembled using COTS devices and components fabricated using standard industry processes, optimised for production and rapid delivery of multiple instruments to meet constellation needs. The high spatial resolution DarkCarb MWIR imagery will deliver provides several key and complementary differentiators to visible imagery and therefore has the potential to become a high value data product for the EO market. MWIR imagery provides the capability to differentiate between objects and surfaces of different temperature and emissivity. As the detectable signal is only dependent on the temperature of the scene, DarkCarb also has the ability to extend imaging opportunities into the night. The video capability allows information on highly dynamic features in scenes to be provided and will be of key interest for applications relating to human activity. The DarkCarb mission is therefore a highly innovative development which has the potential to seriously disrupt the status quo of the commercial satellite imagery market by providing affordable high quality and high resolution MWIR data which will address a range of applications. With the DarkCarb Imager currently in production this paper will showcase the development to date with initial results from recent airborne flight trials and further explain the details of the unique payload which has been designed to meet the market need for responsive delivery at the right price

Mapping the G-structures and supersymmetric vacua of five-dimensional N=4 supergravity

We classify the supersymmetric vacua of N=4, d=5 supergravity in terms of G-structures. We identify three classes of solutions: with R^3, SU(2) and generic SO(4) structure. Using the Killing spinor equations, we fully characterize the first two classes and partially solve the latter. With the N=4 graviton multiplet decomposed in terms of N=2 multiplets: the graviton, vector and gravitino multiplets, we obtain new supersymmetric solutions corresponding to turning on fields in the gravitino multiplet. These vacua are described in terms of an SO(5) vector sigma-model coupled with gravity, in three or four dimensions. A new feature of these N=4 vacua, which is not seen from an N=2 point of view, is the possibility for preserving more exotic fractions of supersymmetry. We give a few concrete examples of these new supersymmetric (albeit singular) solutions. Additionally, we show how by truncating the N=4, d=5 set of fields to minimal supergravity coupled with one vector multiplet we recover the known two-charge solutions.Comment: 31 pages, late